|Institutional Source||Beutler Lab|
|Gene Name||a disintegrin and metallopeptidase domain 7|
|Is this an essential gene?||Probably non essential (E-score: 0.073)|
|Stock #||R2353 (G1)|
|Chromosomal Location||68497336-68533741 bp(-) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||T to A at 68505088 bp|
|Amino Acid Change||Glutamine to Leucine at position 692 (Q692L)|
|Ref Sequence||ENSEMBL: ENSMUSP00000022640 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000022640]|
|Predicted Effect||probably benign
AA Change: Q692L
PolyPhen 2 Score 0.010 (Sensitivity: 0.96; Specificity: 0.77)
AA Change: Q692L
|Predicted Effect||noncoding transcript
|Meta Mutation Damage Score||0.0898|
|Coding Region Coverage||
|Validation Efficiency||100% (32/32)|
FUNCTION: This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. This gene is specifically expressed in epididymis where the encoded protein is transferred to the sperm surface during epididymal transit. This gene is located adjacent to a related gene from the ADAM family of proteins on chromosome 14. [provided by RefSeq, Oct 2015]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit reduced male fertility with decreased cell height in caput epididymis, spermatic granuloma, kinked sperm flagellum and reduced sperm motility. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Adam7||
(F):5'- ACACACAAGTTAAGTGATAGGTAGC -3'
(R):5'- CCTTTAGGGAAGAGATAAAGTTGC -3'
(F):5'- AGGTAGCTTGTACTTTCTATCAGTTC -3'
(R):5'- GCAACTATTGTTAGCAATCCACTGTC -3'