Incidental Mutation 'R2365:Or10ak7'
| ID |
246286 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Or10ak7
|
| Ensembl Gene |
ENSMUSG00000111259 |
| Gene Name |
olfactory receptor family 10 subfamily AK member 7 |
| Synonyms |
Olfr1519, MOR259-1, MOR259-13, GA_x6K02T2QD9B-18602750-18603691, MOR259-1, Olfr1328 |
| MMRRC Submission |
040346-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.083)
|
| Stock # |
R2365 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
4 |
| Chromosomal Location |
118791096-118792037 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 118791230 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamic Acid to Lysine
at position 272
(E272K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000149039
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000081960]
[ENSMUST00000215312]
|
| AlphaFold |
A0A1L1SQF6 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000081960
AA Change: E270K
PolyPhen 2
Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
|
| SMART Domains |
Protein: ENSMUSP00000080626
Gene: ENSMUSG00000111259
AA Change: E270K
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7tm_4
|
32 |
309 |
1.1e-53 |
PFAM |
|
Pfam:7TM_GPCR_Srsx
|
36 |
306 |
9.1e-8 |
PFAM |
|
Pfam:7tm_1
|
42 |
291 |
1.7e-26 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000215312
AA Change: E272K
PolyPhen 2
Score 0.022 (Sensitivity: 0.95; Specificity: 0.81)
|
| Meta Mutation Damage Score |
0.1555 |
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.7%
- 10x: 97.3%
- 20x: 94.9%
|
| Validation Efficiency |
94% (34/36) |
| MGI Phenotype |
FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 34 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Atp13a5 |
T |
A |
16: 29,070,008 (GRCm39) |
K959N |
probably benign |
Het |
| C4b |
G |
A |
17: 34,955,032 (GRCm39) |
|
probably benign |
Het |
| Cdhr2 |
T |
G |
13: 54,865,901 (GRCm39) |
S268R |
probably benign |
Het |
| Erc1 |
A |
G |
6: 119,552,656 (GRCm39) |
L1094P |
probably damaging |
Het |
| Fat3 |
G |
A |
9: 15,909,567 (GRCm39) |
S2145F |
probably damaging |
Het |
| Fat4 |
A |
G |
3: 39,034,568 (GRCm39) |
H2740R |
probably benign |
Het |
| Galnt13 |
A |
G |
2: 54,744,709 (GRCm39) |
Y136C |
possibly damaging |
Het |
| Gipc2 |
A |
G |
3: 151,833,831 (GRCm39) |
I150T |
possibly damaging |
Het |
| Gkn3 |
C |
T |
6: 87,360,507 (GRCm39) |
A163T |
probably damaging |
Het |
| Gm21957 |
T |
C |
7: 124,818,629 (GRCm39) |
|
noncoding transcript |
Het |
| Gm5591 |
T |
A |
7: 38,218,825 (GRCm39) |
R683W |
probably damaging |
Het |
| Gm826 |
A |
G |
2: 160,169,130 (GRCm39) |
S60P |
unknown |
Het |
| Hsd17b7 |
T |
C |
1: 169,792,009 (GRCm39) |
D133G |
probably damaging |
Het |
| Kera |
A |
G |
10: 97,444,805 (GRCm39) |
T55A |
probably benign |
Het |
| Mff |
T |
C |
1: 82,713,192 (GRCm39) |
V129A |
possibly damaging |
Het |
| Myo7b |
A |
G |
18: 32,147,384 (GRCm39) |
L53P |
probably damaging |
Het |
| Neo1 |
A |
G |
9: 58,863,286 (GRCm39) |
V427A |
probably benign |
Het |
| Or52e19 |
A |
T |
7: 102,959,380 (GRCm39) |
I151L |
probably benign |
Het |
| Pfkfb3 |
C |
T |
2: 11,498,713 (GRCm39) |
|
probably null |
Het |
| Pom121l2 |
A |
G |
13: 22,167,954 (GRCm39) |
T742A |
probably benign |
Het |
| Pon1 |
A |
G |
6: 5,171,746 (GRCm39) |
S302P |
probably damaging |
Het |
| Rhox3f |
G |
T |
X: 36,763,672 (GRCm39) |
E140* |
probably null |
Het |
| Sall3 |
G |
C |
18: 81,015,007 (GRCm39) |
P974A |
probably benign |
Het |
| Slc1a2 |
T |
A |
2: 102,578,798 (GRCm39) |
|
probably null |
Het |
| Slc22a6 |
A |
G |
19: 8,596,761 (GRCm39) |
T180A |
probably benign |
Het |
| Slc40a1 |
T |
C |
1: 45,963,873 (GRCm39) |
|
probably null |
Het |
| Slc6a5 |
T |
C |
7: 49,596,284 (GRCm39) |
S585P |
possibly damaging |
Het |
| Tbpl1 |
A |
G |
10: 22,581,785 (GRCm39) |
V164A |
possibly damaging |
Het |
| Tmem98 |
A |
T |
11: 80,706,511 (GRCm39) |
I95F |
probably damaging |
Het |
| Ush2a |
C |
A |
1: 188,111,188 (GRCm39) |
P571T |
possibly damaging |
Het |
| Vars1 |
A |
G |
17: 35,234,428 (GRCm39) |
N1125D |
probably benign |
Het |
| Vps13d |
T |
C |
4: 144,813,894 (GRCm39) |
|
probably benign |
Het |
| Zbtb18 |
A |
T |
1: 177,275,723 (GRCm39) |
E361V |
probably benign |
Het |
| Zc3hav1 |
A |
G |
6: 38,317,168 (GRCm39) |
F144S |
probably damaging |
Het |
|
| Other mutations in Or10ak7 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL02491:Or10ak7
|
APN |
4 |
118,791,358 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02685:Or10ak7
|
APN |
4 |
118,791,134 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
IGL02886:Or10ak7
|
APN |
4 |
118,792,027 (GRCm39) |
missense |
probably benign |
|
|
IGL02899:Or10ak7
|
APN |
4 |
118,791,859 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02957:Or10ak7
|
APN |
4 |
118,791,316 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4453001:Or10ak7
|
UTSW |
4 |
118,791,823 (GRCm39) |
missense |
probably benign |
|
|
R0211:Or10ak7
|
UTSW |
4 |
118,791,467 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0211:Or10ak7
|
UTSW |
4 |
118,791,467 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1158:Or10ak7
|
UTSW |
4 |
118,791,614 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1450:Or10ak7
|
UTSW |
4 |
118,791,707 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1682:Or10ak7
|
UTSW |
4 |
118,791,778 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1978:Or10ak7
|
UTSW |
4 |
118,791,381 (GRCm39) |
nonsense |
probably null |
|
|
R2363:Or10ak7
|
UTSW |
4 |
118,791,230 (GRCm39) |
missense |
probably benign |
0.02 |
|
R2364:Or10ak7
|
UTSW |
4 |
118,791,230 (GRCm39) |
missense |
probably benign |
0.02 |
|
R2507:Or10ak7
|
UTSW |
4 |
118,791,122 (GRCm39) |
missense |
probably benign |
|
|
R2912:Or10ak7
|
UTSW |
4 |
118,791,898 (GRCm39) |
missense |
probably benign |
0.28 |
|
R3937:Or10ak7
|
UTSW |
4 |
118,791,880 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4058:Or10ak7
|
UTSW |
4 |
118,791,880 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4089:Or10ak7
|
UTSW |
4 |
118,791,230 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4090:Or10ak7
|
UTSW |
4 |
118,791,230 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4419:Or10ak7
|
UTSW |
4 |
118,791,586 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R4717:Or10ak7
|
UTSW |
4 |
118,791,626 (GRCm39) |
missense |
probably benign |
0.45 |
|
R5570:Or10ak7
|
UTSW |
4 |
118,791,263 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R5591:Or10ak7
|
UTSW |
4 |
118,791,658 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6149:Or10ak7
|
UTSW |
4 |
118,791,628 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7202:Or10ak7
|
UTSW |
4 |
118,791,215 (GRCm39) |
missense |
probably benign |
|
|
R7214:Or10ak7
|
UTSW |
4 |
118,791,146 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R7391:Or10ak7
|
UTSW |
4 |
118,791,198 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R7666:Or10ak7
|
UTSW |
4 |
118,791,461 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7676:Or10ak7
|
UTSW |
4 |
118,791,347 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8053:Or10ak7
|
UTSW |
4 |
118,791,308 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8311:Or10ak7
|
UTSW |
4 |
118,791,347 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9540:Or10ak7
|
UTSW |
4 |
118,792,034 (GRCm39) |
missense |
probably benign |
|
|
Z1176:Or10ak7
|
UTSW |
4 |
118,791,115 (GRCm39) |
missense |
probably benign |
0.19 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGGTTCAAATGCACAGATCAACTTC -3'
(R):5'- ACCCACCTCATTGAGATGGTG -3'
Sequencing Primer
(F):5'- AGACACTGAACTTTTCTTAAAGAGTG -3'
(R):5'- CACCTCATTGAGATGGTGGACTTTG -3'
|
| Posted On |
2014-10-30 |
Incidental Mutation