Mutagenetix > Incidental Mutation

Incidental Mutation 'R2365:Gm21957'

246295

Institutional Source

Beutler Lab

Gene Symbol

Gm21957

Ensembl Gene

ENSMUSG00000073844

Gene Name

predicted gene, 21957

Synonyms

MMRRC Submission

040346-MU

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.349) question?

Stock #

R2365 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

124818621-124819058 bp(-) (GRCm39)

Type of Mutation

exon

DNA Base Change (assembly)

T to C at 124818629 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Gene Model

predicted gene model for transcript(s):

AlphaFold

no structure available at present

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000073056

SMART Domains

Protein: ENSMUSP00000137545
Gene: ENSMUSG00000073844

Domain	Start	End	E-Value	Type
Pfam:Ribosomal_S7e	7	140	1.8e-45	PFAM

Meta Mutation Damage Score

0.0869

Coding Region Coverage

1x: 99.3%
3x: 98.7%
10x: 97.3%
20x: 94.9%

Validation Efficiency

94% (34/36)

Allele List at MGI

Other mutations in this stock

Total: 34 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Atp13a5	T	A	16: 29,070,008 (GRCm39)	K959N	probably benign	Het
C4b	G	A	17: 34,955,032 (GRCm39)		probably benign	Het
Cdhr2	T	G	13: 54,865,901 (GRCm39)	S268R	probably benign	Het
Erc1	A	G	6: 119,552,656 (GRCm39)	L1094P	probably damaging	Het
Fat3	G	A	9: 15,909,567 (GRCm39)	S2145F	probably damaging	Het
Fat4	A	G	3: 39,034,568 (GRCm39)	H2740R	probably benign	Het
Galnt13	A	G	2: 54,744,709 (GRCm39)	Y136C	possibly damaging	Het
Gipc2	A	G	3: 151,833,831 (GRCm39)	I150T	possibly damaging	Het
Gkn3	C	T	6: 87,360,507 (GRCm39)	A163T	probably damaging	Het
Gm5591	T	A	7: 38,218,825 (GRCm39)	R683W	probably damaging	Het
Gm826	A	G	2: 160,169,130 (GRCm39)	S60P	unknown	Het
Hsd17b7	T	C	1: 169,792,009 (GRCm39)	D133G	probably damaging	Het
Kera	A	G	10: 97,444,805 (GRCm39)	T55A	probably benign	Het
Mff	T	C	1: 82,713,192 (GRCm39)	V129A	possibly damaging	Het
Myo7b	A	G	18: 32,147,384 (GRCm39)	L53P	probably damaging	Het
Neo1	A	G	9: 58,863,286 (GRCm39)	V427A	probably benign	Het
Or10ak7	C	T	4: 118,791,230 (GRCm39)	E272K	probably benign	Het
Or52e19	A	T	7: 102,959,380 (GRCm39)	I151L	probably benign	Het
Pfkfb3	C	T	2: 11,498,713 (GRCm39)		probably null	Het
Pom121l2	A	G	13: 22,167,954 (GRCm39)	T742A	probably benign	Het
Pon1	A	G	6: 5,171,746 (GRCm39)	S302P	probably damaging	Het
Rhox3f	G	T	X: 36,763,672 (GRCm39)	E140*	probably null	Het
Sall3	G	C	18: 81,015,007 (GRCm39)	P974A	probably benign	Het
Slc1a2	T	A	2: 102,578,798 (GRCm39)		probably null	Het
Slc22a6	A	G	19: 8,596,761 (GRCm39)	T180A	probably benign	Het
Slc40a1	T	C	1: 45,963,873 (GRCm39)		probably null	Het
Slc6a5	T	C	7: 49,596,284 (GRCm39)	S585P	possibly damaging	Het
Tbpl1	A	G	10: 22,581,785 (GRCm39)	V164A	possibly damaging	Het
Tmem98	A	T	11: 80,706,511 (GRCm39)	I95F	probably damaging	Het
Ush2a	C	A	1: 188,111,188 (GRCm39)	P571T	possibly damaging	Het
Vars1	A	G	17: 35,234,428 (GRCm39)	N1125D	probably benign	Het
Vps13d	T	C	4: 144,813,894 (GRCm39)		probably benign	Het
Zbtb18	A	T	1: 177,275,723 (GRCm39)	E361V	probably benign	Het
Zc3hav1	A	G	6: 38,317,168 (GRCm39)	F144S	probably damaging	Het

Other mutations in Gm21957

Allele	Source	Chr	Coord	Type	Predicted Effect
IGL01951:Gm21957	APN	7	124,819,004 (GRCm39)	exon	noncoding transcript
IGL03008:Gm21957	APN	7	124,818,733 (GRCm39)	exon	noncoding transcript
R2086:Gm21957	UTSW	7	124,818,878 (GRCm39)	exon	noncoding transcript
R2141:Gm21957	UTSW	7	124,818,625 (GRCm39)	exon	noncoding transcript

Predicted Primers

PCR Primer
(F):5'- TCCCAGCAAGGACAAGAGTTAC -3'
(R):5'- TCCAAGTCTGGCTAGTTCATG -3'

Sequencing Primer
(F):5'- CAAGAGTTACAGCGGGGAC -3'
(R):5'- CCAAGTCTGGCTAGTTCATGAATTG -3'

Posted On

2014-10-30