Incidental Mutation 'R2332:Rmdn3'
ID 246453
Institutional Source Beutler Lab
Gene Symbol Rmdn3
Ensembl Gene ENSMUSG00000070730
Gene Name regulator of microtubule dynamics 3
Synonyms Fam82a2, 1200015F23Rik
MMRRC Submission 040322-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R2332 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 118967482-118987515 bp(-) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) A to T at 118984008 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000115973 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000094695] [ENSMUST00000129351] [ENSMUST00000135419] [ENSMUST00000139519]
AlphaFold Q3UJU9
Predicted Effect probably benign
Transcript: ENSMUST00000094695
SMART Domains Protein: ENSMUSP00000092283
Gene: ENSMUSG00000070730

DomainStartEndE-ValueType
transmembrane domain 13 35 N/A INTRINSIC
coiled coil region 91 122 N/A INTRINSIC
low complexity region 135 148 N/A INTRINSIC
low complexity region 216 234 N/A INTRINSIC
SCOP:d1hxia_ 354 445 1e-7 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000129351
SMART Domains Protein: ENSMUSP00000119498
Gene: ENSMUSG00000070730

DomainStartEndE-ValueType
transmembrane domain 10 32 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000135419
SMART Domains Protein: ENSMUSP00000123373
Gene: ENSMUSG00000070730

DomainStartEndE-ValueType
transmembrane domain 10 32 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000139519
SMART Domains Protein: ENSMUSP00000115973
Gene: ENSMUSG00000070730

DomainStartEndE-ValueType
transmembrane domain 10 32 N/A INTRINSIC
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 94.8%
Validation Efficiency 98% (47/48)
MGI Phenotype PHENOTYPE: Phenotypic analysis of mice homozygous for a gene trap allele indicates this mutation has no notable phenotype in any parameter tested. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Apc T C 18: 34,450,112 (GRCm39) I2302T possibly damaging Het
Apoa4 G A 9: 46,153,653 (GRCm39) V85I probably benign Het
Banf1 C T 19: 5,415,058 (GRCm39) W84* probably null Het
Cdk13 A G 13: 17,893,280 (GRCm39) L627P probably damaging Het
Cep250 A G 2: 155,832,527 (GRCm39) E1483G probably damaging Het
Crygs C T 16: 22,624,301 (GRCm39) G102D possibly damaging Het
Ddx60 A G 8: 62,490,125 (GRCm39) E1698G probably benign Het
Depdc1a C A 3: 159,229,503 (GRCm39) Q612K probably damaging Het
Dnaja2 G A 8: 86,266,765 (GRCm39) R321C probably damaging Het
Fam186b T A 15: 99,178,309 (GRCm39) E339V probably benign Het
Fga T C 3: 82,938,704 (GRCm39) F360L probably damaging Het
Fut9 C T 4: 25,619,823 (GRCm39) W330* probably null Het
Ghr T C 15: 3,349,891 (GRCm39) N429S probably benign Het
Gm5444 A T 13: 4,883,624 (GRCm39) noncoding transcript Het
Hjurp G C 1: 88,204,937 (GRCm39) probably benign Het
Hoxa5 T C 6: 52,179,659 (GRCm39) I239V probably damaging Het
Hps6 T C 19: 45,992,930 (GRCm39) V289A possibly damaging Het
Iqcb1 A G 16: 36,663,801 (GRCm39) N190D possibly damaging Het
Map3k13 G A 16: 21,717,427 (GRCm39) probably null Het
Or10ag53 T C 2: 87,083,217 (GRCm39) V312A possibly damaging Het
Or52d13 A G 7: 103,110,293 (GRCm39) Y41H probably damaging Het
Pacsin1 A G 17: 27,923,885 (GRCm39) E93G possibly damaging Het
Pds5a A G 5: 65,784,422 (GRCm39) probably null Het
Ppp1r9b A T 11: 94,887,435 (GRCm39) E482D probably damaging Het
Rhobtb3 A G 13: 76,058,971 (GRCm39) S276P probably benign Het
Rimbp2 A G 5: 128,866,705 (GRCm39) V538A probably benign Het
Setx GTGGCT GT 2: 29,044,073 (GRCm39) 1814 probably null Het
Sh3rf1 C T 8: 61,679,321 (GRCm39) P121L probably benign Het
Slc4a11 A T 2: 130,526,379 (GRCm39) V855D probably benign Het
Speer4f1 C A 5: 17,684,522 (GRCm39) N183K probably damaging Het
Sstr4 A T 2: 148,238,330 (GRCm39) N314Y probably damaging Het
Synj2 A G 17: 6,074,069 (GRCm39) K288E probably damaging Het
Trhde T A 10: 114,428,070 (GRCm39) N409Y probably damaging Het
Ttn A T 2: 76,611,483 (GRCm39) W15604R probably damaging Het
Ugdh C T 5: 65,584,827 (GRCm39) V32I possibly damaging Het
Uhrf1 C A 17: 56,617,671 (GRCm39) probably null Het
Vps13d G T 4: 144,875,256 (GRCm39) D1750E probably benign Het
Wdfy3 A G 5: 102,036,189 (GRCm39) probably benign Het
Wnt4 C A 4: 137,023,831 (GRCm39) T266K probably benign Het
Wtap C T 17: 13,186,425 (GRCm39) R374Q possibly damaging Het
Zfp322a A T 13: 23,541,494 (GRCm39) C83S probably damaging Het
Other mutations in Rmdn3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01374:Rmdn3 APN 2 118,984,428 (GRCm39) missense probably damaging 1.00
IGL01684:Rmdn3 APN 2 118,978,055 (GRCm39) missense probably damaging 1.00
IGL02892:Rmdn3 APN 2 118,984,561 (GRCm39) missense probably benign 0.00
R0534:Rmdn3 UTSW 2 118,976,851 (GRCm39) missense probably benign 0.00
R1126:Rmdn3 UTSW 2 118,984,476 (GRCm39) missense probably benign 0.01
R3850:Rmdn3 UTSW 2 118,986,903 (GRCm39) missense possibly damaging 0.65
R5034:Rmdn3 UTSW 2 118,978,058 (GRCm39) missense probably damaging 1.00
R5221:Rmdn3 UTSW 2 118,986,935 (GRCm39) missense probably damaging 1.00
R5942:Rmdn3 UTSW 2 118,978,058 (GRCm39) missense probably damaging 1.00
R6049:Rmdn3 UTSW 2 118,983,906 (GRCm39) missense probably damaging 1.00
R6188:Rmdn3 UTSW 2 118,969,831 (GRCm39) critical splice donor site probably null
R7011:Rmdn3 UTSW 2 118,968,904 (GRCm39) missense probably damaging 1.00
R7181:Rmdn3 UTSW 2 118,969,849 (GRCm39) missense probably damaging 1.00
R8277:Rmdn3 UTSW 2 118,976,905 (GRCm39) missense probably damaging 1.00
R8721:Rmdn3 UTSW 2 118,969,846 (GRCm39) missense possibly damaging 0.87
R9144:Rmdn3 UTSW 2 118,969,847 (GRCm39) missense probably benign 0.21
R9172:Rmdn3 UTSW 2 118,968,863 (GRCm39) missense probably benign 0.00
R9317:Rmdn3 UTSW 2 118,986,991 (GRCm39) missense unknown
R9727:Rmdn3 UTSW 2 118,968,827 (GRCm39) critical splice donor site probably null
Predicted Primers PCR Primer
(F):5'- AGTACAATGTCGCTGGACG -3'
(R):5'- TAATCGCGTTGCTCCTGCTG -3'

Sequencing Primer
(F):5'- AATGTCGCTGGACGCACAC -3'
(R):5'- TTGGCCTATTGAAGCAGCC -3'
Posted On 2014-10-30