Incidental Mutation 'R2332:Sstr4'
ID 246455
Institutional Source Beutler Lab
Gene Symbol Sstr4
Ensembl Gene ENSMUSG00000037014
Gene Name somatostatin receptor 4
Synonyms Smstr4, sst4
MMRRC Submission 040322-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.192) question?
Stock # R2332 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 148237297-148238684 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 148238330 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Tyrosine at position 314 (N314Y)
Ref Sequence ENSEMBL: ENSMUSP00000105588 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000109962]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000109962
AA Change: N314Y

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000105588
Gene: ENSMUSG00000037014
AA Change: N314Y

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srsx 55 323 4.7e-16 PFAM
Pfam:7tm_1 61 308 2.2e-61 PFAM
Pfam:7TM_GPCR_Srv 117 325 1.8e-10 PFAM
Pfam:7TM_GPCR_Srw 203 326 8.1e-9 PFAM
Meta Mutation Damage Score 0.5412 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 94.8%
Validation Efficiency 98% (47/48)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR4 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in fetal and adult brain and lung. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygote null mice have increased susceptibility to inflammation, delayed type hypersensitivity, hyperalgesia and airway hypersensitivity. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Apc T C 18: 34,450,112 (GRCm39) I2302T possibly damaging Het
Apoa4 G A 9: 46,153,653 (GRCm39) V85I probably benign Het
Banf1 C T 19: 5,415,058 (GRCm39) W84* probably null Het
Cdk13 A G 13: 17,893,280 (GRCm39) L627P probably damaging Het
Cep250 A G 2: 155,832,527 (GRCm39) E1483G probably damaging Het
Crygs C T 16: 22,624,301 (GRCm39) G102D possibly damaging Het
Ddx60 A G 8: 62,490,125 (GRCm39) E1698G probably benign Het
Depdc1a C A 3: 159,229,503 (GRCm39) Q612K probably damaging Het
Dnaja2 G A 8: 86,266,765 (GRCm39) R321C probably damaging Het
Fam186b T A 15: 99,178,309 (GRCm39) E339V probably benign Het
Fga T C 3: 82,938,704 (GRCm39) F360L probably damaging Het
Fut9 C T 4: 25,619,823 (GRCm39) W330* probably null Het
Ghr T C 15: 3,349,891 (GRCm39) N429S probably benign Het
Gm5444 A T 13: 4,883,624 (GRCm39) noncoding transcript Het
Hjurp G C 1: 88,204,937 (GRCm39) probably benign Het
Hoxa5 T C 6: 52,179,659 (GRCm39) I239V probably damaging Het
Hps6 T C 19: 45,992,930 (GRCm39) V289A possibly damaging Het
Iqcb1 A G 16: 36,663,801 (GRCm39) N190D possibly damaging Het
Map3k13 G A 16: 21,717,427 (GRCm39) probably null Het
Or10ag53 T C 2: 87,083,217 (GRCm39) V312A possibly damaging Het
Or52d13 A G 7: 103,110,293 (GRCm39) Y41H probably damaging Het
Pacsin1 A G 17: 27,923,885 (GRCm39) E93G possibly damaging Het
Pds5a A G 5: 65,784,422 (GRCm39) probably null Het
Ppp1r9b A T 11: 94,887,435 (GRCm39) E482D probably damaging Het
Rhobtb3 A G 13: 76,058,971 (GRCm39) S276P probably benign Het
Rimbp2 A G 5: 128,866,705 (GRCm39) V538A probably benign Het
Rmdn3 A T 2: 118,984,008 (GRCm39) probably benign Het
Setx GTGGCT GT 2: 29,044,073 (GRCm39) 1814 probably null Het
Sh3rf1 C T 8: 61,679,321 (GRCm39) P121L probably benign Het
Slc4a11 A T 2: 130,526,379 (GRCm39) V855D probably benign Het
Speer4f1 C A 5: 17,684,522 (GRCm39) N183K probably damaging Het
Synj2 A G 17: 6,074,069 (GRCm39) K288E probably damaging Het
Trhde T A 10: 114,428,070 (GRCm39) N409Y probably damaging Het
Ttn A T 2: 76,611,483 (GRCm39) W15604R probably damaging Het
Ugdh C T 5: 65,584,827 (GRCm39) V32I possibly damaging Het
Uhrf1 C A 17: 56,617,671 (GRCm39) probably null Het
Vps13d G T 4: 144,875,256 (GRCm39) D1750E probably benign Het
Wdfy3 A G 5: 102,036,189 (GRCm39) probably benign Het
Wnt4 C A 4: 137,023,831 (GRCm39) T266K probably benign Het
Wtap C T 17: 13,186,425 (GRCm39) R374Q possibly damaging Het
Zfp322a A T 13: 23,541,494 (GRCm39) C83S probably damaging Het
Other mutations in Sstr4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01325:Sstr4 APN 2 148,237,472 (GRCm39) missense probably benign 0.00
IGL01536:Sstr4 APN 2 148,237,800 (GRCm39) missense probably damaging 1.00
IGL02210:Sstr4 APN 2 148,238,229 (GRCm39) missense probably damaging 1.00
IGL02670:Sstr4 APN 2 148,238,453 (GRCm39) nonsense probably null
R0396:Sstr4 UTSW 2 148,238,181 (GRCm39) missense probably damaging 1.00
R1428:Sstr4 UTSW 2 148,238,279 (GRCm39) missense probably benign 0.01
R1839:Sstr4 UTSW 2 148,237,453 (GRCm39) missense probably benign 0.21
R2943:Sstr4 UTSW 2 148,238,085 (GRCm39) missense probably damaging 0.96
R3700:Sstr4 UTSW 2 148,238,273 (GRCm39) missense possibly damaging 0.57
R5502:Sstr4 UTSW 2 148,237,471 (GRCm39) small insertion probably benign
R5503:Sstr4 UTSW 2 148,237,471 (GRCm39) small insertion probably benign
R5596:Sstr4 UTSW 2 148,237,652 (GRCm39) missense possibly damaging 0.65
R5726:Sstr4 UTSW 2 148,238,003 (GRCm39) missense probably damaging 1.00
R6985:Sstr4 UTSW 2 148,238,169 (GRCm39) missense probably damaging 0.97
R8939:Sstr4 UTSW 2 148,238,228 (GRCm39) missense probably damaging 1.00
R8943:Sstr4 UTSW 2 148,237,782 (GRCm39) missense possibly damaging 0.94
X0022:Sstr4 UTSW 2 148,237,452 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- CTTATTGTGGGCAAGATGCG -3'
(R):5'- TTGCTTGCAGCCAGGTTCTG -3'

Sequencing Primer
(F):5'- AGATCACTAGGCTCGTGCTAATG -3'
(R):5'- AGCCAGGTTCTGCTTGCAC -3'
Posted On 2014-10-30