Incidental Mutation 'R2354:Zfp358'
ID 246830
Institutional Source Beutler Lab
Gene Symbol Zfp358
Ensembl Gene ENSMUSG00000047264
Gene Name zinc finger protein 358
Synonyms Zfend
MMRRC Submission 040336-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.140) question?
Stock # R2354 (G1)
Quality Score 225
Status Validated
Chromosome 8
Chromosomal Location 3543138-3547208 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 3545454 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Leucine at position 12 (H12L)
Ref Sequence ENSEMBL: ENSMUSP00000146953 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000061508] [ENSMUST00000207318] [ENSMUST00000208423]
AlphaFold E9Q8M1
Predicted Effect possibly damaging
Transcript: ENSMUST00000061508
AA Change: H12L

PolyPhen 2 Score 0.948 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000060344
Gene: ENSMUSG00000047264
AA Change: H12L

DomainStartEndE-ValueType
low complexity region 24 49 N/A INTRINSIC
ZnF_C2H2 154 176 1.47e-3 SMART
ZnF_C2H2 182 204 2.95e-3 SMART
ZnF_C2H2 210 232 1.67e-2 SMART
ZnF_C2H2 238 260 3.63e-3 SMART
ZnF_C2H2 266 288 2.4e-3 SMART
ZnF_C2H2 294 316 1.4e-4 SMART
ZnF_C2H2 322 344 4.01e-5 SMART
ZnF_C2H2 350 372 2.4e-3 SMART
ZnF_C2H2 378 400 1.84e-4 SMART
low complexity region 422 430 N/A INTRINSIC
low complexity region 447 473 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000207318
AA Change: H39L

PolyPhen 2 Score 0.663 (Sensitivity: 0.86; Specificity: 0.91)
Predicted Effect possibly damaging
Transcript: ENSMUST00000208423
AA Change: H12L

PolyPhen 2 Score 0.948 (Sensitivity: 0.79; Specificity: 0.95)
Meta Mutation Damage Score 0.1737 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.2%
Validation Efficiency 97% (34/35)
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ap3b2 C T 7: 81,123,598 (GRCm39) probably benign Het
B4galt3 C A 1: 171,101,613 (GRCm39) H196N probably damaging Het
Bpifb9b C T 2: 154,153,662 (GRCm39) L243F probably benign Het
Cd226 A T 18: 89,265,107 (GRCm39) probably null Het
Cdh15 G A 8: 123,588,763 (GRCm39) R279Q probably damaging Het
Cep295 A G 9: 15,246,080 (GRCm39) I792T possibly damaging Het
Cfap46 T C 7: 139,240,962 (GRCm39) Y469C probably damaging Het
Col9a2 C G 4: 120,911,455 (GRCm39) R599G probably damaging Het
D630045J12Rik G A 6: 38,135,026 (GRCm39) P1385S possibly damaging Het
Ddb1 A T 19: 10,584,337 (GRCm39) M64L probably benign Het
Dyrk1b G A 7: 27,884,797 (GRCm39) R404Q possibly damaging Het
Gal3st2b A G 1: 93,867,508 (GRCm39) T52A probably damaging Het
Galk2 C A 2: 125,773,193 (GRCm39) S208R probably benign Het
Hap1 A T 11: 100,245,541 (GRCm39) I141N probably damaging Het
Hif3a T C 7: 16,775,030 (GRCm39) S523G probably damaging Het
Kirrel1 C T 3: 86,995,792 (GRCm39) V381I probably damaging Het
Lmbrd1 T C 1: 24,724,622 (GRCm39) S69P probably damaging Het
Lrriq1 C T 10: 103,025,848 (GRCm39) V925M probably damaging Het
Mmp16 A G 4: 18,112,001 (GRCm39) Y459C probably damaging Het
Mtr A G 13: 12,203,043 (GRCm39) probably benign Het
Nadk2 T A 15: 9,085,862 (GRCm39) I167N probably damaging Het
Neo1 A G 9: 58,892,917 (GRCm39) F242L probably benign Het
Pitpnm2 A T 5: 124,260,982 (GRCm39) V1010E probably damaging Het
Prp2rt G A 13: 97,235,309 (GRCm39) T146I probably damaging Het
Semp2l2b G T 10: 21,943,155 (GRCm39) T275K probably benign Het
Shox2 A G 3: 66,888,822 (GRCm39) I23T possibly damaging Het
Slc5a12 T C 2: 110,439,777 (GRCm39) V141A probably damaging Het
Sstr5 A G 17: 25,710,875 (GRCm39) I118T probably benign Het
Taar4 A G 10: 23,836,912 (GRCm39) N174S probably damaging Het
Tpcn2 C A 7: 144,810,955 (GRCm39) G581W probably damaging Het
Umod C T 7: 119,065,416 (GRCm39) V538M probably damaging Het
Vmn2r44 T G 7: 8,373,639 (GRCm39) S517R probably damaging Het
Zc3h12d G T 10: 7,743,702 (GRCm39) V491L probably benign Het
Zkscan7 A G 9: 122,723,892 (GRCm39) D287G probably benign Het
Other mutations in Zfp358
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01405:Zfp358 APN 8 3,545,663 (GRCm39) missense probably benign 0.19
IGL02301:Zfp358 APN 8 3,546,858 (GRCm39) missense probably benign
IGL02510:Zfp358 APN 8 3,546,786 (GRCm39) missense probably benign 0.04
IGL02860:Zfp358 APN 8 3,546,074 (GRCm39) missense probably damaging 1.00
R1018:Zfp358 UTSW 8 3,546,843 (GRCm39) nonsense probably null
R1960:Zfp358 UTSW 8 3,545,742 (GRCm39) missense possibly damaging 0.46
R2047:Zfp358 UTSW 8 3,545,934 (GRCm39) missense probably damaging 1.00
R2202:Zfp358 UTSW 8 3,546,995 (GRCm39) missense possibly damaging 0.80
R4688:Zfp358 UTSW 8 3,545,493 (GRCm39) missense probably damaging 1.00
R4689:Zfp358 UTSW 8 3,546,146 (GRCm39) splice site probably null
R4876:Zfp358 UTSW 8 3,546,170 (GRCm39) missense probably damaging 0.98
R5830:Zfp358 UTSW 8 3,545,846 (GRCm39) missense probably benign 0.36
R6589:Zfp358 UTSW 8 3,545,907 (GRCm39) missense probably damaging 0.99
R6834:Zfp358 UTSW 8 3,545,613 (GRCm39) missense probably benign 0.19
R9043:Zfp358 UTSW 8 3,545,810 (GRCm39) missense probably benign 0.01
R9357:Zfp358 UTSW 8 3,545,568 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TCTTCCAAATCCTAGCTGGGAC -3'
(R):5'- TCTGCTTCAGGGTCCAGATC -3'

Sequencing Primer
(F):5'- GACACCGGTTAGGACTCTTC -3'
(R):5'- CAGGGTCCAGATCTTCTAAGCTG -3'
Posted On 2014-10-30