Incidental Mutation 'R2354:Taar4'
| ID |
246837 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Taar4
|
| Ensembl Gene |
ENSMUSG00000069707 |
| Gene Name |
trace amine-associated receptor 4 |
| Synonyms |
|
| MMRRC Submission |
040336-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.122)
|
| Stock # |
R2354 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
10 |
| Chromosomal Location |
23836392-23837435 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 23836912 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Asparagine to Serine
at position 174
(N174S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000090330
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000092660]
|
| AlphaFold |
Q5QD15 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000092660
AA Change: N174S
PolyPhen 2
Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000090330
Gene: ENSMUSG00000069707
AA Change: N174S
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7TM_GPCR_Srsx
|
44 |
328 |
9.2e-11 |
PFAM |
|
Pfam:7tm_1
|
50 |
313 |
4.6e-63 |
PFAM |
|
| Meta Mutation Damage Score |
0.6467 |
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.7%
- 10x: 97.4%
- 20x: 95.2%
|
| Validation Efficiency |
97% (34/35) |
| MGI Phenotype |
PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired olfactory response and aversion to PEA and puma urine. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 34 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Ap3b2 |
C |
T |
7: 81,123,598 (GRCm39) |
|
probably benign |
Het |
| B4galt3 |
C |
A |
1: 171,101,613 (GRCm39) |
H196N |
probably damaging |
Het |
| Bpifb9b |
C |
T |
2: 154,153,662 (GRCm39) |
L243F |
probably benign |
Het |
| Cd226 |
A |
T |
18: 89,265,107 (GRCm39) |
|
probably null |
Het |
| Cdh15 |
G |
A |
8: 123,588,763 (GRCm39) |
R279Q |
probably damaging |
Het |
| Cep295 |
A |
G |
9: 15,246,080 (GRCm39) |
I792T |
possibly damaging |
Het |
| Cfap46 |
T |
C |
7: 139,240,962 (GRCm39) |
Y469C |
probably damaging |
Het |
| Col9a2 |
C |
G |
4: 120,911,455 (GRCm39) |
R599G |
probably damaging |
Het |
| D630045J12Rik |
G |
A |
6: 38,135,026 (GRCm39) |
P1385S |
possibly damaging |
Het |
| Ddb1 |
A |
T |
19: 10,584,337 (GRCm39) |
M64L |
probably benign |
Het |
| Dyrk1b |
G |
A |
7: 27,884,797 (GRCm39) |
R404Q |
possibly damaging |
Het |
| Gal3st2b |
A |
G |
1: 93,867,508 (GRCm39) |
T52A |
probably damaging |
Het |
| Galk2 |
C |
A |
2: 125,773,193 (GRCm39) |
S208R |
probably benign |
Het |
| Hap1 |
A |
T |
11: 100,245,541 (GRCm39) |
I141N |
probably damaging |
Het |
| Hif3a |
T |
C |
7: 16,775,030 (GRCm39) |
S523G |
probably damaging |
Het |
| Kirrel1 |
C |
T |
3: 86,995,792 (GRCm39) |
V381I |
probably damaging |
Het |
| Lmbrd1 |
T |
C |
1: 24,724,622 (GRCm39) |
S69P |
probably damaging |
Het |
| Lrriq1 |
C |
T |
10: 103,025,848 (GRCm39) |
V925M |
probably damaging |
Het |
| Mmp16 |
A |
G |
4: 18,112,001 (GRCm39) |
Y459C |
probably damaging |
Het |
| Mtr |
A |
G |
13: 12,203,043 (GRCm39) |
|
probably benign |
Het |
| Nadk2 |
T |
A |
15: 9,085,862 (GRCm39) |
I167N |
probably damaging |
Het |
| Neo1 |
A |
G |
9: 58,892,917 (GRCm39) |
F242L |
probably benign |
Het |
| Pitpnm2 |
A |
T |
5: 124,260,982 (GRCm39) |
V1010E |
probably damaging |
Het |
| Prp2rt |
G |
A |
13: 97,235,309 (GRCm39) |
T146I |
probably damaging |
Het |
| Semp2l2b |
G |
T |
10: 21,943,155 (GRCm39) |
T275K |
probably benign |
Het |
| Shox2 |
A |
G |
3: 66,888,822 (GRCm39) |
I23T |
possibly damaging |
Het |
| Slc5a12 |
T |
C |
2: 110,439,777 (GRCm39) |
V141A |
probably damaging |
Het |
| Sstr5 |
A |
G |
17: 25,710,875 (GRCm39) |
I118T |
probably benign |
Het |
| Tpcn2 |
C |
A |
7: 144,810,955 (GRCm39) |
G581W |
probably damaging |
Het |
| Umod |
C |
T |
7: 119,065,416 (GRCm39) |
V538M |
probably damaging |
Het |
| Vmn2r44 |
T |
G |
7: 8,373,639 (GRCm39) |
S517R |
probably damaging |
Het |
| Zc3h12d |
G |
T |
10: 7,743,702 (GRCm39) |
V491L |
probably benign |
Het |
| Zfp358 |
A |
T |
8: 3,545,454 (GRCm39) |
H12L |
possibly damaging |
Het |
| Zkscan7 |
A |
G |
9: 122,723,892 (GRCm39) |
D287G |
probably benign |
Het |
|
| Other mutations in Taar4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL02576:Taar4
|
APN |
10 |
23,836,909 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03202:Taar4
|
APN |
10 |
23,836,692 (GRCm39) |
missense |
probably damaging |
1.00 |
|
I2288:Taar4
|
UTSW |
10 |
23,836,818 (GRCm39) |
missense |
probably benign |
0.03 |
|
R0103:Taar4
|
UTSW |
10 |
23,837,304 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0103:Taar4
|
UTSW |
10 |
23,837,304 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0514:Taar4
|
UTSW |
10 |
23,836,780 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1222:Taar4
|
UTSW |
10 |
23,837,230 (GRCm39) |
missense |
probably benign |
0.05 |
|
R1248:Taar4
|
UTSW |
10 |
23,836,936 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1514:Taar4
|
UTSW |
10 |
23,836,510 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R1921:Taar4
|
UTSW |
10 |
23,837,239 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2074:Taar4
|
UTSW |
10 |
23,837,071 (GRCm39) |
missense |
probably benign |
0.18 |
|
R2392:Taar4
|
UTSW |
10 |
23,837,172 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2698:Taar4
|
UTSW |
10 |
23,837,328 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3902:Taar4
|
UTSW |
10 |
23,836,913 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4688:Taar4
|
UTSW |
10 |
23,836,731 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5495:Taar4
|
UTSW |
10 |
23,837,181 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5595:Taar4
|
UTSW |
10 |
23,836,639 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5773:Taar4
|
UTSW |
10 |
23,837,056 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7403:Taar4
|
UTSW |
10 |
23,836,957 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7581:Taar4
|
UTSW |
10 |
23,837,052 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7736:Taar4
|
UTSW |
10 |
23,836,897 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7859:Taar4
|
UTSW |
10 |
23,837,032 (GRCm39) |
missense |
probably benign |
0.35 |
|
R8676:Taar4
|
UTSW |
10 |
23,836,801 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
| Predicted Primers |
PCR Primer
(F):5'- CAGCTGCTGTGACATCATGC -3'
(R):5'- GGCCTGTTTTGTCCTAGGAC -3'
Sequencing Primer
(F):5'- GCTGTGACATCATGCTCTGTAC -3'
(R):5'- AGGACCTGTACCAATCTGCCTG -3'
|
| Posted On |
2014-10-30 |
Incidental Mutation