Incidental Mutation 'R2360:Vmn1r209'
ID |
247125 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Vmn1r209
|
Ensembl Gene |
ENSMUSG00000071491 |
Gene Name |
vomeronasal 1 receptor 209 |
Synonyms |
Gm11315 |
MMRRC Submission |
040342-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.108)
|
Stock # |
R2360 (G1)
|
Quality Score |
225 |
Status
|
Validated
|
Chromosome |
13 |
Chromosomal Location |
22989750-22990688 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to A
at 22989836 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Isoleucine to Phenylalanine
at position 285
(I285F)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000153997
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000095961]
[ENSMUST00000227038]
[ENSMUST00000227265]
|
AlphaFold |
Q5NC97 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000095961
AA Change: I285F
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
SMART Domains |
Protein: ENSMUSP00000093657 Gene: ENSMUSG00000071491 AA Change: I285F
Domain | Start | End | E-Value | Type |
Pfam:TAS2R
|
2 |
294 |
9.8e-9 |
PFAM |
Pfam:V1R
|
34 |
297 |
3e-36 |
PFAM |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000227038
AA Change: I285F
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000227265
AA Change: I285F
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
Meta Mutation Damage Score |
0.6467 |
Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.7%
- 10x: 97.3%
- 20x: 95.1%
|
Validation Efficiency |
93% (37/40) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 38 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
4930432E11Rik |
A |
T |
7: 29,274,214 (GRCm39) |
|
noncoding transcript |
Het |
Abca14 |
A |
G |
7: 119,850,431 (GRCm39) |
E761G |
probably benign |
Het |
Apc |
C |
T |
18: 34,394,179 (GRCm39) |
T35I |
probably damaging |
Het |
Arhgef2 |
T |
A |
3: 88,541,723 (GRCm39) |
I228N |
probably damaging |
Het |
Atp6v1g2 |
A |
G |
17: 35,456,638 (GRCm39) |
E74G |
probably damaging |
Het |
Ccdc70 |
A |
G |
8: 22,463,447 (GRCm39) |
E79G |
probably damaging |
Het |
Cdc42ep4 |
A |
G |
11: 113,619,528 (GRCm39) |
S288P |
probably damaging |
Het |
Cip2a |
C |
T |
16: 48,837,828 (GRCm39) |
Q843* |
probably null |
Het |
Cpn2 |
T |
C |
16: 30,078,321 (GRCm39) |
D460G |
probably benign |
Het |
Crtam |
A |
G |
9: 40,884,811 (GRCm39) |
*393Q |
probably null |
Het |
Cwc22 |
A |
G |
2: 77,757,591 (GRCm39) |
I179T |
probably damaging |
Het |
Cyp3a41b |
T |
C |
5: 145,507,221 (GRCm39) |
M240V |
probably benign |
Het |
Dnah8 |
A |
T |
17: 30,896,178 (GRCm39) |
D864V |
probably benign |
Het |
Map3k7 |
T |
C |
4: 31,964,302 (GRCm39) |
S14P |
unknown |
Het |
Med25 |
A |
G |
7: 44,534,566 (GRCm39) |
S150P |
probably damaging |
Het |
Mex3b |
T |
C |
7: 82,517,070 (GRCm39) |
V71A |
probably benign |
Het |
Morc3 |
T |
C |
16: 93,638,275 (GRCm39) |
L19S |
probably damaging |
Het |
Morn1 |
T |
A |
4: 155,176,770 (GRCm39) |
S98T |
probably damaging |
Het |
Mthfd1l |
G |
T |
10: 4,006,771 (GRCm39) |
A678S |
probably damaging |
Het |
Napa |
A |
G |
7: 15,848,083 (GRCm39) |
Y200C |
probably damaging |
Het |
Nr5a2 |
T |
C |
1: 136,876,565 (GRCm39) |
I33V |
probably benign |
Het |
Or14j6 |
A |
G |
17: 38,215,345 (GRCm39) |
K303E |
possibly damaging |
Het |
Pcnx1 |
A |
G |
12: 81,996,960 (GRCm39) |
D952G |
probably damaging |
Het |
Phf20l1 |
G |
A |
15: 66,466,769 (GRCm39) |
R66Q |
probably damaging |
Het |
Resf1 |
A |
G |
6: 149,236,145 (GRCm39) |
I1488M |
probably benign |
Het |
Rfk |
A |
G |
19: 17,375,960 (GRCm39) |
T85A |
probably benign |
Het |
Sbno2 |
T |
C |
10: 79,893,855 (GRCm39) |
D1179G |
possibly damaging |
Het |
Serpina3k |
C |
T |
12: 104,307,166 (GRCm39) |
Q133* |
probably null |
Het |
Setd4 |
T |
C |
16: 93,383,122 (GRCm39) |
|
probably benign |
Het |
Sh2d4b |
C |
T |
14: 40,582,548 (GRCm39) |
|
probably null |
Het |
Slc1a6 |
G |
A |
10: 78,648,718 (GRCm39) |
V480I |
possibly damaging |
Het |
Slc39a3 |
A |
T |
10: 80,867,104 (GRCm39) |
V214E |
possibly damaging |
Het |
Tll1 |
A |
G |
8: 64,504,435 (GRCm39) |
Y654H |
probably damaging |
Het |
Traf3ip1 |
T |
A |
1: 91,427,374 (GRCm39) |
C115S |
unknown |
Het |
Vmn2r87 |
G |
T |
10: 130,315,631 (GRCm39) |
T145K |
probably damaging |
Het |
Zan |
T |
C |
5: 137,394,388 (GRCm39) |
T4484A |
unknown |
Het |
Zfp768 |
T |
C |
7: 126,943,810 (GRCm39) |
E106G |
probably benign |
Het |
Zfp984 |
A |
G |
4: 147,839,234 (GRCm39) |
I539T |
possibly damaging |
Het |
|
Other mutations in Vmn1r209 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01773:Vmn1r209
|
APN |
13 |
22,990,450 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01788:Vmn1r209
|
APN |
13 |
22,989,832 (GRCm39) |
missense |
probably damaging |
0.97 |
IGL02738:Vmn1r209
|
APN |
13 |
22,990,290 (GRCm39) |
nonsense |
probably null |
|
IGL03177:Vmn1r209
|
APN |
13 |
22,990,024 (GRCm39) |
missense |
possibly damaging |
0.46 |
IGL03199:Vmn1r209
|
APN |
13 |
22,990,220 (GRCm39) |
missense |
possibly damaging |
0.89 |
R0437:Vmn1r209
|
UTSW |
13 |
22,990,526 (GRCm39) |
missense |
probably benign |
0.01 |
R0497:Vmn1r209
|
UTSW |
13 |
22,990,118 (GRCm39) |
missense |
probably damaging |
1.00 |
R0506:Vmn1r209
|
UTSW |
13 |
22,990,114 (GRCm39) |
missense |
probably damaging |
0.98 |
R1496:Vmn1r209
|
UTSW |
13 |
22,989,934 (GRCm39) |
missense |
probably damaging |
1.00 |
R1644:Vmn1r209
|
UTSW |
13 |
22,990,652 (GRCm39) |
missense |
possibly damaging |
0.52 |
R1829:Vmn1r209
|
UTSW |
13 |
22,990,409 (GRCm39) |
missense |
possibly damaging |
0.95 |
R3434:Vmn1r209
|
UTSW |
13 |
22,990,267 (GRCm39) |
missense |
probably benign |
0.04 |
R3435:Vmn1r209
|
UTSW |
13 |
22,990,267 (GRCm39) |
missense |
probably benign |
0.04 |
R4082:Vmn1r209
|
UTSW |
13 |
22,989,785 (GRCm39) |
missense |
probably null |
0.15 |
R4451:Vmn1r209
|
UTSW |
13 |
22,990,668 (GRCm39) |
missense |
probably benign |
0.02 |
R4616:Vmn1r209
|
UTSW |
13 |
22,990,135 (GRCm39) |
missense |
probably damaging |
1.00 |
R4618:Vmn1r209
|
UTSW |
13 |
22,990,619 (GRCm39) |
missense |
possibly damaging |
0.87 |
R4801:Vmn1r209
|
UTSW |
13 |
22,989,826 (GRCm39) |
missense |
probably damaging |
1.00 |
R4802:Vmn1r209
|
UTSW |
13 |
22,989,826 (GRCm39) |
missense |
probably damaging |
1.00 |
R6035:Vmn1r209
|
UTSW |
13 |
22,990,202 (GRCm39) |
missense |
probably benign |
0.02 |
R6035:Vmn1r209
|
UTSW |
13 |
22,990,202 (GRCm39) |
missense |
probably benign |
0.02 |
R6908:Vmn1r209
|
UTSW |
13 |
22,990,400 (GRCm39) |
missense |
possibly damaging |
0.60 |
R7162:Vmn1r209
|
UTSW |
13 |
22,990,128 (GRCm39) |
missense |
probably damaging |
1.00 |
R7772:Vmn1r209
|
UTSW |
13 |
22,990,664 (GRCm39) |
missense |
possibly damaging |
0.77 |
R8328:Vmn1r209
|
UTSW |
13 |
22,990,643 (GRCm39) |
missense |
probably benign |
0.00 |
R8335:Vmn1r209
|
UTSW |
13 |
22,989,977 (GRCm39) |
missense |
probably damaging |
1.00 |
R8903:Vmn1r209
|
UTSW |
13 |
22,990,684 (GRCm39) |
missense |
probably benign |
0.00 |
R8919:Vmn1r209
|
UTSW |
13 |
22,990,223 (GRCm39) |
missense |
probably benign |
|
R8932:Vmn1r209
|
UTSW |
13 |
22,990,343 (GRCm39) |
missense |
probably damaging |
1.00 |
R9307:Vmn1r209
|
UTSW |
13 |
22,990,072 (GRCm39) |
missense |
probably damaging |
0.98 |
R9343:Vmn1r209
|
UTSW |
13 |
22,990,546 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Predicted Primers |
PCR Primer
(F):5'- TTCAATGCTGTAAATCACCTGGAAG -3'
(R):5'- AGCATGTCCTCTACCTTCAGAAC -3'
Sequencing Primer
(F):5'- GCTGTAAATCACCTGGAAGACTGTC -3'
(R):5'- AGAACTCCCCCTGAGCTGAGAG -3'
|
Posted On |
2014-10-30 |