Incidental Mutation 'R2357:Or4f61'
ID 247417
Institutional Source Beutler Lab
Gene Symbol Or4f61
Ensembl Gene ENSMUSG00000074945
Gene Name olfactory receptor family 4 subfamily F member 61
Synonyms MOR245-2, Olfr1314, GA_x6K02T2Q125-73139026-73138088
MMRRC Submission 040339-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.063) question?
Stock # R2357 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 111922106-111923044 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 111922743 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 101 (I101T)
Ref Sequence ENSEMBL: ENSMUSP00000146418 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099598] [ENSMUST00000207976]
AlphaFold A2AVL6
Predicted Effect possibly damaging
Transcript: ENSMUST00000099598
AA Change: I101T

PolyPhen 2 Score 0.693 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000097193
Gene: ENSMUSG00000074945
AA Change: I101T

DomainStartEndE-ValueType
Pfam:7tm_4 30 305 9.2e-42 PFAM
Pfam:7tm_1 41 287 1.6e-23 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000207976
AA Change: I101T

PolyPhen 2 Score 0.693 (Sensitivity: 0.86; Specificity: 0.92)
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.8%
  • 20x: 93.3%
Validation Efficiency 97% (66/68)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 66 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4932414N04Rik C A 2: 68,569,844 (GRCm39) T520K possibly damaging Het
Abca13 T C 11: 9,247,336 (GRCm39) L2361P probably damaging Het
Acsl6 T A 11: 54,218,106 (GRCm39) M248K probably damaging Het
Adam11 G T 11: 102,665,334 (GRCm39) V467L probably benign Het
Afap1 C T 5: 36,141,618 (GRCm39) H501Y probably damaging Het
Ankrd28 A T 14: 31,486,251 (GRCm39) Y22* probably null Het
Ccdc124 A T 8: 71,321,179 (GRCm39) L187Q probably damaging Het
Cdc42bpa G A 1: 179,894,792 (GRCm39) S324N possibly damaging Het
Cgnl1 T A 9: 71,632,950 (GRCm39) K134* probably null Het
Cnpy3 G T 17: 47,062,909 (GRCm39) S47R probably damaging Het
Cpne8 A T 15: 90,503,877 (GRCm39) L96Q probably damaging Het
Crisp3 A T 17: 40,533,396 (GRCm39) Y212N probably damaging Het
Cryba1 A T 11: 77,613,427 (GRCm39) probably benign Het
Cyc1 A G 15: 76,229,766 (GRCm39) M288V possibly damaging Het
Dnah8 T A 17: 30,990,846 (GRCm39) D3296E probably benign Het
Dnah8 A G 17: 31,093,909 (GRCm39) T4668A probably benign Het
Dnajb6 T A 5: 29,958,638 (GRCm39) F113I probably damaging Het
Dync2h1 A G 9: 7,081,053 (GRCm39) I2881T probably benign Het
Eps8l1 T C 7: 4,473,354 (GRCm39) S179P probably benign Het
Esco2 C A 14: 66,064,000 (GRCm39) A395S probably benign Het
Evi5l T C 8: 4,243,113 (GRCm39) probably benign Het
Exoc6b T C 6: 84,966,321 (GRCm39) T218A possibly damaging Het
Gde1 A T 7: 118,290,814 (GRCm39) F170L probably benign Het
Ggt5 A C 10: 75,445,075 (GRCm39) I361L probably benign Het
Golga3 C T 5: 110,350,514 (GRCm39) T683M probably damaging Het
Golgb1 A G 16: 36,732,370 (GRCm39) Q539R probably damaging Het
Grm2 A G 9: 106,524,780 (GRCm39) V645A probably damaging Het
Gtf2h4 A T 17: 35,978,891 (GRCm39) V408D probably damaging Het
Gucy1a2 A T 9: 3,797,299 (GRCm39) H583L probably damaging Het
Hivep2 C T 10: 14,019,043 (GRCm39) A1938V probably benign Het
Iars1 T C 13: 49,841,679 (GRCm39) Y56H probably damaging Het
Il17re A G 6: 113,445,431 (GRCm39) I381V possibly damaging Het
Klrd1 T A 6: 129,573,872 (GRCm39) *71K probably null Het
Kng1 A T 16: 22,897,815 (GRCm39) Y405F possibly damaging Het
Kptn G T 7: 15,859,709 (GRCm39) C311F probably damaging Het
Lama5 T C 2: 179,821,890 (GRCm39) I2982V probably benign Het
Mamstr G T 7: 45,291,754 (GRCm39) D35Y probably damaging Het
Mdc1 A G 17: 36,158,337 (GRCm39) D239G probably benign Het
Mindy3 T G 2: 12,408,987 (GRCm39) probably benign Het
Mrpl39 A T 16: 84,524,452 (GRCm39) H204Q probably benign Het
Myo16 G A 8: 10,644,905 (GRCm39) D1746N possibly damaging Het
Myo5a T A 9: 75,108,647 (GRCm39) M1476K probably damaging Het
Nol4 A G 18: 23,172,967 (GRCm39) S45P probably benign Het
Nol8 T C 13: 49,807,980 (GRCm39) probably null Het
Or5d18 A T 2: 87,865,028 (GRCm39) W152R probably damaging Het
Or6c207 C A 10: 129,104,642 (GRCm39) K183N probably benign Het
Or8b56 T C 9: 38,739,634 (GRCm39) S216P probably benign Het
Plau T A 14: 20,888,683 (GRCm39) V100D probably damaging Het
Plpp7 T C 2: 31,999,654 (GRCm39) V6A probably benign Het
Prr14 T C 7: 127,074,535 (GRCm39) S356P probably benign Het
Rabl3 A G 16: 37,362,293 (GRCm39) D44G probably null Het
Rasa4 T C 5: 136,120,101 (GRCm39) V59A probably damaging Het
Rbm46 A T 3: 82,771,765 (GRCm39) D283E probably benign Het
Rictor A T 15: 6,813,043 (GRCm39) N932I probably damaging Het
Rpl9-ps6 A G 19: 32,443,743 (GRCm39) V70A probably benign Het
S100a7l2 A T 3: 90,995,733 (GRCm39) S56R probably benign Het
St3gal1 A G 15: 66,985,631 (GRCm39) Y8H probably benign Het
Strn G A 17: 78,963,028 (GRCm39) T745I probably damaging Het
Tbx15 C T 3: 99,223,672 (GRCm39) probably null Het
Tbx20 T A 9: 24,681,072 (GRCm39) D140V possibly damaging Het
Ttn A C 2: 76,666,923 (GRCm39) Y42* probably null Het
Usp9y G A Y: 1,394,050 (GRCm39) T560I possibly damaging Het
Vmn2r111 A G 17: 22,778,151 (GRCm39) probably benign Het
Vps13d GG GGGGGG 4: 144,801,547 (GRCm39) probably null Het
Wfdc12 A T 2: 164,032,170 (GRCm39) I40N probably damaging Het
Zfp78 G A 7: 6,382,056 (GRCm39) G369R probably damaging Het
Other mutations in Or4f61
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00972:Or4f61 APN 2 111,922,439 (GRCm39) missense probably damaging 0.99
IGL01701:Or4f61 APN 2 111,922,851 (GRCm39) missense possibly damaging 0.69
IGL02085:Or4f61 APN 2 111,922,869 (GRCm39) missense probably damaging 1.00
IGL02156:Or4f61 APN 2 111,922,361 (GRCm39) missense probably benign 0.12
IGL02266:Or4f61 APN 2 111,922,588 (GRCm39) missense probably benign 0.05
IGL02396:Or4f61 APN 2 111,922,812 (GRCm39) missense probably benign 0.20
IGL02602:Or4f61 APN 2 111,922,906 (GRCm39) missense probably benign 0.00
IGL03130:Or4f61 APN 2 111,922,166 (GRCm39) missense probably benign
R0452:Or4f61 UTSW 2 111,922,981 (GRCm39) nonsense probably null
R1498:Or4f61 UTSW 2 111,922,938 (GRCm39) missense probably benign 0.40
R1514:Or4f61 UTSW 2 111,922,381 (GRCm39) missense probably benign 0.01
R1852:Or4f61 UTSW 2 111,922,192 (GRCm39) missense probably benign 0.03
R2118:Or4f61 UTSW 2 111,922,675 (GRCm39) missense probably benign 0.02
R2219:Or4f61 UTSW 2 111,922,752 (GRCm39) missense probably damaging 0.99
R3743:Or4f61 UTSW 2 111,922,965 (GRCm39) missense probably benign 0.33
R4692:Or4f61 UTSW 2 111,923,026 (GRCm39) missense probably damaging 1.00
R5092:Or4f61 UTSW 2 111,922,452 (GRCm39) missense possibly damaging 0.94
R5150:Or4f61 UTSW 2 111,922,880 (GRCm39) missense possibly damaging 0.95
R5230:Or4f61 UTSW 2 111,922,734 (GRCm39) missense probably benign 0.12
R5991:Or4f61 UTSW 2 111,922,960 (GRCm39) missense probably benign 0.30
R7894:Or4f61 UTSW 2 111,922,822 (GRCm39) missense probably benign
R8991:Or4f61 UTSW 2 111,922,682 (GRCm39) missense probably damaging 1.00
R9206:Or4f61 UTSW 2 111,922,410 (GRCm39) missense probably benign 0.12
R9595:Or4f61 UTSW 2 111,922,375 (GRCm39) missense probably damaging 0.96
Z1177:Or4f61 UTSW 2 111,922,929 (GRCm39) missense possibly damaging 0.88
Predicted Primers PCR Primer
(F):5'- ACCAGAGAATGCATAAGGCC -3'
(R):5'- CTGGAAGATGCAAGTGCTTC -3'

Sequencing Primer
(F):5'- GAGAATGCATAAGGCCAACCAC -3'
(R):5'- TATGGCTAGCATGATGGGAAACTCC -3'
Posted On 2014-11-11