Incidental Mutation 'R2384:Il36g'
ID 247629
Institutional Source Beutler Lab
Gene Symbol Il36g
Ensembl Gene ENSMUSG00000044103
Gene Name interleukin 36G
Synonyms IL-36gamma, If36g, Il1f9
MMRRC Submission 040358-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.051) question?
Stock # R2384 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 24076488-24083579 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 24082660 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Arginine at position 145 (H145R)
Ref Sequence ENSEMBL: ENSMUSP00000053391 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000057567]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000057567
AA Change: H145R

PolyPhen 2 Score 0.430 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000053391
Gene: ENSMUSG00000044103
AA Change: H145R

DomainStartEndE-ValueType
IL1 43 190 7.91e-5 SMART
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.6%
  • 20x: 92.5%
Validation Efficiency 100% (37/37)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the interleukin 1 cytokine family. The activity of this cytokine is mediated by interleukin 1 receptor-like 2 (IL1RL2/IL1R-rp2), and is specifically inhibited by interleukin 1 family, member 5 (IL1F5/IL-1 delta). Interferon-gamma, tumor necrosis factor-alpha and interleukin 1, beta (IL1B) are reported to stimulate the expression of this cytokine in keratinocytes. The expression of this cytokine in keratinocytes can also be induced by a contact hypersensitivity reaction or herpes simplex virus infection. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013]
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2700049A03Rik G T 12: 71,211,320 (GRCm39) E685* probably null Het
2700049A03Rik A T 12: 71,211,321 (GRCm39) E685V possibly damaging Het
4933414I15Rik A G 11: 50,833,333 (GRCm39) S90P unknown Het
Abca13 T C 11: 9,217,450 (GRCm39) probably benign Het
Chpf C T 1: 75,451,753 (GRCm39) R567H probably benign Het
Cnp A G 11: 100,467,279 (GRCm39) Y74C probably damaging Het
Cul3 A T 1: 80,261,406 (GRCm39) V273D probably damaging Het
Dnmt3a A G 12: 3,951,591 (GRCm39) Y656C probably damaging Het
Erich3 A T 3: 154,470,288 (GRCm39) E107V possibly damaging Het
Fscn2 T C 11: 120,257,559 (GRCm39) S307P possibly damaging Het
Grm5 A G 7: 87,251,936 (GRCm39) E62G probably damaging Het
Hdac4 T C 1: 91,912,207 (GRCm39) Y394C probably benign Het
Hipk2 A G 6: 38,795,306 (GRCm39) I314T probably damaging Het
Hsd17b12 T A 2: 93,863,964 (GRCm39) I293L probably benign Het
Ints12 T A 3: 132,814,864 (GRCm39) probably null Het
Khdrbs2 T C 1: 32,558,976 (GRCm39) S369G probably damaging Het
Klrh1 T A 6: 129,749,343 (GRCm39) H84L probably benign Het
Mup5 T A 4: 61,753,261 (GRCm39) probably null Het
Nlrp4g A G 9: 124,349,707 (GRCm38) noncoding transcript Het
Obscn A G 11: 58,933,663 (GRCm39) probably null Het
Ogdh C A 11: 6,292,526 (GRCm39) A413D probably damaging Het
Podn T C 4: 107,879,269 (GRCm39) E283G probably damaging Het
Ripk1 A G 13: 34,214,026 (GRCm39) D456G probably benign Het
Saxo4 A C 19: 10,458,646 (GRCm39) probably null Het
Scg3 T C 9: 75,573,008 (GRCm39) T308A probably damaging Het
Sele A G 1: 163,878,344 (GRCm39) T228A probably benign Het
Slc41a3 A G 6: 90,603,393 (GRCm39) E138G probably damaging Het
Tmem161a T C 8: 70,630,204 (GRCm39) V104A probably benign Het
Tmem232 G A 17: 65,709,852 (GRCm39) R479W probably damaging Het
Trim26 C T 17: 37,161,781 (GRCm39) P67S probably damaging Het
Trpm8 A G 1: 88,287,378 (GRCm39) Y787C probably benign Het
Ttc28 T A 5: 111,424,074 (GRCm39) V1447D possibly damaging Het
Uaca G A 9: 60,777,199 (GRCm39) A527T probably damaging Het
Ucp2 A G 7: 100,147,461 (GRCm39) I172V probably benign Het
Zzef1 T A 11: 72,749,220 (GRCm39) Y903N probably damaging Het
Other mutations in Il36g
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02027:Il36g APN 2 24,082,797 (GRCm39) missense probably benign 0.06
IGL03190:Il36g APN 2 24,077,272 (GRCm39) nonsense probably null
IGL03047:Il36g UTSW 2 24,082,719 (GRCm39) missense probably damaging 1.00
R5158:Il36g UTSW 2 24,082,798 (GRCm39) missense probably damaging 0.99
R5916:Il36g UTSW 2 24,082,806 (GRCm39) makesense probably null
R6875:Il36g UTSW 2 24,078,633 (GRCm39) critical splice acceptor site probably null
R8187:Il36g UTSW 2 24,082,617 (GRCm39) missense probably damaging 1.00
R8357:Il36g UTSW 2 24,078,661 (GRCm39) missense probably benign 0.45
R8457:Il36g UTSW 2 24,078,661 (GRCm39) missense probably benign 0.45
Predicted Primers PCR Primer
(F):5'- ATCCTGTTGTAAGAGAGGCTTCC -3'
(R):5'- AATGTTGGTCCTGCTTACCTTTCAG -3'

Sequencing Primer
(F):5'- TGTAAGAGAGGCTTCCTTGAAC -3'
(R):5'- TTAAGAGGAAGAGTTCTAACCAACC -3'
Posted On 2014-11-11