|Institutional Source||Beutler Lab|
|Gene Name||interleukin 1 receptor, type II|
|Synonyms||IL-1 receptor beta chain, CD121b, Il1r-2|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R0299 (G1)|
|Chromosomal Location||40074079-40125231 bp(+) (GRCm38)|
|Type of Mutation||nonsense|
|DNA Base Change (assembly)||T to A at 40123149 bp|
|Amino Acid Change||Tyrosine to Stop codon at position 317 (Y317*)|
|Ref Sequence||ENSEMBL: ENSMUSP00000027243 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000027243] [ENSMUST00000195770]|
|Predicted Effect||probably null
AA Change: Y317*
AA Change: Y317*
|Predicted Effect||probably benign
|Meta Mutation Damage Score||0.9755|
|Coding Region Coverage||
|Validation Efficiency||100% (61/61)|
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Alternative splicing results in multiple transcript variants and protein isoforms. Alternative splicing produces both membrane-bound and soluble proteins. A soluble protein is also produced by proteolytic cleavage. [provided by RefSeq, May 2012]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Il1r2||
(F):5'- GCTCTACACACATCATGCTCTGCATAC -3'
(R):5'- GCTTTCAGTGCCCTACAAGAAGACATC -3'
(F):5'- catcatgctctgcatacatacatc -3'
(R):5'- TGCCCTACAAGAAGACATCTAAATAC -3'