Incidental Mutation 'R2389:Rxfp3'
ID 247744
Institutional Source Beutler Lab
Gene Symbol Rxfp3
Ensembl Gene ENSMUSG00000060735
Gene Name relaxin family peptide receptor 3
Synonyms Rln3r1, Salpr
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R2389 (G1)
Quality Score 225
Status Not validated
Chromosome 15
Chromosomal Location 11033803-11038054 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 11036770 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Arginine at position 201 (C201R)
Ref Sequence ENSEMBL: ENSMUSP00000062741 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000058007]
AlphaFold Q8BGE9
Predicted Effect probably damaging
Transcript: ENSMUST00000058007
AA Change: C201R

PolyPhen 2 Score 0.974 (Sensitivity: 0.76; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000062741
Gene: ENSMUSG00000060735
AA Change: C201R

DomainStartEndE-ValueType
low complexity region 4 17 N/A INTRINSIC
low complexity region 59 71 N/A INTRINSIC
Pfam:7tm_1 98 392 1.7e-48 PFAM
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 93.8%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a null mutation display a subtle decrease in anxiety related behaviors and hypoactivity in their home cages. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 25 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actr5 T C 2: 158,467,132 (GRCm39) V24A probably benign Het
Adrm1 C A 2: 179,816,116 (GRCm39) probably benign Het
Cdk13 T A 13: 17,926,361 (GRCm39) H813L probably damaging Het
Cdkal1 T A 13: 29,736,219 (GRCm39) H300L probably damaging Het
Cnksr1 T C 4: 133,961,057 (GRCm39) I235V probably benign Het
Ctnnd1 T A 2: 84,454,615 (GRCm39) Q11L probably null Het
Dync2h1 T C 9: 7,122,618 (GRCm39) I2113V possibly damaging Het
Eng T C 2: 32,547,684 (GRCm39) probably null Het
Gria2 A G 3: 80,609,932 (GRCm39) W626R probably damaging Het
Kctd1 A G 18: 15,195,268 (GRCm39) S452P possibly damaging Het
Kdm4c T C 4: 74,252,107 (GRCm39) probably null Het
Kntc1 C T 5: 123,919,255 (GRCm39) L845F probably damaging Het
Lmf1 G A 17: 25,873,445 (GRCm39) V317M probably damaging Het
Nat8f7 C A 6: 85,684,476 (GRCm39) M121I probably benign Het
Ppfibp1 A T 6: 146,923,669 (GRCm39) H667L probably damaging Het
Pramel31 T A 4: 144,089,983 (GRCm39) L341H probably damaging Het
Prss12 A G 3: 123,280,670 (GRCm39) N452D possibly damaging Het
Rab17 T C 1: 90,891,926 (GRCm39) T33A probably benign Het
Spag17 A G 3: 100,014,153 (GRCm39) Y2142C probably benign Het
Stx6 T C 1: 155,073,164 (GRCm39) V225A possibly damaging Het
Ugt2b5 G A 5: 87,275,541 (GRCm39) P437S probably damaging Het
Usp13 A G 3: 32,959,613 (GRCm39) K568R probably benign Het
Zan A G 5: 137,474,642 (GRCm39) probably null Het
Zbtb8b T C 4: 129,327,066 (GRCm39) E33G probably benign Het
Zcchc17 T A 4: 130,220,997 (GRCm39) K185* probably null Het
Other mutations in Rxfp3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00870:Rxfp3 APN 15 11,036,391 (GRCm39) missense probably damaging 0.98
IGL00870:Rxfp3 APN 15 11,036,301 (GRCm39) missense probably damaging 0.99
IGL01844:Rxfp3 APN 15 11,037,132 (GRCm39) missense probably damaging 0.97
IGL02998:Rxfp3 APN 15 11,037,054 (GRCm39) missense probably damaging 0.98
IGL03079:Rxfp3 APN 15 11,036,909 (GRCm39) missense possibly damaging 0.91
R0462:Rxfp3 UTSW 15 11,037,063 (GRCm39) missense probably damaging 1.00
R1567:Rxfp3 UTSW 15 11,036,187 (GRCm39) missense probably benign 0.00
R1616:Rxfp3 UTSW 15 11,036,389 (GRCm39) missense probably damaging 0.96
R2432:Rxfp3 UTSW 15 11,036,226 (GRCm39) missense probably damaging 1.00
R3081:Rxfp3 UTSW 15 11,037,303 (GRCm39) missense probably benign 0.00
R4936:Rxfp3 UTSW 15 11,036,866 (GRCm39) missense probably damaging 1.00
R4963:Rxfp3 UTSW 15 11,036,367 (GRCm39) missense probably damaging 1.00
R5788:Rxfp3 UTSW 15 11,036,250 (GRCm39) missense possibly damaging 0.58
R6679:Rxfp3 UTSW 15 11,035,956 (GRCm39) missense probably damaging 1.00
R7148:Rxfp3 UTSW 15 11,036,863 (GRCm39) missense possibly damaging 0.66
R7252:Rxfp3 UTSW 15 11,036,025 (GRCm39) missense probably benign 0.40
R7495:Rxfp3 UTSW 15 11,036,011 (GRCm39) missense probably damaging 1.00
R7555:Rxfp3 UTSW 15 11,036,362 (GRCm39) missense probably damaging 1.00
R7743:Rxfp3 UTSW 15 11,037,216 (GRCm39) missense probably damaging 0.99
R8361:Rxfp3 UTSW 15 11,036,784 (GRCm39) missense probably benign 0.05
R9717:Rxfp3 UTSW 15 11,037,111 (GRCm39) missense possibly damaging 0.90
X0065:Rxfp3 UTSW 15 11,036,515 (GRCm39) missense probably benign 0.45
Predicted Primers PCR Primer
(F):5'- AGACTGATGATGCTCAGCG -3'
(R):5'- AGACTTCAAGTGGCCCTTCG -3'

Sequencing Primer
(F):5'- TTCTGCAGGTGGTACAAACC -3'
(R):5'- CCATGAACATGTACGCCA -3'
Posted On 2014-11-11