Incidental Mutation 'R2391:Naa16'
ID 247774
Institutional Source Beutler Lab
Gene Symbol Naa16
Ensembl Gene ENSMUSG00000022020
Gene Name N(alpha)-acetyltransferase 16, NatA auxiliary subunit
Synonyms 1300019C06Rik, Narg1l
MMRRC Submission 040359-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.097) question?
Stock # R2391 (G1)
Quality Score 225
Status Validated
Chromosome 14
Chromosomal Location 79571947-79628228 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 79607489 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Leucine at position 287 (H287L)
Ref Sequence ENSEMBL: ENSMUSP00000022597 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000022597] [ENSMUST00000163486] [ENSMUST00000169500]
AlphaFold Q9DBB4
Predicted Effect probably benign
Transcript: ENSMUST00000022597
AA Change: H287L

PolyPhen 2 Score 0.155 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000022597
Gene: ENSMUSG00000022020
AA Change: H287L

DomainStartEndE-ValueType
TPR 46 79 2.99e1 SMART
TPR 80 113 2.98e-3 SMART
Blast:TPR 224 257 1e-10 BLAST
TPR 374 407 9.96e0 SMART
TPR 408 441 7.47e0 SMART
low complexity region 616 633 N/A INTRINSIC
Blast:TPR 672 705 3e-12 BLAST
low complexity region 830 841 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000163486
AA Change: H253L

PolyPhen 2 Score 0.024 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000131268
Gene: ENSMUSG00000022020
AA Change: H253L

DomainStartEndE-ValueType
TPR 12 45 2.99e1 SMART
TPR 46 79 2.98e-3 SMART
Blast:TPR 190 223 3e-10 BLAST
TPR 340 373 9.96e0 SMART
TPR 374 407 7.47e0 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000169500
SMART Domains Protein: ENSMUSP00000127298
Gene: ENSMUSG00000022020

DomainStartEndE-ValueType
PDB:4KVO|D 1 46 1e-6 PDB
Meta Mutation Damage Score 0.1184 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.2%
Validation Efficiency 100% (36/36)
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110004F10Rik T A 7: 115,703,461 (GRCm39) D24E probably damaging Het
Abca4 A G 3: 121,952,071 (GRCm39) H689R probably benign Het
Acss3 T G 10: 106,959,348 (GRCm39) T33P probably benign Het
BC005537 T A 13: 24,993,898 (GRCm39) Y124* probably null Het
Capn2 T C 1: 182,306,174 (GRCm39) D524G probably benign Het
Catsperb A G 12: 101,590,965 (GRCm39) Y1011C probably damaging Het
Cdk18 G T 1: 132,043,212 (GRCm39) Q438K probably benign Het
Cimap1d A T 10: 79,481,484 (GRCm39) V15E probably benign Het
Ckap5 A G 2: 91,416,214 (GRCm39) M1047V possibly damaging Het
Dab1 C T 4: 104,588,948 (GRCm39) A524V probably benign Het
Dmbt1 T A 7: 130,708,198 (GRCm39) I1306N probably damaging Het
Emp2 A T 16: 10,102,452 (GRCm39) I120N probably damaging Het
Gm2888 A T 14: 3,037,656 (GRCm38) D216V possibly damaging Het
Olfm5 A G 7: 103,810,041 (GRCm39) S107P probably benign Het
Or10q3 G T 19: 11,848,180 (GRCm39) Y133* probably null Het
Or51e2 C A 7: 102,391,581 (GRCm39) V210F possibly damaging Het
Or6k8-ps1 T C 1: 173,979,664 (GRCm39) V194A probably benign Het
Ptpn2 A T 18: 67,808,959 (GRCm39) probably null Het
Serpinb8 A G 1: 107,534,799 (GRCm39) D290G probably damaging Het
Sfmbt2 T C 2: 10,450,504 (GRCm39) Y260H possibly damaging Het
Slc6a20a A T 9: 123,493,686 (GRCm39) V65E probably damaging Het
Spon1 C T 7: 113,486,080 (GRCm39) T210M probably damaging Het
Sugp1 T C 8: 70,512,061 (GRCm39) probably null Het
Tas2r143 C A 6: 42,377,810 (GRCm39) H213Q probably damaging Het
Terf1 C A 1: 15,875,963 (GRCm39) S21* probably null Het
Trim12a T C 7: 103,956,138 (GRCm39) E134G probably damaging Het
Trip12 TATACATACATACATACATACATACATACATAC TATACATACATACATACATACATACATACATACATAC 1: 84,792,511 (GRCm39) probably null Het
Tssk5 T C 15: 76,258,751 (GRCm39) Y45C probably benign Het
Usp29 T A 7: 6,966,770 (GRCm39) probably null Het
Wdfy4 A T 14: 32,884,764 (GRCm39) M46K possibly damaging Het
Wdr90 G A 17: 26,070,429 (GRCm39) P1104L probably damaging Het
Znhit6 T C 3: 145,300,413 (GRCm39) S230P probably damaging Het
Other mutations in Naa16
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00551:Naa16 APN 14 79,593,169 (GRCm39) missense probably damaging 1.00
IGL01025:Naa16 APN 14 79,622,196 (GRCm39) missense probably damaging 1.00
IGL01155:Naa16 APN 14 79,622,155 (GRCm39) missense probably damaging 0.98
IGL01335:Naa16 APN 14 79,582,556 (GRCm39) splice site probably benign
IGL01981:Naa16 APN 14 79,618,956 (GRCm39) missense probably benign 0.05
IGL02230:Naa16 APN 14 79,614,801 (GRCm39) splice site probably benign
IGL02313:Naa16 APN 14 79,622,108 (GRCm39) missense probably damaging 1.00
IGL02418:Naa16 APN 14 79,620,806 (GRCm39) missense probably damaging 1.00
IGL02544:Naa16 APN 14 79,573,260 (GRCm39) missense probably damaging 1.00
IGL03051:Naa16 APN 14 79,606,522 (GRCm39) missense probably benign 0.01
IGL03064:Naa16 APN 14 79,577,068 (GRCm39) missense probably damaging 0.98
IGL03205:Naa16 APN 14 79,593,952 (GRCm39) missense possibly damaging 0.89
PIT4508001:Naa16 UTSW 14 79,606,527 (GRCm39) missense probably benign 0.15
R0651:Naa16 UTSW 14 79,588,832 (GRCm39) missense probably damaging 1.00
R1429:Naa16 UTSW 14 79,596,967 (GRCm39) missense probably benign 0.01
R1674:Naa16 UTSW 14 79,624,497 (GRCm39) start codon destroyed probably null 0.65
R1693:Naa16 UTSW 14 79,588,896 (GRCm39) missense probably damaging 1.00
R1874:Naa16 UTSW 14 79,593,183 (GRCm39) missense possibly damaging 0.62
R1992:Naa16 UTSW 14 79,593,931 (GRCm39) missense probably damaging 1.00
R2015:Naa16 UTSW 14 79,582,499 (GRCm39) missense probably damaging 1.00
R2847:Naa16 UTSW 14 79,573,323 (GRCm39) missense probably damaging 1.00
R2848:Naa16 UTSW 14 79,573,323 (GRCm39) missense probably damaging 1.00
R2877:Naa16 UTSW 14 79,580,738 (GRCm39) missense probably benign 0.00
R3884:Naa16 UTSW 14 79,580,702 (GRCm39) missense probably damaging 0.98
R4001:Naa16 UTSW 14 79,580,561 (GRCm39) splice site probably null
R4199:Naa16 UTSW 14 79,593,311 (GRCm39) missense probably damaging 1.00
R4638:Naa16 UTSW 14 79,577,473 (GRCm39) splice site probably null
R4676:Naa16 UTSW 14 79,573,788 (GRCm39) unclassified probably benign
R4690:Naa16 UTSW 14 79,582,497 (GRCm39) missense probably damaging 1.00
R4952:Naa16 UTSW 14 79,582,525 (GRCm39) missense probably damaging 1.00
R5087:Naa16 UTSW 14 79,614,855 (GRCm39) missense possibly damaging 0.68
R5104:Naa16 UTSW 14 79,622,140 (GRCm39) nonsense probably null
R5729:Naa16 UTSW 14 79,593,220 (GRCm39) missense probably damaging 1.00
R6178:Naa16 UTSW 14 79,620,780 (GRCm39) missense possibly damaging 0.93
R6960:Naa16 UTSW 14 79,596,911 (GRCm39) missense possibly damaging 0.65
R7794:Naa16 UTSW 14 79,614,934 (GRCm39) missense probably damaging 1.00
R7936:Naa16 UTSW 14 79,578,486 (GRCm39) missense possibly damaging 0.47
R8356:Naa16 UTSW 14 79,596,915 (GRCm39) missense probably benign 0.00
R8456:Naa16 UTSW 14 79,596,915 (GRCm39) missense probably benign 0.00
R8892:Naa16 UTSW 14 79,628,016 (GRCm39) missense probably benign 0.32
R8931:Naa16 UTSW 14 79,582,395 (GRCm39) missense probably damaging 1.00
R9010:Naa16 UTSW 14 79,607,482 (GRCm39) missense probably benign 0.01
R9068:Naa16 UTSW 14 79,612,289 (GRCm39) missense probably benign 0.18
R9360:Naa16 UTSW 14 79,593,943 (GRCm39) missense probably benign 0.05
R9688:Naa16 UTSW 14 79,573,309 (GRCm39) nonsense probably null
X0064:Naa16 UTSW 14 79,588,829 (GRCm39) missense probably damaging 1.00
Z1177:Naa16 UTSW 14 79,582,419 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GCGTGCTGTATCTCAATCAGG -3'
(R):5'- AGGGTGATGATTTCCTGATTACAG -3'

Sequencing Primer
(F):5'- GTGCTGTATCTCAATCAGGAGAATAG -3'
(R):5'- CCTGATTACAGTATTTTTACCACCAC -3'
Posted On 2014-11-11