Incidental Mutation 'R2405:Vmn2r96'
ID 247986
Institutional Source Beutler Lab
Gene Symbol Vmn2r96
Ensembl Gene ENSMUSG00000091679
Gene Name vomeronasal 2, receptor 96
Synonyms EG433070
MMRRC Submission 040371-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.157) question?
Stock # R2405 (G1)
Quality Score 225
Status Not validated
Chromosome 17
Chromosomal Location 18793282-18818419 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 18818102 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Serine at position 560 (C560S)
Ref Sequence ENSEMBL: ENSMUSP00000131564 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000165692] [ENSMUST00000177244] [ENSMUST00000231261] [ENSMUST00000231286]
AlphaFold E9PZU5
Predicted Effect probably damaging
Transcript: ENSMUST00000165692
AA Change: C560S

PolyPhen 2 Score 0.965 (Sensitivity: 0.78; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000131564
Gene: ENSMUSG00000091679
AA Change: C560S

DomainStartEndE-ValueType
Pfam:ANF_receptor 1 257 8.6e-20 PFAM
Pfam:NCD3G 317 370 3.7e-22 PFAM
Pfam:7tm_3 402 638 3.9e-53 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000177244
AA Change: C752S

PolyPhen 2 Score 0.139 (Sensitivity: 0.92; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000135095
Gene: ENSMUSG00000091679
AA Change: C752S

DomainStartEndE-ValueType
Pfam:ANF_receptor 1 245 4.2e-19 PFAM
Pfam:NCD3G 317 370 6.9e-21 PFAM
Pfam:7tm_3 400 639 3.4e-75 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000231261
Predicted Effect probably benign
Transcript: ENSMUST00000231286
AA Change: C752S

PolyPhen 2 Score 0.139 (Sensitivity: 0.92; Specificity: 0.86)
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 94.0%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700012B07Rik G T 11: 109,684,980 (GRCm39) C172* probably null Het
Abl1 T C 2: 31,690,986 (GRCm39) L835P possibly damaging Het
Ascc3 T A 10: 50,607,774 (GRCm39) V1426D probably damaging Het
Ccny A G 18: 9,353,480 (GRCm39) Y98H probably benign Het
Ccser2 G A 14: 36,660,626 (GRCm39) T509M probably damaging Het
Crnkl1 A T 2: 145,770,077 (GRCm39) Y255* probably null Het
Cyp2d11 C T 15: 82,273,467 (GRCm39) S468N possibly damaging Het
Dnah7b C A 1: 46,402,114 (GRCm39) T3983N probably benign Het
Ebf1 T A 11: 44,882,349 (GRCm39) M427K probably damaging Het
Fxr1 T A 3: 34,116,003 (GRCm39) S438T probably damaging Het
Gabrr1 A T 4: 33,157,110 (GRCm39) D209V probably damaging Het
Gbx2 G T 1: 89,858,630 (GRCm39) probably benign Het
Gng14 A G 8: 85,794,270 (GRCm39) I56T possibly damaging Het
Gulo A G 14: 66,228,477 (GRCm39) probably null Het
Hhla1 A T 15: 65,808,160 (GRCm39) L295* probably null Het
Hmcn1 T A 1: 150,736,092 (GRCm39) I126L probably damaging Het
Hpse A G 5: 100,856,637 (GRCm39) S121P possibly damaging Het
Inpp5d A G 1: 87,627,451 (GRCm39) H321R possibly damaging Het
Kalrn C T 16: 33,810,180 (GRCm39) D2525N possibly damaging Het
Kdm5b T A 1: 134,536,754 (GRCm39) M658K probably damaging Het
Kidins220 A T 12: 25,061,508 (GRCm39) E875V probably damaging Het
Lrrc37 T C 11: 103,511,810 (GRCm39) M53V unknown Het
Nlrp4b A G 7: 10,448,655 (GRCm39) E286G probably benign Het
Nsf C T 11: 103,821,578 (GRCm39) E26K possibly damaging Het
Pde3a A T 6: 141,426,968 (GRCm39) I710F probably damaging Het
Phb1 T C 11: 95,566,094 (GRCm39) I126T probably benign Het
Ppp4r1 C T 17: 66,118,341 (GRCm39) T164I possibly damaging Het
Psmc1 G A 12: 100,086,362 (GRCm39) R333Q probably benign Het
Pygb A G 2: 150,662,695 (GRCm39) Y554C probably benign Het
Ror2 G A 13: 53,284,980 (GRCm39) P144L possibly damaging Het
Serpina3a A T 12: 104,087,577 (GRCm39) M357L possibly damaging Het
Serpinb9e T A 13: 33,444,063 (GRCm39) M361K probably benign Het
Sgms1 G A 19: 32,137,072 (GRCm39) R165* probably null Het
Slc15a2 G A 16: 36,572,199 (GRCm39) Q691* probably null Het
Slc25a25 C T 2: 32,307,731 (GRCm39) probably null Het
Slc34a2 A G 5: 53,215,523 (GRCm39) N9S probably benign Het
Slc4a2 A G 5: 24,640,599 (GRCm39) T665A probably damaging Het
Spef2 C A 15: 9,626,120 (GRCm39) E1149* probably null Het
Tmem179 A G 12: 112,468,347 (GRCm39) W45R probably damaging Het
Tmpo C A 10: 90,999,216 (GRCm39) K190N probably damaging Het
Triml1 T C 8: 43,583,320 (GRCm39) Y427C probably damaging Het
Trpm2 A G 10: 77,770,558 (GRCm39) L720P probably damaging Het
Vmn1r60 A G 7: 5,547,912 (GRCm39) Y63H probably benign Het
Vps35l G C 7: 118,391,818 (GRCm39) A410P probably damaging Het
Zdhhc13 A G 7: 48,472,478 (GRCm39) probably null Het
Other mutations in Vmn2r96
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00562:Vmn2r96 APN 17 18,804,077 (GRCm39) missense probably benign 0.00
IGL00563:Vmn2r96 APN 17 18,804,077 (GRCm39) missense probably benign 0.00
IGL00769:Vmn2r96 APN 17 18,804,081 (GRCm39) missense probably benign 0.00
IGL01314:Vmn2r96 APN 17 18,803,226 (GRCm39) missense probably benign 0.00
IGL01983:Vmn2r96 APN 17 18,817,527 (GRCm39) missense probably damaging 0.99
IGL02314:Vmn2r96 APN 17 18,804,221 (GRCm39) missense probably benign 0.01
IGL02600:Vmn2r96 APN 17 18,817,829 (GRCm39) missense probably benign
IGL02672:Vmn2r96 APN 17 18,818,376 (GRCm39) missense probably benign 0.02
IGL02750:Vmn2r96 APN 17 18,802,851 (GRCm39) missense probably benign 0.01
IGL03068:Vmn2r96 APN 17 18,803,137 (GRCm39) missense probably benign 0.00
IGL03411:Vmn2r96 APN 17 18,806,634 (GRCm39) missense possibly damaging 0.88
R0316:Vmn2r96 UTSW 17 18,802,827 (GRCm39) missense probably damaging 1.00
R0502:Vmn2r96 UTSW 17 18,804,262 (GRCm39) missense probably benign
R0580:Vmn2r96 UTSW 17 18,802,900 (GRCm39) missense probably damaging 1.00
R0652:Vmn2r96 UTSW 17 18,817,830 (GRCm39) missense probably benign 0.05
R0789:Vmn2r96 UTSW 17 18,802,738 (GRCm39) missense possibly damaging 0.81
R1462:Vmn2r96 UTSW 17 18,817,660 (GRCm39) missense possibly damaging 0.94
R1462:Vmn2r96 UTSW 17 18,817,660 (GRCm39) missense possibly damaging 0.94
R1660:Vmn2r96 UTSW 17 18,817,988 (GRCm39) missense probably benign 0.00
R1755:Vmn2r96 UTSW 17 18,802,915 (GRCm39) missense possibly damaging 0.50
R1843:Vmn2r96 UTSW 17 18,818,183 (GRCm39) missense probably benign 0.14
R1943:Vmn2r96 UTSW 17 18,806,664 (GRCm39) missense probably benign 0.09
R1993:Vmn2r96 UTSW 17 18,804,138 (GRCm39) missense probably damaging 1.00
R2018:Vmn2r96 UTSW 17 18,804,263 (GRCm39) missense probably benign
R3977:Vmn2r96 UTSW 17 18,817,941 (GRCm39) missense probably damaging 1.00
R3979:Vmn2r96 UTSW 17 18,817,941 (GRCm39) missense probably damaging 1.00
R4059:Vmn2r96 UTSW 17 18,818,339 (GRCm39) missense probably benign 0.20
R4693:Vmn2r96 UTSW 17 18,803,270 (GRCm39) missense probably benign 0.03
R4709:Vmn2r96 UTSW 17 18,803,088 (GRCm39) missense probably benign 0.36
R4776:Vmn2r96 UTSW 17 18,817,770 (GRCm39) missense probably damaging 1.00
R4882:Vmn2r96 UTSW 17 18,817,866 (GRCm39) missense probably damaging 1.00
R4920:Vmn2r96 UTSW 17 18,802,918 (GRCm39) missense probably benign 0.07
R5143:Vmn2r96 UTSW 17 18,804,120 (GRCm39) missense possibly damaging 0.65
R5301:Vmn2r96 UTSW 17 18,817,950 (GRCm39) missense probably damaging 0.98
R5507:Vmn2r96 UTSW 17 18,818,091 (GRCm39) missense probably damaging 1.00
R6151:Vmn2r96 UTSW 17 18,804,221 (GRCm39) missense probably benign 0.01
R6181:Vmn2r96 UTSW 17 18,804,126 (GRCm39) missense probably benign
R6339:Vmn2r96 UTSW 17 18,804,124 (GRCm39) missense possibly damaging 0.84
R6404:Vmn2r96 UTSW 17 18,817,793 (GRCm39) missense probably damaging 1.00
R6452:Vmn2r96 UTSW 17 18,804,117 (GRCm39) missense probably benign 0.07
R6749:Vmn2r96 UTSW 17 18,818,352 (GRCm39) missense probably damaging 0.99
R6813:Vmn2r96 UTSW 17 18,802,116 (GRCm39) missense probably benign 0.04
R6851:Vmn2r96 UTSW 17 18,802,800 (GRCm39) missense possibly damaging 0.95
R6944:Vmn2r96 UTSW 17 18,817,891 (GRCm39) missense probably benign 0.16
R6949:Vmn2r96 UTSW 17 18,818,100 (GRCm39) missense probably damaging 1.00
R6962:Vmn2r96 UTSW 17 18,818,283 (GRCm39) missense probably damaging 0.99
R6990:Vmn2r96 UTSW 17 18,804,082 (GRCm39) missense probably benign
R7149:Vmn2r96 UTSW 17 18,817,989 (GRCm39) missense possibly damaging 0.89
R7346:Vmn2r96 UTSW 17 18,803,029 (GRCm39) missense probably benign 0.15
R7385:Vmn2r96 UTSW 17 18,803,302 (GRCm39) missense probably damaging 1.00
R7442:Vmn2r96 UTSW 17 18,793,662 (GRCm39) missense probably benign 0.02
R7509:Vmn2r96 UTSW 17 18,802,995 (GRCm39) missense probably benign 0.02
R7652:Vmn2r96 UTSW 17 18,793,832 (GRCm39) missense probably benign
R7659:Vmn2r96 UTSW 17 18,793,749 (GRCm39) missense probably benign 0.00
R7753:Vmn2r96 UTSW 17 18,806,663 (GRCm39) missense possibly damaging 0.46
R7855:Vmn2r96 UTSW 17 18,818,130 (GRCm39) missense possibly damaging 0.59
R8166:Vmn2r96 UTSW 17 18,802,744 (GRCm39) missense probably damaging 1.00
R8260:Vmn2r96 UTSW 17 18,804,243 (GRCm39) missense probably benign 0.04
R8323:Vmn2r96 UTSW 17 18,803,023 (GRCm39) missense probably damaging 0.99
R8787:Vmn2r96 UTSW 17 18,818,250 (GRCm39) missense probably damaging 1.00
R8837:Vmn2r96 UTSW 17 18,802,888 (GRCm39) missense probably benign
R8933:Vmn2r96 UTSW 17 18,804,241 (GRCm39) missense probably benign 0.11
R9306:Vmn2r96 UTSW 17 18,803,226 (GRCm39) missense probably benign 0.00
R9481:Vmn2r96 UTSW 17 18,793,621 (GRCm39) start gained probably benign
R9626:Vmn2r96 UTSW 17 18,793,758 (GRCm39) missense probably benign 0.14
R9629:Vmn2r96 UTSW 17 18,803,257 (GRCm39) missense probably benign 0.15
Z1088:Vmn2r96 UTSW 17 18,817,628 (GRCm39) missense possibly damaging 0.86
Z1177:Vmn2r96 UTSW 17 18,818,376 (GRCm39) missense probably benign 0.02
Predicted Primers PCR Primer
(F):5'- GGGTCCGAACTACATCATTCC -3'
(R):5'- ACTTGGGACCGAATATGAAGGC -3'

Sequencing Primer
(F):5'- GGTCCGAACTACATCATTCCTATCTG -3'
(R):5'- GATAGAGAATACTTCCATGGCTACC -3'
Posted On 2014-11-11