Incidental Mutation 'R2408:Zmynd19'
ID 248082
Institutional Source Beutler Lab
Gene Symbol Zmynd19
Ensembl Gene ENSMUSG00000026974
Gene Name zinc finger, MYND domain containing 19
Synonyms 2700064H14Rik
MMRRC Submission 040374-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R2408 (G1)
Quality Score 210
Status Validated
Chromosome 2
Chromosomal Location 24839789-24850882 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 24848937 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 144 (E144G)
Ref Sequence ENSEMBL: ENSMUSP00000141788 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000028350] [ENSMUST00000028351] [ENSMUST00000124383] [ENSMUST00000126909] [ENSMUST00000135339] [ENSMUST00000143253] [ENSMUST00000148042] [ENSMUST00000153375]
AlphaFold Q9CQG3
Predicted Effect possibly damaging
Transcript: ENSMUST00000028350
AA Change: E183G

PolyPhen 2 Score 0.538 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000028350
Gene: ENSMUSG00000026974
AA Change: E183G

DomainStartEndE-ValueType
Pfam:HNH_3 66 105 1.9e-10 PFAM
Pfam:zf-MYND 167 212 1.2e-10 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000028351
SMART Domains Protein: ENSMUSP00000028351
Gene: ENSMUSG00000026975

DomainStartEndE-ValueType
Blast:WD40 74 118 3e-10 BLAST
Blast:WD40 128 175 3e-15 BLAST
WD40 183 223 7.43e-1 SMART
WD40 227 267 1.08e-4 SMART
WD40 271 310 1.37e2 SMART
WD40 420 455 1.97e2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000124383
Predicted Effect probably benign
Transcript: ENSMUST00000126909
Predicted Effect probably benign
Transcript: ENSMUST00000135339
SMART Domains Protein: ENSMUSP00000142067
Gene: ENSMUSG00000026975

DomainStartEndE-ValueType
low complexity region 54 67 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000143253
SMART Domains Protein: ENSMUSP00000142315
Gene: ENSMUSG00000026975

DomainStartEndE-ValueType
low complexity region 54 67 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000146382
Predicted Effect possibly damaging
Transcript: ENSMUST00000148042
AA Change: E144G

PolyPhen 2 Score 0.538 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000141788
Gene: ENSMUSG00000026974
AA Change: E144G

DomainStartEndE-ValueType
Pfam:HNH_3 27 66 1.4e-10 PFAM
Pfam:zf-MYND 124 173 5e-10 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000153375
Meta Mutation Damage Score 0.5870 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.9%
  • 20x: 93.8%
Validation Efficiency 97% (33/34)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] ZMYND19 is a MYND zinc finger domain-containing protein that binds to the C terminus of melanin-concentrating hormone receptor-1 (MCHR1; MIM 601751) (Bachner et al., 2002 [PubMed 12208518]), and to the N termini of alpha-tubulin (TUBA1; MIM 191110), and beta-tubulin (TUBB; MIM 191130) (Francke et al., 2005 [PubMed 16039987]).[supplied by OMIM, Mar 2008]
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrg1 T G 8: 95,730,121 (GRCm39) L103V probably null Het
BC051076 C T 5: 88,111,684 (GRCm39) noncoding transcript Het
Ccdc191 A T 16: 43,751,561 (GRCm39) Q239L probably benign Het
Dennd4b G T 3: 90,178,882 (GRCm39) G538* probably null Het
Dipk1a T C 5: 108,062,291 (GRCm39) D78G possibly damaging Het
Dusp7 C T 9: 106,246,361 (GRCm39) A122V probably benign Het
Exd2 T G 12: 80,531,015 (GRCm39) probably benign Het
Gm10782 C A 13: 56,510,944 (GRCm39) noncoding transcript Het
Gm5117 T C 8: 32,227,306 (GRCm39) noncoding transcript Het
Hhipl1 T A 12: 108,284,806 (GRCm39) D386E probably benign Het
Hnf1a C T 5: 115,098,070 (GRCm39) probably null Het
Ifi204 A G 1: 173,583,198 (GRCm39) F340S possibly damaging Het
Kalrn C T 16: 33,810,180 (GRCm39) D2525N possibly damaging Het
Med26 T C 8: 73,249,476 (GRCm39) D541G probably benign Het
Mgam T A 6: 40,663,456 (GRCm39) L1218Q probably damaging Het
Msh5 T C 17: 35,264,095 (GRCm39) D136G probably damaging Het
Nbl1 C T 4: 138,810,843 (GRCm39) C117Y probably damaging Het
Niban2 A G 2: 32,813,482 (GRCm39) Y565C probably damaging Het
Noct T C 3: 51,132,710 (GRCm39) probably null Het
Nsf C T 11: 103,821,578 (GRCm39) E26K possibly damaging Het
Prmt2 A T 10: 76,044,301 (GRCm39) M417K probably damaging Het
Rptor A G 11: 119,748,277 (GRCm39) E3G probably damaging Het
Sgms1 G A 19: 32,137,072 (GRCm39) R165* probably null Het
Slc13a5 A G 11: 72,152,902 (GRCm39) S60P probably damaging Het
Sycp1 T C 3: 102,832,575 (GRCm39) Y197C probably damaging Het
Tmem222 T C 4: 132,998,335 (GRCm39) H73R possibly damaging Het
Trmt1l G A 1: 151,315,267 (GRCm39) G151D possibly damaging Het
Ttc16 A G 2: 32,658,020 (GRCm39) F409L probably benign Het
Ubap2l T C 3: 89,916,439 (GRCm39) Q925R probably null Het
Ucn3 T G 13: 3,991,413 (GRCm39) I80L probably benign Het
Vwa3a T C 7: 120,372,517 (GRCm39) S302P probably benign Het
Zfp804b A T 5: 7,229,410 (GRCm39) probably benign Het
Other mutations in Zmynd19
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01905:Zmynd19 APN 2 24,841,541 (GRCm39) missense probably benign 0.04
watson UTSW 2 24,848,201 (GRCm39) nonsense probably null
R0432:Zmynd19 UTSW 2 24,848,134 (GRCm39) missense probably benign 0.01
R1531:Zmynd19 UTSW 2 24,848,123 (GRCm39) missense probably benign 0.02
R2130:Zmynd19 UTSW 2 24,842,648 (GRCm39) nonsense probably null
R3612:Zmynd19 UTSW 2 24,841,492 (GRCm39) missense probably damaging 1.00
R4595:Zmynd19 UTSW 2 24,849,000 (GRCm39) missense probably damaging 1.00
R5165:Zmynd19 UTSW 2 24,848,201 (GRCm39) nonsense probably null
R6133:Zmynd19 UTSW 2 24,848,131 (GRCm39) missense possibly damaging 0.71
R9613:Zmynd19 UTSW 2 24,848,217 (GRCm39) missense
Predicted Primers PCR Primer
(F):5'- TTTCTTAGGGAGAACAAGTGCTGG -3'
(R):5'- CCTCCAGGTTCAACTGACAG -3'

Sequencing Primer
(F):5'- AACAAGTGCTGGGGCTTTAATCC -3'
(R):5'- GAGCTGGAAACTTTGAACCTGC -3'
Posted On 2014-11-11