Mutagenetix > Incidental Mutation

Incidental Mutation 'R2409:Vmn2r78'

248122

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r78

Ensembl Gene

ENSMUSG00000091962

Gene Name

vomeronasal 2, receptor 78

Synonyms

MMRRC Submission

040375-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.091) question?

Stock #

R2409 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

86915300-86955177 bp(+) (GRCm38)

Type of Mutation

splice site

DNA Base Change (assembly)

T to A at 86920745 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000126698 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000170835]

AlphaFold

K7N6U5

Predicted Effect

probably benign
Transcript: ENSMUST00000170835

SMART Domains

Protein: ENSMUSP00000126698
Gene: ENSMUSG00000091962

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
Pfam:ANF_receptor	75	464	5.9e-31	PFAM
Pfam:NCD3G	507	559	8.1e-21	PFAM
Pfam:7tm_3	592	827	1e-52	PFAM

Coding Region Coverage

1x: 99.1%
3x: 98.4%
10x: 96.9%
20x: 94.0%

Validation Efficiency

100% (32/32)

Allele List at MGI

Other mutations in this stock

Total: 29 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcb1a	C	T	5: 8,738,747 (GRCm38)	T1042I	probably benign	Het
Adamts13	A	G	2: 26,978,362 (GRCm38)	T162A	probably benign	Het
Adamts7	T	A	9: 90,180,687 (GRCm38)	I398N	probably damaging	Het
Cib2	A	G	9: 54,545,467 (GRCm38)		probably null	Het
Cyp3a16	T	C	5: 145,440,367 (GRCm38)	K470R	probably benign	Het
Dpy19l2	A	G	9: 24,658,628 (GRCm38)	M343T	probably benign	Het
Dyrk2	A	G	10: 118,860,627 (GRCm38)	V242A	probably benign	Het
Extl3	T	C	14: 65,077,568 (GRCm38)	D55G	probably benign	Het
Fabp7	A	G	10: 57,785,676 (GRCm38)	K82E	possibly damaging	Het
Fat1	G	T	8: 45,040,530 (GRCm38)		probably benign	Het
Gen1	A	G	12: 11,249,164 (GRCm38)	I280T	possibly damaging	Het
Gm5117	T	C	8: 31,737,278 (GRCm38)		noncoding transcript	Het
Gucy1b2	CCGTGTTT	C	14: 62,406,179 (GRCm38)		probably null	Het
Il3ra	G	A	14: 14,349,377 (GRCm38)		probably null	Het
Myo1f	A	G	17: 33,576,667 (GRCm38)	N66D	probably damaging	Het
Nfkb1	C	T	3: 135,613,943 (GRCm38)	E264K	possibly damaging	Het
Nsf	C	T	11: 103,930,752 (GRCm38)	E26K	possibly damaging	Het
Or7d10	G	T	9: 19,920,776 (GRCm38)	R189L	probably benign	Het
Or7d10	G	C	9: 19,920,781 (GRCm38)	D191H	probably damaging	Het
Prdm10	A	G	9: 31,349,122 (GRCm38)	H624R	possibly damaging	Het
Rgs5	G	T	1: 169,676,882 (GRCm38)	V34F	possibly damaging	Het
Sec14l4	T	C	11: 4,040,048 (GRCm38)	S116P	probably benign	Het
Septin1	T	C	7: 127,215,971 (GRCm38)		probably null	Het
Septin9	T	A	11: 117,360,461 (GRCm38)	I535N	probably damaging	Het
Sh2b1	C	T	7: 126,471,479 (GRCm38)	G350D	probably damaging	Het
Slc6a21	T	C	7: 45,280,326 (GRCm38)	V107A	probably benign	Het
Trim26	C	A	17: 36,851,003 (GRCm38)	H105N	probably damaging	Het
Trim71	A	T	9: 114,513,713 (GRCm38)	D500E	possibly damaging	Het
Vmn2r84	A	G	10: 130,392,071 (GRCm38)	S99P	probably damaging	Het

Other mutations in Vmn2r78

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01302:Vmn2r78	APN	7	86,915,361 (GRCm38)	missense	unknown
IGL01473:Vmn2r78	APN	7	86,920,312 (GRCm38)	missense	possibly damaging	0.61
IGL01767:Vmn2r78	APN	7	86,954,435 (GRCm38)	missense	probably benign	0.28
IGL02322:Vmn2r78	APN	7	86,921,479 (GRCm38)	missense	probably damaging	0.96
IGL02537:Vmn2r78	APN	7	86,954,288 (GRCm38)	missense	probably damaging	0.99
IGL03297:Vmn2r78	APN	7	86,920,761 (GRCm38)	nonsense	probably null
ANU74:Vmn2r78	UTSW	7	86,921,065 (GRCm38)	missense	possibly damaging	0.62
R0035:Vmn2r78	UTSW	7	86,920,205 (GRCm38)	missense	probably benign	0.22
R0081:Vmn2r78	UTSW	7	86,923,027 (GRCm38)	missense	probably benign	0.35
R0401:Vmn2r78	UTSW	7	86,921,311 (GRCm38)	missense	probably benign	0.04
R0751:Vmn2r78	UTSW	7	86,954,380 (GRCm38)	missense	possibly damaging	0.77
R1341:Vmn2r78	UTSW	7	86,922,269 (GRCm38)	missense	possibly damaging	0.71
R1386:Vmn2r78	UTSW	7	86,915,407 (GRCm38)	missense	unknown
R1526:Vmn2r78	UTSW	7	86,922,257 (GRCm38)	splice site	probably null
R1712:Vmn2r78	UTSW	7	86,954,924 (GRCm38)	missense	probably damaging	1.00
R1739:Vmn2r78	UTSW	7	86,920,789 (GRCm38)	missense	probably benign
R1812:Vmn2r78	UTSW	7	86,920,787 (GRCm38)	missense	probably benign	0.38
R2011:Vmn2r78	UTSW	7	86,955,079 (GRCm38)	missense	possibly damaging	0.52
R2144:Vmn2r78	UTSW	7	86,954,482 (GRCm38)	missense	probably damaging	1.00
R2197:Vmn2r78	UTSW	7	86,921,327 (GRCm38)	missense	probably damaging	0.96
R2291:Vmn2r78	UTSW	7	86,920,154 (GRCm38)	missense	probably damaging	1.00
R3023:Vmn2r78	UTSW	7	86,954,966 (GRCm38)	missense	probably damaging	1.00
R4486:Vmn2r78	UTSW	7	86,920,751 (GRCm38)	critical splice acceptor site	probably null
R4512:Vmn2r78	UTSW	7	86,920,244 (GRCm38)	missense	probably benign	0.00
R4515:Vmn2r78	UTSW	7	86,954,258 (GRCm38)	missense	probably damaging	0.99
R4544:Vmn2r78	UTSW	7	86,921,191 (GRCm38)	missense	probably benign
R4546:Vmn2r78	UTSW	7	86,954,603 (GRCm38)	missense	probably damaging	1.00
R4872:Vmn2r78	UTSW	7	86,954,708 (GRCm38)	missense	possibly damaging	0.87
R4928:Vmn2r78	UTSW	7	86,954,627 (GRCm38)	missense	probably damaging	1.00
R5101:Vmn2r78	UTSW	7	86,922,355 (GRCm38)	missense	probably damaging	1.00
R5265:Vmn2r78	UTSW	7	86,920,124 (GRCm38)	missense	probably damaging	1.00
R5328:Vmn2r78	UTSW	7	86,921,030 (GRCm38)	missense	probably damaging	0.98
R5442:Vmn2r78	UTSW	7	86,920,122 (GRCm38)	missense	possibly damaging	0.95
R5567:Vmn2r78	UTSW	7	86,921,529 (GRCm38)	missense	probably benign	0.17
R5572:Vmn2r78	UTSW	7	86,915,512 (GRCm38)	missense	probably benign	0.01
R5636:Vmn2r78	UTSW	7	86,954,429 (GRCm38)	missense	probably damaging	0.99
R5901:Vmn2r78	UTSW	7	86,954,588 (GRCm38)	missense	probably damaging	1.00
R5977:Vmn2r78	UTSW	7	86,954,907 (GRCm38)	missense	probably benign	0.00
R5977:Vmn2r78	UTSW	7	86,920,333 (GRCm38)	missense	possibly damaging	0.74
R6276:Vmn2r78	UTSW	7	86,921,110 (GRCm38)	missense	probably benign	0.00
R6386:Vmn2r78	UTSW	7	86,922,337 (GRCm38)	nonsense	probably null
R6724:Vmn2r78	UTSW	7	86,954,258 (GRCm38)	missense	probably damaging	0.99
R6852:Vmn2r78	UTSW	7	86,954,603 (GRCm38)	missense	probably damaging	1.00
R6896:Vmn2r78	UTSW	7	86,922,350 (GRCm38)	missense	probably benign	0.10
R7385:Vmn2r78	UTSW	7	86,922,425 (GRCm38)	missense	probably benign	0.18
R7578:Vmn2r78	UTSW	7	86,954,344 (GRCm38)	nonsense	probably null
R7680:Vmn2r78	UTSW	7	86,954,941 (GRCm38)	missense	probably damaging	1.00
R7748:Vmn2r78	UTSW	7	86,921,135 (GRCm38)	missense	probably benign	0.00
R7852:Vmn2r78	UTSW	7	86,920,170 (GRCm38)	nonsense	probably null
R8031:Vmn2r78	UTSW	7	86,954,867 (GRCm38)	missense	probably damaging	1.00
R8070:Vmn2r78	UTSW	7	86,922,487 (GRCm38)	missense	probably benign	0.01
R8085:Vmn2r78	UTSW	7	86,954,790 (GRCm38)	missense	probably benign	0.00
R8163:Vmn2r78	UTSW	7	86,954,452 (GRCm38)	missense	probably damaging	1.00
R8501:Vmn2r78	UTSW	7	86,920,886 (GRCm38)	missense	probably damaging	0.99
R8749:Vmn2r78	UTSW	7	86,954,305 (GRCm38)	missense	possibly damaging	0.81
R9209:Vmn2r78	UTSW	7	86,920,223 (GRCm38)	missense	probably benign	0.08
RF018:Vmn2r78	UTSW	7	86,954,431 (GRCm38)	nonsense	probably null
Z1177:Vmn2r78	UTSW	7	86,954,774 (GRCm38)	missense	probably benign	0.02
Z1177:Vmn2r78	UTSW	7	86,921,207 (GRCm38)	missense	probably benign	0.44

Predicted Primers

PCR Primer
(F):5'- CTTTATGACAAATGGGCAGGAG -3'
(R):5'- AACTGAATTCCATGGTCATCATCTG -3'

Sequencing Primer
(F):5'- GGCAGGAGAAACAACATAATGTTAG -3'
(R):5'- ATCTGTAATGATGACTCCTACCCAG -3'

Posted On

2014-11-11