Incidental Mutation 'R2374:Gm10754'
ID 248239
Institutional Source Beutler Lab
Gene Symbol Gm10754
Ensembl Gene ENSMUSG00000074776
Gene Name predicted gene 10754
Synonyms
MMRRC Submission 040353-MU
Accession Numbers
Essential gene? Not available question?
Stock # R2374 (G1)
Quality Score 225
Status Validated
Chromosome 10
Chromosomal Location 97517276-97802952 bp(-) (GRCm39)
Type of Mutation utr 3 prime
DNA Base Change (assembly) A to G at 97518013 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000100922 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000020094] [ENSMUST00000105285]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000020094
SMART Domains Protein: ENSMUSP00000020094
Gene: ENSMUSG00000019936

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
LRRNT 117 147 1.79e-6 SMART
LRR 166 189 1.73e0 SMART
LRR 190 215 3.47e0 SMART
LRR 258 280 3.18e1 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000099324
Predicted Effect probably benign
Transcript: ENSMUST00000105285
SMART Domains Protein: ENSMUSP00000100922
Gene: ENSMUSG00000019936

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
LRRNT 117 147 1.79e-6 SMART
LRR 166 189 1.73e0 SMART
LRR 190 215 3.47e0 SMART
LRR 258 280 3.18e1 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000220233
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.6%
  • 20x: 92.7%
Validation Efficiency 97% (33/34)
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adnp2 C T 18: 80,174,202 (GRCm39) R69Q probably damaging Het
Bltp1 A G 3: 36,939,545 (GRCm39) D133G probably benign Het
Celsr3 G A 9: 108,719,751 (GRCm39) R2450H probably benign Het
Clec4b1 T G 6: 123,027,597 (GRCm39) L18R probably damaging Het
Cntrl G A 2: 35,043,288 (GRCm39) V706I possibly damaging Het
Dhx30 A G 9: 109,920,632 (GRCm39) L294P probably damaging Het
Dnaaf9 A G 2: 130,662,494 (GRCm39) Y60H probably damaging Het
Dysf T C 6: 84,074,711 (GRCm39) L504P probably damaging Het
Grid1 G A 14: 35,043,764 (GRCm39) probably benign Het
Hydin A G 8: 111,291,780 (GRCm39) N3424S probably damaging Het
Itgb2 G A 10: 77,395,515 (GRCm39) V539I probably benign Het
Itgb5 T A 16: 33,740,168 (GRCm39) V426E probably damaging Het
Ly6e A G 15: 74,830,470 (GRCm39) S107G probably damaging Het
Mc3r G A 2: 172,091,074 (GRCm39) A99T possibly damaging Het
Myo15a T G 11: 60,369,669 (GRCm39) S810A possibly damaging Het
Neb A G 2: 52,153,669 (GRCm39) W2419R probably damaging Het
Nkpd1 A T 7: 19,257,900 (GRCm39) T560S possibly damaging Het
Or2n1c T C 17: 38,519,958 (GRCm39) M274T probably damaging Het
Or4b1b A T 2: 90,112,795 (GRCm39) S41R possibly damaging Het
Rasa3 A G 8: 13,627,411 (GRCm39) L697P probably damaging Het
Sptbn4 A G 7: 27,059,517 (GRCm39) Y2443H probably damaging Het
Steap2 A G 5: 5,725,845 (GRCm39) I393T probably damaging Het
Tbc1d12 T A 19: 38,825,614 (GRCm39) L155Q possibly damaging Het
Tnni3k A T 3: 154,492,422 (GRCm39) M816K probably benign Het
Ugt2a3 T C 5: 87,475,050 (GRCm39) D398G probably damaging Het
Vmn1r25 A T 6: 57,955,543 (GRCm39) S249T probably benign Het
Vmn2r17 C A 5: 109,575,104 (GRCm39) P137Q probably benign Het
Zbtb26 A G 2: 37,326,497 (GRCm39) S180P probably benign Het
Zfy1 A T Y: 726,391 (GRCm39) L458Q probably damaging Het
Zfy1 G C Y: 726,392 (GRCm39) L458V possibly damaging Het
Zmpste24 T C 4: 120,931,734 (GRCm39) E297G probably benign Het
Other mutations in Gm10754
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00264:Gm10754 APN 10 97,518,274 (GRCm39) utr 3 prime probably benign
IGL02869:Gm10754 APN 10 97,518,136 (GRCm39) utr 3 prime probably benign
R1481:Gm10754 UTSW 10 97,518,089 (GRCm39) utr 3 prime probably benign
R2138:Gm10754 UTSW 10 97,518,132 (GRCm39) utr 3 prime probably benign
R4026:Gm10754 UTSW 10 97,517,978 (GRCm39) utr 3 prime probably benign
R4947:Gm10754 UTSW 10 97,518,010 (GRCm39) utr 3 prime probably benign
X0025:Gm10754 UTSW 10 97,518,044 (GRCm39) utr 3 prime probably benign
Predicted Primers PCR Primer
(F):5'- ATCACTACACTTGGGAAAGCAAAG -3'
(R):5'- GGCCATATTCACATATCCATGGAATG -3'

Sequencing Primer
(F):5'- AAGGAGAGGGTGTCTTTTGAAATC -3'
(R):5'- TGGAATGACTTCAGAATGCCAG -3'
Posted On 2014-11-11