Incidental Mutation 'R2379:Or14c46'
| ID |
248382 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Or14c46
|
| Ensembl Gene |
ENSMUSG00000057540 |
| Gene Name |
olfactory receptor family 14 subfamily C member 46 |
| Synonyms |
GA_x6K02T2NHDJ-9838699-9839697, Olfr310, MOR227-6P |
| MMRRC Submission |
040355-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.080)
|
| Stock # |
R2379 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
85917938-85919019 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 85918857 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Alanine
at position 47
(T47A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000151989
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000081918]
[ENSMUST00000217724]
|
| AlphaFold |
B2RVZ1 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000081918
AA Change: T47A
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000080589
Gene: ENSMUSG00000057540
AA Change: T47A
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7tm_4
|
29 |
307 |
8.9e-46 |
PFAM |
|
Pfam:7tm_1
|
39 |
289 |
1.8e-18 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000217724
AA Change: T47A
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
| Meta Mutation Damage Score |
0.4106 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.8%
- 20x: 93.3%
|
| Validation Efficiency |
93% (37/40) |
| MGI Phenotype |
FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 34 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aff4 |
T |
C |
11: 53,299,305 (GRCm39) |
|
probably benign |
Het |
| Anpep |
T |
C |
7: 79,490,966 (GRCm39) |
T209A |
probably benign |
Het |
| Asb16 |
A |
G |
11: 102,163,357 (GRCm39) |
T116A |
probably benign |
Het |
| Brd10 |
G |
T |
19: 29,696,275 (GRCm39) |
Q1140K |
probably benign |
Het |
| Btc |
A |
T |
5: 91,524,768 (GRCm39) |
|
probably benign |
Het |
| C4b |
T |
C |
17: 34,954,717 (GRCm39) |
D860G |
possibly damaging |
Het |
| Cd177 |
G |
A |
7: 24,457,468 (GRCm39) |
T191I |
possibly damaging |
Het |
| Cngb1 |
A |
G |
8: 95,986,758 (GRCm39) |
L378P |
probably damaging |
Het |
| Ddx60 |
T |
C |
8: 62,490,122 (GRCm39) |
F1697S |
probably damaging |
Het |
| Dop1a |
G |
A |
9: 86,403,138 (GRCm39) |
S1446N |
probably damaging |
Het |
| Fn1 |
T |
A |
1: 71,688,443 (GRCm39) |
K154* |
probably null |
Het |
| Gm10801 |
G |
T |
2: 98,494,185 (GRCm39) |
S109I |
probably benign |
Het |
| Ifi204 |
T |
A |
1: 173,583,559 (GRCm39) |
R220* |
probably null |
Het |
| Limk1 |
A |
G |
5: 134,708,335 (GRCm39) |
|
probably benign |
Het |
| Mcm2 |
G |
A |
6: 88,869,990 (GRCm39) |
R60C |
probably damaging |
Het |
| Mms22l |
T |
A |
4: 24,496,929 (GRCm39) |
S8T |
possibly damaging |
Het |
| Mpp7 |
T |
A |
18: 7,403,345 (GRCm39) |
R322* |
probably null |
Het |
| Mycbp2 |
T |
C |
14: 103,412,386 (GRCm39) |
N2529S |
probably benign |
Het |
| Npr3 |
A |
G |
15: 11,883,449 (GRCm39) |
F327L |
probably damaging |
Het |
| Or12j3 |
A |
T |
7: 139,952,748 (GRCm39) |
Y258* |
probably null |
Het |
| Or14c41 |
T |
G |
7: 86,235,400 (GRCm39) |
F306V |
probably benign |
Het |
| Or51f5 |
A |
T |
7: 102,424,052 (GRCm39) |
H107L |
probably benign |
Het |
| Or5p1 |
T |
C |
7: 107,916,499 (GRCm39) |
S133P |
probably benign |
Het |
| Or6c217 |
A |
T |
10: 129,737,781 (GRCm39) |
V266E |
probably damaging |
Het |
| Or7e177 |
T |
C |
9: 20,211,963 (GRCm39) |
S157P |
possibly damaging |
Het |
| Pld2 |
A |
T |
11: 70,445,140 (GRCm39) |
Y580F |
probably benign |
Het |
| Scart2 |
A |
T |
7: 139,879,682 (GRCm39) |
D990V |
probably benign |
Het |
| Sik3 |
A |
G |
9: 46,066,707 (GRCm39) |
E162G |
probably damaging |
Het |
| Sla2 |
G |
A |
2: 156,717,862 (GRCm39) |
R137C |
probably damaging |
Het |
| Spen |
T |
C |
4: 141,244,238 (GRCm39) |
T266A |
unknown |
Het |
| Tnks1bp1 |
A |
G |
2: 84,894,182 (GRCm39) |
S1370G |
probably benign |
Het |
| Usp28 |
A |
G |
9: 48,914,395 (GRCm39) |
R99G |
probably null |
Het |
| Vmn2r13 |
T |
G |
5: 109,319,644 (GRCm39) |
E445D |
probably benign |
Het |
| Vmn2r27 |
A |
G |
6: 124,201,342 (GRCm39) |
I205T |
possibly damaging |
Het |
|
| Other mutations in Or14c46 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00095:Or14c46
|
APN |
7 |
85,918,877 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00917:Or14c46
|
APN |
7 |
85,918,649 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02145:Or14c46
|
APN |
7 |
85,918,466 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02639:Or14c46
|
APN |
7 |
85,918,928 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0139:Or14c46
|
UTSW |
7 |
85,918,187 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0554:Or14c46
|
UTSW |
7 |
85,918,865 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1392:Or14c46
|
UTSW |
7 |
85,918,063 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1392:Or14c46
|
UTSW |
7 |
85,918,063 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1474:Or14c46
|
UTSW |
7 |
85,918,270 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3692:Or14c46
|
UTSW |
7 |
85,918,703 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4290:Or14c46
|
UTSW |
7 |
85,918,968 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4291:Or14c46
|
UTSW |
7 |
85,918,968 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4295:Or14c46
|
UTSW |
7 |
85,918,968 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5071:Or14c46
|
UTSW |
7 |
85,918,799 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5072:Or14c46
|
UTSW |
7 |
85,918,799 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5074:Or14c46
|
UTSW |
7 |
85,918,799 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5828:Or14c46
|
UTSW |
7 |
85,918,728 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6174:Or14c46
|
UTSW |
7 |
85,918,009 (GRCm39) |
missense |
probably benign |
|
|
R6207:Or14c46
|
UTSW |
7 |
85,918,968 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6493:Or14c46
|
UTSW |
7 |
85,918,090 (GRCm39) |
missense |
probably benign |
0.21 |
|
R7068:Or14c46
|
UTSW |
7 |
85,918,745 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7196:Or14c46
|
UTSW |
7 |
85,918,649 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7694:Or14c46
|
UTSW |
7 |
85,918,983 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7794:Or14c46
|
UTSW |
7 |
85,918,341 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9315:Or14c46
|
UTSW |
7 |
85,918,495 (GRCm39) |
nonsense |
probably null |
|
|
Z1176:Or14c46
|
UTSW |
7 |
85,918,155 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TTGCAGATGGCCACATAGCG -3'
(R):5'- CTCTGTGTATTACAAGGTAACCATG -3'
Sequencing Primer
(F):5'- AGATGGCCACATAGCGGTCTTG -3'
(R):5'- TGGGAGCTCAGGATCTTA -3'
|
| Posted On |
2014-11-11 |
Incidental Mutation