Incidental Mutation 'R2395:Or10al2'
ID 248507
Institutional Source Beutler Lab
Gene Symbol Or10al2
Ensembl Gene ENSMUSG00000080990
Gene Name olfactory receptor family 10 subfamily AL member 2
Synonyms GA_x6K02T2PSCP-2131124-2132089, MOR263-13, Olfr118
MMRRC Submission 040363-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.070) question?
Stock # R2395 (G1)
Quality Score 225
Status Validated
Chromosome 17
Chromosomal Location 37982916-37983888 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) T to G at 37983587 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Stop codon at position 224 (Y224*)
Ref Sequence ENSEMBL: ENSMUSP00000151212 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000122036] [ENSMUST00000215811] [ENSMUST00000216551]
AlphaFold Q7TRJ6
Predicted Effect probably null
Transcript: ENSMUST00000122036
AA Change: Y224*
SMART Domains Protein: ENSMUSP00000113988
Gene: ENSMUSG00000080990
AA Change: Y224*

Pfam:7TM_GPCR_Srv 32 173 2e-6 PFAM
Pfam:7tm_4 37 314 2.1e-57 PFAM
Pfam:7TM_GPCR_Srsx 41 311 5.8e-6 PFAM
Pfam:7tm_1 47 296 1.4e-24 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000215811
AA Change: Y224*
Predicted Effect probably null
Transcript: ENSMUST00000216551
AA Change: Y224*
Meta Mutation Damage Score 0.9718 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.2%
  • 20x: 94.8%
Validation Efficiency 100% (30/30)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca8a A G 11: 109,959,614 (GRCm39) Y707H probably damaging Het
Abcc3 A G 11: 94,248,132 (GRCm39) V1156A possibly damaging Het
Acsl3 T C 1: 78,683,085 (GRCm39) V661A probably benign Het
Atosb C A 4: 43,035,964 (GRCm39) E256* probably null Het
B3glct A G 5: 149,677,651 (GRCm39) T427A probably damaging Het
Cblc C A 7: 19,519,305 (GRCm39) C341F probably damaging Het
Cntn2 T C 1: 132,454,110 (GRCm39) S299G probably benign Het
Dcp1b T C 6: 119,192,025 (GRCm39) S314P probably benign Het
Dnah6 T C 6: 73,068,950 (GRCm39) probably null Het
Fmn1 A G 2: 113,195,526 (GRCm39) T409A unknown Het
Hltf C T 3: 20,146,906 (GRCm39) A555V probably benign Het
Kmt2c T C 5: 25,520,150 (GRCm39) I1987V probably benign Het
Map3k10 T C 7: 27,373,418 (GRCm39) E11G unknown Het
Micu1 G T 10: 59,699,024 (GRCm39) E434* probably null Het
Mlph A G 1: 90,861,228 (GRCm39) T288A probably benign Het
Myh13 A G 11: 67,255,748 (GRCm39) E1679G probably benign Het
Myh15 A G 16: 48,889,877 (GRCm39) N156S probably benign Het
Nab1 A G 1: 52,529,741 (GRCm39) I52T probably damaging Het
Naip1 T C 13: 100,559,614 (GRCm39) H1130R possibly damaging Het
Or8k23 A G 2: 86,186,609 (GRCm39) V39A probably benign Het
P2rx2 A G 5: 110,489,527 (GRCm39) Y136H probably damaging Het
Phf8-ps T C 17: 33,284,936 (GRCm39) E622G probably benign Het
Prss40 A G 1: 34,598,986 (GRCm39) V59A possibly damaging Het
Riox1 A T 12: 83,997,418 (GRCm39) probably null Het
Rxrb T G 17: 34,256,412 (GRCm39) C384W probably damaging Het
Srebf2 C T 15: 82,076,456 (GRCm39) T702I probably benign Het
Tmprss5 T A 9: 49,026,435 (GRCm39) L373* probably null Het
Trpm2 A C 10: 77,783,714 (GRCm39) I253S possibly damaging Het
Ush2a C T 1: 188,679,237 (GRCm39) T4815I probably damaging Het
Vmn2r73 A T 7: 85,506,975 (GRCm39) M779K probably damaging Het
Other mutations in Or10al2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01300:Or10al2 APN 17 37,983,778 (GRCm39) missense probably damaging 1.00
IGL02456:Or10al2 APN 17 37,983,340 (GRCm39) missense possibly damaging 0.90
IGL02750:Or10al2 APN 17 37,983,500 (GRCm39) nonsense probably null
IGL03083:Or10al2 APN 17 37,983,551 (GRCm39) nonsense probably null
IGL03339:Or10al2 APN 17 37,983,448 (GRCm39) missense possibly damaging 0.87
R0032:Or10al2 UTSW 17 37,983,378 (GRCm39) missense probably damaging 1.00
R1457:Or10al2 UTSW 17 37,983,816 (GRCm39) nonsense probably null
R1542:Or10al2 UTSW 17 37,983,142 (GRCm39) missense probably damaging 1.00
R1771:Or10al2 UTSW 17 37,983,554 (GRCm39) missense probably damaging 1.00
R1893:Or10al2 UTSW 17 37,983,747 (GRCm39) nonsense probably null
R3619:Or10al2 UTSW 17 37,983,531 (GRCm39) missense probably benign 0.05
R3917:Or10al2 UTSW 17 37,983,684 (GRCm39) missense probably damaging 1.00
R3937:Or10al2 UTSW 17 37,983,858 (GRCm39) missense probably benign 0.01
R5600:Or10al2 UTSW 17 37,983,176 (GRCm39) missense possibly damaging 0.91
R6415:Or10al2 UTSW 17 37,983,448 (GRCm39) missense possibly damaging 0.87
R6462:Or10al2 UTSW 17 37,983,111 (GRCm39) missense probably damaging 1.00
R7355:Or10al2 UTSW 17 37,983,301 (GRCm39) missense probably benign 0.02
R7861:Or10al2 UTSW 17 37,983,408 (GRCm39) missense possibly damaging 0.91
R7913:Or10al2 UTSW 17 37,982,999 (GRCm39) missense probably benign
R7952:Or10al2 UTSW 17 37,983,708 (GRCm39) missense probably damaging 1.00
R7969:Or10al2 UTSW 17 37,983,547 (GRCm39) missense probably damaging 1.00
R8879:Or10al2 UTSW 17 37,983,302 (GRCm39) nonsense probably null
R8923:Or10al2 UTSW 17 37,983,702 (GRCm39) missense probably benign 0.00
R9253:Or10al2 UTSW 17 37,983,637 (GRCm39) missense probably benign 0.00
R9778:Or10al2 UTSW 17 37,983,145 (GRCm39) missense probably damaging 0.97
R9789:Or10al2 UTSW 17 37,983,059 (GRCm39) missense probably damaging 1.00
RF003:Or10al2 UTSW 17 37,983,749 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer

Sequencing Primer
Posted On 2014-11-11