Incidental Mutation 'R2401:Fam162b'
ID 248697
Institutional Source Beutler Lab
Gene Symbol Fam162b
Ensembl Gene ENSMUSG00000019909
Gene Name family with sequence similarity 162, member B
Synonyms 9430073N08Rik
MMRRC Submission 040367-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.068) question?
Stock # R2401 (G1)
Quality Score 143
Status Validated
Chromosome 10
Chromosomal Location 51585416-51590517 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) C to A at 51587218 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Alanine to Serine at position 118 (A118S)
Ref Sequence ENSEMBL: ENSMUSP00000020064 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000020064]
AlphaFold Q9CX19
Predicted Effect probably damaging
Transcript: ENSMUST00000020064
AA Change: A118S

PolyPhen 2 Score 0.987 (Sensitivity: 0.73; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000020064
Gene: ENSMUSG00000019909
AA Change: A118S

DomainStartEndE-ValueType
Pfam:DUF1075 15 154 3.8e-56 PFAM
Meta Mutation Damage Score 0.1440 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.0%
Validation Efficiency 100% (40/40)
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca14 T C 7: 120,283,089 L1158P probably damaging Het
Acnat1 A T 4: 49,451,077 N11K possibly damaging Het
Ammecr1l T A 18: 31,776,003 I217N possibly damaging Het
Ankrd11 G A 8: 122,908,734 R54* probably null Het
Ccdc178 C T 18: 22,131,414 probably null Het
Ccdc36 G T 9: 108,413,006 T133N possibly damaging Het
Clcn7 T C 17: 25,153,140 S425P probably benign Het
Cnmd A G 14: 79,656,605 V114A probably damaging Het
Col13a1 T C 10: 61,851,162 T651A unknown Het
Col1a2 G A 6: 4,518,822 probably benign Het
Cyp3a25 T C 5: 145,986,968 probably null Het
Dmrta1 A T 4: 89,691,616 D271V probably benign Het
Efcab3 T A 11: 105,072,318 probably null Het
Exo5 T C 4: 120,921,997 I224V probably damaging Het
Glb1 A G 9: 114,454,257 T406A possibly damaging Het
Grk3 T C 5: 112,914,983 N666S probably benign Het
Hars2 T C 18: 36,789,523 F370L possibly damaging Het
Ighv8-11 T G 12: 115,567,603 probably benign Het
Inpp4b A T 8: 81,997,339 D500V probably benign Het
Itgb4 A G 11: 116,006,563 D1534G possibly damaging Het
Kcnk2 G C 1: 189,340,017 T38S possibly damaging Het
Kif16b C T 2: 142,756,122 V527I probably benign Het
Kmt2b A G 7: 30,576,708 Y1789H probably damaging Het
Lpl A C 8: 68,901,243 D412A possibly damaging Het
Lrrc27 T G 7: 139,223,613 L151R probably damaging Het
Muc3 T C 5: 137,154,041 probably benign Het
Nup205 T A 6: 35,208,134 Y829* probably null Het
Obscn T C 11: 59,131,646 R758G possibly damaging Het
Olfm4 A G 14: 80,021,752 Y447C probably damaging Het
Olfr1308 T C 2: 111,960,149 Y308C probably benign Het
Pcdhb6 T C 18: 37,335,169 V381A probably benign Het
Prmt2 C T 10: 76,225,415 W79* probably null Het
Skiv2l T C 17: 34,840,385 M1029V probably benign Het
Stil A G 4: 115,016,286 R369G probably null Het
Ttc41 T C 10: 86,724,374 I387T probably benign Het
Tubgcp6 A G 15: 89,102,984 L1262P probably benign Het
Vmn2r112 T A 17: 22,603,115 V258E probably damaging Het
Zfp804b T C 5: 6,769,445 H1206R probably damaging Het
Other mutations in Fam162b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00567:Fam162b APN 10 51590294 missense possibly damaging 0.94
IGL02948:Fam162b APN 10 51587296 missense probably damaging 1.00
R0709:Fam162b UTSW 10 51587251 missense probably damaging 1.00
R1185:Fam162b UTSW 10 51590343 missense probably benign
R1185:Fam162b UTSW 10 51590343 missense probably benign
R1185:Fam162b UTSW 10 51590343 missense probably benign
R1505:Fam162b UTSW 10 51587202 missense probably damaging 1.00
R1735:Fam162b UTSW 10 51587211 missense probably damaging 1.00
R1961:Fam162b UTSW 10 51590334 missense probably benign 0.00
R6059:Fam162b UTSW 10 51590307 missense probably benign 0.28
R6196:Fam162b UTSW 10 51587410 splice site probably null
R6284:Fam162b UTSW 10 51585502 missense probably damaging 0.99
R6625:Fam162b UTSW 10 51590295 missense probably damaging 1.00
R7324:Fam162b UTSW 10 51590186 splice site probably null
R7380:Fam162b UTSW 10 51590476 start gained probably benign
R8945:Fam162b UTSW 10 51590373 missense probably benign 0.02
R9415:Fam162b UTSW 10 51590059 critical splice donor site probably null
Predicted Primers PCR Primer
(F):5'- GCTGAATGCAGAACAAGGTCC -3'
(R):5'- GGGGAAATATTTGGGCTACTCC -3'

Sequencing Primer
(F):5'- TGCAGAACAAGGTCCATAGCATTTC -3'
(R):5'- GCAATCAACCATCATTTATCATGC -3'
Posted On 2014-11-11