|Institutional Source||Beutler Lab|
|Gene Name||YEATS domain containing 4|
|Synonyms||4930573H17Rik, NuBI-1, GAS41, B230215M10Rik|
|Is this an essential gene?||Probably essential (E-score: 0.952)|
|Stock #||R0305 (G1)|
|Chromosomal Location||117215221-117224507 bp(-) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||A to G at 117215836 bp|
|Amino Acid Change||Phenylalanine to Serine at position 172 (F172S)|
|Ref Sequence||ENSEMBL: ENSMUSP00000020382 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000020382] [ENSMUST00000218887]|
|Predicted Effect||probably damaging
AA Change: F172S
PolyPhen 2 Score 0.987 (Sensitivity: 0.73; Specificity: 0.96)
AA Change: F172S
|Predicted Effect||probably benign
|Predicted Effect||noncoding transcript
|Meta Mutation Damage Score||0.26|
|Coding Region Coverage||
|Validation Efficiency||100% (59/59)|
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is found in the nucleoli. It has high sequence homology to human MLLT1, and yeast and human MLLT3 proteins. Both MLLT1 and MLLT3 proteins belong to a class of transcription factors, indicating that the encoded protein might also represent a transcription factor. This protein is thought to be required for RNA transcription. This gene has been shown to be amplified in tumors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Yeats4||
(F):5'- ACCTGGAGTCCTCTCTGAGAAAGC -3'
(R):5'- TCAAAGTCAACCGTGAGTTAGCAGC -3'
(F):5'- TACCGCCAGTTGCTCAAATG -3'
(R):5'- GTTCAGTGCTCTGTCTCCAT -3'