Mutagenetix > Incidental Mutation

Incidental Mutation 'R2422:Vmn2r105'

249407

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r105

Ensembl Gene

ENSMUSG00000091670

Gene Name

vomeronasal 2, receptor 105

Synonyms

EG627743

MMRRC Submission

040384-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R2422 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

20208230-20234872 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 20227835 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Arginine to Serine at position 242 (R242S)

Ref Sequence

ENSEMBL: ENSMUSP00000129762 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000167382]

AlphaFold

E9Q3A5

Predicted Effect

probably benign
Transcript: ENSMUST00000167382
AA Change: R242S

PolyPhen 2 Score 0.149 (Sensitivity: 0.92; Specificity: 0.87)

SMART Domains

Protein: ENSMUSP00000129762
Gene: ENSMUSG00000091670
AA Change: R242S

Domain	Start	End	E-Value	Type
Pfam:ANF_receptor	85	469	6.5e-42	PFAM
Pfam:NCD3G	512	565	3.2e-21	PFAM
Pfam:7tm_3	598	833	2.5e-51	PFAM

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.1%
3x: 98.5%
10x: 97.1%
20x: 94.5%

Validation Efficiency

99% (77/78)

Allele List at MGI

Other mutations in this stock

Total: 77 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4933409G03Rik	A	T	2: 68,591,520 (GRCm38)	N47I	probably benign	Het
Actr5	T	C	2: 158,636,081 (GRCm38)	F457S	probably damaging	Het
Adamts3	A	G	5: 89,683,175 (GRCm38)	S1007P	probably damaging	Het
Adck2	C	T	6: 39,583,998 (GRCm38)	A440V	possibly damaging	Het
Birc6	T	A	17: 74,660,614 (GRCm38)	L301Q	probably damaging	Het
Ccdc121rt3	A	T	5: 112,355,118 (GRCm38)	V240D	probably damaging	Het
Ccdc18	A	C	5: 108,228,588 (GRCm38)	E1298D	probably damaging	Het
Ccdc77	A	G	6: 120,339,159 (GRCm38)	C186R	probably benign	Het
Cdk12	T	G	11: 98,219,074 (GRCm38)	S640R	probably benign	Het
Cdv3	T	C	9: 103,365,118 (GRCm38)		probably benign	Het
Celf2	G	A	2: 6,553,889 (GRCm38)	T364I	probably damaging	Het
Cmtr2	C	A	8: 110,222,781 (GRCm38)	S574R	probably benign	Het
Col14a1	T	C	15: 55,449,922 (GRCm38)	L56P	unknown	Het
Cracdl	C	A	1: 37,613,475 (GRCm38)	V1084L	probably benign	Het
Dctn1	C	T	6: 83,199,800 (GRCm38)	L1241F	possibly damaging	Het
Depdc5	T	C	5: 32,991,035 (GRCm38)	F1505S	probably damaging	Het
Dhcr24	G	T	4: 106,561,094 (GRCm38)		probably benign	Het
Dnajc21	A	G	15: 10,461,935 (GRCm38)	S127P	probably benign	Het
Entpd7	A	T	19: 43,728,088 (GRCm38)	Y507F	possibly damaging	Het
Fbp1	T	C	13: 62,871,306 (GRCm38)	K24E	probably benign	Het
Galr1	A	T	18: 82,405,923 (GRCm38)	N76K	probably damaging	Het
Glrb	A	G	3: 80,860,235 (GRCm38)	I226T	probably damaging	Het
Gm17421	T	A	12: 113,369,487 (GRCm38)		noncoding transcript	Het
Gm4950	T	A	18: 51,865,784 (GRCm38)	Q33L	probably benign	Het
Gnat2	A	T	3: 108,095,539 (GRCm38)	M88L	probably damaging	Het
Gpr183	A	G	14: 121,954,177 (GRCm38)	Y311H	probably damaging	Het
H2-M10.5	A	G	17: 36,774,999 (GRCm38)	I308V	probably benign	Het
Hipk3	C	T	2: 104,471,485 (GRCm38)	G121R	probably benign	Het
Hjurp	A	G	1: 88,266,561 (GRCm38)		probably benign	Het
Homez	C	A	14: 54,857,574 (GRCm38)	V226F	probably benign	Het
Inf2	C	A	12: 112,610,824 (GRCm38)	A1034D	unknown	Het
Kcnc4	G	T	3: 107,445,547 (GRCm38)	P572T	probably benign	Het
Kmt2d	T	C	15: 98,862,266 (GRCm38)	E1037G	unknown	Het
Krt78	T	C	15: 101,947,264 (GRCm38)	E704G	probably damaging	Het
Lama1	A	T	17: 67,750,553 (GRCm38)	M541L	probably benign	Het
Lmbrd2	C	T	15: 9,194,765 (GRCm38)	T618M	possibly damaging	Het
Ly6g6e	G	A	17: 35,078,146 (GRCm38)	R121Q	probably benign	Het
Mettl22	T	C	16: 8,487,361 (GRCm38)	F293L	probably damaging	Het
Mib1	T	C	18: 10,751,906 (GRCm38)	S263P	probably damaging	Het
Ndufaf1	T	C	2: 119,655,737 (GRCm38)	E298G	probably damaging	Het
Nek1	T	C	8: 61,019,901 (GRCm38)	V152A	probably damaging	Het
Nlrp4d	T	A	7: 10,362,945 (GRCm38)	D876V	probably benign	Het
Or10d5	A	G	9: 39,950,528 (GRCm38)	L81P	possibly damaging	Het
Or11g7	T	C	14: 50,453,436 (GRCm38)	L128P	probably damaging	Het
Or5an11	A	T	19: 12,268,919 (GRCm38)	T230S	probably damaging	Het
Or5k15	T	C	16: 58,889,965 (GRCm38)	E85G	probably benign	Het
Pcdha11	G	T	18: 37,007,272 (GRCm38)	L651F	probably damaging	Het
Plekhg1	G	A	10: 3,958,048 (GRCm38)	M988I	probably benign	Het
Plxnb1	G	A	9: 109,108,438 (GRCm38)	R1169H	probably benign	Het
Ppp4r3a	A	G	12: 101,042,653 (GRCm38)		probably benign	Het
Pum2	A	T	12: 8,748,931 (GRCm38)	Q930L	possibly damaging	Het
Rbp4	T	C	19: 38,124,344 (GRCm38)	E67G	probably damaging	Het
Rgs9	C	A	11: 109,225,777 (GRCm38)		probably null	Het
Semp2l1	C	T	1: 32,545,861 (GRCm38)	A323T	possibly damaging	Het
Sipa1	A	T	19: 5,652,112 (GRCm38)	D923E	possibly damaging	Het
Smc1a	A	G	X: 152,047,975 (GRCm38)		probably benign	Het
Snx33	C	A	9: 56,918,538 (GRCm38)	M546I	probably benign	Het
Spag17	T	A	3: 100,027,619 (GRCm38)	W714R	probably benign	Het
Spata2	C	T	2: 167,484,206 (GRCm38)	R231Q	probably damaging	Het
Stard9	C	T	2: 120,700,284 (GRCm38)	R2341C	probably benign	Het
Tas2r116	A	T	6: 132,855,594 (GRCm38)	I53F	possibly damaging	Het
Tlk1	T	C	2: 70,770,005 (GRCm38)	E110G	probably damaging	Het
Tmem102	T	A	11: 69,804,537 (GRCm38)	E203V	probably benign	Het
Top2b	T	G	14: 16,409,189 (GRCm38)	I777M	probably damaging	Het
Ttc23l	G	A	15: 10,537,566 (GRCm38)	S206L	probably benign	Het
Ttc23l	CT	CTTGGATT	15: 10,537,562 (GRCm38)		probably benign	Het
Tyw5	A	G	1: 57,396,748 (GRCm38)	I82T	possibly damaging	Het
Uba6	A	G	5: 86,132,616 (GRCm38)		probably null	Het
Ugcg	C	T	4: 59,207,798 (GRCm38)	P46S	probably benign	Het
Unc13c	T	C	9: 73,931,547 (GRCm38)	Y674C	probably damaging	Het
Vmn2r12	A	G	5: 109,086,532 (GRCm38)	Y605H	probably benign	Het
Wdr77	A	T	3: 105,960,021 (GRCm38)	K62*	probably null	Het
Zfhx4	C	A	3: 5,390,405 (GRCm38)	A1153E	probably benign	Het
Zfp266	C	A	9: 20,499,262 (GRCm38)	V540L	possibly damaging	Het
Zfp638	C	A	6: 83,966,439 (GRCm38)		probably benign	Het
Zfp644	A	G	5: 106,637,244 (GRCm38)	M479T	possibly damaging	Het
Zfp951	G	A	5: 104,815,277 (GRCm38)	T141I	probably benign	Het

Other mutations in Vmn2r105

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01433:Vmn2r105	APN	17	20,228,555 (GRCm38)	missense	probably benign	0.01
IGL01909:Vmn2r105	APN	17	20,224,656 (GRCm38)	missense	probably damaging	1.00
IGL01925:Vmn2r105	APN	17	20,208,711 (GRCm38)	missense	possibly damaging	0.94
IGL02021:Vmn2r105	APN	17	20,227,895 (GRCm38)	missense	possibly damaging	0.49
IGL02828:Vmn2r105	APN	17	20,209,083 (GRCm38)	missense	possibly damaging	0.80
IGL02838:Vmn2r105	APN	17	20,227,585 (GRCm38)	missense	probably damaging	1.00
IGL03343:Vmn2r105	APN	17	20,226,369 (GRCm38)	nonsense	probably null
R0096:Vmn2r105	UTSW	17	20,227,479 (GRCm38)	missense	possibly damaging	0.49
R0096:Vmn2r105	UTSW	17	20,227,479 (GRCm38)	missense	possibly damaging	0.49
R0212:Vmn2r105	UTSW	17	20,208,565 (GRCm38)	missense	possibly damaging	0.90
R0268:Vmn2r105	UTSW	17	20,208,676 (GRCm38)	missense	probably benign	0.18
R0271:Vmn2r105	UTSW	17	20,234,703 (GRCm38)	missense	probably damaging	0.96
R0613:Vmn2r105	UTSW	17	20,208,316 (GRCm38)	missense	probably damaging	1.00
R0765:Vmn2r105	UTSW	17	20,227,857 (GRCm38)	missense	probably damaging	0.98
R0765:Vmn2r105	UTSW	17	20,227,711 (GRCm38)	missense	probably benign	0.20
R1162:Vmn2r105	UTSW	17	20,227,711 (GRCm38)	missense	probably benign	0.20
R1263:Vmn2r105	UTSW	17	20,208,322 (GRCm38)	missense	probably damaging	1.00
R1363:Vmn2r105	UTSW	17	20,208,670 (GRCm38)	missense	probably benign	0.00
R1464:Vmn2r105	UTSW	17	20,228,742 (GRCm38)	splice site	probably benign
R2029:Vmn2r105	UTSW	17	20,224,578 (GRCm38)	missense	probably damaging	0.99
R2420:Vmn2r105	UTSW	17	20,227,835 (GRCm38)	missense	probably benign	0.15
R2421:Vmn2r105	UTSW	17	20,227,835 (GRCm38)	missense	probably benign	0.15
R2570:Vmn2r105	UTSW	17	20,227,323 (GRCm38)	missense	probably damaging	1.00
R3847:Vmn2r105	UTSW	17	20,208,690 (GRCm38)	missense	possibly damaging	0.85
R3848:Vmn2r105	UTSW	17	20,208,690 (GRCm38)	missense	possibly damaging	0.85
R4030:Vmn2r105	UTSW	17	20,208,754 (GRCm38)	missense	probably damaging	0.99
R4275:Vmn2r105	UTSW	17	20,228,640 (GRCm38)	missense	probably damaging	1.00
R4551:Vmn2r105	UTSW	17	20,226,351 (GRCm38)	missense	probably benign
R4801:Vmn2r105	UTSW	17	20,227,294 (GRCm38)	missense	probably benign	0.00
R4802:Vmn2r105	UTSW	17	20,227,294 (GRCm38)	missense	probably benign	0.00
R4816:Vmn2r105	UTSW	17	20,208,691 (GRCm38)	missense	probably benign	0.27
R4929:Vmn2r105	UTSW	17	20,228,018 (GRCm38)	missense	probably benign	0.44
R5022:Vmn2r105	UTSW	17	20,208,414 (GRCm38)	missense	probably damaging	0.99
R5475:Vmn2r105	UTSW	17	20,234,782 (GRCm38)	missense	probably benign
R5576:Vmn2r105	UTSW	17	20,224,574 (GRCm38)	critical splice donor site	probably null
R5795:Vmn2r105	UTSW	17	20,228,736 (GRCm38)	missense	probably benign	0.00
R5895:Vmn2r105	UTSW	17	20,228,667 (GRCm38)	missense	probably benign	0.10
R6017:Vmn2r105	UTSW	17	20,208,627 (GRCm38)	missense	probably damaging	0.97
R6210:Vmn2r105	UTSW	17	20,228,496 (GRCm38)	missense	probably damaging	1.00
R6491:Vmn2r105	UTSW	17	20,227,730 (GRCm38)	nonsense	probably null
R6542:Vmn2r105	UTSW	17	20,228,541 (GRCm38)	missense	probably benign	0.03
R6729:Vmn2r105	UTSW	17	20,208,343 (GRCm38)	missense	probably damaging	0.99
R7020:Vmn2r105	UTSW	17	20,209,074 (GRCm38)	missense	probably damaging	1.00
R7033:Vmn2r105	UTSW	17	20,208,612 (GRCm38)	missense	probably damaging	0.97
R7488:Vmn2r105	UTSW	17	20,208,783 (GRCm38)	missense	probably damaging	1.00
R7491:Vmn2r105	UTSW	17	20,228,565 (GRCm38)	missense	probably benign	0.02
R7555:Vmn2r105	UTSW	17	20,227,675 (GRCm38)	missense	probably damaging	0.98
R7863:Vmn2r105	UTSW	17	20,208,675 (GRCm38)	missense	probably benign	0.18
R8137:Vmn2r105	UTSW	17	20,234,704 (GRCm38)	missense	probably benign	0.02
R8166:Vmn2r105	UTSW	17	20,208,642 (GRCm38)	missense	probably benign	0.07
R8186:Vmn2r105	UTSW	17	20,224,618 (GRCm38)	nonsense	probably null
R8214:Vmn2r105	UTSW	17	20,228,513 (GRCm38)	missense	probably benign	0.02
R8497:Vmn2r105	UTSW	17	20,234,872 (GRCm38)	start codon destroyed	probably null	0.75
R8850:Vmn2r105	UTSW	17	20,208,610 (GRCm38)	missense	probably damaging	1.00
R8880:Vmn2r105	UTSW	17	20,208,967 (GRCm38)	missense	probably damaging	0.99
R9272:Vmn2r105	UTSW	17	20,227,423 (GRCm38)	missense	probably damaging	1.00
R9506:Vmn2r105	UTSW	17	20,209,142 (GRCm38)	missense	probably benign	0.00
R9549:Vmn2r105	UTSW	17	20,227,761 (GRCm38)	missense	probably benign	0.12

Predicted Primers

PCR Primer
(F):5'- AGGCTCCCATGAAATGAGTC -3'
(R):5'- GGCCCTTATGATCCTATTTTGAGTG -3'

Sequencing Primer
(F):5'- GAGGTTCAATGTTCATGACCCAGAC -3'
(R):5'- CCTATTTTGAGTGACCGAAATCAG -3'

Posted On

2014-11-12