|Institutional Source||Beutler Lab|
|Gene Name||galanin receptor 1|
|Essential gene?||Non essential (E-score: 0.000)|
|Stock #||R2422 (G1)|
|Chromosomal Location||82392496-82406777 bp(-) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||A to T at 82405923 bp (GRCm38)|
|Amino Acid Change||Asparagine to Lysine at position 76 (N76K)|
|Ref Sequence||ENSEMBL: ENSMUSP00000066381 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000065224]|
AA Change: N76K
PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
AA Change: N76K
|Meta Mutation Damage Score||0.6467|
|Coding Region Coverage||
|Validation Efficiency||99% (77/78)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The neuropeptide galanin elicits a range of biological effects by interaction with specific G-protein-coupled receptors. Galanin receptors are seven-transmembrane proteins shown to activate a variety of intracellular second-messenger pathways. GALR1 inhibits adenylyl cyclase via a G protein of the Gi/Go family. GALR1 is widely expressed in the brain and spinal cord, as well as in peripheral sites such as the small intestine and heart. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous mutation of this gene does not appear to result in a phenotype. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Galr1||
(F):5'- TAGCGATCCACAGACATCGC -3'
(R):5'- ATGGAACTGGCTATGGTGAACC -3'
(F):5'- ACAGACATCGCGGCCAG -3'
(R):5'- AACTGGCTATGGTGAACCTCAGTG -3'