Incidental Mutation 'R2424:Fbxw21'
ID 249495
Institutional Source Beutler Lab
Gene Symbol Fbxw21
Ensembl Gene ENSMUSG00000047237
Gene Name F-box and WD-40 domain protein 21
Synonyms E330009P21Rik
MMRRC Submission 040386-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.059) question?
Stock # R2424 (G1)
Quality Score 225
Status Validated
Chromosome 9
Chromosomal Location 108968522-108991090 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) A to T at 108986587 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Stop codon at position 97 (Y97*)
Ref Sequence ENSEMBL: ENSMUSP00000143200 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000054925] [ENSMUST00000198076] [ENSMUST00000199540]
AlphaFold Q8BI38
Predicted Effect probably null
Transcript: ENSMUST00000054925
AA Change: Y97*
SMART Domains Protein: ENSMUSP00000056358
Gene: ENSMUSG00000047237
AA Change: Y97*

DomainStartEndE-ValueType
FBOX 5 45 1.46e-6 SMART
SCOP:d1tbga_ 119 249 1e-7 SMART
Blast:WD40 137 176 1e-6 BLAST
Predicted Effect probably null
Transcript: ENSMUST00000198076
AA Change: Y97*
SMART Domains Protein: ENSMUSP00000143095
Gene: ENSMUSG00000047237
AA Change: Y97*

DomainStartEndE-ValueType
FBOX 5 45 1.46e-6 SMART
SCOP:d1tbga_ 119 249 9e-8 SMART
Blast:WD40 137 176 1e-6 BLAST
Predicted Effect probably null
Transcript: ENSMUST00000199540
AA Change: Y97*
SMART Domains Protein: ENSMUSP00000143200
Gene: ENSMUSG00000047237
AA Change: Y97*

DomainStartEndE-ValueType
FBOX 5 45 9e-9 SMART
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.1%
  • 20x: 94.3%
Validation Efficiency 100% (64/64)
Allele List at MGI
Other mutations in this stock
Total: 65 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aacs A G 5: 125,590,159 (GRCm39) probably null Het
Acot3 G T 12: 84,100,638 (GRCm39) R138L probably damaging Het
Ago3 A G 4: 126,298,040 (GRCm39) V160A probably damaging Het
Akap9 A C 5: 4,115,279 (GRCm39) E166D probably damaging Het
Arid5a T C 1: 36,357,582 (GRCm39) Y136H probably damaging Het
Ascc3 T C 10: 50,494,297 (GRCm39) V244A probably benign Het
Atp10a A T 7: 58,444,303 (GRCm39) H560L probably benign Het
Btbd6 A G 12: 112,941,980 (GRCm39) T482A probably benign Het
Cacna1d A T 14: 29,770,980 (GRCm39) Y1828N probably damaging Het
Capzb A G 4: 138,921,441 (GRCm39) M1V probably null Het
Cdh9 T G 15: 16,850,440 (GRCm39) F524L probably damaging Het
Ctnna1 T C 18: 35,386,760 (GRCm39) S846P probably benign Het
Dab1 C T 4: 104,588,948 (GRCm39) A524V probably benign Het
Dock7 T A 4: 98,833,544 (GRCm39) R1886* probably null Het
Dpp3 A T 19: 4,957,735 (GRCm39) L711* probably null Het
Dst T A 1: 34,206,141 (GRCm39) I566N probably damaging Het
Eif2b3 T A 4: 116,928,045 (GRCm39) S421R probably benign Het
Epg5 T C 18: 78,011,828 (GRCm39) V825A probably benign Het
Eya1 T A 1: 14,341,072 (GRCm39) probably benign Het
Fam187a T C 11: 102,776,780 (GRCm39) Y195H probably damaging Het
Fbn2 C T 18: 58,336,859 (GRCm39) C132Y probably damaging Het
Grin1 A T 2: 25,208,664 (GRCm39) C79S probably null Het
Haao T A 17: 84,142,991 (GRCm39) Y118F probably damaging Het
Il11ra1 T A 4: 41,768,222 (GRCm39) S378T probably damaging Het
Kcnj5 A T 9: 32,234,116 (GRCm39) N66K probably damaging Het
Kif21a T A 15: 90,855,399 (GRCm39) N668I probably damaging Het
Kprp A T 3: 92,732,912 (GRCm39) L46Q probably damaging Het
Lama1 C T 17: 68,105,660 (GRCm39) T2056I probably benign Het
Madd G C 2: 90,996,967 (GRCm39) D824E probably damaging Het
Mapk9 A G 11: 49,754,499 (GRCm39) N84S probably damaging Het
Mrpl39 A G 16: 84,527,748 (GRCm39) V160A probably benign Het
Mrpl9 T C 3: 94,351,113 (GRCm39) S98P probably benign Het
Mybpc3 A T 2: 90,966,138 (GRCm39) M1233L probably benign Het
Neb A G 2: 52,099,671 (GRCm39) probably benign Het
Ngly1 A G 14: 16,290,721 (GRCm38) probably null Het
Nt5c1b A T 12: 10,420,072 (GRCm39) T4S probably damaging Het
Obscn T C 11: 58,885,277 (GRCm39) probably benign Het
Or2h2c T C 17: 37,422,408 (GRCm39) I155M probably benign Het
Or4k15b T C 14: 50,272,281 (GRCm39) Y193C probably damaging Het
Or8b1b T C 9: 38,376,128 (GRCm39) S264P probably damaging Het
Or8g53 A G 9: 39,683,593 (GRCm39) F168L probably benign Het
Otog A T 7: 45,947,593 (GRCm39) K64* probably null Het
Papola A G 12: 105,793,311 (GRCm39) T544A probably benign Het
Phc1 A G 6: 122,297,002 (GRCm39) V790A probably damaging Het
Phf3 G T 1: 30,845,430 (GRCm39) R1252S probably damaging Het
Phf8-ps T C 17: 33,284,730 (GRCm39) T691A probably benign Het
Plxna2 C T 1: 194,431,625 (GRCm39) S538F probably damaging Het
Rgs17 T A 10: 5,783,111 (GRCm39) I159F probably damaging Het
Rgs17 T A 10: 5,792,560 (GRCm39) E62V probably benign Het
Rnase1 A G 14: 51,383,004 (GRCm39) Y117H possibly damaging Het
Rnf214 T C 9: 45,811,096 (GRCm39) D189G probably damaging Het
Sema4b A G 7: 79,869,023 (GRCm39) N365S probably damaging Het
Setd2 A G 9: 110,446,590 (GRCm39) H2480R probably benign Het
Slc27a6 G T 18: 58,738,189 (GRCm39) C415F probably benign Het
Stim1 A G 7: 102,057,612 (GRCm39) I142V probably benign Het
Supt5 T C 7: 28,014,590 (GRCm39) I1070V possibly damaging Het
Tbp T C 17: 15,733,795 (GRCm39) F174L possibly damaging Het
Tex26 A G 5: 149,393,913 (GRCm39) probably benign Het
Tmem132d A G 5: 127,941,663 (GRCm39) V479A probably benign Het
Ttn T C 2: 76,711,489 (GRCm39) probably benign Het
Urb2 T A 8: 124,757,165 (GRCm39) N957K probably benign Het
Usp24 T C 4: 106,256,310 (GRCm39) probably null Het
Vmn2r114 T C 17: 23,515,842 (GRCm39) T550A possibly damaging Het
Vmn2r72 A G 7: 85,400,161 (GRCm39) V296A probably damaging Het
Vmn2r91 C A 17: 18,356,431 (GRCm39) Y699* probably null Het
Other mutations in Fbxw21
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00679:Fbxw21 APN 9 108,991,032 (GRCm39) missense probably damaging 1.00
IGL00901:Fbxw21 APN 9 108,985,467 (GRCm39) missense probably benign 0.00
IGL01377:Fbxw21 APN 9 108,975,713 (GRCm39) nonsense probably null
IGL01941:Fbxw21 APN 9 108,977,224 (GRCm39) missense probably benign 0.07
IGL02491:Fbxw21 APN 9 108,972,887 (GRCm39) missense probably benign
IGL03163:Fbxw21 APN 9 108,974,552 (GRCm39) missense probably benign 0.01
IGL03377:Fbxw21 APN 9 108,968,597 (GRCm39) missense probably benign 0.01
R0148:Fbxw21 UTSW 9 108,977,085 (GRCm39) critical splice donor site probably null
R0328:Fbxw21 UTSW 9 108,975,653 (GRCm39) missense possibly damaging 0.52
R0909:Fbxw21 UTSW 9 108,985,476 (GRCm39) missense possibly damaging 0.84
R1506:Fbxw21 UTSW 9 108,977,257 (GRCm39) missense probably damaging 1.00
R1575:Fbxw21 UTSW 9 108,990,984 (GRCm39) missense probably benign 0.00
R1615:Fbxw21 UTSW 9 108,972,794 (GRCm39) missense probably damaging 1.00
R1719:Fbxw21 UTSW 9 108,977,242 (GRCm39) missense possibly damaging 0.85
R2415:Fbxw21 UTSW 9 108,985,469 (GRCm39) missense possibly damaging 0.71
R2508:Fbxw21 UTSW 9 108,974,553 (GRCm39) missense probably benign 0.31
R2898:Fbxw21 UTSW 9 108,985,404 (GRCm39) missense possibly damaging 0.52
R2964:Fbxw21 UTSW 9 108,974,578 (GRCm39) missense probably benign 0.10
R2965:Fbxw21 UTSW 9 108,974,578 (GRCm39) missense probably benign 0.10
R2966:Fbxw21 UTSW 9 108,974,578 (GRCm39) missense probably benign 0.10
R4809:Fbxw21 UTSW 9 108,972,458 (GRCm39) missense probably damaging 1.00
R4911:Fbxw21 UTSW 9 108,974,731 (GRCm39) missense probably damaging 1.00
R5669:Fbxw21 UTSW 9 108,974,578 (GRCm39) missense probably benign 0.12
R5928:Fbxw21 UTSW 9 108,972,893 (GRCm39) missense possibly damaging 0.55
R6043:Fbxw21 UTSW 9 108,974,607 (GRCm39) missense possibly damaging 0.69
R6277:Fbxw21 UTSW 9 108,974,623 (GRCm39) missense possibly damaging 0.95
R6805:Fbxw21 UTSW 9 108,986,633 (GRCm39) missense probably damaging 1.00
R6944:Fbxw21 UTSW 9 108,986,603 (GRCm39) missense probably damaging 1.00
R7079:Fbxw21 UTSW 9 108,974,578 (GRCm39) missense probably benign 0.10
R7081:Fbxw21 UTSW 9 108,990,990 (GRCm39) missense probably damaging 1.00
R7744:Fbxw21 UTSW 9 108,986,720 (GRCm39) missense possibly damaging 0.81
R7774:Fbxw21 UTSW 9 108,972,908 (GRCm39) missense probably benign 0.00
R7980:Fbxw21 UTSW 9 108,985,639 (GRCm39) splice site probably null
R8043:Fbxw21 UTSW 9 108,975,694 (GRCm39) missense probably benign 0.01
R8260:Fbxw21 UTSW 9 108,975,614 (GRCm39) critical splice donor site probably null
R9142:Fbxw21 UTSW 9 108,985,413 (GRCm39) missense probably damaging 1.00
R9172:Fbxw21 UTSW 9 108,975,764 (GRCm39) missense probably benign 0.00
R9250:Fbxw21 UTSW 9 108,972,846 (GRCm39) missense probably benign 0.31
R9251:Fbxw21 UTSW 9 108,974,687 (GRCm39) missense probably damaging 1.00
R9294:Fbxw21 UTSW 9 108,972,830 (GRCm39) missense probably damaging 0.99
R9303:Fbxw21 UTSW 9 108,986,727 (GRCm39) missense probably benign
R9479:Fbxw21 UTSW 9 108,968,612 (GRCm39) missense probably benign 0.00
R9509:Fbxw21 UTSW 9 108,977,217 (GRCm39) missense possibly damaging 0.90
R9765:Fbxw21 UTSW 9 108,975,625 (GRCm39) missense possibly damaging 0.71
R9773:Fbxw21 UTSW 9 108,977,128 (GRCm39) missense possibly damaging 0.89
R9774:Fbxw21 UTSW 9 108,991,057 (GRCm39) start codon destroyed probably null 0.98
Z1088:Fbxw21 UTSW 9 108,974,605 (GRCm39) missense probably benign
Z1176:Fbxw21 UTSW 9 108,974,605 (GRCm39) missense probably benign
Z1177:Fbxw21 UTSW 9 108,974,605 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- GTTGAGCAAGCACTCAGAAG -3'
(R):5'- ACTGTAACCATGGCTCTAAGGTG -3'

Sequencing Primer
(F):5'- AGATCACAGATTGGCTCCATGGC -3'
(R):5'- TCAGCCTGATGGGATTGCAAC -3'
Posted On 2014-11-12