Mutagenetix > Incidental Mutation

Incidental Mutation 'R2424:Vmn2r91'

249514

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r91

Ensembl Gene

ENSMUSG00000091206

Gene Name

vomeronasal 2, receptor 91

Synonyms

EG665210

MMRRC Submission

040386-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.105) question?

Stock #

R2424 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

18085057-18136643 bp(+) (GRCm38)

Type of Mutation

nonsense

DNA Base Change (assembly)

C to A at 18136169 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Stop codon at position 699 (Y699*)

Ref Sequence

ENSEMBL: ENSMUSP00000127465 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000172359]

AlphaFold

E9Q2U5

Predicted Effect

probably null
Transcript: ENSMUST00000172359
AA Change: Y699*

SMART Domains

Protein: ENSMUSP00000127465
Gene: ENSMUSG00000091206
AA Change: Y699*

Domain	Start	End	E-Value	Type
signal peptide	1	20	N/A	INTRINSIC
Pfam:ANF_receptor	83	462	2.2e-38	PFAM
Pfam:NCD3G	510	564	6.7e-20	PFAM
Pfam:7tm_3	597	832	2.1e-53	PFAM

Meta Mutation Damage Score

0.9755

Coding Region Coverage

1x: 99.1%
3x: 98.5%
10x: 97.1%
20x: 94.3%

Validation Efficiency

100% (64/64)

Allele List at MGI

Other mutations in this stock

Total: 65 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4921501E09Rik	T	C	17: 33,065,756	T691A	probably benign	Het
Aacs	A	G	5: 125,513,095		probably null	Het
Acot3	G	T	12: 84,053,864	R138L	probably damaging	Het
Ago3	A	G	4: 126,404,247	V160A	probably damaging	Het
Akap9	A	C	5: 4,065,279	E166D	probably damaging	Het
Arid5a	T	C	1: 36,318,501	Y136H	probably damaging	Het
Ascc3	T	C	10: 50,618,201	V244A	probably benign	Het
Atp10a	A	T	7: 58,794,555	H560L	probably benign	Het
Btbd6	A	G	12: 112,978,360	T482A	probably benign	Het
Cacna1d	A	T	14: 30,049,023	Y1828N	probably damaging	Het
Capzb	A	G	4: 139,194,130	M1V	probably null	Het
Cdh9	T	G	15: 16,850,354	F524L	probably damaging	Het
Ctnna1	T	C	18: 35,253,707	S846P	probably benign	Het
Dab1	C	T	4: 104,731,751	A524V	probably benign	Het
Dock7	T	A	4: 98,945,307	R1886*	probably null	Het
Dpp3	A	T	19: 4,907,707	L711*	probably null	Het
Dst	T	A	1: 34,167,060	I566N	probably damaging	Het
Eif2b3	T	A	4: 117,070,848	S421R	probably benign	Het
Epg5	T	C	18: 77,968,613	V825A	probably benign	Het
Eya1	T	A	1: 14,270,848		probably benign	Het
Fam187a	T	C	11: 102,885,954	Y195H	probably damaging	Het
Fbn2	C	T	18: 58,203,787	C132Y	probably damaging	Het
Fbxw21	A	T	9: 109,157,519	Y97*	probably null	Het
Grin1	A	T	2: 25,318,652	C79S	probably null	Het
Haao	T	A	17: 83,835,562	Y118F	probably damaging	Het
Il11ra1	T	A	4: 41,768,222	S378T	probably damaging	Het
Kcnj5	A	T	9: 32,322,820	N66K	probably damaging	Het
Kif21a	T	A	15: 90,971,196	N668I	probably damaging	Het
Kprp	A	T	3: 92,825,605	L46Q	probably damaging	Het
Lama1	C	T	17: 67,798,665	T2056I	probably benign	Het
Madd	G	C	2: 91,166,622	D824E	probably damaging	Het
Mapk9	A	G	11: 49,863,672	N84S	probably damaging	Het
Mrpl39	A	G	16: 84,730,860	V160A	probably benign	Het
Mrpl9	T	C	3: 94,443,806	S98P	probably benign	Het
Mybpc3	A	T	2: 91,135,793	M1233L	probably benign	Het
Neb	A	G	2: 52,209,659		probably benign	Het
Ngly1	A	G	14: 16,290,721		probably null	Het
Nt5c1b	A	T	12: 10,370,072	T4S	probably damaging	Het
Obscn	T	C	11: 58,994,451		probably benign	Het
Olfr725	T	C	14: 50,034,824	Y193C	probably damaging	Het
Olfr904	T	C	9: 38,464,832	S264P	probably damaging	Het
Olfr92	T	C	17: 37,111,516	I155M	probably benign	Het
Olfr968	A	G	9: 39,772,297	F168L	probably benign	Het
Otog	A	T	7: 46,298,169	K64*	probably null	Het
Papola	A	G	12: 105,827,052	T544A	probably benign	Het
Phc1	A	G	6: 122,320,043	V790A	probably damaging	Het
Phf3	G	T	1: 30,806,349	R1252S	probably damaging	Het
Plxna2	C	T	1: 194,749,317	S538F	probably damaging	Het
Rgs17	T	A	10: 5,833,111	I159F	probably damaging	Het
Rgs17	T	A	10: 5,842,560	E62V	probably benign	Het
Rnase1	A	G	14: 51,145,547	Y117H	possibly damaging	Het
Rnf214	T	C	9: 45,899,798	D189G	probably damaging	Het
Sema4b	A	G	7: 80,219,275	N365S	probably damaging	Het
Setd2	A	G	9: 110,617,522	H2480R	probably benign	Het
Slc27a6	G	T	18: 58,605,117	C415F	probably benign	Het
Stim1	A	G	7: 102,408,405	I142V	probably benign	Het
Supt5	T	C	7: 28,315,165	I1070V	possibly damaging	Het
Tbp	T	C	17: 15,513,533	F174L	possibly damaging	Het
Tex26	A	G	5: 149,470,448		probably benign	Het
Tmem132d	A	G	5: 127,864,599	V479A	probably benign	Het
Ttn	T	C	2: 76,881,145		probably benign	Het
Urb2	T	A	8: 124,030,426	N957K	probably benign	Het
Usp24	T	C	4: 106,399,113		probably null	Het
Vmn2r114	T	C	17: 23,296,868	T550A	possibly damaging	Het
Vmn2r72	A	G	7: 85,750,953	V296A	probably damaging	Het

Other mutations in Vmn2r91

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00983:Vmn2r91	APN	17	18105558	missense	probably benign	0.00
IGL01121:Vmn2r91	APN	17	18136504	missense	possibly damaging	0.94
IGL01464:Vmn2r91	APN	17	18107602	missense	probably null	0.00
IGL02003:Vmn2r91	APN	17	18107659	missense	probably benign
IGL02709:Vmn2r91	APN	17	18105449	missense	possibly damaging	0.74
IGL02795:Vmn2r91	APN	17	18085277	missense	probably benign	0.01
IGL02813:Vmn2r91	APN	17	18136086	missense	possibly damaging	0.91
IGL02830:Vmn2r91	APN	17	18136622	missense	probably benign	0.01
IGL03130:Vmn2r91	APN	17	18110111	splice site	probably benign
BB006:Vmn2r91	UTSW	17	18107644	missense	probably damaging	1.00
BB016:Vmn2r91	UTSW	17	18107644	missense	probably damaging	1.00
R0164:Vmn2r91	UTSW	17	18106137	missense	probably benign	0.00
R0164:Vmn2r91	UTSW	17	18106137	missense	probably benign	0.00
R0393:Vmn2r91	UTSW	17	18105450	missense	probably damaging	1.00
R1142:Vmn2r91	UTSW	17	18136443	missense	probably damaging	1.00
R1603:Vmn2r91	UTSW	17	18106143	missense	probably benign	0.04
R1992:Vmn2r91	UTSW	17	18135880	missense	probably damaging	1.00
R2182:Vmn2r91	UTSW	17	18105429	missense	possibly damaging	0.94
R2512:Vmn2r91	UTSW	17	18135786	missense	probably benign
R2885:Vmn2r91	UTSW	17	18105366	missense	probably benign	0.00
R2909:Vmn2r91	UTSW	17	18136399	missense	probably damaging	1.00
R3009:Vmn2r91	UTSW	17	18105455	missense	probably benign	0.11
R3079:Vmn2r91	UTSW	17	18135711	splice site	probably null
R3080:Vmn2r91	UTSW	17	18135711	splice site	probably null
R3434:Vmn2r91	UTSW	17	18110108	splice site	probably benign
R3723:Vmn2r91	UTSW	17	18085278	critical splice donor site	probably null
R3829:Vmn2r91	UTSW	17	18105497	missense	probably damaging	1.00
R3845:Vmn2r91	UTSW	17	18107598	missense	probably benign	0.00
R3846:Vmn2r91	UTSW	17	18107598	missense	probably benign	0.00
R4118:Vmn2r91	UTSW	17	18110096	missense	probably damaging	1.00
R4285:Vmn2r91	UTSW	17	18135768	missense	probably benign	0.00
R4729:Vmn2r91	UTSW	17	18107644	missense	probably damaging	1.00
R4793:Vmn2r91	UTSW	17	18105396	missense	probably damaging	1.00
R4932:Vmn2r91	UTSW	17	18136489	missense	possibly damaging	0.84
R5016:Vmn2r91	UTSW	17	18110060	nonsense	probably null
R5018:Vmn2r91	UTSW	17	18136438	missense	probably damaging	1.00
R5605:Vmn2r91	UTSW	17	18136501	missense	probably damaging	1.00
R5815:Vmn2r91	UTSW	17	18106202	missense	probably benign	0.01
R6146:Vmn2r91	UTSW	17	18136256	missense	probably benign	0.07
R6187:Vmn2r91	UTSW	17	18106626	missense	probably benign	0.05
R6426:Vmn2r91	UTSW	17	18135603	splice site	probably null
R6450:Vmn2r91	UTSW	17	18085265	missense	probably damaging	0.98
R6767:Vmn2r91	UTSW	17	18107545	missense	probably damaging	0.98
R6986:Vmn2r91	UTSW	17	18136009	missense	probably benign	0.10
R7112:Vmn2r91	UTSW	17	18105618	missense	possibly damaging	0.83
R7178:Vmn2r91	UTSW	17	18136162	missense	probably damaging	1.00
R7330:Vmn2r91	UTSW	17	18106167	missense	probably damaging	1.00
R7368:Vmn2r91	UTSW	17	18136278	missense	possibly damaging	0.75
R7380:Vmn2r91	UTSW	17	18136576	nonsense	probably null
R7397:Vmn2r91	UTSW	17	18135798	missense	probably benign	0.02
R7625:Vmn2r91	UTSW	17	18105431	missense	probably damaging	1.00
R7739:Vmn2r91	UTSW	17	18135818	missense	probably benign	0.00
R7749:Vmn2r91	UTSW	17	18136278	missense	possibly damaging	0.75
R7755:Vmn2r91	UTSW	17	18110049	missense	possibly damaging	0.88
R7929:Vmn2r91	UTSW	17	18107644	missense	probably damaging	1.00
R7981:Vmn2r91	UTSW	17	18107625	missense	probably benign	0.02
R8211:Vmn2r91	UTSW	17	18106500	missense	probably damaging	1.00
R8325:Vmn2r91	UTSW	17	18136363	missense	probably damaging	1.00
R8781:Vmn2r91	UTSW	17	18085061	missense	possibly damaging	0.78
R8974:Vmn2r91	UTSW	17	18105374	missense	probably benign	0.27
R9047:Vmn2r91	UTSW	17	18106034	missense	probably benign	0.00
R9048:Vmn2r91	UTSW	17	18135860	missense	probably benign	0.00
R9109:Vmn2r91	UTSW	17	18107643	missense	probably damaging	1.00
R9211:Vmn2r91	UTSW	17	18136557	nonsense	probably null
R9555:Vmn2r91	UTSW	17	18105530	missense	possibly damaging	0.78
R9616:Vmn2r91	UTSW	17	18136043	missense	possibly damaging	0.81

Predicted Primers

PCR Primer
(F):5'- TGAACTTCATTGGTCAGCCC -3'
(R):5'- GGATTCGTTGAATGTATCAGGC -3'

Sequencing Primer
(F):5'- GCCCAACACAGCTGCCTG -3'
(R):5'- GCCATGGTATAACTCACAAGGGC -3'

Posted On

2014-11-12