Mutagenetix > Incidental Mutation

Incidental Mutation 'R2424:Olfr92'

249517

Institutional Source

Beutler Lab

Gene Symbol

Olfr92

Ensembl Gene

ENSMUSG00000096477

Gene Name

olfactory receptor 92

Synonyms

MOR256-29, GA_x6K02T2PSCP-1552066-1551128

MMRRC Submission

040386-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.086) question?

Stock #

R2424 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

37110512-37120088 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 37111516 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Methionine at position 155 (I155M)

Ref Sequence

ENSEMBL: ENSMUSP00000150988 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000168659] [ENSMUST00000214994] [ENSMUST00000216341]

AlphaFold

L7N475

Predicted Effect

probably benign
Transcript: ENSMUST00000168659
AA Change: I155M

PolyPhen 2 Score 0.021 (Sensitivity: 0.95; Specificity: 0.80)

SMART Domains

Protein: ENSMUSP00000128393
Gene: ENSMUSG00000096477
AA Change: I155M

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srv	23	304	5.1e-7	PFAM
Pfam:7tm_4	29	306	3.4e-50	PFAM
Pfam:7tm_1	39	288	1.1e-26	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000174626

Predicted Effect

probably benign
Transcript: ENSMUST00000214994
AA Change: I155M

PolyPhen 2 Score 0.021 (Sensitivity: 0.95; Specificity: 0.80)

Predicted Effect

probably benign
Transcript: ENSMUST00000216341
AA Change: I155M

PolyPhen 2 Score 0.021 (Sensitivity: 0.95; Specificity: 0.80)

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.1%
3x: 98.5%
10x: 97.1%
20x: 94.3%

Validation Efficiency

100% (64/64)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 65 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4921501E09Rik	T	C	17: 33,065,756	T691A	probably benign	Het
Aacs	A	G	5: 125,513,095		probably null	Het
Acot3	G	T	12: 84,053,864	R138L	probably damaging	Het
Ago3	A	G	4: 126,404,247	V160A	probably damaging	Het
Akap9	A	C	5: 4,065,279	E166D	probably damaging	Het
Arid5a	T	C	1: 36,318,501	Y136H	probably damaging	Het
Ascc3	T	C	10: 50,618,201	V244A	probably benign	Het
Atp10a	A	T	7: 58,794,555	H560L	probably benign	Het
Btbd6	A	G	12: 112,978,360	T482A	probably benign	Het
Cacna1d	A	T	14: 30,049,023	Y1828N	probably damaging	Het
Capzb	A	G	4: 139,194,130	M1V	probably null	Het
Cdh9	T	G	15: 16,850,354	F524L	probably damaging	Het
Ctnna1	T	C	18: 35,253,707	S846P	probably benign	Het
Dab1	C	T	4: 104,731,751	A524V	probably benign	Het
Dock7	T	A	4: 98,945,307	R1886*	probably null	Het
Dpp3	A	T	19: 4,907,707	L711*	probably null	Het
Dst	T	A	1: 34,167,060	I566N	probably damaging	Het
Eif2b3	T	A	4: 117,070,848	S421R	probably benign	Het
Epg5	T	C	18: 77,968,613	V825A	probably benign	Het
Eya1	T	A	1: 14,270,848		probably benign	Het
Fam187a	T	C	11: 102,885,954	Y195H	probably damaging	Het
Fbn2	C	T	18: 58,203,787	C132Y	probably damaging	Het
Fbxw21	A	T	9: 109,157,519	Y97*	probably null	Het
Grin1	A	T	2: 25,318,652	C79S	probably null	Het
Haao	T	A	17: 83,835,562	Y118F	probably damaging	Het
Il11ra1	T	A	4: 41,768,222	S378T	probably damaging	Het
Kcnj5	A	T	9: 32,322,820	N66K	probably damaging	Het
Kif21a	T	A	15: 90,971,196	N668I	probably damaging	Het
Kprp	A	T	3: 92,825,605	L46Q	probably damaging	Het
Lama1	C	T	17: 67,798,665	T2056I	probably benign	Het
Madd	G	C	2: 91,166,622	D824E	probably damaging	Het
Mapk9	A	G	11: 49,863,672	N84S	probably damaging	Het
Mrpl39	A	G	16: 84,730,860	V160A	probably benign	Het
Mrpl9	T	C	3: 94,443,806	S98P	probably benign	Het
Mybpc3	A	T	2: 91,135,793	M1233L	probably benign	Het
Neb	A	G	2: 52,209,659		probably benign	Het
Ngly1	A	G	14: 16,290,721		probably null	Het
Nt5c1b	A	T	12: 10,370,072	T4S	probably damaging	Het
Obscn	T	C	11: 58,994,451		probably benign	Het
Olfr725	T	C	14: 50,034,824	Y193C	probably damaging	Het
Olfr904	T	C	9: 38,464,832	S264P	probably damaging	Het
Olfr968	A	G	9: 39,772,297	F168L	probably benign	Het
Otog	A	T	7: 46,298,169	K64*	probably null	Het
Papola	A	G	12: 105,827,052	T544A	probably benign	Het
Phc1	A	G	6: 122,320,043	V790A	probably damaging	Het
Phf3	G	T	1: 30,806,349	R1252S	probably damaging	Het
Plxna2	C	T	1: 194,749,317	S538F	probably damaging	Het
Rgs17	T	A	10: 5,833,111	I159F	probably damaging	Het
Rgs17	T	A	10: 5,842,560	E62V	probably benign	Het
Rnase1	A	G	14: 51,145,547	Y117H	possibly damaging	Het
Rnf214	T	C	9: 45,899,798	D189G	probably damaging	Het
Sema4b	A	G	7: 80,219,275	N365S	probably damaging	Het
Setd2	A	G	9: 110,617,522	H2480R	probably benign	Het
Slc27a6	G	T	18: 58,605,117	C415F	probably benign	Het
Stim1	A	G	7: 102,408,405	I142V	probably benign	Het
Supt5	T	C	7: 28,315,165	I1070V	possibly damaging	Het
Tbp	T	C	17: 15,513,533	F174L	possibly damaging	Het
Tex26	A	G	5: 149,470,448		probably benign	Het
Tmem132d	A	G	5: 127,864,599	V479A	probably benign	Het
Ttn	T	C	2: 76,881,145		probably benign	Het
Urb2	T	A	8: 124,030,426	N957K	probably benign	Het
Usp24	T	C	4: 106,399,113		probably null	Het
Vmn2r114	T	C	17: 23,296,868	T550A	possibly damaging	Het
Vmn2r72	A	G	7: 85,750,953	V296A	probably damaging	Het
Vmn2r91	C	A	17: 18,136,169	Y699*	probably null	Het

Other mutations in Olfr92

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01527:Olfr92	APN	17	37111809	missense	probably damaging	1.00
IGL02850:Olfr92	APN	17	37111973	missense	probably benign	0.35
IGL03209:Olfr92	APN	17	37111521	missense	probably benign	0.04
R0579:Olfr92	UTSW	17	37111455	missense	probably benign	0.00
R0580:Olfr92	UTSW	17	37111455	missense	probably benign	0.00
R0582:Olfr92	UTSW	17	37111455	missense	probably benign	0.00
R0615:Olfr92	UTSW	17	37111455	missense	probably benign	0.00
R0669:Olfr92	UTSW	17	37111455	missense	probably benign	0.00
R0674:Olfr92	UTSW	17	37111455	missense	probably benign	0.00
R0675:Olfr92	UTSW	17	37111455	missense	probably benign	0.00
R3714:Olfr92	UTSW	17	37111335	missense	probably damaging	1.00
R4393:Olfr92	UTSW	17	37114084	intron	probably benign
R5811:Olfr92	UTSW	17	37111757	missense	probably benign	0.00
R6615:Olfr92	UTSW	17	37111602	missense	probably damaging	1.00
R6853:Olfr92	UTSW	17	37111508	missense	probably benign	0.02
R6876:Olfr92	UTSW	17	37111206	missense	probably damaging	1.00
R7665:Olfr92	UTSW	17	37111391	missense	probably benign	0.20
R8087:Olfr92	UTSW	17	37111548	missense	probably benign
R9224:Olfr92	UTSW	17	37111875	missense	possibly damaging	0.53
R9439:Olfr92	UTSW	17	37111313	missense	probably damaging	1.00
R9541:Olfr92	UTSW	17	37111932	missense	probably benign	0.00
R9559:Olfr92	UTSW	17	37111617	missense	possibly damaging	0.84
Z1177:Olfr92	UTSW	17	37111430	missense	probably benign	0.09

Predicted Primers

PCR Primer
(F):5'- TGGCAATGGCACCATAAGAGAC -3'
(R):5'- GCTTCACCACAACCTGTGTC -3'

Sequencing Primer
(F):5'- CCATAAGAGACAAGGATGAGGCTC -3'
(R):5'- AAGACCATCAGCTTCCTGGGATG -3'

Posted On

2014-11-12