Incidental Mutation 'R2436:Adgrg7'
ID |
249604 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Adgrg7
|
Ensembl Gene |
ENSMUSG00000022755 |
Gene Name |
adhesion G protein-coupled receptor G7 |
Synonyms |
9130020O16Rik, Gpr128 |
MMRRC Submission |
040397-MU
|
Accession Numbers |
|
Essential gene? |
Non essential
(E-score: 0.000)
|
Stock # |
R2436 (G1)
|
Quality Score |
225 |
Status
|
Not validated
|
Chromosome |
16 |
Chromosomal Location |
56544972-56616218 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to G
at 56582308 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Serine to Proline
at position 277
(S277P)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000023437
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000023437]
|
AlphaFold |
Q8BM96 |
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000023437
AA Change: S277P
PolyPhen 2
Score 0.784 (Sensitivity: 0.85; Specificity: 0.93)
|
SMART Domains |
Protein: ENSMUSP00000023437 Gene: ENSMUSG00000022755 AA Change: S277P
Domain | Start | End | E-Value | Type |
transmembrane domain
|
12 |
34 |
N/A |
INTRINSIC |
SCOP:d1edmb_
|
52 |
76 |
1e-3 |
SMART |
GPS
|
376 |
424 |
6.16e-8 |
SMART |
Pfam:7tm_2
|
428 |
712 |
4.5e-40 |
PFAM |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000120470
|
Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.5%
- 10x: 97.0%
- 20x: 94.1%
|
Validation Efficiency |
|
MGI Phenotype |
PHENOTYPE: Mice homozygous for a knock-out allele exhibit reduced body weight gain and increased frequency of peristalsis and slow wave potential in the small intestine. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 36 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Arl6ip4 |
T |
C |
5: 124,254,662 (GRCm39) |
S52P |
probably benign |
Het |
Barx2 |
T |
C |
9: 31,824,383 (GRCm39) |
H2R |
probably damaging |
Het |
Calhm3 |
T |
C |
19: 47,140,404 (GRCm39) |
T230A |
probably damaging |
Het |
Card11 |
C |
T |
5: 140,868,117 (GRCm39) |
V844M |
possibly damaging |
Het |
Dnah6 |
C |
T |
6: 73,126,156 (GRCm39) |
R1327Q |
probably benign |
Het |
Dnai4 |
T |
C |
4: 102,923,549 (GRCm39) |
I427V |
probably benign |
Het |
Ehbp1 |
C |
A |
11: 22,039,524 (GRCm39) |
|
probably null |
Het |
Fgg |
T |
A |
3: 82,921,496 (GRCm39) |
I393N |
possibly damaging |
Het |
Foxq1 |
A |
T |
13: 31,742,516 (GRCm39) |
|
probably benign |
Het |
Hmgxb3 |
T |
C |
18: 61,280,566 (GRCm39) |
T646A |
probably benign |
Het |
Homer3 |
G |
A |
8: 70,745,706 (GRCm39) |
E324K |
possibly damaging |
Het |
Krt80 |
A |
G |
15: 101,257,384 (GRCm39) |
F183L |
probably damaging |
Het |
Map3k21 |
A |
T |
8: 126,668,354 (GRCm39) |
K647* |
probably null |
Het |
Mcm3ap |
A |
G |
10: 76,325,891 (GRCm39) |
Y1067C |
probably damaging |
Het |
Myh1 |
G |
T |
11: 67,104,097 (GRCm39) |
Q921H |
probably benign |
Het |
Nme8 |
A |
G |
13: 19,862,029 (GRCm39) |
F200S |
probably damaging |
Het |
Nploc4 |
T |
C |
11: 120,309,143 (GRCm39) |
N153S |
possibly damaging |
Het |
Or14c45 |
T |
C |
7: 86,176,591 (GRCm39) |
F209L |
probably damaging |
Het |
Or2ak6 |
T |
C |
11: 58,592,952 (GRCm39) |
C142R |
probably damaging |
Het |
Or4a73 |
A |
G |
2: 89,421,117 (GRCm39) |
V114A |
probably benign |
Het |
Or5k1 |
C |
T |
16: 58,617,607 (GRCm39) |
V201I |
probably benign |
Het |
Pipox |
T |
A |
11: 77,782,943 (GRCm39) |
L86F |
probably damaging |
Het |
Polr3h |
G |
T |
15: 81,801,406 (GRCm39) |
L157I |
probably benign |
Het |
Prex2 |
G |
A |
1: 11,336,376 (GRCm39) |
V1525M |
possibly damaging |
Het |
Rapgef2 |
A |
T |
3: 78,996,079 (GRCm39) |
D561E |
possibly damaging |
Het |
Sacs |
A |
T |
14: 61,440,354 (GRCm39) |
D800V |
possibly damaging |
Het |
Sbsn |
A |
T |
7: 30,451,655 (GRCm39) |
L223F |
possibly damaging |
Het |
Slc16a9 |
TCCCC |
TCCCCC |
10: 70,091,911 (GRCm39) |
|
probably null |
Het |
Srrm3 |
G |
T |
5: 135,864,030 (GRCm39) |
E43* |
probably null |
Het |
Tcaf3 |
G |
A |
6: 42,570,663 (GRCm39) |
A363V |
probably damaging |
Het |
Tmem138 |
A |
G |
19: 10,552,268 (GRCm39) |
F78S |
probably damaging |
Het |
Tnfrsf17 |
G |
A |
16: 11,137,676 (GRCm39) |
D138N |
probably damaging |
Het |
Tubgcp6 |
C |
T |
15: 88,986,568 (GRCm39) |
V1344I |
probably benign |
Het |
Usp24 |
T |
A |
4: 106,266,842 (GRCm39) |
L1875* |
probably null |
Het |
Vmn2r109 |
C |
A |
17: 20,774,798 (GRCm39) |
G186C |
probably damaging |
Het |
Zfp541 |
A |
G |
7: 15,810,373 (GRCm39) |
N137D |
possibly damaging |
Het |
|
Other mutations in Adgrg7 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01783:Adgrg7
|
APN |
16 |
56,568,282 (GRCm39) |
critical splice donor site |
probably null |
|
IGL03122:Adgrg7
|
APN |
16 |
56,590,725 (GRCm39) |
splice site |
probably benign |
|
orchard
|
UTSW |
16 |
56,545,342 (GRCm39) |
missense |
probably damaging |
1.00 |
sevin
|
UTSW |
16 |
56,562,769 (GRCm39) |
missense |
probably damaging |
1.00 |
R0632:Adgrg7
|
UTSW |
16 |
56,562,952 (GRCm39) |
missense |
possibly damaging |
0.89 |
R0673:Adgrg7
|
UTSW |
16 |
56,593,849 (GRCm39) |
missense |
possibly damaging |
0.48 |
R1690:Adgrg7
|
UTSW |
16 |
56,615,993 (GRCm39) |
missense |
probably damaging |
0.99 |
R2009:Adgrg7
|
UTSW |
16 |
56,582,236 (GRCm39) |
missense |
probably benign |
0.08 |
R2017:Adgrg7
|
UTSW |
16 |
56,553,169 (GRCm39) |
missense |
probably benign |
0.02 |
R2132:Adgrg7
|
UTSW |
16 |
56,588,281 (GRCm39) |
missense |
probably damaging |
1.00 |
R2153:Adgrg7
|
UTSW |
16 |
56,572,791 (GRCm39) |
missense |
possibly damaging |
0.75 |
R2229:Adgrg7
|
UTSW |
16 |
56,572,766 (GRCm39) |
missense |
probably benign |
|
R2878:Adgrg7
|
UTSW |
16 |
56,570,817 (GRCm39) |
missense |
probably benign |
0.14 |
R2981:Adgrg7
|
UTSW |
16 |
56,570,769 (GRCm39) |
critical splice donor site |
probably null |
|
R4014:Adgrg7
|
UTSW |
16 |
56,562,651 (GRCm39) |
missense |
probably damaging |
1.00 |
R4023:Adgrg7
|
UTSW |
16 |
56,550,661 (GRCm39) |
missense |
probably damaging |
1.00 |
R4024:Adgrg7
|
UTSW |
16 |
56,550,661 (GRCm39) |
missense |
probably damaging |
1.00 |
R4026:Adgrg7
|
UTSW |
16 |
56,550,661 (GRCm39) |
missense |
probably damaging |
1.00 |
R4551:Adgrg7
|
UTSW |
16 |
56,568,375 (GRCm39) |
missense |
probably damaging |
1.00 |
R4834:Adgrg7
|
UTSW |
16 |
56,553,232 (GRCm39) |
missense |
probably damaging |
1.00 |
R5041:Adgrg7
|
UTSW |
16 |
56,550,711 (GRCm39) |
missense |
probably benign |
0.21 |
R5145:Adgrg7
|
UTSW |
16 |
56,562,682 (GRCm39) |
missense |
probably benign |
0.04 |
R5377:Adgrg7
|
UTSW |
16 |
56,550,669 (GRCm39) |
missense |
possibly damaging |
0.68 |
R5549:Adgrg7
|
UTSW |
16 |
56,570,790 (GRCm39) |
missense |
probably damaging |
1.00 |
R5915:Adgrg7
|
UTSW |
16 |
56,550,748 (GRCm39) |
splice site |
probably null |
|
R5957:Adgrg7
|
UTSW |
16 |
56,593,790 (GRCm39) |
missense |
probably damaging |
0.96 |
R6146:Adgrg7
|
UTSW |
16 |
56,593,829 (GRCm39) |
missense |
probably benign |
0.21 |
R6198:Adgrg7
|
UTSW |
16 |
56,597,556 (GRCm39) |
missense |
possibly damaging |
0.64 |
R6233:Adgrg7
|
UTSW |
16 |
56,599,005 (GRCm39) |
missense |
possibly damaging |
0.52 |
R6337:Adgrg7
|
UTSW |
16 |
56,572,788 (GRCm39) |
missense |
probably damaging |
0.96 |
R6633:Adgrg7
|
UTSW |
16 |
56,550,649 (GRCm39) |
missense |
probably benign |
0.05 |
R6693:Adgrg7
|
UTSW |
16 |
56,590,587 (GRCm39) |
missense |
probably damaging |
0.97 |
R6812:Adgrg7
|
UTSW |
16 |
56,616,161 (GRCm39) |
start gained |
probably benign |
|
R6841:Adgrg7
|
UTSW |
16 |
56,570,787 (GRCm39) |
missense |
probably damaging |
1.00 |
R6868:Adgrg7
|
UTSW |
16 |
56,593,839 (GRCm39) |
missense |
probably benign |
|
R7076:Adgrg7
|
UTSW |
16 |
56,562,769 (GRCm39) |
missense |
probably damaging |
1.00 |
R7146:Adgrg7
|
UTSW |
16 |
56,550,605 (GRCm39) |
missense |
probably damaging |
1.00 |
R7232:Adgrg7
|
UTSW |
16 |
56,597,515 (GRCm39) |
splice site |
probably null |
|
R7266:Adgrg7
|
UTSW |
16 |
56,590,674 (GRCm39) |
missense |
probably benign |
0.00 |
R7376:Adgrg7
|
UTSW |
16 |
56,545,342 (GRCm39) |
missense |
probably damaging |
1.00 |
R7390:Adgrg7
|
UTSW |
16 |
56,553,207 (GRCm39) |
missense |
probably damaging |
0.98 |
R7401:Adgrg7
|
UTSW |
16 |
56,562,781 (GRCm39) |
missense |
probably benign |
0.43 |
R7496:Adgrg7
|
UTSW |
16 |
56,553,220 (GRCm39) |
missense |
probably benign |
|
R7540:Adgrg7
|
UTSW |
16 |
56,570,792 (GRCm39) |
missense |
probably damaging |
1.00 |
R8147:Adgrg7
|
UTSW |
16 |
56,562,876 (GRCm39) |
missense |
probably damaging |
1.00 |
R8354:Adgrg7
|
UTSW |
16 |
56,616,045 (GRCm39) |
start gained |
probably benign |
|
R8372:Adgrg7
|
UTSW |
16 |
56,616,114 (GRCm39) |
start gained |
probably benign |
|
R8393:Adgrg7
|
UTSW |
16 |
56,582,477 (GRCm39) |
missense |
probably damaging |
1.00 |
R8454:Adgrg7
|
UTSW |
16 |
56,616,045 (GRCm39) |
start gained |
probably benign |
|
R8723:Adgrg7
|
UTSW |
16 |
56,582,282 (GRCm39) |
missense |
probably benign |
0.00 |
R8891:Adgrg7
|
UTSW |
16 |
56,572,762 (GRCm39) |
missense |
probably benign |
0.03 |
R9017:Adgrg7
|
UTSW |
16 |
56,553,211 (GRCm39) |
missense |
probably benign |
0.01 |
R9570:Adgrg7
|
UTSW |
16 |
56,570,813 (GRCm39) |
missense |
probably damaging |
1.00 |
R9604:Adgrg7
|
UTSW |
16 |
56,597,570 (GRCm39) |
missense |
probably damaging |
0.99 |
R9628:Adgrg7
|
UTSW |
16 |
56,553,193 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Predicted Primers |
PCR Primer
(F):5'- TACTGCATCAGAGCCTAAAGAC -3'
(R):5'- ATAGCAATCCAGTCCGTCACTC -3'
Sequencing Primer
(F):5'- TTCCCTTCATGGACTTTTAAGTTAG -3'
(R):5'- GTCACTCGAGACGACAATTCAGG -3'
|
Posted On |
2014-11-12 |