Incidental Mutation 'R2437:Arhgef26'
ID 249632
Institutional Source Beutler Lab
Gene Symbol Arhgef26
Ensembl Gene ENSMUSG00000036885
Gene Name Rho guanine nucleotide exchange factor 26
Synonyms 8430436L14Rik, 4631416L12Rik
MMRRC Submission 040398-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.230) question?
Stock # R2437 (G1)
Quality Score 225
Status Validated
Chromosome 3
Chromosomal Location 62245765-62369642 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 62340002 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 675 (S675P)
Ref Sequence ENSEMBL: ENSMUSP00000078281 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079300]
AlphaFold D3YYY8
Predicted Effect probably damaging
Transcript: ENSMUST00000079300
AA Change: S675P

PolyPhen 2 Score 0.965 (Sensitivity: 0.78; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000078281
Gene: ENSMUSG00000036885
AA Change: S675P

DomainStartEndE-ValueType
low complexity region 133 144 N/A INTRINSIC
low complexity region 392 403 N/A INTRINSIC
RhoGEF 441 620 1e-45 SMART
PH 654 782 4.04e-9 SMART
SH3 790 847 3.82e-13 SMART
Predicted Effect unknown
Transcript: ENSMUST00000161057
AA Change: S141P
SMART Domains Protein: ENSMUSP00000124392
Gene: ENSMUSG00000036885
AA Change: S141P

DomainStartEndE-ValueType
Pfam:RhoGEF 2 87 2.3e-19 PFAM
PH 121 249 4.04e-9 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000192138
Meta Mutation Damage Score 0.4511 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.0%
Validation Efficiency 100% (75/75)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the Rho-guanine nucleotide exchange factor (Rho-GEF) family. These proteins regulate Rho GTPases by catalyzing the exchange of GDP for GTP. The encoded protein specifically activates RhoG and plays a role in the promotion of macropinocytosis. Underexpression of the encoded protein may be a predictive marker of chemoresistant disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit defective activation of RhoG and reduced membrane protrusion after ICAM-1 clustering. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 72 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2510039O18Rik A G 4: 148,031,075 (GRCm39) *635W probably null Het
Anxa2 A G 9: 69,397,046 (GRCm39) Y317C probably damaging Het
Bltp1 T A 3: 37,012,834 (GRCm39) probably null Het
Camk2d A G 3: 126,628,277 (GRCm39) N53S probably damaging Het
Carns1 A T 19: 4,215,782 (GRCm39) M800K possibly damaging Het
Ces1f A T 8: 93,996,767 (GRCm39) probably null Het
Chrne T A 11: 70,506,086 (GRCm39) D426V possibly damaging Het
Cntfr T C 4: 41,671,035 (GRCm39) T43A probably damaging Het
Cntn5 A T 9: 10,048,758 (GRCm39) C63* probably null Het
Col12a1 G A 9: 79,599,501 (GRCm39) T884I probably damaging Het
Dnah5 T C 15: 28,307,537 (GRCm39) probably null Het
Dnajc2 A T 5: 21,965,389 (GRCm39) S537R probably benign Het
Dnajc25 T C 4: 59,020,234 (GRCm39) I100T probably damaging Het
Ephx1 C A 1: 180,823,661 (GRCm39) G149C probably damaging Het
Fam163b G T 2: 27,002,698 (GRCm39) P100T probably damaging Het
Fbxl9 A G 8: 106,039,675 (GRCm39) probably null Het
Fgd5 A T 6: 92,039,850 (GRCm39) R1017* probably null Het
Fibin A T 2: 110,192,848 (GRCm39) L98Q probably damaging Het
Fndc3b A T 3: 27,505,481 (GRCm39) L929H probably damaging Het
Frem1 T A 4: 82,918,410 (GRCm39) S512C probably damaging Het
Gm4922 T A 10: 18,659,829 (GRCm39) M298L probably benign Het
Gstm2 G A 3: 107,891,369 (GRCm39) probably benign Het
Gtf3c2 A G 5: 31,317,042 (GRCm39) probably null Het
Ibtk A C 9: 85,590,178 (GRCm39) L1026V probably benign Het
Il9 T A 13: 56,629,684 (GRCm39) probably benign Het
Inpp4a T C 1: 37,432,037 (GRCm39) S146P probably damaging Het
Kcnab1 G T 3: 65,264,435 (GRCm39) probably benign Het
Mgat4c T C 10: 102,224,436 (GRCm39) S217P probably damaging Het
Mr1 T C 1: 155,008,277 (GRCm39) M233V probably benign Het
Ncoa2 G A 1: 13,218,584 (GRCm39) T1415I probably damaging Het
Oasl2 G A 5: 115,049,357 (GRCm39) D486N probably benign Het
Or1j14 A T 2: 36,418,258 (GRCm39) Y278F probably damaging Het
Or9a7 G A 6: 40,521,856 (GRCm39) T19I probably benign Het
Or9s27 T C 1: 92,516,688 (GRCm39) I212T possibly damaging Het
Pcnx4 T C 12: 72,588,587 (GRCm39) F132L probably damaging Het
Pde5a T A 3: 122,636,702 (GRCm39) L717Q probably damaging Het
Peli2 A T 14: 48,465,389 (GRCm39) probably benign Het
Phf14 A G 6: 11,962,657 (GRCm39) S435G probably damaging Het
Plekhg1 T A 10: 3,913,564 (GRCm39) H1095Q probably damaging Het
Plekhh2 A G 17: 84,893,907 (GRCm39) probably null Het
Plekho1 T G 3: 95,899,497 (GRCm39) N99H probably damaging Het
Plxnc1 T A 10: 94,742,395 (GRCm39) K457N probably benign Het
Ppp1r3a T C 6: 14,718,322 (GRCm39) E864G probably benign Het
Prkab2 T A 3: 97,574,715 (GRCm39) L237Q probably damaging Het
Ptch1 T G 13: 63,672,773 (GRCm39) E944A probably benign Het
Ptger3 T A 3: 157,273,207 (GRCm39) C185S probably damaging Het
Ptprk T C 10: 28,230,709 (GRCm39) Y267H probably damaging Het
Pum2 A G 12: 8,794,654 (GRCm39) I715V probably benign Het
R3hdm1 T C 1: 128,114,573 (GRCm39) V518A probably damaging Het
Rab3d T C 9: 21,827,147 (GRCm39) I28V probably damaging Het
Rad54b T C 4: 11,606,272 (GRCm39) L560P probably damaging Het
Rgs20 A G 1: 5,140,370 (GRCm39) probably null Het
Sesn1 T A 10: 41,781,315 (GRCm39) L460H probably damaging Het
Slc39a14 A G 14: 70,553,885 (GRCm39) probably null Het
Slco6c1 T A 1: 96,990,201 (GRCm39) H663L probably benign Het
Snx13 T A 12: 35,132,926 (GRCm39) C63S probably benign Het
Spmip4 T A 6: 50,560,959 (GRCm39) D212V probably damaging Het
Strip2 T C 6: 29,941,940 (GRCm39) probably null Het
Syncrip A G 9: 88,361,620 (GRCm39) probably benign Het
Taf15 A G 11: 83,395,579 (GRCm39) probably benign Het
Tbc1d8 T C 1: 39,444,368 (GRCm39) probably null Het
Tgm4 T A 9: 122,877,614 (GRCm39) C205* probably null Het
Tmem212 A T 3: 27,940,628 (GRCm39) L63Q possibly damaging Het
Tmem63a G A 1: 180,790,054 (GRCm39) probably null Het
Trpm5 C A 7: 142,636,298 (GRCm39) V525L probably benign Het
Ttn A G 2: 76,537,171 (GRCm39) L34919P probably damaging Het
Ttn T C 2: 76,694,619 (GRCm39) probably benign Het
Tuba4a T C 1: 75,194,069 (GRCm39) I4V possibly damaging Het
Ubr4 A G 4: 139,200,853 (GRCm39) D4679G possibly damaging Het
Usp2 T G 9: 44,003,445 (GRCm39) V448G probably damaging Het
Usp3 A G 9: 66,453,024 (GRCm39) probably null Het
Zfp341 T A 2: 154,470,721 (GRCm39) V246E probably damaging Het
Other mutations in Arhgef26
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00160:Arhgef26 APN 3 62,247,804 (GRCm39) missense probably benign
IGL01060:Arhgef26 APN 3 62,247,542 (GRCm39) missense probably benign 0.44
IGL01942:Arhgef26 APN 3 62,247,515 (GRCm39) missense probably benign 0.03
IGL02085:Arhgef26 APN 3 62,367,145 (GRCm39) intron probably benign
IGL02172:Arhgef26 APN 3 62,367,097 (GRCm39) missense probably benign 0.03
IGL03017:Arhgef26 APN 3 62,355,702 (GRCm39) missense possibly damaging 0.46
IGL03101:Arhgef26 APN 3 62,327,082 (GRCm39) missense possibly damaging 0.95
IGL03296:Arhgef26 APN 3 62,330,926 (GRCm39) missense probably damaging 1.00
IGL03401:Arhgef26 APN 3 62,330,953 (GRCm39) missense possibly damaging 0.95
R0138:Arhgef26 UTSW 3 62,355,680 (GRCm39) missense probably benign 0.06
R0140:Arhgef26 UTSW 3 62,355,666 (GRCm39) missense probably benign 0.02
R0152:Arhgef26 UTSW 3 62,330,965 (GRCm39) missense probably damaging 0.99
R0157:Arhgef26 UTSW 3 62,288,392 (GRCm39) missense probably damaging 1.00
R0308:Arhgef26 UTSW 3 62,247,820 (GRCm39) missense probably benign 0.01
R0317:Arhgef26 UTSW 3 62,330,965 (GRCm39) missense probably damaging 0.99
R0529:Arhgef26 UTSW 3 62,247,146 (GRCm39) missense probably benign
R0825:Arhgef26 UTSW 3 62,334,014 (GRCm39) missense probably damaging 0.97
R1331:Arhgef26 UTSW 3 62,247,449 (GRCm39) missense probably benign 0.00
R1333:Arhgef26 UTSW 3 62,247,744 (GRCm39) missense probably benign 0.04
R1351:Arhgef26 UTSW 3 62,288,262 (GRCm39) missense probably damaging 1.00
R1740:Arhgef26 UTSW 3 62,331,004 (GRCm39) missense probably damaging 1.00
R2121:Arhgef26 UTSW 3 62,247,704 (GRCm39) missense probably damaging 0.96
R2404:Arhgef26 UTSW 3 62,336,336 (GRCm39) missense possibly damaging 0.90
R2939:Arhgef26 UTSW 3 62,288,331 (GRCm39) missense possibly damaging 0.72
R3084:Arhgef26 UTSW 3 62,285,037 (GRCm39) missense probably benign 0.19
R3712:Arhgef26 UTSW 3 62,331,050 (GRCm39) missense probably damaging 1.00
R4005:Arhgef26 UTSW 3 62,247,816 (GRCm39) missense probably benign
R4225:Arhgef26 UTSW 3 62,288,343 (GRCm39) missense probably benign 0.00
R4635:Arhgef26 UTSW 3 62,247,861 (GRCm39) missense probably damaging 1.00
R4961:Arhgef26 UTSW 3 62,367,046 (GRCm39) missense probably damaging 1.00
R4989:Arhgef26 UTSW 3 62,247,806 (GRCm39) missense possibly damaging 0.94
R5249:Arhgef26 UTSW 3 62,247,981 (GRCm39) missense probably damaging 1.00
R5284:Arhgef26 UTSW 3 62,327,052 (GRCm39) missense probably damaging 0.99
R5661:Arhgef26 UTSW 3 62,285,075 (GRCm39) splice site probably benign
R5970:Arhgef26 UTSW 3 62,247,468 (GRCm39) missense probably benign
R6022:Arhgef26 UTSW 3 62,336,360 (GRCm39) missense probably damaging 1.00
R6193:Arhgef26 UTSW 3 62,247,213 (GRCm39) missense possibly damaging 0.49
R6247:Arhgef26 UTSW 3 62,288,381 (GRCm39) missense probably damaging 1.00
R6434:Arhgef26 UTSW 3 62,336,335 (GRCm39) missense probably damaging 0.99
R6827:Arhgef26 UTSW 3 62,330,919 (GRCm39) splice site probably null
R7111:Arhgef26 UTSW 3 62,252,689 (GRCm39) missense possibly damaging 0.90
R7128:Arhgef26 UTSW 3 62,326,971 (GRCm39) missense possibly damaging 0.94
R7360:Arhgef26 UTSW 3 62,355,626 (GRCm39) missense possibly damaging 0.63
R7456:Arhgef26 UTSW 3 62,247,476 (GRCm39) missense probably benign 0.00
R8039:Arhgef26 UTSW 3 62,247,351 (GRCm39) missense probably benign 0.32
R8120:Arhgef26 UTSW 3 62,248,796 (GRCm39) missense probably damaging 1.00
R8511:Arhgef26 UTSW 3 62,336,350 (GRCm39) missense probably damaging 0.98
R8887:Arhgef26 UTSW 3 62,247,401 (GRCm39) missense probably benign 0.04
R8979:Arhgef26 UTSW 3 62,246,969 (GRCm39) missense possibly damaging 0.78
R8993:Arhgef26 UTSW 3 62,355,525 (GRCm39) missense probably benign 0.43
R9213:Arhgef26 UTSW 3 62,340,000 (GRCm39) missense probably benign 0.03
R9269:Arhgef26 UTSW 3 62,247,920 (GRCm39) missense probably damaging 0.98
R9712:Arhgef26 UTSW 3 62,331,034 (GRCm39) missense probably damaging 1.00
R9776:Arhgef26 UTSW 3 62,246,803 (GRCm39) start gained probably benign
Z1177:Arhgef26 UTSW 3 62,247,351 (GRCm39) missense probably benign 0.32
Predicted Primers PCR Primer
(F):5'- TGGAGAATATGCCATCTCCAAGTG -3'
(R):5'- GTGCTTAGAGACAGTGAAGGCC -3'

Sequencing Primer
(F):5'- TGCCTGCCAGATAATGCTAC -3'
(R):5'- TGAAGGCCAAATGTGACTTTG -3'
Posted On 2014-11-12