Incidental Mutation 'R2444:Or7g30'
ID 249918
Institutional Source Beutler Lab
Gene Symbol Or7g30
Ensembl Gene ENSMUSG00000052182
Gene Name olfactory receptor family 7 subfamily G member 30
Synonyms Olfr849, GA_x6K02T2PVTD-13176842-13177780, MOR151-1
MMRRC Submission 040402-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.146) question?
Stock # R2444 (G1)
Quality Score 225
Status Not validated
Chromosome 9
Chromosomal Location 19352211-19353149 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 19352311 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Lysine at position 34 (I34K)
Ref Sequence ENSEMBL: ENSMUSP00000149769 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000063923] [ENSMUST00000217273]
AlphaFold Q8VFF6
Predicted Effect possibly damaging
Transcript: ENSMUST00000063923
AA Change: I34K

PolyPhen 2 Score 0.777 (Sensitivity: 0.85; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000064123
Gene: ENSMUSG00000052182
AA Change: I34K

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 1.9e-51 PFAM
Pfam:7TM_GPCR_Srsx 35 305 7.6e-6 PFAM
Pfam:7tm_1 41 290 2.6e-23 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000157237
Predicted Effect possibly damaging
Transcript: ENSMUST00000217273
AA Change: I34K

PolyPhen 2 Score 0.777 (Sensitivity: 0.85; Specificity: 0.92)
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.2%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2610008E11Rik A T 10: 78,904,561 (GRCm39) D112E possibly damaging Het
Abca15 A G 7: 119,965,120 (GRCm39) Y794C probably damaging Het
Bicd2 T C 13: 49,532,500 (GRCm39) V362A probably benign Het
Cep126 G A 9: 8,101,307 (GRCm39) T409M probably damaging Het
Cep131 A G 11: 119,961,321 (GRCm39) F610S probably damaging Het
Cfap61 T C 2: 145,877,239 (GRCm39) probably null Het
Chd1l A G 3: 97,497,882 (GRCm39) Y320H probably damaging Het
Dnajc30 A G 5: 135,093,439 (GRCm39) D112G probably damaging Het
Dync2i1 T C 12: 116,196,289 (GRCm39) D486G possibly damaging Het
Fam184a A C 10: 53,517,045 (GRCm39) L410R probably damaging Het
Fat2 T C 11: 55,172,799 (GRCm39) N2638S probably damaging Het
Fgf15 A G 7: 144,453,429 (GRCm39) D134G probably benign Het
Flywch2 A T 17: 23,996,024 (GRCm39) S124R possibly damaging Het
Gabra5 G A 7: 57,058,623 (GRCm39) T375I probably benign Het
Gpat3 C T 5: 101,005,039 (GRCm39) P58L probably benign Het
Hltf T A 3: 20,118,071 (GRCm39) N44K possibly damaging Het
Hoatz A G 9: 51,011,298 (GRCm39) probably null Het
Kcnb2 A T 1: 15,779,791 (GRCm39) N221I probably benign Het
Marco G A 1: 120,422,499 (GRCm39) T61M probably damaging Het
Med13 A G 11: 86,222,786 (GRCm39) I180T probably damaging Het
Mei1 C T 15: 81,997,142 (GRCm39) T626M probably damaging Het
Mtnr1a C T 8: 45,540,695 (GRCm39) Q219* probably null Het
Nav3 A G 10: 109,600,776 (GRCm39) S1284P probably benign Het
Or1j10 T C 2: 36,267,625 (GRCm39) V279A possibly damaging Het
Pcdh9 T A 14: 94,124,227 (GRCm39) T648S probably benign Het
Proz A T 8: 13,111,027 (GRCm39) probably benign Het
Rec114 G T 9: 58,567,602 (GRCm39) A128E probably damaging Het
Rspry1 G T 8: 95,349,735 (GRCm39) G41V probably damaging Het
Sbf2 A T 7: 109,929,905 (GRCm39) M1388K probably benign Het
Spice1 C T 16: 44,186,931 (GRCm39) Q143* probably null Het
Tcstv3 A T 13: 120,779,365 (GRCm39) K88M probably damaging Het
Terb2 T A 2: 122,023,788 (GRCm39) probably null Het
Tmx3 A T 18: 90,558,307 (GRCm39) K453M probably damaging Het
Tnc T C 4: 63,933,200 (GRCm39) Y688C probably damaging Het
Tshz2 T G 2: 169,726,726 (GRCm39) S441A probably benign Het
Usp45 A T 4: 21,817,528 (GRCm39) M399L probably benign Het
Vmn2r82 A T 10: 79,213,702 (GRCm39) H96L possibly damaging Het
Wls G A 3: 159,612,867 (GRCm39) R261Q probably damaging Het
Other mutations in Or7g30
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01285:Or7g30 APN 9 19,352,266 (GRCm39) missense probably benign 0.01
IGL01599:Or7g30 APN 9 19,353,111 (GRCm39) missense probably benign 0.00
IGL01885:Or7g30 APN 9 19,352,760 (GRCm39) missense probably benign 0.01
IGL02258:Or7g30 APN 9 19,352,295 (GRCm39) missense probably benign 0.00
IGL02258:Or7g30 APN 9 19,352,293 (GRCm39) missense possibly damaging 0.66
IGL02282:Or7g30 APN 9 19,352,914 (GRCm39) missense probably benign 0.42
R1293:Or7g30 UTSW 9 19,352,728 (GRCm39) missense probably benign 0.27
R1931:Or7g30 UTSW 9 19,352,647 (GRCm39) missense possibly damaging 0.93
R4181:Or7g30 UTSW 9 19,353,031 (GRCm39) missense possibly damaging 0.86
R4231:Or7g30 UTSW 9 19,352,886 (GRCm39) missense probably damaging 1.00
R4233:Or7g30 UTSW 9 19,352,886 (GRCm39) missense probably damaging 1.00
R4236:Or7g30 UTSW 9 19,352,886 (GRCm39) missense probably damaging 1.00
R4302:Or7g30 UTSW 9 19,352,295 (GRCm39) missense probably benign 0.00
R4651:Or7g30 UTSW 9 19,352,591 (GRCm39) nonsense probably null
R5006:Or7g30 UTSW 9 19,352,545 (GRCm39) missense probably benign 0.30
R5088:Or7g30 UTSW 9 19,353,067 (GRCm39) missense probably damaging 1.00
R5501:Or7g30 UTSW 9 19,352,290 (GRCm39) missense possibly damaging 0.93
R6775:Or7g30 UTSW 9 19,352,718 (GRCm39) missense possibly damaging 0.56
R7038:Or7g30 UTSW 9 19,352,888 (GRCm39) missense possibly damaging 0.88
R8010:Or7g30 UTSW 9 19,352,988 (GRCm39) missense probably benign 0.02
R8850:Or7g30 UTSW 9 19,352,817 (GRCm39) missense probably damaging 0.96
R9154:Or7g30 UTSW 9 19,352,531 (GRCm39) missense probably benign 0.39
R9523:Or7g30 UTSW 9 19,352,580 (GRCm39) missense possibly damaging 0.73
Predicted Primers PCR Primer
(F):5'- CCCTGTCAAACAAAACAGTGTTTC -3'
(R):5'- TGTGATGGTGTGATCCTCCC -3'

Sequencing Primer
(F):5'- CCATGATGTTTACTATGAAACCTTGC -3'
(R):5'- ATGGTGTGATCCTCCCTCTGAATG -3'
Posted On 2014-11-12