Mutagenetix > Incidental Mutation

Incidental Mutation 'R2410:Vmn2r9'

249944

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r9

Ensembl Gene

ENSMUSG00000091624

Gene Name

vomeronasal 2, receptor 9

Synonyms

EG435864

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.118) question?

Stock #

R2410 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

108990813-109000376 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 108996123 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glycine at position 175 (D175G)

Ref Sequence

ENSEMBL: ENSMUSP00000129520 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000170419]

AlphaFold

K7N6Z8

Predicted Effect

probably damaging
Transcript: ENSMUST00000170419
AA Change: D175G

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000129520
Gene: ENSMUSG00000091624
AA Change: D175G

Domain	Start	End	E-Value	Type
signal peptide	1	26	N/A	INTRINSIC
Pfam:ANF_receptor	77	412	8.1e-29	PFAM
Pfam:NCD3G	507	561	2.3e-16	PFAM
Pfam:7tm_3	592	829	3.4e-54	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000176157

Coding Region Coverage

1x: 99.2%
3x: 98.5%
10x: 97.0%
20x: 94.3%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 26 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700012B07Rik	G	T	11: 109,684,980 (GRCm39)	C172*	probably null	Het
Adgrf5	C	A	17: 43,766,157 (GRCm39)	N1326K	probably benign	Het
Ciita	A	G	16: 10,328,568 (GRCm39)	E284G	probably damaging	Het
Ctbp2	T	C	7: 132,616,083 (GRCm39)	Y284C	probably benign	Het
Dnah11	T	C	12: 117,991,262 (GRCm39)	D2368G	probably damaging	Het
Enpp3	C	T	10: 24,650,716 (GRCm39)	V807I	probably benign	Het
Erich3	A	G	3: 154,439,240 (GRCm39)	D491G	probably damaging	Het
Ero1a	C	T	14: 45,542,723 (GRCm39)	V101I	possibly damaging	Het
Fbxl7	A	G	15: 26,895,111 (GRCm39)	Y9H	possibly damaging	Het
Fzd2	A	G	11: 102,496,453 (GRCm39)	Y299C	possibly damaging	Het
Lamc1	G	A	1: 153,123,141 (GRCm39)	T683M	possibly damaging	Het
Lrrc39	C	T	3: 116,374,899 (GRCm39)	P327S	probably benign	Het
Marf1	A	T	16: 13,933,691 (GRCm39)	F1566I	probably benign	Het
Me2	A	T	18: 73,924,183 (GRCm39)	M343K	probably damaging	Het
Mlxip	T	A	5: 123,581,132 (GRCm39)	W260R	probably damaging	Het
Mrps17	T	C	5: 129,795,047 (GRCm39)	V64A	probably damaging	Het
Or4c118	A	T	2: 88,974,899 (GRCm39)	I156N	possibly damaging	Het
Phldb3	C	T	7: 24,323,719 (GRCm39)	S450L	probably benign	Het
Pi4k2a	A	G	19: 42,093,316 (GRCm39)	E219G	possibly damaging	Het
Polr1a	T	C	6: 71,951,866 (GRCm39)	S1478P	probably benign	Het
Rab14	T	C	2: 35,076,762 (GRCm39)		probably null	Het
Rnf43	T	C	11: 87,623,085 (GRCm39)	Y729H	possibly damaging	Het
Sgms1	G	A	19: 32,137,072 (GRCm39)	R165*	probably null	Het
Sorbs1	T	A	19: 40,361,959 (GRCm39)	I142F	probably damaging	Het
Tmem255b	A	G	8: 13,491,278 (GRCm39)	I66V	probably benign	Het
Zfp954	A	T	7: 7,120,808 (GRCm39)	I74N	probably benign	Het

Other mutations in Vmn2r9

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00920:Vmn2r9	APN	5	108,995,890 (GRCm39)	missense	possibly damaging	0.79
IGL00972:Vmn2r9	APN	5	108,996,903 (GRCm39)	missense	probably benign	0.02
IGL01102:Vmn2r9	APN	5	108,990,811 (GRCm39)	splice site	probably null
IGL01892:Vmn2r9	APN	5	108,995,700 (GRCm39)	missense	probably damaging	1.00
IGL02086:Vmn2r9	APN	5	108,995,433 (GRCm39)	missense	probably damaging	1.00
IGL02118:Vmn2r9	APN	5	108,991,502 (GRCm39)	missense	probably damaging	1.00
IGL02119:Vmn2r9	APN	5	108,991,502 (GRCm39)	missense	probably damaging	1.00
IGL02120:Vmn2r9	APN	5	108,991,502 (GRCm39)	missense	probably damaging	1.00
IGL02121:Vmn2r9	APN	5	108,991,502 (GRCm39)	missense	probably damaging	1.00
IGL02123:Vmn2r9	APN	5	108,991,502 (GRCm39)	missense	probably damaging	1.00
IGL02131:Vmn2r9	APN	5	108,991,502 (GRCm39)	missense	probably damaging	1.00
IGL02132:Vmn2r9	APN	5	108,991,502 (GRCm39)	missense	probably damaging	1.00
IGL02171:Vmn2r9	APN	5	108,991,502 (GRCm39)	missense	probably damaging	1.00
IGL02185:Vmn2r9	APN	5	108,991,502 (GRCm39)	missense	probably damaging	1.00
IGL02186:Vmn2r9	APN	5	108,991,502 (GRCm39)	missense	probably damaging	1.00
IGL02346:Vmn2r9	APN	5	108,990,850 (GRCm39)	missense	probably benign	0.07
IGL02508:Vmn2r9	APN	5	108,996,067 (GRCm39)	missense	possibly damaging	0.70
IGL02815:Vmn2r9	APN	5	108,990,856 (GRCm39)	missense	possibly damaging	0.69
IGL03077:Vmn2r9	APN	5	108,996,173 (GRCm39)	splice site	probably benign
IGL03269:Vmn2r9	APN	5	108,995,820 (GRCm39)	missense	probably damaging	1.00
IGL03293:Vmn2r9	APN	5	108,995,997 (GRCm39)	missense	probably damaging	1.00
R0112:Vmn2r9	UTSW	5	108,990,991 (GRCm39)	missense	probably damaging	1.00
R0328:Vmn2r9	UTSW	5	108,995,405 (GRCm39)	missense	probably benign	0.11
R0382:Vmn2r9	UTSW	5	108,995,463 (GRCm39)	missense	probably damaging	1.00
R0521:Vmn2r9	UTSW	5	108,996,154 (GRCm39)	nonsense	probably null
R0975:Vmn2r9	UTSW	5	108,991,169 (GRCm39)	missense	probably damaging	1.00
R1216:Vmn2r9	UTSW	5	108,995,440 (GRCm39)	missense	probably damaging	1.00
R1458:Vmn2r9	UTSW	5	108,996,850 (GRCm39)	missense	probably benign	0.44
R1469:Vmn2r9	UTSW	5	108,991,694 (GRCm39)	missense	probably benign
R1469:Vmn2r9	UTSW	5	108,991,694 (GRCm39)	missense	probably benign
R1704:Vmn2r9	UTSW	5	108,994,266 (GRCm39)	missense	probably damaging	1.00
R1967:Vmn2r9	UTSW	5	108,995,388 (GRCm39)	missense	probably benign	0.03
R1991:Vmn2r9	UTSW	5	108,994,305 (GRCm39)	missense	probably damaging	0.99
R3419:Vmn2r9	UTSW	5	108,994,299 (GRCm39)	missense	probably damaging	0.96
R3852:Vmn2r9	UTSW	5	108,995,997 (GRCm39)	missense	probably damaging	1.00
R3873:Vmn2r9	UTSW	5	108,995,701 (GRCm39)	missense	probably benign	0.14
R3905:Vmn2r9	UTSW	5	108,995,785 (GRCm39)	missense	probably benign	0.37
R3908:Vmn2r9	UTSW	5	108,995,785 (GRCm39)	missense	probably benign	0.37
R3921:Vmn2r9	UTSW	5	108,996,921 (GRCm39)	missense	probably benign
R4156:Vmn2r9	UTSW	5	108,995,743 (GRCm39)	missense	possibly damaging	0.64
R4477:Vmn2r9	UTSW	5	108,994,143 (GRCm39)	missense	probably benign
R4478:Vmn2r9	UTSW	5	108,994,143 (GRCm39)	missense	probably benign
R4544:Vmn2r9	UTSW	5	108,995,551 (GRCm39)	missense	probably benign	0.00
R4546:Vmn2r9	UTSW	5	108,995,551 (GRCm39)	missense	probably benign	0.00
R4627:Vmn2r9	UTSW	5	108,995,463 (GRCm39)	missense	probably damaging	1.00
R5215:Vmn2r9	UTSW	5	108,994,351 (GRCm39)	missense	probably benign	0.03
R5361:Vmn2r9	UTSW	5	108,995,929 (GRCm39)	missense	probably damaging	1.00
R5587:Vmn2r9	UTSW	5	108,995,427 (GRCm39)	missense	probably damaging	1.00
R6054:Vmn2r9	UTSW	5	108,996,126 (GRCm39)	missense	probably damaging	0.99
R6106:Vmn2r9	UTSW	5	108,992,902 (GRCm39)	missense	probably benign
R6125:Vmn2r9	UTSW	5	108,990,836 (GRCm39)	missense	probably benign	0.01
R6137:Vmn2r9	UTSW	5	108,996,882 (GRCm39)	missense	probably benign	0.00
R6920:Vmn2r9	UTSW	5	108,996,912 (GRCm39)	missense	possibly damaging	0.72
R7579:Vmn2r9	UTSW	5	108,992,948 (GRCm39)	missense	probably damaging	1.00
R8683:Vmn2r9	UTSW	5	108,996,873 (GRCm39)	missense	probably benign
R8964:Vmn2r9	UTSW	5	108,996,031 (GRCm39)	missense	probably benign	0.05
R9022:Vmn2r9	UTSW	5	108,992,923 (GRCm39)	missense	possibly damaging	0.90
R9118:Vmn2r9	UTSW	5	108,990,937 (GRCm39)	missense	probably damaging	0.99
R9125:Vmn2r9	UTSW	5	108,996,047 (GRCm39)	missense
R9240:Vmn2r9	UTSW	5	108,996,099 (GRCm39)	missense	possibly damaging	0.78
R9327:Vmn2r9	UTSW	5	108,996,841 (GRCm39)	missense	probably damaging	0.96
R9412:Vmn2r9	UTSW	5	108,991,484 (GRCm39)	missense	probably damaging	1.00
R9499:Vmn2r9	UTSW	5	108,995,584 (GRCm39)	missense	probably damaging	1.00
R9757:Vmn2r9	UTSW	5	108,995,908 (GRCm39)	missense	possibly damaging	0.87
R9790:Vmn2r9	UTSW	5	108,995,409 (GRCm39)	missense	probably damaging	0.99
R9791:Vmn2r9	UTSW	5	108,995,409 (GRCm39)	missense	probably damaging	0.99

Predicted Primers

PCR Primer
(F):5'- GCTAAACAGATTCCATGTCTTTGC -3'
(R):5'- TCAGACTTCTCAGGAATACTCTAGACC -3'

Sequencing Primer
(F):5'- AACAGATTCCATGTCTTTGCATTTC -3'
(R):5'- TCAGGAATACTCTAGACCCTATAGG -3'

Posted On

2014-11-12