Incidental Mutation 'R2411:Lilra6'
ID 249985
Institutional Source Beutler Lab
Gene Symbol Lilra6
Ensembl Gene ENSMUSG00000030427
Gene Name leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6
Synonyms 7M1, Pira3
MMRRC Submission 040376-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.086) question?
Stock # R2411 (G1)
Quality Score 181
Status Validated
Chromosome 7
Chromosomal Location 3911279-3918502 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 3914453 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 566 (Y566C)
Ref Sequence ENSEMBL: ENSMUSP00000088188 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000038176] [ENSMUST00000090689] [ENSMUST00000206077]
AlphaFold A0A0B4J1F3
Predicted Effect probably damaging
Transcript: ENSMUST00000038176
AA Change: Y604C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000042636
Gene: ENSMUSG00000030427
AA Change: Y604C

DomainStartEndE-ValueType
low complexity region 8 17 N/A INTRINSIC
IG_like 40 105 3.11e0 SMART
IG 129 315 4.53e-2 SMART
IG_like 237 302 1.54e-1 SMART
IG_like 328 415 1.79e1 SMART
IG_like 429 517 2.66e1 SMART
IG 529 618 8.59e-3 SMART
low complexity region 637 646 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000090689
AA Change: Y566C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000088188
Gene: ENSMUSG00000030427
AA Change: Y566C

DomainStartEndE-ValueType
low complexity region 8 17 N/A INTRINSIC
IG_like 34 118 7.25e0 SMART
IG_like 129 220 1.62e2 SMART
IG_like 290 377 1.79e1 SMART
IG_like 391 479 2.66e1 SMART
IG 491 580 8.59e-3 SMART
low complexity region 599 608 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000131255
Predicted Effect probably damaging
Transcript: ENSMUST00000206077
AA Change: Y264C

PolyPhen 2 Score 0.984 (Sensitivity: 0.74; Specificity: 0.96)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000206851
Meta Mutation Damage Score 0.3459 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 93.9%
Validation Efficiency 98% (42/43)
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700012B07Rik G T 11: 109,684,980 (GRCm39) C172* probably null Het
4933402D24Rik A G 1: 63,795,373 (GRCm39) probably benign Het
9030612E09Rik G T 10: 43,050,796 (GRCm39) R30L possibly damaging Het
Aadacl2 A G 3: 59,924,844 (GRCm39) D137G possibly damaging Het
Acad11 T G 9: 103,963,222 (GRCm39) probably benign Het
Acap1 A T 11: 69,776,311 (GRCm39) N229K probably damaging Het
Agbl1 A G 7: 76,369,898 (GRCm39) T666A probably damaging Het
Btbd16 T C 7: 130,391,954 (GRCm39) F160L probably damaging Het
Clock A C 5: 76,379,360 (GRCm39) H525Q probably benign Het
Col6a1 G T 10: 76,546,922 (GRCm39) Q767K unknown Het
Creld1 A G 6: 113,466,737 (GRCm39) H240R probably benign Het
Dlg4 G A 11: 69,932,755 (GRCm39) probably null Het
Fam204a A T 19: 60,187,870 (GRCm39) *237R probably null Het
Filip1 T A 9: 79,805,715 (GRCm39) N13I probably damaging Het
Gm14295 G T 2: 176,499,206 (GRCm39) A19S probably benign Het
Hddc3 A T 7: 79,993,341 (GRCm39) Q56L probably damaging Het
Hes6 A C 1: 91,340,986 (GRCm39) probably null Het
Hormad1 A G 3: 95,487,326 (GRCm39) D270G probably benign Het
Ifitm1 A G 7: 140,549,711 (GRCm39) probably null Het
Igbp1b A C 6: 138,634,871 (GRCm39) V191G probably damaging Het
Impg2 T A 16: 56,072,517 (GRCm39) N316K probably damaging Het
Kalrn C T 16: 33,810,180 (GRCm39) D2525N possibly damaging Het
Map4k4 A G 1: 40,046,656 (GRCm39) D775G probably damaging Het
Mtmr10 A T 7: 63,947,245 (GRCm39) K53N probably damaging Het
Mybpc2 G A 7: 44,155,662 (GRCm39) R864W probably damaging Het
Nckap1l C A 15: 103,391,995 (GRCm39) P810Q probably damaging Het
Nsf C T 11: 103,821,578 (GRCm39) E26K possibly damaging Het
Or14c44 T C 7: 86,062,290 (GRCm39) V281A possibly damaging Het
Or1ad1 A G 11: 50,875,758 (GRCm39) T77A probably damaging Het
Or4a27 C T 2: 88,559,741 (GRCm39) M67I probably benign Het
Ppp2r3c T C 12: 55,345,269 (GRCm39) K73R probably benign Het
Ptpru A T 4: 131,498,780 (GRCm39) F1311Y probably damaging Het
Ror2 G A 13: 53,284,980 (GRCm39) P144L possibly damaging Het
Setd2 A G 9: 110,379,497 (GRCm39) E1104G possibly damaging Het
St14 G A 9: 31,019,530 (GRCm39) T97I probably benign Het
Stag3 A G 5: 138,281,290 (GRCm39) probably benign Het
Sytl3 T C 17: 7,003,892 (GRCm39) S326P probably damaging Het
Tor1b G T 2: 30,845,824 (GRCm39) S167I probably damaging Het
Ttn T A 2: 76,568,359 (GRCm39) E27511D probably damaging Het
Uso1 T A 5: 92,306,258 (GRCm39) probably benign Het
Vmn1r10 G T 6: 57,091,124 (GRCm39) V239F probably benign Het
Vps35l G C 7: 118,391,818 (GRCm39) A410P probably damaging Het
Zfp160 C T 17: 21,246,007 (GRCm39) R186C possibly damaging Het
Zfp869 A G 8: 70,159,179 (GRCm39) C465R probably damaging Het
Zfp957 T C 14: 79,451,782 (GRCm39) K6E unknown Het
Other mutations in Lilra6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00508:Lilra6 APN 7 3,914,553 (GRCm39) missense probably benign 0.04
IGL00569:Lilra6 APN 7 3,917,588 (GRCm39) missense probably damaging 0.99
IGL00899:Lilra6 APN 7 3,916,056 (GRCm39) missense probably damaging 1.00
IGL00955:Lilra6 APN 7 3,914,403 (GRCm39) splice site probably benign
IGL01585:Lilra6 APN 7 3,917,498 (GRCm39) missense probably benign 0.01
IGL02195:Lilra6 APN 7 3,917,549 (GRCm39) missense probably benign 0.00
IGL02586:Lilra6 APN 7 3,911,819 (GRCm39) missense probably benign 0.36
IGL02719:Lilra6 APN 7 3,915,991 (GRCm39) missense possibly damaging 0.96
IGL03166:Lilra6 APN 7 3,915,626 (GRCm39) missense possibly damaging 0.69
IGL03329:Lilra6 APN 7 3,917,647 (GRCm39) splice site probably benign
R0233:Lilra6 UTSW 7 3,917,935 (GRCm39) missense possibly damaging 0.69
R0233:Lilra6 UTSW 7 3,917,935 (GRCm39) missense possibly damaging 0.69
R0423:Lilra6 UTSW 7 3,917,774 (GRCm39) splice site probably benign
R0483:Lilra6 UTSW 7 3,916,138 (GRCm39) missense probably benign 0.02
R0511:Lilra6 UTSW 7 3,915,784 (GRCm39) missense possibly damaging 0.77
R1472:Lilra6 UTSW 7 3,915,718 (GRCm39) missense probably damaging 1.00
R1560:Lilra6 UTSW 7 3,914,407 (GRCm39) critical splice donor site probably null
R1584:Lilra6 UTSW 7 3,915,661 (GRCm39) missense probably damaging 1.00
R1781:Lilra6 UTSW 7 3,918,066 (GRCm39) missense probably benign 0.28
R2420:Lilra6 UTSW 7 3,917,857 (GRCm39) missense probably damaging 1.00
R4021:Lilra6 UTSW 7 3,914,417 (GRCm39) missense probably benign 0.20
R4074:Lilra6 UTSW 7 3,917,889 (GRCm39) missense probably benign 0.23
R4284:Lilra6 UTSW 7 3,911,803 (GRCm39) missense possibly damaging 0.76
R4508:Lilra6 UTSW 7 3,915,028 (GRCm39) nonsense probably null
R4894:Lilra6 UTSW 7 3,915,530 (GRCm39) missense probably benign 0.01
R4977:Lilra6 UTSW 7 3,917,382 (GRCm39) missense probably benign 0.01
R5048:Lilra6 UTSW 7 3,918,440 (GRCm39) critical splice donor site probably null
R5164:Lilra6 UTSW 7 3,917,880 (GRCm39) missense probably damaging 1.00
R5185:Lilra6 UTSW 7 3,917,635 (GRCm39) missense probably benign 0.00
R5527:Lilra6 UTSW 7 3,917,586 (GRCm39) start gained probably benign
R6281:Lilra6 UTSW 7 3,914,972 (GRCm39) missense probably damaging 1.00
R6480:Lilra6 UTSW 7 3,915,932 (GRCm39) missense probably damaging 1.00
R6512:Lilra6 UTSW 7 3,917,387 (GRCm39) missense probably benign 0.06
R6565:Lilra6 UTSW 7 3,918,019 (GRCm39) missense probably benign
R7017:Lilra6 UTSW 7 3,911,707 (GRCm39) missense possibly damaging 0.93
R7095:Lilra6 UTSW 7 3,916,196 (GRCm39) missense probably damaging 1.00
R7747:Lilra6 UTSW 7 3,915,995 (GRCm39) missense probably benign 0.16
R8056:Lilra6 UTSW 7 3,915,551 (GRCm39) missense probably damaging 1.00
R8280:Lilra6 UTSW 7 3,916,046 (GRCm39) missense probably benign 0.01
R9197:Lilra6 UTSW 7 3,915,716 (GRCm39) missense possibly damaging 0.94
R9354:Lilra6 UTSW 7 3,914,628 (GRCm39) missense probably damaging 1.00
R9379:Lilra6 UTSW 7 3,916,166 (GRCm39) missense probably damaging 1.00
R9406:Lilra6 UTSW 7 3,917,853 (GRCm39) missense probably benign
R9462:Lilra6 UTSW 7 3,914,994 (GRCm39) missense probably damaging 0.97
R9649:Lilra6 UTSW 7 3,917,521 (GRCm39) missense possibly damaging 0.47
Z1176:Lilra6 UTSW 7 3,918,073 (GRCm39) critical splice acceptor site probably null
Z1177:Lilra6 UTSW 7 3,915,580 (GRCm39) missense possibly damaging 0.48
Predicted Primers PCR Primer
(F):5'- TATCCTGTTATGTGCTGACGAATG -3'
(R):5'- TGCAGCCTAACCACACAGTG -3'

Sequencing Primer
(F):5'- GCTGACGAATGTGCCTATGTCTAAC -3'
(R):5'- CAGTGCACTCAGGAGAGACC -3'
Posted On 2014-11-12