Incidental Mutation 'R2425:Fkbp15'
ID 250140
Institutional Source Beutler Lab
Gene Symbol Fkbp15
Ensembl Gene ENSMUSG00000066151
Gene Name FK506 binding protein 15
Synonyms C430014M02Rik, FKBP133
MMRRC Submission 040387-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R2425 (G1)
Quality Score 225
Status Not validated
Chromosome 4
Chromosomal Location 62218579-62278785 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 62230602 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 704 (T704A)
Ref Sequence ENSEMBL: ENSMUSP00000081575 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000084527] [ENSMUST00000084528]
AlphaFold Q6P9Q6
Predicted Effect probably benign
Transcript: ENSMUST00000084527
AA Change: T704A

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
SMART Domains Protein: ENSMUSP00000081575
Gene: ENSMUSG00000066151
AA Change: T704A

DomainStartEndE-ValueType
low complexity region 59 68 N/A INTRINSIC
Pfam:FKBP_C 190 286 4.8e-21 PFAM
low complexity region 302 322 N/A INTRINSIC
low complexity region 326 338 N/A INTRINSIC
internal_repeat_1 403 431 1.88e-10 PROSPERO
internal_repeat_1 472 500 1.88e-10 PROSPERO
coiled coil region 560 662 N/A INTRINSIC
coiled coil region 684 790 N/A INTRINSIC
coiled coil region 816 865 N/A INTRINSIC
coiled coil region 916 943 N/A INTRINSIC
low complexity region 952 964 N/A INTRINSIC
low complexity region 983 994 N/A INTRINSIC
low complexity region 1034 1045 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000084528
AA Change: T704A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000081576
Gene: ENSMUSG00000066151
AA Change: T704A

DomainStartEndE-ValueType
low complexity region 59 68 N/A INTRINSIC
Pfam:FKBP_C 190 286 2.4e-21 PFAM
low complexity region 302 322 N/A INTRINSIC
low complexity region 326 338 N/A INTRINSIC
internal_repeat_1 403 431 2.74e-10 PROSPERO
internal_repeat_1 472 500 2.74e-10 PROSPERO
coiled coil region 560 662 N/A INTRINSIC
coiled coil region 684 745 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000139308
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 93.5%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca15 T C 7: 119,959,033 (GRCm39) F621S probably damaging Het
Abcc10 A G 17: 46,621,083 (GRCm39) Y976H probably damaging Het
Abhd6 T A 14: 8,049,857 (GRCm38) N215K probably benign Het
Adcy4 T C 14: 56,015,474 (GRCm39) T479A probably damaging Het
Amacr A G 15: 10,983,454 (GRCm39) Q88R possibly damaging Het
Ankrd11 T A 8: 123,619,902 (GRCm39) I1317F possibly damaging Het
Ano3 C A 2: 110,693,188 (GRCm39) A137S probably benign Het
Astn1 T G 1: 158,407,236 (GRCm39) S562A probably damaging Het
Cd44 T A 2: 102,691,931 (GRCm39) Y119F probably damaging Het
CN725425 A C 15: 91,130,058 (GRCm39) D307A probably damaging Het
Col12a1 T C 9: 79,585,648 (GRCm39) Y1243C probably damaging Het
Cyp2c50 T C 19: 40,078,292 (GRCm39) I50T probably benign Het
Dhrs9 A G 2: 69,223,308 (GRCm39) K19E probably benign Het
Dnajb14 T G 3: 137,598,666 (GRCm39) F135V probably null Het
Draxin T A 4: 148,197,213 (GRCm39) T195S possibly damaging Het
Elane C T 10: 79,723,610 (GRCm39) R192C probably benign Het
Fam171a2 A C 11: 102,329,187 (GRCm39) I524S possibly damaging Het
Fbxo10 C T 4: 45,051,642 (GRCm39) E490K possibly damaging Het
Fndc1 T A 17: 8,023,850 (GRCm39) D35V probably damaging Het
Galntl5 A G 5: 25,425,079 (GRCm39) K366E probably damaging Het
Gas7 G A 11: 67,534,121 (GRCm39) A74T probably benign Het
Gjd4 G T 18: 9,280,811 (GRCm39) S89* probably null Het
Gldc T A 19: 30,109,190 (GRCm39) N583Y probably damaging Het
Gpr161 T A 1: 165,138,192 (GRCm39) S259R possibly damaging Het
Igfn1 T A 1: 135,890,840 (GRCm39) T2387S probably damaging Het
Il3 A T 11: 54,156,375 (GRCm39) V119D possibly damaging Het
Ints3 T C 3: 90,301,417 (GRCm39) T822A possibly damaging Het
Jakmip1 C T 5: 37,299,149 (GRCm39) Q790* probably null Het
Kcne1 A G 16: 92,145,646 (GRCm39) I66T probably damaging Het
Nipbl A G 15: 8,380,966 (GRCm39) S609P probably benign Het
Or10d5 T C 9: 39,861,137 (GRCm39) E310G probably null Het
Or2t48 A G 11: 58,420,137 (GRCm39) I225T probably damaging Het
Or8k21 A G 2: 86,144,739 (GRCm39) V297A probably damaging Het
Pdxdc1 A T 16: 13,697,372 (GRCm39) S103T possibly damaging Het
Pla2g2a C A 4: 138,560,229 (GRCm39) A24E possibly damaging Het
Plxna2 C T 1: 194,431,625 (GRCm39) S538F probably damaging Het
Pramel1 T G 4: 143,125,036 (GRCm39) L320R probably damaging Het
Rad23b T A 4: 55,385,438 (GRCm39) I325N probably damaging Het
Rasgrp1 C G 2: 117,119,931 (GRCm39) probably null Het
Rbm12b1 T A 4: 12,146,443 (GRCm39) I805N probably damaging Het
Shld2 A G 14: 33,990,646 (GRCm39) S87P probably damaging Het
Slc12a9 G T 5: 137,313,859 (GRCm39) A700E probably damaging Het
Tbc1d24 A T 17: 24,404,982 (GRCm39) V54E probably damaging Het
Tmc8 A G 11: 117,683,395 (GRCm39) D650G probably damaging Het
Upf1 C T 8: 70,791,110 (GRCm39) R544H probably damaging Het
Ush2a T A 1: 188,270,001 (GRCm39) N1749K possibly damaging Het
Usp42 T C 5: 143,701,594 (GRCm39) T810A probably benign Het
Wdr70 C A 15: 7,916,840 (GRCm39) E526* probably null Het
Zfp935 G T 13: 62,602,922 (GRCm39) Q93K probably benign Het
Other mutations in Fkbp15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00659:Fkbp15 APN 4 62,251,917 (GRCm39) splice site probably benign
IGL01326:Fkbp15 APN 4 62,241,487 (GRCm39) missense probably damaging 0.98
IGL01822:Fkbp15 APN 4 62,270,741 (GRCm39) missense probably benign
IGL01925:Fkbp15 APN 4 62,241,450 (GRCm39) missense probably damaging 1.00
IGL02190:Fkbp15 APN 4 62,223,059 (GRCm39) missense possibly damaging 0.69
IGL02276:Fkbp15 APN 4 62,254,703 (GRCm39) nonsense probably null
IGL02310:Fkbp15 APN 4 62,258,553 (GRCm39) missense probably damaging 1.00
IGL02954:Fkbp15 APN 4 62,239,302 (GRCm39) splice site probably benign
IGL02967:Fkbp15 APN 4 62,222,627 (GRCm39) missense probably damaging 0.96
IGL03136:Fkbp15 APN 4 62,258,466 (GRCm39) splice site probably benign
IGL03185:Fkbp15 APN 4 62,250,423 (GRCm39) splice site probably null
IGL03280:Fkbp15 APN 4 62,221,504 (GRCm39) unclassified probably benign
dura UTSW 4 62,242,363 (GRCm39) missense probably damaging 0.96
mater UTSW 4 62,244,373 (GRCm39) missense probably benign 0.22
R0419:Fkbp15 UTSW 4 62,244,373 (GRCm39) missense probably benign 0.22
R0838:Fkbp15 UTSW 4 62,242,363 (GRCm39) missense probably damaging 0.96
R1241:Fkbp15 UTSW 4 62,222,846 (GRCm39) missense possibly damaging 0.87
R1394:Fkbp15 UTSW 4 62,246,109 (GRCm39) missense probably benign 0.00
R1622:Fkbp15 UTSW 4 62,241,439 (GRCm39) missense possibly damaging 0.94
R1682:Fkbp15 UTSW 4 62,242,431 (GRCm39) missense probably damaging 0.98
R1823:Fkbp15 UTSW 4 62,255,328 (GRCm39) missense probably damaging 1.00
R1994:Fkbp15 UTSW 4 62,222,618 (GRCm39) missense probably benign 0.00
R2132:Fkbp15 UTSW 4 62,246,136 (GRCm39) missense probably damaging 1.00
R2133:Fkbp15 UTSW 4 62,246,136 (GRCm39) missense probably damaging 1.00
R2938:Fkbp15 UTSW 4 62,222,900 (GRCm39) missense probably benign 0.23
R3034:Fkbp15 UTSW 4 62,225,129 (GRCm39) splice site probably null
R3957:Fkbp15 UTSW 4 62,252,489 (GRCm39) missense probably benign 0.01
R3963:Fkbp15 UTSW 4 62,258,914 (GRCm39) missense probably damaging 1.00
R4235:Fkbp15 UTSW 4 62,254,693 (GRCm39) missense probably benign 0.38
R4334:Fkbp15 UTSW 4 62,221,456 (GRCm39) missense possibly damaging 0.95
R4366:Fkbp15 UTSW 4 62,254,651 (GRCm39) missense probably benign 0.38
R4717:Fkbp15 UTSW 4 62,226,306 (GRCm39) missense probably damaging 1.00
R4790:Fkbp15 UTSW 4 62,226,234 (GRCm39) missense probably benign 0.05
R5075:Fkbp15 UTSW 4 62,239,266 (GRCm39) missense probably damaging 0.96
R5176:Fkbp15 UTSW 4 62,230,560 (GRCm39) missense possibly damaging 0.68
R5419:Fkbp15 UTSW 4 62,246,114 (GRCm39) missense probably damaging 0.98
R5503:Fkbp15 UTSW 4 62,246,124 (GRCm39) missense probably benign 0.05
R5731:Fkbp15 UTSW 4 62,225,166 (GRCm39) missense probably benign 0.01
R5733:Fkbp15 UTSW 4 62,225,166 (GRCm39) missense probably benign 0.01
R5820:Fkbp15 UTSW 4 62,263,783 (GRCm39) missense probably benign 0.00
R5878:Fkbp15 UTSW 4 62,225,145 (GRCm39) missense probably benign
R5898:Fkbp15 UTSW 4 62,244,294 (GRCm39) critical splice donor site probably null
R5914:Fkbp15 UTSW 4 62,246,047 (GRCm39) splice site probably null
R6113:Fkbp15 UTSW 4 62,258,884 (GRCm39) missense probably benign 0.38
R6377:Fkbp15 UTSW 4 62,242,429 (GRCm39) missense probably damaging 1.00
R6427:Fkbp15 UTSW 4 62,241,439 (GRCm39) missense probably benign 0.01
R6464:Fkbp15 UTSW 4 62,226,315 (GRCm39) missense possibly damaging 0.92
R6528:Fkbp15 UTSW 4 62,250,507 (GRCm39) missense probably damaging 1.00
R6790:Fkbp15 UTSW 4 62,222,996 (GRCm39) missense probably benign 0.01
R6880:Fkbp15 UTSW 4 62,254,732 (GRCm39) missense possibly damaging 0.71
R6911:Fkbp15 UTSW 4 62,258,527 (GRCm39) missense probably damaging 1.00
R7371:Fkbp15 UTSW 4 62,239,293 (GRCm39) missense possibly damaging 0.89
R7410:Fkbp15 UTSW 4 62,258,536 (GRCm39) missense probably damaging 1.00
R7660:Fkbp15 UTSW 4 62,232,578 (GRCm39) missense probably benign 0.08
R7992:Fkbp15 UTSW 4 62,230,538 (GRCm39) missense probably damaging 1.00
R8486:Fkbp15 UTSW 4 62,230,521 (GRCm39) nonsense probably null
R8697:Fkbp15 UTSW 4 62,239,295 (GRCm39) nonsense probably null
R8880:Fkbp15 UTSW 4 62,232,602 (GRCm39) missense probably benign
R8998:Fkbp15 UTSW 4 62,242,365 (GRCm39) missense probably damaging 1.00
R9236:Fkbp15 UTSW 4 62,254,664 (GRCm39) missense probably damaging 0.97
R9382:Fkbp15 UTSW 4 62,237,210 (GRCm39) missense probably damaging 0.99
R9654:Fkbp15 UTSW 4 62,230,553 (GRCm39) missense probably benign 0.01
X0013:Fkbp15 UTSW 4 62,230,607 (GRCm39) missense probably benign 0.36
Predicted Primers PCR Primer
(F):5'- TGGTTTACTAATCAGCTACGCC -3'
(R):5'- TGCTTGCGCAGAAGGTGTATAC -3'

Sequencing Primer
(F):5'- AATCAGCTACGCCTGCACTTG -3'
(R):5'- CTTGCGCAGAAGGTGTATACATATAG -3'
Posted On 2014-11-12