Incidental Mutation 'R2426:Tnik'
ID 250196
Institutional Source Beutler Lab
Gene Symbol Tnik
Ensembl Gene ENSMUSG00000027692
Gene Name TRAF2 and NCK interacting kinase
Synonyms C630040K21Rik, 1500031A17Rik, 4831440I19Rik, C530008O15Rik
MMRRC Submission 040388-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R2426 (G1)
Quality Score 225
Status Not validated
Chromosome 3
Chromosomal Location 28263214-28675858 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to G at 28646681 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Serine to Glycine at position 907 (S907G)
Ref Sequence ENSEMBL: ENSMUSP00000124011 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000159236] [ENSMUST00000159308] [ENSMUST00000159680] [ENSMUST00000160307] [ENSMUST00000160518] [ENSMUST00000160934] [ENSMUST00000161964] [ENSMUST00000162485] [ENSMUST00000162777]
AlphaFold P83510
Predicted Effect probably damaging
Transcript: ENSMUST00000159236
AA Change: S899G

PolyPhen 2 Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000124681
Gene: ENSMUSG00000027692
AA Change: S899G

DomainStartEndE-ValueType
S_TKc 25 289 1.23e-96 SMART
low complexity region 317 340 N/A INTRINSIC
coiled coil region 360 482 N/A INTRINSIC
low complexity region 691 726 N/A INTRINSIC
low complexity region 793 812 N/A INTRINSIC
low complexity region 951 958 N/A INTRINSIC
CNH 1005 1303 1.92e-117 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000159308
AA Change: S852G

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000125466
Gene: ENSMUSG00000027692
AA Change: S852G

DomainStartEndE-ValueType
S_TKc 25 289 1.23e-96 SMART
low complexity region 317 340 N/A INTRINSIC
coiled coil region 360 482 N/A INTRINSIC
low complexity region 636 671 N/A INTRINSIC
low complexity region 746 765 N/A INTRINSIC
low complexity region 904 911 N/A INTRINSIC
CNH 958 1256 1.92e-117 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000159680
AA Change: S928G

PolyPhen 2 Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000124876
Gene: ENSMUSG00000027692
AA Change: S928G

DomainStartEndE-ValueType
S_TKc 25 289 1.23e-96 SMART
low complexity region 317 340 N/A INTRINSIC
coiled coil region 360 511 N/A INTRINSIC
low complexity region 720 755 N/A INTRINSIC
low complexity region 822 841 N/A INTRINSIC
low complexity region 980 987 N/A INTRINSIC
CNH 1034 1332 1.92e-117 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000159733
Predicted Effect probably damaging
Transcript: ENSMUST00000160307
AA Change: S936G

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000125081
Gene: ENSMUSG00000027692
AA Change: S936G

DomainStartEndE-ValueType
S_TKc 25 289 1.23e-96 SMART
low complexity region 317 340 N/A INTRINSIC
coiled coil region 360 511 N/A INTRINSIC
low complexity region 720 755 N/A INTRINSIC
low complexity region 830 849 N/A INTRINSIC
low complexity region 988 995 N/A INTRINSIC
CNH 1042 1340 1.92e-117 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000160518
AA Change: S907G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000124011
Gene: ENSMUSG00000027692
AA Change: S907G

DomainStartEndE-ValueType
S_TKc 25 289 5.9e-99 SMART
low complexity region 317 340 N/A INTRINSIC
coiled coil region 360 482 N/A INTRINSIC
low complexity region 691 726 N/A INTRINSIC
low complexity region 801 820 N/A INTRINSIC
low complexity region 959 966 N/A INTRINSIC
CNH 1013 1311 9.3e-120 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000160934
SMART Domains Protein: ENSMUSP00000123859
Gene: ENSMUSG00000027692

DomainStartEndE-ValueType
Pfam:Pkinase_Tyr 25 212 2.2e-37 PFAM
Pfam:Pkinase 25 219 5.9e-52 PFAM
Predicted Effect unknown
Transcript: ENSMUST00000161964
AA Change: S844G
SMART Domains Protein: ENSMUSP00000125411
Gene: ENSMUSG00000027692
AA Change: S844G

DomainStartEndE-ValueType
S_TKc 25 289 1.23e-96 SMART
low complexity region 317 340 N/A INTRINSIC
coiled coil region 360 482 N/A INTRINSIC
low complexity region 636 671 N/A INTRINSIC
low complexity region 738 757 N/A INTRINSIC
low complexity region 896 903 N/A INTRINSIC
CNH 950 1248 1.92e-117 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000162037
Predicted Effect probably damaging
Transcript: ENSMUST00000162485
AA Change: S881G

PolyPhen 2 Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000124387
Gene: ENSMUSG00000027692
AA Change: S881G

DomainStartEndE-ValueType
S_TKc 25 289 1.23e-96 SMART
low complexity region 317 340 N/A INTRINSIC
coiled coil region 360 511 N/A INTRINSIC
low complexity region 665 700 N/A INTRINSIC
low complexity region 775 794 N/A INTRINSIC
low complexity region 933 940 N/A INTRINSIC
CNH 987 1285 1.92e-117 SMART
Predicted Effect unknown
Transcript: ENSMUST00000162777
AA Change: S873G
SMART Domains Protein: ENSMUSP00000124726
Gene: ENSMUSG00000027692
AA Change: S873G

DomainStartEndE-ValueType
S_TKc 25 289 1.23e-96 SMART
low complexity region 317 340 N/A INTRINSIC
coiled coil region 360 511 N/A INTRINSIC
low complexity region 665 700 N/A INTRINSIC
low complexity region 767 786 N/A INTRINSIC
low complexity region 925 932 N/A INTRINSIC
CNH 979 1277 1.92e-117 SMART
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 93.8%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Germinal center kinases (GCKs), such as TNIK, are characterized by an N-terminal kinase domain and a C-terminal GCK domain that serves a regulatory function (Fu et al., 1999 [PubMed 10521462]).[supplied by OMIM, Mar 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired postsynaptic signaling and cognitive function. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 67 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
0610010F05Rik T A 11: 23,576,801 (GRCm38) R190W probably damaging Het
Abca14 G T 7: 120,283,223 (GRCm38) V1203L probably benign Het
Adamtsl1 G A 4: 86,156,788 (GRCm38) V131I probably benign Het
Adgra3 A T 5: 50,009,449 (GRCm38) M187K possibly damaging Het
Agbl1 T C 7: 76,421,902 (GRCm38) V324A probably damaging Het
Ahnak A T 19: 9,002,851 (GRCm38) I500F possibly damaging Het
Aldh1l1 A G 6: 90,598,284 (GRCm38) D851G probably damaging Het
Amot T C X: 145,476,291 (GRCm38) K460E probably damaging Het
Arhgef3 G T 14: 27,384,181 (GRCm38) E161* probably null Het
Atg9b A T 5: 24,386,994 (GRCm38) I669N probably damaging Het
AY761184 T G 8: 21,702,637 (GRCm38) K114N possibly damaging Het
Ccdc83 A G 7: 90,228,431 (GRCm38) Y268H probably damaging Het
Cep170 A G 1: 176,774,635 (GRCm38) S302P probably benign Het
Cyp4a31 T A 4: 115,571,016 (GRCm38) M303K probably damaging Het
Cyp4v3 T A 8: 45,317,776 (GRCm38) Y231F probably benign Het
Dock3 A T 9: 106,914,541 (GRCm38) L1411Q possibly damaging Het
Dsg1a T A 18: 20,336,804 (GRCm38) I629N probably damaging Het
Dst A T 1: 34,192,812 (GRCm38) H2837L probably benign Het
Fam114a2 G A 11: 57,493,080 (GRCm38) P343L probably benign Het
Fbrs A G 7: 127,487,339 (GRCm38) probably null Het
Fbxl13 A C 5: 21,522,137 (GRCm38) D620E probably damaging Het
Frmd4a T A 2: 4,529,862 (GRCm38) S164T probably damaging Het
Gdi2 T G 13: 3,562,034 (GRCm38) S330A probably benign Het
Gm5878 A T 6: 85,118,631 (GRCm38) M70K probably benign Het
H2-Q6 G T 17: 35,424,937 (GRCm38) A21S probably benign Het
Hfm1 A T 5: 106,847,653 (GRCm38) probably null Het
Hnmt C T 2: 24,019,155 (GRCm38) C82Y probably benign Het
Il1rl1 C A 1: 40,446,619 (GRCm38) A310D probably damaging Het
Ints1 A T 5: 139,771,814 (GRCm38) probably null Het
Kcne4 C A 1: 78,817,971 (GRCm38) A112E possibly damaging Het
Krt32 T C 11: 100,086,366 (GRCm38) K236R possibly damaging Het
Maml2 T C 9: 13,706,498 (GRCm38) L380P probably damaging Het
Meis1 A T 11: 18,988,356 (GRCm38) D218E possibly damaging Het
Mon1b G A 8: 113,639,120 (GRCm38) G360D probably damaging Het
Mpp4 A G 1: 59,130,057 (GRCm38) S383P probably damaging Het
Neb A G 2: 52,169,053 (GRCm38) probably null Het
Nlgn2 A T 11: 69,827,086 (GRCm38) I431N probably damaging Het
Nr2e1 A G 10: 42,563,485 (GRCm38) L134P probably damaging Het
Olfr329-ps A T 11: 58,543,094 (GRCm38) Y127* probably null Het
Olfr371 T C 8: 85,231,064 (GRCm38) S190P probably damaging Het
Olfr777 T C 10: 129,269,266 (GRCm38) Q19R probably benign Het
Opcml G A 9: 28,903,367 (GRCm38) probably null Het
Pate2 A T 9: 35,670,480 (GRCm38) probably null Het
Pgr G A 9: 8,900,717 (GRCm38) V84M probably damaging Het
Pigu A T 2: 155,299,082 (GRCm38) V296D probably damaging Het
Plcb2 G A 2: 118,715,649 (GRCm38) T555M probably damaging Het
Pld5 T G 1: 175,963,976 (GRCm38) D426A probably benign Het
Prdm2 G T 4: 143,111,750 (GRCm38) C1679* probably null Het
Psme2b A T 11: 48,946,063 (GRCm38) V19D probably benign Het
Ptpn9 A T 9: 57,027,428 (GRCm38) N159Y possibly damaging Het
Sdc3 A T 4: 130,818,803 (GRCm38) T64S unknown Het
Serping1 T G 2: 84,770,219 (GRCm38) S260R probably damaging Het
Slc20a1 T C 2: 129,208,230 (GRCm38) F436S probably benign Het
Sntb1 A T 15: 55,906,179 (GRCm38) I138N probably damaging Het
Sorcs3 A T 19: 48,722,925 (GRCm38) Y643F probably damaging Het
Spink1 G T 18: 43,735,222 (GRCm38) S23* probably null Het
Stag1 T C 9: 100,845,116 (GRCm38) probably null Het
Tnfaip8l1 G A 17: 56,172,030 (GRCm38) V107I probably benign Het
Ttf1 T A 2: 29,067,185 (GRCm38) M489K probably damaging Het
Ugcg C T 4: 59,207,798 (GRCm38) P46S probably benign Het
Usp54 G A 14: 20,564,940 (GRCm38) A811V probably benign Het
Xirp2 A G 2: 67,514,471 (GRCm38) N2352S probably benign Het
Zan T C 5: 137,388,992 (GRCm38) Y4933C unknown Het
Zbtb8a A G 4: 129,360,219 (GRCm38) S161P probably benign Het
Zkscan5 A T 5: 145,220,940 (GRCm38) I751L probably benign Het
Zscan4d A G 7: 11,165,095 (GRCm38) F85S probably damaging Het
Zzef1 A G 11: 72,915,265 (GRCm38) M2647V probably benign Het
Other mutations in Tnik
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00516:Tnik APN 3 28,654,218 (GRCm38) missense probably damaging 1.00
IGL00726:Tnik APN 3 28,532,898 (GRCm38) missense probably damaging 1.00
IGL01022:Tnik APN 3 28,625,228 (GRCm38) splice site probably null
IGL01145:Tnik APN 3 28,604,167 (GRCm38) intron probably benign
IGL01664:Tnik APN 3 28,638,479 (GRCm38) missense probably damaging 1.00
IGL01843:Tnik APN 3 28,570,858 (GRCm38) splice site probably null
IGL02378:Tnik APN 3 28,638,459 (GRCm38) nonsense probably null
IGL02448:Tnik APN 3 28,621,077 (GRCm38) missense probably null 0.01
IGL02756:Tnik APN 3 28,542,030 (GRCm38) missense probably damaging 1.00
IGL03332:Tnik APN 3 28,666,155 (GRCm38) missense probably damaging 1.00
delightful UTSW 3 28,604,185 (GRCm38) missense probably damaging 1.00
Hottie UTSW 3 28,263,643 (GRCm38) start codon destroyed probably null 0.93
Knockout UTSW 3 28,661,778 (GRCm38) missense possibly damaging 0.91
Looker UTSW 3 28,661,704 (GRCm38) nonsense probably null
Lovely UTSW 3 28,611,970 (GRCm38) critical splice donor site probably null
Usher UTSW 3 28,564,097 (GRCm38) missense possibly damaging 0.61
R0135:Tnik UTSW 3 28,607,245 (GRCm38) missense possibly damaging 0.67
R0418:Tnik UTSW 3 28,570,880 (GRCm38) nonsense probably null
R0540:Tnik UTSW 3 28,650,159 (GRCm38) missense probably damaging 1.00
R0549:Tnik UTSW 3 28,570,920 (GRCm38) missense possibly damaging 0.87
R0556:Tnik UTSW 3 28,625,218 (GRCm38) missense possibly damaging 0.95
R0586:Tnik UTSW 3 28,577,361 (GRCm38) splice site probably benign
R0607:Tnik UTSW 3 28,650,159 (GRCm38) missense probably damaging 1.00
R0842:Tnik UTSW 3 28,594,086 (GRCm38) missense possibly damaging 0.72
R1068:Tnik UTSW 3 28,532,975 (GRCm38) missense probably damaging 1.00
R1171:Tnik UTSW 3 28,532,940 (GRCm38) missense probably damaging 1.00
R1597:Tnik UTSW 3 28,604,269 (GRCm38) missense probably damaging 1.00
R1638:Tnik UTSW 3 28,665,740 (GRCm38) missense probably damaging 0.99
R1652:Tnik UTSW 3 28,604,293 (GRCm38) missense probably benign 0.22
R1996:Tnik UTSW 3 28,665,680 (GRCm38) missense probably damaging 1.00
R2333:Tnik UTSW 3 28,532,996 (GRCm38) missense probably damaging 1.00
R2509:Tnik UTSW 3 28,667,915 (GRCm38) missense probably damaging 1.00
R3774:Tnik UTSW 3 28,638,419 (GRCm38) missense probably damaging 0.98
R3775:Tnik UTSW 3 28,638,419 (GRCm38) missense probably damaging 0.98
R4007:Tnik UTSW 3 28,604,281 (GRCm38) missense probably damaging 1.00
R4119:Tnik UTSW 3 28,666,175 (GRCm38) missense probably damaging 1.00
R4209:Tnik UTSW 3 28,359,065 (GRCm38) splice site probably benign
R4441:Tnik UTSW 3 28,564,097 (GRCm38) missense possibly damaging 0.61
R4611:Tnik UTSW 3 28,542,100 (GRCm38) critical splice donor site probably null
R4714:Tnik UTSW 3 28,594,077 (GRCm38) missense possibly damaging 0.53
R4772:Tnik UTSW 3 28,607,210 (GRCm38) missense probably benign 0.09
R4829:Tnik UTSW 3 28,539,541 (GRCm38) intron probably benign
R4839:Tnik UTSW 3 28,596,075 (GRCm38) missense possibly damaging 0.86
R4898:Tnik UTSW 3 28,650,086 (GRCm38) missense probably damaging 1.00
R5029:Tnik UTSW 3 28,665,844 (GRCm38) splice site probably null
R5278:Tnik UTSW 3 28,650,060 (GRCm38) missense probably damaging 1.00
R5307:Tnik UTSW 3 28,541,972 (GRCm38) missense probably damaging 1.00
R5330:Tnik UTSW 3 28,542,018 (GRCm38) missense probably damaging 1.00
R5375:Tnik UTSW 3 28,594,092 (GRCm38) missense probably benign 0.02
R5459:Tnik UTSW 3 28,661,741 (GRCm38) missense probably damaging 1.00
R5708:Tnik UTSW 3 28,611,971 (GRCm38) critical splice donor site probably null
R5749:Tnik UTSW 3 28,594,092 (GRCm38) missense probably benign 0.02
R5751:Tnik UTSW 3 28,594,092 (GRCm38) missense probably benign 0.02
R5780:Tnik UTSW 3 28,594,092 (GRCm38) missense probably benign 0.02
R5837:Tnik UTSW 3 28,668,053 (GRCm38) unclassified probably benign
R5969:Tnik UTSW 3 28,620,948 (GRCm38) missense probably damaging 1.00
R6244:Tnik UTSW 3 28,650,179 (GRCm38) missense probably damaging 1.00
R6273:Tnik UTSW 3 28,577,500 (GRCm38) missense possibly damaging 0.94
R6457:Tnik UTSW 3 28,539,448 (GRCm38) missense probably damaging 1.00
R6464:Tnik UTSW 3 28,611,970 (GRCm38) critical splice donor site probably null
R6473:Tnik UTSW 3 28,263,643 (GRCm38) start codon destroyed probably null 0.93
R6737:Tnik UTSW 3 28,596,086 (GRCm38) missense possibly damaging 0.72
R7049:Tnik UTSW 3 28,661,704 (GRCm38) nonsense probably null
R7237:Tnik UTSW 3 28,638,419 (GRCm38) missense probably damaging 0.98
R7267:Tnik UTSW 3 28,646,627 (GRCm38) missense probably damaging 0.99
R7445:Tnik UTSW 3 28,663,909 (GRCm38) splice site probably null
R7499:Tnik UTSW 3 28,630,594 (GRCm38) missense possibly damaging 0.47
R7629:Tnik UTSW 3 28,661,728 (GRCm38) missense probably damaging 0.96
R7654:Tnik UTSW 3 28,604,185 (GRCm38) missense probably damaging 1.00
R7886:Tnik UTSW 3 28,666,139 (GRCm38) missense probably damaging 1.00
R8096:Tnik UTSW 3 28,661,778 (GRCm38) missense possibly damaging 0.91
R8210:Tnik UTSW 3 28,604,333 (GRCm38) missense possibly damaging 0.95
R8233:Tnik UTSW 3 28,554,937 (GRCm38) missense unknown
R8386:Tnik UTSW 3 28,263,674 (GRCm38) missense unknown
R8399:Tnik UTSW 3 28,494,010 (GRCm38) missense unknown
R8490:Tnik UTSW 3 28,596,172 (GRCm38) missense probably damaging 0.97
R8539:Tnik UTSW 3 28,542,003 (GRCm38) missense probably damaging 1.00
R8751:Tnik UTSW 3 28,611,908 (GRCm38) missense probably damaging 0.98
R8804:Tnik UTSW 3 28,594,053 (GRCm38) missense unknown
R8966:Tnik UTSW 3 28,532,895 (GRCm38) missense unknown
R8998:Tnik UTSW 3 28,665,771 (GRCm38) missense probably damaging 1.00
R8999:Tnik UTSW 3 28,665,771 (GRCm38) missense probably damaging 1.00
R9016:Tnik UTSW 3 28,638,395 (GRCm38) missense probably damaging 1.00
R9154:Tnik UTSW 3 28,650,086 (GRCm38) missense probably damaging 0.99
R9284:Tnik UTSW 3 28,539,421 (GRCm38) missense unknown
R9290:Tnik UTSW 3 28,620,975 (GRCm38) missense probably benign 0.00
R9411:Tnik UTSW 3 28,630,605 (GRCm38) missense probably damaging 1.00
R9484:Tnik UTSW 3 28,594,944 (GRCm38) missense unknown
X0022:Tnik UTSW 3 28,667,951 (GRCm38) missense probably damaging 1.00
Z1176:Tnik UTSW 3 28,607,328 (GRCm38) missense probably damaging 0.96
Z1176:Tnik UTSW 3 28,604,324 (GRCm38) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GTGAGGTATTGATCTAGGTACCATC -3'
(R):5'- GTTCAGAGAGTCTGGCAAAGC -3'

Sequencing Primer
(F):5'- GGTACCATCTTAGACTCCCTGGAAG -3'
(R):5'- GGCAAAGCCTGATTGTTTAAGTC -3'
Posted On 2014-11-12