Incidental Mutation 'R2426:Tnik'
| ID |
250196 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Tnik
|
| Ensembl Gene |
ENSMUSG00000027692 |
| Gene Name |
TRAF2 and NCK interacting kinase |
| Synonyms |
C630040K21Rik, 1500031A17Rik, 4831440I19Rik, C530008O15Rik |
| MMRRC Submission |
040388-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R2426 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
3 |
| Chromosomal Location |
28263214-28675858 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 28646681 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Glycine
at position 907
(S907G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000124011
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000159236]
[ENSMUST00000159308]
[ENSMUST00000159680]
[ENSMUST00000160307]
[ENSMUST00000160518]
[ENSMUST00000160934]
[ENSMUST00000161964]
[ENSMUST00000162485]
[ENSMUST00000162777]
|
| AlphaFold |
P83510 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000159236
AA Change: S899G
PolyPhen 2
Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000124681
Gene: ENSMUSG00000027692
AA Change: S899G
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
482 |
N/A |
INTRINSIC |
|
low complexity region
|
691 |
726 |
N/A |
INTRINSIC |
|
low complexity region
|
793 |
812 |
N/A |
INTRINSIC |
|
low complexity region
|
951 |
958 |
N/A |
INTRINSIC |
|
CNH
|
1005 |
1303 |
1.92e-117 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000159308
AA Change: S852G
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000125466
Gene: ENSMUSG00000027692
AA Change: S852G
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
482 |
N/A |
INTRINSIC |
|
low complexity region
|
636 |
671 |
N/A |
INTRINSIC |
|
low complexity region
|
746 |
765 |
N/A |
INTRINSIC |
|
low complexity region
|
904 |
911 |
N/A |
INTRINSIC |
|
CNH
|
958 |
1256 |
1.92e-117 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000159680
AA Change: S928G
PolyPhen 2
Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000124876
Gene: ENSMUSG00000027692
AA Change: S928G
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
511 |
N/A |
INTRINSIC |
|
low complexity region
|
720 |
755 |
N/A |
INTRINSIC |
|
low complexity region
|
822 |
841 |
N/A |
INTRINSIC |
|
low complexity region
|
980 |
987 |
N/A |
INTRINSIC |
|
CNH
|
1034 |
1332 |
1.92e-117 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000159733
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000160307
AA Change: S936G
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000125081
Gene: ENSMUSG00000027692
AA Change: S936G
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
511 |
N/A |
INTRINSIC |
|
low complexity region
|
720 |
755 |
N/A |
INTRINSIC |
|
low complexity region
|
830 |
849 |
N/A |
INTRINSIC |
|
low complexity region
|
988 |
995 |
N/A |
INTRINSIC |
|
CNH
|
1042 |
1340 |
1.92e-117 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000160518
AA Change: S907G
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000124011
Gene: ENSMUSG00000027692
AA Change: S907G
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
5.9e-99 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
482 |
N/A |
INTRINSIC |
|
low complexity region
|
691 |
726 |
N/A |
INTRINSIC |
|
low complexity region
|
801 |
820 |
N/A |
INTRINSIC |
|
low complexity region
|
959 |
966 |
N/A |
INTRINSIC |
|
CNH
|
1013 |
1311 |
9.3e-120 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000160934
|
| SMART Domains |
Protein: ENSMUSP00000123859
Gene: ENSMUSG00000027692
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Pkinase_Tyr
|
25 |
212 |
2.2e-37 |
PFAM |
|
Pfam:Pkinase
|
25 |
219 |
5.9e-52 |
PFAM |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000161964
AA Change: S844G
|
| SMART Domains |
Protein: ENSMUSP00000125411
Gene: ENSMUSG00000027692
AA Change: S844G
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
482 |
N/A |
INTRINSIC |
|
low complexity region
|
636 |
671 |
N/A |
INTRINSIC |
|
low complexity region
|
738 |
757 |
N/A |
INTRINSIC |
|
low complexity region
|
896 |
903 |
N/A |
INTRINSIC |
|
CNH
|
950 |
1248 |
1.92e-117 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000162037
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000162485
AA Change: S881G
PolyPhen 2
Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000124387
Gene: ENSMUSG00000027692
AA Change: S881G
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
511 |
N/A |
INTRINSIC |
|
low complexity region
|
665 |
700 |
N/A |
INTRINSIC |
|
low complexity region
|
775 |
794 |
N/A |
INTRINSIC |
|
low complexity region
|
933 |
940 |
N/A |
INTRINSIC |
|
CNH
|
987 |
1285 |
1.92e-117 |
SMART |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000162777
AA Change: S873G
|
| SMART Domains |
Protein: ENSMUSP00000124726
Gene: ENSMUSG00000027692
AA Change: S873G
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
511 |
N/A |
INTRINSIC |
|
low complexity region
|
665 |
700 |
N/A |
INTRINSIC |
|
low complexity region
|
767 |
786 |
N/A |
INTRINSIC |
|
low complexity region
|
925 |
932 |
N/A |
INTRINSIC |
|
CNH
|
979 |
1277 |
1.92e-117 |
SMART |
|
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.5%
- 10x: 96.9%
- 20x: 93.8%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Germinal center kinases (GCKs), such as TNIK, are characterized by an N-terminal kinase domain and a C-terminal GCK domain that serves a regulatory function (Fu et al., 1999 [PubMed 10521462]).[supplied by OMIM, Mar 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired postsynaptic signaling and cognitive function. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 67 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 0610010F05Rik |
T |
A |
11: 23,576,801 (GRCm38) |
R190W |
probably damaging |
Het |
| Abca14 |
G |
T |
7: 120,283,223 (GRCm38) |
V1203L |
probably benign |
Het |
| Adamtsl1 |
G |
A |
4: 86,156,788 (GRCm38) |
V131I |
probably benign |
Het |
| Adgra3 |
A |
T |
5: 50,009,449 (GRCm38) |
M187K |
possibly damaging |
Het |
| Agbl1 |
T |
C |
7: 76,421,902 (GRCm38) |
V324A |
probably damaging |
Het |
| Ahnak |
A |
T |
19: 9,002,851 (GRCm38) |
I500F |
possibly damaging |
Het |
| Aldh1l1 |
A |
G |
6: 90,598,284 (GRCm38) |
D851G |
probably damaging |
Het |
| Amot |
T |
C |
X: 145,476,291 (GRCm38) |
K460E |
probably damaging |
Het |
| Arhgef3 |
G |
T |
14: 27,384,181 (GRCm38) |
E161* |
probably null |
Het |
| Atg9b |
A |
T |
5: 24,386,994 (GRCm38) |
I669N |
probably damaging |
Het |
| AY761184 |
T |
G |
8: 21,702,637 (GRCm38) |
K114N |
possibly damaging |
Het |
| Ccdc83 |
A |
G |
7: 90,228,431 (GRCm38) |
Y268H |
probably damaging |
Het |
| Cep170 |
A |
G |
1: 176,774,635 (GRCm38) |
S302P |
probably benign |
Het |
| Cyp4a31 |
T |
A |
4: 115,571,016 (GRCm38) |
M303K |
probably damaging |
Het |
| Cyp4v3 |
T |
A |
8: 45,317,776 (GRCm38) |
Y231F |
probably benign |
Het |
| Dock3 |
A |
T |
9: 106,914,541 (GRCm38) |
L1411Q |
possibly damaging |
Het |
| Dsg1a |
T |
A |
18: 20,336,804 (GRCm38) |
I629N |
probably damaging |
Het |
| Dst |
A |
T |
1: 34,192,812 (GRCm38) |
H2837L |
probably benign |
Het |
| Fam114a2 |
G |
A |
11: 57,493,080 (GRCm38) |
P343L |
probably benign |
Het |
| Fbrs |
A |
G |
7: 127,487,339 (GRCm38) |
|
probably null |
Het |
| Fbxl13 |
A |
C |
5: 21,522,137 (GRCm38) |
D620E |
probably damaging |
Het |
| Frmd4a |
T |
A |
2: 4,529,862 (GRCm38) |
S164T |
probably damaging |
Het |
| Gdi2 |
T |
G |
13: 3,562,034 (GRCm38) |
S330A |
probably benign |
Het |
| Gm5878 |
A |
T |
6: 85,118,631 (GRCm38) |
M70K |
probably benign |
Het |
| H2-Q6 |
G |
T |
17: 35,424,937 (GRCm38) |
A21S |
probably benign |
Het |
| Hfm1 |
A |
T |
5: 106,847,653 (GRCm38) |
|
probably null |
Het |
| Hnmt |
C |
T |
2: 24,019,155 (GRCm38) |
C82Y |
probably benign |
Het |
| Il1rl1 |
C |
A |
1: 40,446,619 (GRCm38) |
A310D |
probably damaging |
Het |
| Ints1 |
A |
T |
5: 139,771,814 (GRCm38) |
|
probably null |
Het |
| Kcne4 |
C |
A |
1: 78,817,971 (GRCm38) |
A112E |
possibly damaging |
Het |
| Krt32 |
T |
C |
11: 100,086,366 (GRCm38) |
K236R |
possibly damaging |
Het |
| Maml2 |
T |
C |
9: 13,706,498 (GRCm38) |
L380P |
probably damaging |
Het |
| Meis1 |
A |
T |
11: 18,988,356 (GRCm38) |
D218E |
possibly damaging |
Het |
| Mon1b |
G |
A |
8: 113,639,120 (GRCm38) |
G360D |
probably damaging |
Het |
| Mpp4 |
A |
G |
1: 59,130,057 (GRCm38) |
S383P |
probably damaging |
Het |
| Neb |
A |
G |
2: 52,169,053 (GRCm38) |
|
probably null |
Het |
| Nlgn2 |
A |
T |
11: 69,827,086 (GRCm38) |
I431N |
probably damaging |
Het |
| Nr2e1 |
A |
G |
10: 42,563,485 (GRCm38) |
L134P |
probably damaging |
Het |
| Olfr329-ps |
A |
T |
11: 58,543,094 (GRCm38) |
Y127* |
probably null |
Het |
| Olfr371 |
T |
C |
8: 85,231,064 (GRCm38) |
S190P |
probably damaging |
Het |
| Olfr777 |
T |
C |
10: 129,269,266 (GRCm38) |
Q19R |
probably benign |
Het |
| Opcml |
G |
A |
9: 28,903,367 (GRCm38) |
|
probably null |
Het |
| Pate2 |
A |
T |
9: 35,670,480 (GRCm38) |
|
probably null |
Het |
| Pgr |
G |
A |
9: 8,900,717 (GRCm38) |
V84M |
probably damaging |
Het |
| Pigu |
A |
T |
2: 155,299,082 (GRCm38) |
V296D |
probably damaging |
Het |
| Plcb2 |
G |
A |
2: 118,715,649 (GRCm38) |
T555M |
probably damaging |
Het |
| Pld5 |
T |
G |
1: 175,963,976 (GRCm38) |
D426A |
probably benign |
Het |
| Prdm2 |
G |
T |
4: 143,111,750 (GRCm38) |
C1679* |
probably null |
Het |
| Psme2b |
A |
T |
11: 48,946,063 (GRCm38) |
V19D |
probably benign |
Het |
| Ptpn9 |
A |
T |
9: 57,027,428 (GRCm38) |
N159Y |
possibly damaging |
Het |
| Sdc3 |
A |
T |
4: 130,818,803 (GRCm38) |
T64S |
unknown |
Het |
| Serping1 |
T |
G |
2: 84,770,219 (GRCm38) |
S260R |
probably damaging |
Het |
| Slc20a1 |
T |
C |
2: 129,208,230 (GRCm38) |
F436S |
probably benign |
Het |
| Sntb1 |
A |
T |
15: 55,906,179 (GRCm38) |
I138N |
probably damaging |
Het |
| Sorcs3 |
A |
T |
19: 48,722,925 (GRCm38) |
Y643F |
probably damaging |
Het |
| Spink1 |
G |
T |
18: 43,735,222 (GRCm38) |
S23* |
probably null |
Het |
| Stag1 |
T |
C |
9: 100,845,116 (GRCm38) |
|
probably null |
Het |
| Tnfaip8l1 |
G |
A |
17: 56,172,030 (GRCm38) |
V107I |
probably benign |
Het |
| Ttf1 |
T |
A |
2: 29,067,185 (GRCm38) |
M489K |
probably damaging |
Het |
| Ugcg |
C |
T |
4: 59,207,798 (GRCm38) |
P46S |
probably benign |
Het |
| Usp54 |
G |
A |
14: 20,564,940 (GRCm38) |
A811V |
probably benign |
Het |
| Xirp2 |
A |
G |
2: 67,514,471 (GRCm38) |
N2352S |
probably benign |
Het |
| Zan |
T |
C |
5: 137,388,992 (GRCm38) |
Y4933C |
unknown |
Het |
| Zbtb8a |
A |
G |
4: 129,360,219 (GRCm38) |
S161P |
probably benign |
Het |
| Zkscan5 |
A |
T |
5: 145,220,940 (GRCm38) |
I751L |
probably benign |
Het |
| Zscan4d |
A |
G |
7: 11,165,095 (GRCm38) |
F85S |
probably damaging |
Het |
| Zzef1 |
A |
G |
11: 72,915,265 (GRCm38) |
M2647V |
probably benign |
Het |
|
| Other mutations in Tnik |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00516:Tnik
|
APN |
3 |
28,654,218 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL00726:Tnik
|
APN |
3 |
28,532,898 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01022:Tnik
|
APN |
3 |
28,625,228 (GRCm38) |
splice site |
probably null |
|
|
IGL01145:Tnik
|
APN |
3 |
28,604,167 (GRCm38) |
intron |
probably benign |
|
|
IGL01664:Tnik
|
APN |
3 |
28,638,479 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01843:Tnik
|
APN |
3 |
28,570,858 (GRCm38) |
splice site |
probably null |
|
|
IGL02378:Tnik
|
APN |
3 |
28,638,459 (GRCm38) |
nonsense |
probably null |
|
|
IGL02448:Tnik
|
APN |
3 |
28,621,077 (GRCm38) |
missense |
probably null |
0.01 |
|
IGL02756:Tnik
|
APN |
3 |
28,542,030 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03332:Tnik
|
APN |
3 |
28,666,155 (GRCm38) |
missense |
probably damaging |
1.00 |
|
delightful
|
UTSW |
3 |
28,604,185 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Hottie
|
UTSW |
3 |
28,263,643 (GRCm38) |
start codon destroyed |
probably null |
0.93 |
|
Knockout
|
UTSW |
3 |
28,661,778 (GRCm38) |
missense |
possibly damaging |
0.91 |
|
Looker
|
UTSW |
3 |
28,661,704 (GRCm38) |
nonsense |
probably null |
|
|
Lovely
|
UTSW |
3 |
28,611,970 (GRCm38) |
critical splice donor site |
probably null |
|
|
Usher
|
UTSW |
3 |
28,564,097 (GRCm38) |
missense |
possibly damaging |
0.61 |
|
R0135:Tnik
|
UTSW |
3 |
28,607,245 (GRCm38) |
missense |
possibly damaging |
0.67 |
|
R0418:Tnik
|
UTSW |
3 |
28,570,880 (GRCm38) |
nonsense |
probably null |
|
|
R0540:Tnik
|
UTSW |
3 |
28,650,159 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0549:Tnik
|
UTSW |
3 |
28,570,920 (GRCm38) |
missense |
possibly damaging |
0.87 |
|
R0556:Tnik
|
UTSW |
3 |
28,625,218 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R0586:Tnik
|
UTSW |
3 |
28,577,361 (GRCm38) |
splice site |
probably benign |
|
|
R0607:Tnik
|
UTSW |
3 |
28,650,159 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0842:Tnik
|
UTSW |
3 |
28,594,086 (GRCm38) |
missense |
possibly damaging |
0.72 |
|
R1068:Tnik
|
UTSW |
3 |
28,532,975 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1171:Tnik
|
UTSW |
3 |
28,532,940 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1597:Tnik
|
UTSW |
3 |
28,604,269 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1638:Tnik
|
UTSW |
3 |
28,665,740 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1652:Tnik
|
UTSW |
3 |
28,604,293 (GRCm38) |
missense |
probably benign |
0.22 |
|
R1996:Tnik
|
UTSW |
3 |
28,665,680 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2333:Tnik
|
UTSW |
3 |
28,532,996 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2509:Tnik
|
UTSW |
3 |
28,667,915 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3774:Tnik
|
UTSW |
3 |
28,638,419 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R3775:Tnik
|
UTSW |
3 |
28,638,419 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R4007:Tnik
|
UTSW |
3 |
28,604,281 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4119:Tnik
|
UTSW |
3 |
28,666,175 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4209:Tnik
|
UTSW |
3 |
28,359,065 (GRCm38) |
splice site |
probably benign |
|
|
R4441:Tnik
|
UTSW |
3 |
28,564,097 (GRCm38) |
missense |
possibly damaging |
0.61 |
|
R4611:Tnik
|
UTSW |
3 |
28,542,100 (GRCm38) |
critical splice donor site |
probably null |
|
|
R4714:Tnik
|
UTSW |
3 |
28,594,077 (GRCm38) |
missense |
possibly damaging |
0.53 |
|
R4772:Tnik
|
UTSW |
3 |
28,607,210 (GRCm38) |
missense |
probably benign |
0.09 |
|
R4829:Tnik
|
UTSW |
3 |
28,539,541 (GRCm38) |
intron |
probably benign |
|
|
R4839:Tnik
|
UTSW |
3 |
28,596,075 (GRCm38) |
missense |
possibly damaging |
0.86 |
|
R4898:Tnik
|
UTSW |
3 |
28,650,086 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5029:Tnik
|
UTSW |
3 |
28,665,844 (GRCm38) |
splice site |
probably null |
|
|
R5278:Tnik
|
UTSW |
3 |
28,650,060 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5307:Tnik
|
UTSW |
3 |
28,541,972 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5330:Tnik
|
UTSW |
3 |
28,542,018 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5375:Tnik
|
UTSW |
3 |
28,594,092 (GRCm38) |
missense |
probably benign |
0.02 |
|
R5459:Tnik
|
UTSW |
3 |
28,661,741 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5708:Tnik
|
UTSW |
3 |
28,611,971 (GRCm38) |
critical splice donor site |
probably null |
|
|
R5749:Tnik
|
UTSW |
3 |
28,594,092 (GRCm38) |
missense |
probably benign |
0.02 |
|
R5751:Tnik
|
UTSW |
3 |
28,594,092 (GRCm38) |
missense |
probably benign |
0.02 |
|
R5780:Tnik
|
UTSW |
3 |
28,594,092 (GRCm38) |
missense |
probably benign |
0.02 |
|
R5837:Tnik
|
UTSW |
3 |
28,668,053 (GRCm38) |
unclassified |
probably benign |
|
|
R5969:Tnik
|
UTSW |
3 |
28,620,948 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6244:Tnik
|
UTSW |
3 |
28,650,179 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6273:Tnik
|
UTSW |
3 |
28,577,500 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R6457:Tnik
|
UTSW |
3 |
28,539,448 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6464:Tnik
|
UTSW |
3 |
28,611,970 (GRCm38) |
critical splice donor site |
probably null |
|
|
R6473:Tnik
|
UTSW |
3 |
28,263,643 (GRCm38) |
start codon destroyed |
probably null |
0.93 |
|
R6737:Tnik
|
UTSW |
3 |
28,596,086 (GRCm38) |
missense |
possibly damaging |
0.72 |
|
R7049:Tnik
|
UTSW |
3 |
28,661,704 (GRCm38) |
nonsense |
probably null |
|
|
R7237:Tnik
|
UTSW |
3 |
28,638,419 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R7267:Tnik
|
UTSW |
3 |
28,646,627 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R7445:Tnik
|
UTSW |
3 |
28,663,909 (GRCm38) |
splice site |
probably null |
|
|
R7499:Tnik
|
UTSW |
3 |
28,630,594 (GRCm38) |
missense |
possibly damaging |
0.47 |
|
R7629:Tnik
|
UTSW |
3 |
28,661,728 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R7654:Tnik
|
UTSW |
3 |
28,604,185 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7886:Tnik
|
UTSW |
3 |
28,666,139 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8096:Tnik
|
UTSW |
3 |
28,661,778 (GRCm38) |
missense |
possibly damaging |
0.91 |
|
R8210:Tnik
|
UTSW |
3 |
28,604,333 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R8233:Tnik
|
UTSW |
3 |
28,554,937 (GRCm38) |
missense |
unknown |
|
|
R8386:Tnik
|
UTSW |
3 |
28,263,674 (GRCm38) |
missense |
unknown |
|
|
R8399:Tnik
|
UTSW |
3 |
28,494,010 (GRCm38) |
missense |
unknown |
|
|
R8490:Tnik
|
UTSW |
3 |
28,596,172 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R8539:Tnik
|
UTSW |
3 |
28,542,003 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8751:Tnik
|
UTSW |
3 |
28,611,908 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R8804:Tnik
|
UTSW |
3 |
28,594,053 (GRCm38) |
missense |
unknown |
|
|
R8966:Tnik
|
UTSW |
3 |
28,532,895 (GRCm38) |
missense |
unknown |
|
|
R8998:Tnik
|
UTSW |
3 |
28,665,771 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8999:Tnik
|
UTSW |
3 |
28,665,771 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9016:Tnik
|
UTSW |
3 |
28,638,395 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9154:Tnik
|
UTSW |
3 |
28,650,086 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R9284:Tnik
|
UTSW |
3 |
28,539,421 (GRCm38) |
missense |
unknown |
|
|
R9290:Tnik
|
UTSW |
3 |
28,620,975 (GRCm38) |
missense |
probably benign |
0.00 |
|
R9411:Tnik
|
UTSW |
3 |
28,630,605 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9484:Tnik
|
UTSW |
3 |
28,594,944 (GRCm38) |
missense |
unknown |
|
|
X0022:Tnik
|
UTSW |
3 |
28,667,951 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Z1176:Tnik
|
UTSW |
3 |
28,607,328 (GRCm38) |
missense |
probably damaging |
0.96 |
|
Z1176:Tnik
|
UTSW |
3 |
28,604,324 (GRCm38) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GTGAGGTATTGATCTAGGTACCATC -3'
(R):5'- GTTCAGAGAGTCTGGCAAAGC -3'
Sequencing Primer
(F):5'- GGTACCATCTTAGACTCCCTGGAAG -3'
(R):5'- GGCAAAGCCTGATTGTTTAAGTC -3'
|
| Posted On |
2014-11-12 |
Incidental Mutation