|Institutional Source||Beutler Lab|
|Gene Name||protease (prosome, macropain) activator subunit 2B|
|Synonyms||Psme2-like, PA28b2, Psme2b, Psme2b-ps|
|Is this an essential gene?||Probably non essential (E-score: 0.167)|
|Stock #||R2426 (G1)|
|Chromosomal Location||48945354-48946190 bp(-) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||A to T at 48946063 bp (GRCm38)|
|Amino Acid Change||Valine to Aspartic acid at position 19 (V19D)|
|Ref Sequence||ENSEMBL: ENSMUSP00000100564 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000059930] [ENSMUST00000097494] [ENSMUST00000104958]|
AA Change: V19D
PolyPhen 2 Score 0.198 (Sensitivity: 0.92; Specificity: 0.88)
AA Change: V19D
|Coding Region Coverage||
|MGI Phenotype||FUNCTION: This gene may encode proteasome activator complex subunit 2 protein (PMID: 10222192). This gene, located on chromosome 11, lacks a structured promoter and is intronless. It has also been described as a pseudogene (PMID: 9914329), however, it has an intact coding region and transcripts can be placed at this location unambiguously. An interferon-inducible gene located on chromosome 14, near the gene that encodes proteasome activator complex subunit 1 protein, is considered the functional gene. [provided by RefSeq, Jul 2013]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Psme2b||
(F):5'- GCCACACTTAGGGACTTCCTTC -3'
(R):5'- CGGAAGAGCAAGATTCAGATTC -3'
(F):5'- GTTTCCATCTCGTCATCCTTGGG -3'
(R):5'- GAAGAGCAAGATTCAGATTCAAAATC -3'