Incidental Mutation 'R2431:Or2a25'
ID 250398
Institutional Source Beutler Lab
Gene Symbol Or2a25
Ensembl Gene ENSMUSG00000045708
Gene Name olfactory receptor family 2 subfamily A member 25
Synonyms GA_x6K02T2P3E9-4647978-4647046, MOR261-1, Olfr447
MMRRC Submission 040392-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.226) question?
Stock # R2431 (G1)
Quality Score 225
Status Not validated
Chromosome 6
Chromosomal Location 42888459-42889391 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 42888946 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Serine at position 163 (L163S)
Ref Sequence ENSEMBL: ENSMUSP00000149325 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000055763] [ENSMUST00000216408]
AlphaFold Q8VGP6
Predicted Effect probably damaging
Transcript: ENSMUST00000055763
AA Change: L163S

PolyPhen 2 Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000052312
Gene: ENSMUSG00000045708
AA Change: L163S

DomainStartEndE-ValueType
Pfam:7tm_4 30 307 1.8e-60 PFAM
Pfam:7tm_1 40 289 6.3e-27 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000216408
AA Change: L163S

PolyPhen 2 Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.8%
  • 20x: 93.2%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arhgap23 T C 11: 97,343,230 (GRCm39) V504A probably benign Het
Atr T G 9: 95,744,945 (GRCm39) N87K probably benign Het
Auts2 A T 5: 132,287,887 (GRCm39) L32* probably null Het
Bptf A G 11: 106,938,066 (GRCm39) V2675A possibly damaging Het
Brdt C T 5: 107,525,881 (GRCm39) probably null Het
Ccdc162 T C 10: 41,445,841 (GRCm39) K444E probably benign Het
Cnot1 T C 8: 96,501,280 (GRCm39) D96G probably damaging Het
Cpq C A 15: 33,594,265 (GRCm39) Y425* probably null Het
Eri1 A G 8: 35,943,632 (GRCm39) Y221H probably damaging Het
Fbln2 A G 6: 91,246,955 (GRCm39) E1065G probably damaging Het
Focad T C 4: 88,249,264 (GRCm39) V837A unknown Het
Ica1 G A 6: 8,658,265 (GRCm39) T284I probably benign Het
Isg15 C T 4: 156,285,158 (GRCm39) probably null Het
Ltbp4 T C 7: 27,019,101 (GRCm39) T1073A possibly damaging Het
Mmp16 A T 4: 18,054,491 (GRCm39) R332S probably benign Het
Myg1 G C 15: 102,246,171 (GRCm39) G349R probably damaging Het
Or2ag19 T C 7: 106,444,598 (GRCm39) V260A possibly damaging Het
Or5b21 T C 19: 12,839,970 (GRCm39) V277A probably damaging Het
Or7g12 A G 9: 18,899,299 (GRCm39) N5S probably damaging Het
Piezo2 T C 18: 63,378,695 (GRCm39) H78R possibly damaging Het
Pkd1l1 T C 11: 8,897,197 (GRCm39) N121D probably damaging Het
Pkhd1 T C 1: 20,271,389 (GRCm39) T3055A possibly damaging Het
Ppp5c C T 7: 16,749,350 (GRCm39) V160M probably damaging Het
Ptpn23 G A 9: 110,215,347 (GRCm39) R1438* probably null Het
Ptpro G A 6: 137,420,583 (GRCm39) W183* probably null Het
Pygm T C 19: 6,443,815 (GRCm39) M592T probably damaging Het
Qdpr A G 5: 45,602,072 (GRCm39) V68A probably damaging Het
Rfc5 A C 5: 117,523,523 (GRCm39) S92A probably damaging Het
Ripor3 T C 2: 167,831,715 (GRCm39) Q362R probably benign Het
Ror1 G A 4: 100,298,352 (GRCm39) C575Y probably damaging Het
Skint9 T A 4: 112,246,464 (GRCm39) D216V probably damaging Het
Sox6 T C 7: 115,149,242 (GRCm39) probably null Het
Ugp2 A T 11: 21,279,025 (GRCm39) V387D probably damaging Het
Umodl1 T C 17: 31,211,062 (GRCm39) S747P possibly damaging Het
Vtcn1 A T 3: 100,732,893 (GRCm39) I7F possibly damaging Het
Zfp507 C T 7: 35,494,827 (GRCm39) R72H probably benign Het
Other mutations in Or2a25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02302:Or2a25 APN 6 42,889,272 (GRCm39) missense probably damaging 1.00
IGL02604:Or2a25 APN 6 42,888,992 (GRCm39) nonsense probably null
IGL02894:Or2a25 APN 6 42,888,451 (GRCm39) splice site probably benign
R0122:Or2a25 UTSW 6 42,888,889 (GRCm39) missense probably benign 0.00
R0172:Or2a25 UTSW 6 42,888,913 (GRCm39) missense probably benign 0.00
R0371:Or2a25 UTSW 6 42,888,872 (GRCm39) missense probably benign 0.14
R1709:Or2a25 UTSW 6 42,889,078 (GRCm39) missense possibly damaging 0.94
R3809:Or2a25 UTSW 6 42,889,271 (GRCm39) missense probably damaging 1.00
R4032:Or2a25 UTSW 6 42,888,559 (GRCm39) missense probably benign 0.08
R4242:Or2a25 UTSW 6 42,888,480 (GRCm39) missense possibly damaging 0.77
R4369:Or2a25 UTSW 6 42,889,211 (GRCm39) nonsense probably null
R4401:Or2a25 UTSW 6 42,889,260 (GRCm39) nonsense probably null
R4565:Or2a25 UTSW 6 42,888,472 (GRCm39) missense probably benign
R5646:Or2a25 UTSW 6 42,888,457 (GRCm39) splice site probably null
R5968:Or2a25 UTSW 6 42,888,480 (GRCm39) missense probably benign
R6804:Or2a25 UTSW 6 42,888,852 (GRCm39) missense probably benign
R6925:Or2a25 UTSW 6 42,888,791 (GRCm39) nonsense probably null
R8170:Or2a25 UTSW 6 42,889,125 (GRCm39) missense possibly damaging 0.73
R8358:Or2a25 UTSW 6 42,888,976 (GRCm39) missense possibly damaging 0.51
R8765:Or2a25 UTSW 6 42,889,102 (GRCm39) missense probably benign 0.34
R9005:Or2a25 UTSW 6 42,889,170 (GRCm39) missense probably damaging 1.00
R9015:Or2a25 UTSW 6 42,888,825 (GRCm39) missense possibly damaging 0.55
R9308:Or2a25 UTSW 6 42,888,931 (GRCm39) missense probably damaging 1.00
R9520:Or2a25 UTSW 6 42,889,051 (GRCm39) missense probably damaging 0.98
R9743:Or2a25 UTSW 6 42,888,835 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TTGCACACACGGAATGTCTC -3'
(R):5'- AAGTGGAGAAGGCTTTCTGG -3'

Sequencing Primer
(F):5'- ACACGGAATGTCTCCTACTGGTG -3'
(R):5'- CTGTGACTTAATCTTCAGGATGGCAC -3'
Posted On 2014-11-12