Mutagenetix > Incidental Mutation

Incidental Mutation 'R2433:Dhrs11'

250498

Institutional Source

Beutler Lab

Gene Symbol

Dhrs11

Ensembl Gene

ENSMUSG00000034449

Gene Name

dehydrogenase/reductase 11

Synonyms

dehydrogenase/reductase (SDR family) member 11

MMRRC Submission

040394-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R2433 (G1)

Quality Score

206

Status

Not validated

Chromosome

Chromosomal Location

84711682-84719820 bp(-) (GRCm39)

Type of Mutation

unclassified

DNA Base Change (assembly)

C to A at 84719745 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000127584 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000018547] [ENSMUST00000047560] [ENSMUST00000100686] [ENSMUST00000108081] [ENSMUST00000151496] [ENSMUST00000154915] [ENSMUST00000172405] [ENSMUST00000168434]

AlphaFold

Q3U0B3

Predicted Effect

probably benign
Transcript: ENSMUST00000018547

SMART Domains

Protein: ENSMUSP00000018547
Gene: ENSMUSG00000020530

Domain	Start	End	E-Value	Type
low complexity region	179	185	N/A	INTRINSIC
coiled coil region	393	426	N/A	INTRINSIC
low complexity region	570	584	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000047560

SMART Domains

Protein: ENSMUSP00000043467
Gene: ENSMUSG00000034449

Domain	Start	End	E-Value	Type
Pfam:adh_short	12	214	1.4e-46	PFAM
Pfam:KR	13	154	1.7e-11	PFAM
Pfam:Epimerase	14	251	4.8e-7	PFAM
Pfam:adh_short_C2	18	245	1.8e-16	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000100686

SMART Domains

Protein: ENSMUSP00000098252
Gene: ENSMUSG00000020530

Domain	Start	End	E-Value	Type
coiled coil region	351	388	N/A	INTRINSIC
low complexity region	508	522	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000108081

SMART Domains

Protein: ENSMUSP00000103716
Gene: ENSMUSG00000020530

Domain	Start	End	E-Value	Type
coiled coil region	353	386	N/A	INTRINSIC
low complexity region	530	544	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000126016

Predicted Effect

probably benign
Transcript: ENSMUST00000151496

SMART Domains

Protein: ENSMUSP00000122267
Gene: ENSMUSG00000034449

Domain	Start	End	E-Value	Type
Pfam:adh_short	12	49	6.3e-8	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000154915

SMART Domains

Protein: ENSMUSP00000117482
Gene: ENSMUSG00000020530

Domain	Start	End	E-Value	Type
coiled coil region	351	384	N/A	INTRINSIC
low complexity region	528	542	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000172405

SMART Domains

Protein: ENSMUSP00000127584
Gene: ENSMUSG00000020530

Domain	Start	End	E-Value	Type
coiled coil region	353	386	N/A	INTRINSIC
low complexity region	530	544	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000168434

SMART Domains

Protein: ENSMUSP00000130013
Gene: ENSMUSG00000020530

Domain	Start	End	E-Value	Type
coiled coil region	351	384	N/A	INTRINSIC
low complexity region	528	542	N/A	INTRINSIC

Coding Region Coverage

1x: 99.1%
3x: 98.5%
10x: 97.1%
20x: 94.3%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 26 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Atp6v0a4	A	G	6: 38,058,964 (GRCm39)		probably null	Het
Bpifb4	A	G	2: 153,801,597 (GRCm39)	K573E	probably damaging	Het
Capn10	T	A	1: 92,870,247 (GRCm39)	D244E	probably benign	Het
Eipr1	G	A	12: 28,913,042 (GRCm39)	G248R	probably damaging	Het
Fam120a	A	C	13: 49,087,444 (GRCm39)	D305E	probably damaging	Het
Hmgcr	A	G	13: 96,802,393 (GRCm39)	L97P	probably damaging	Het
Htt	A	T	5: 35,064,885 (GRCm39)	S3033C	possibly damaging	Het
Igkv10-94	T	C	6: 68,681,559 (GRCm39)	T94A	probably benign	Het
Krtap16-3	T	C	16: 88,759,533 (GRCm39)	Y60C	unknown	Het
Lrp4	G	A	2: 91,336,360 (GRCm39)	V1724I	probably benign	Het
Myo5b	A	G	18: 74,892,158 (GRCm39)	Y1634C	probably damaging	Het
Nrxn3	A	G	12: 89,943,160 (GRCm39)	Y96C	probably damaging	Het
Obscn	A	T	11: 58,929,912 (GRCm39)		probably null	Het
Pde3b	T	C	7: 114,126,072 (GRCm39)	C769R	probably benign	Het
Phlpp2	T	G	8: 110,666,634 (GRCm39)	C1054W	probably damaging	Het
Pttg1	A	T	11: 43,311,178 (GRCm39)	V193D	probably damaging	Het
Robo1	T	C	16: 72,767,127 (GRCm39)	L433S	probably benign	Het
Sema4f	A	T	6: 82,916,490 (GRCm39)	C13S	possibly damaging	Het
Slc12a3	T	C	8: 95,072,944 (GRCm39)	L689P	probably benign	Het
Slc7a6os	T	C	8: 106,931,003 (GRCm39)	N211S	possibly damaging	Het
Smurf2	T	A	11: 106,759,490 (GRCm39)	I69F	probably benign	Het
St8sia3	A	T	18: 64,402,787 (GRCm39)	H198L	probably benign	Het
Tacc3	A	G	5: 33,829,083 (GRCm39)	K594R	possibly damaging	Het
Trip12	A	T	1: 84,721,544 (GRCm39)	I1396K	possibly damaging	Het
Ugcg	A	G	4: 59,207,876 (GRCm39)	T72A	possibly damaging	Het
Zfp944	A	T	17: 22,558,193 (GRCm39)	Y351*	probably null	Het

Other mutations in Dhrs11

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02217:Dhrs11	APN	11	84,713,221 (GRCm39)	nonsense	probably null
R0023:Dhrs11	UTSW	11	84,713,976 (GRCm39)	missense	probably damaging	1.00
R1583:Dhrs11	UTSW	11	84,713,943 (GRCm39)	missense	probably damaging	1.00
R1985:Dhrs11	UTSW	11	84,719,633 (GRCm39)	missense	probably damaging	1.00
R3911:Dhrs11	UTSW	11	84,712,579 (GRCm39)	missense	probably damaging	1.00
R4510:Dhrs11	UTSW	11	84,716,342 (GRCm39)	makesense	probably null
R4511:Dhrs11	UTSW	11	84,716,342 (GRCm39)	makesense	probably null
R4798:Dhrs11	UTSW	11	84,719,626 (GRCm39)	missense	probably benign	0.03
R5936:Dhrs11	UTSW	11	84,716,350 (GRCm39)	nonsense	probably null
R6162:Dhrs11	UTSW	11	84,719,605 (GRCm39)	missense	probably damaging	1.00
R9591:Dhrs11	UTSW	11	84,719,584 (GRCm39)	missense	probably benign	0.01

Predicted Primers

PCR Primer
(F):5'- AGCCTTACCTCGATGTTGC -3'
(R):5'- GGTAAAAGCAACTCCACCGG -3'

Sequencing Primer
(F):5'- TACCTCGATGTTGCCAACGG -3'
(R):5'- TATCCTCAAGGCTGTGCGG -3'

Posted On

2014-11-12