Incidental Mutation 'R2434:Vmn1r205'
ID 250536
Institutional Source Beutler Lab
Gene Symbol Vmn1r205
Ensembl Gene ENSMUSG00000100296
Gene Name vomeronasal 1 receptor 205
Synonyms V1rh8
MMRRC Submission 040395-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.140) question?
Stock # R2434 (G1)
Quality Score 225
Status Not validated
Chromosome 13
Chromosomal Location 22776150-22777100 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 22776524 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Leucine at position 193 (M193L)
Ref Sequence ENSEMBL: ENSMUSP00000139977 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074324] [ENSMUST00000185475]
AlphaFold Q8R276
Predicted Effect probably benign
Transcript: ENSMUST00000074324
AA Change: M193L

PolyPhen 2 Score 0.370 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000073934
Gene: ENSMUSG00000101073
AA Change: M193L

DomainStartEndE-ValueType
Pfam:V1R 24 307 5.5e-36 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000185475
AA Change: M193L

PolyPhen 2 Score 0.370 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000139977
Gene: ENSMUSG00000100296
AA Change: M193L

DomainStartEndE-ValueType
Pfam:V1R 24 307 5.5e-36 PFAM
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.0%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Agbl5 A G 5: 31,051,357 (GRCm39) Q493R probably damaging Het
Ank3 T C 10: 69,837,948 (GRCm39) V785A probably damaging Het
Capsl A T 15: 9,462,795 (GRCm39) H145L probably damaging Het
Carns1 A C 19: 4,215,448 (GRCm39) C911W probably damaging Het
Celsr2 A C 3: 108,311,795 (GRCm39) F1351V probably damaging Het
Cpne8 T C 15: 90,393,714 (GRCm39) I432V probably benign Het
Cpxm1 A T 2: 130,236,004 (GRCm39) I386N probably damaging Het
E2f5 T A 3: 14,644,074 (GRCm39) D65E probably damaging Het
Eif3a T C 19: 60,752,488 (GRCm39) probably benign Het
Fcrl2 A G 3: 87,164,005 (GRCm39) Y375H probably damaging Het
Fip1l1 C A 5: 74,707,485 (GRCm39) T196K possibly damaging Het
Fmo6 A T 1: 162,744,439 (GRCm39) N484K probably benign Het
Foxred1 G T 9: 35,116,954 (GRCm39) D345E probably damaging Het
Gbe1 T A 16: 70,238,100 (GRCm39) N295K probably damaging Het
Gipc2 T A 3: 151,843,317 (GRCm39) I107L probably benign Het
Kcnn1 GTCCTCCTCCTCCTCCTCCTC GTCCTCCTCCTCCTCCTC 8: 71,307,810 (GRCm39) probably benign Het
Lgr5 T A 10: 115,423,311 (GRCm39) I30L probably benign Het
Nbea A T 3: 55,554,881 (GRCm39) V2589E possibly damaging Het
Ncam2 A T 16: 81,392,113 (GRCm39) N699I probably benign Het
Nlrp1b T C 11: 71,047,552 (GRCm39) probably null Het
Or11l3 A G 11: 58,515,937 (GRCm39) Y312H possibly damaging Het
Rnasel T C 1: 153,630,396 (GRCm39) V304A probably damaging Het
Serinc4 C T 2: 121,286,186 (GRCm39) R134H probably benign Het
Sim1 T A 10: 50,784,054 (GRCm39) Y103N probably damaging Het
Slc47a1 A T 11: 61,258,548 (GRCm39) probably null Het
Slc6a6 T A 6: 91,712,193 (GRCm39) S241T probably benign Het
Son G T 16: 91,451,575 (GRCm39) K107N probably damaging Het
St3gal6 T C 16: 58,291,015 (GRCm39) T329A probably damaging Het
Stab2 G A 10: 86,805,183 (GRCm39) P265L possibly damaging Het
Tmem199 G A 11: 78,400,570 (GRCm39) T119I probably damaging Het
Ttc14 A G 3: 33,855,227 (GRCm39) D125G probably benign Het
Vmn2r-ps158 A G 7: 42,696,881 (GRCm39) Y646C probably damaging Het
Other mutations in Vmn1r205
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01329:Vmn1r205 APN 13 22,776,273 (GRCm39) missense probably benign 0.06
IGL02148:Vmn1r205 APN 13 22,776,395 (GRCm39) missense probably damaging 1.00
IGL02608:Vmn1r205 APN 13 22,776,370 (GRCm39) missense probably damaging 1.00
IGL03140:Vmn1r205 APN 13 22,776,746 (GRCm39) missense possibly damaging 0.78
R0831:Vmn1r205 UTSW 13 22,776,586 (GRCm39) missense probably benign 0.12
R1418:Vmn1r205 UTSW 13 22,777,049 (GRCm39) missense probably benign 0.00
R1873:Vmn1r205 UTSW 13 22,776,223 (GRCm39) missense possibly damaging 0.95
R2358:Vmn1r205 UTSW 13 22,776,566 (GRCm39) missense probably benign 0.11
R3105:Vmn1r205 UTSW 13 22,777,109 (GRCm39) unclassified probably benign
R3725:Vmn1r205 UTSW 13 22,776,671 (GRCm39) missense probably damaging 1.00
R4758:Vmn1r205 UTSW 13 22,777,016 (GRCm39) missense possibly damaging 0.49
R4851:Vmn1r205 UTSW 13 22,777,074 (GRCm39) missense probably benign 0.15
R5642:Vmn1r205 UTSW 13 22,776,206 (GRCm39) missense probably benign 0.16
R6447:Vmn1r205 UTSW 13 22,776,912 (GRCm39) missense probably damaging 1.00
R7453:Vmn1r205 UTSW 13 22,776,931 (GRCm39) missense probably damaging 0.99
R8177:Vmn1r205 UTSW 13 22,776,415 (GRCm39) missense probably benign 0.03
R8813:Vmn1r205 UTSW 13 22,776,424 (GRCm39) missense probably benign 0.36
Predicted Primers PCR Primer
(F):5'- TAGAAAAGGCACAATCTGTCCAG -3'
(R):5'- AAGCCAAAGTCTGCATGGC -3'

Sequencing Primer
(F):5'- GGCACAATCTGTCCAGTAGAAG -3'
(R):5'- GGCACATTCTTCCATTCTTCTCATTC -3'
Posted On 2014-11-12