Incidental Mutation 'R2483:Cdh26'
ID 250633
Institutional Source Beutler Lab
Gene Symbol Cdh26
Ensembl Gene ENSMUSG00000039155
Gene Name cadherin-like 26
Synonyms LOC381409
MMRRC Submission 040407-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R2483 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 178072324-178129159 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 178108382 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Cysteine at position 327 (S327C)
Ref Sequence ENSEMBL: ENSMUSP00000104540 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000042092] [ENSMUST00000108912]
AlphaFold P59862
Predicted Effect probably damaging
Transcript: ENSMUST00000042092
AA Change: S327C

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000048829
Gene: ENSMUSG00000039155
AA Change: S327C

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
CA 36 138 5.06e-2 SMART
CA 162 248 1.23e-19 SMART
CA 271 370 1.01e-6 SMART
CA 393 476 2.86e-20 SMART
transmembrane domain 592 614 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000108912
AA Change: S327C

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000104540
Gene: ENSMUSG00000039155
AA Change: S327C

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
CA 36 138 5.06e-2 SMART
CA 162 248 1.23e-19 SMART
CA 271 370 1.01e-6 SMART
CA 393 476 2.86e-20 SMART
transmembrane domain 592 614 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000176869
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.5%
  • 20x: 95.6%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the cadherin protein family. Cadherins are a family of calcium-dependent adhesion molecules that mediate cell-cell adhesion in all solid tissues and modulate a wide variety of processes, including cell polarization, migration and differentiation. Cadherin domains occur as repeats in the extracellular region and are thought to contribute to the sorting of heterogeneous cell types and the maintenance of orderly structures such as epithelium. This protein is expressed in gastrointestinal epithelial cells and may be upregulated during allergic inflammation. This protein interacts with alpha integrins and may also be involved in leukocyte migration and adhesion. [provided by RefSeq, Jan 2017]
Allele List at MGI
Other mutations in this stock
Total: 81 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adcy1 A G 11: 7,080,348 (GRCm39) T364A probably benign Het
Adpgk G A 9: 59,221,036 (GRCm39) V281I probably benign Het
Akap9 C A 5: 4,026,235 (GRCm39) Q1297K possibly damaging Het
Ankrd13d T C 19: 4,331,968 (GRCm39) E110G probably damaging Het
Ankrd53 A G 6: 83,740,244 (GRCm39) E104G possibly damaging Het
Ano6 A T 15: 95,863,855 (GRCm39) T792S probably benign Het
Atm A T 9: 53,421,566 (GRCm39) V715D probably damaging Het
Avl9 A G 6: 56,713,828 (GRCm39) D362G probably benign Het
Bin1 T A 18: 32,547,280 (GRCm39) S152R probably damaging Het
Bscl2 T A 19: 8,818,514 (GRCm39) C40S probably benign Het
Btaf1 A G 19: 36,958,486 (GRCm39) T668A probably benign Het
Btrc A G 19: 45,504,497 (GRCm39) D397G probably damaging Het
Cables2 A T 2: 179,902,222 (GRCm39) V379E probably damaging Het
Cacna2d2 T C 9: 107,389,221 (GRCm39) L228P probably damaging Het
Cd109 A T 9: 78,574,639 (GRCm39) D541V probably damaging Het
Cep78 T C 19: 15,938,344 (GRCm39) K535E probably damaging Het
Ces1a A G 8: 93,753,969 (GRCm39) Y345H probably damaging Het
Col6a5 C A 9: 105,741,347 (GRCm39) R2524I probably damaging Het
Cracd A T 5: 77,004,256 (GRCm39) I206F probably damaging Het
Dctn1 G A 6: 83,171,169 (GRCm39) R661H probably damaging Het
Ddias T C 7: 92,508,800 (GRCm39) T372A probably benign Het
Dffb T C 4: 154,049,976 (GRCm39) T296A probably damaging Het
Dock8 A G 19: 25,057,241 (GRCm39) Q216R probably benign Het
Emx1 T C 6: 85,165,237 (GRCm39) S105P probably benign Het
Ep400 T C 5: 110,867,102 (GRCm39) Y1014C unknown Het
Fam193a A T 5: 34,623,102 (GRCm39) K1230M possibly damaging Het
Fgf9 A G 14: 58,347,028 (GRCm39) Q207R probably benign Het
Gm5460 G A 14: 33,767,775 (GRCm39) C461Y possibly damaging Het
Gpc1 T C 1: 92,783,660 (GRCm39) I249T probably benign Het
Htr1d T C 4: 136,170,815 (GRCm39) I348T probably damaging Het
Hyal4 A T 6: 24,765,737 (GRCm39) S364C probably damaging Het
Igfn1 T C 1: 135,897,275 (GRCm39) E1097G probably benign Het
Igkv1-133 A T 6: 67,701,944 (GRCm39) Q16L probably benign Het
Kcnh5 A T 12: 75,161,245 (GRCm39) I221N probably damaging Het
Kmt2a A G 9: 44,760,263 (GRCm39) Y529H probably damaging Het
Kyat1 T C 2: 30,076,710 (GRCm39) H218R possibly damaging Het
Lamb2 T G 9: 108,357,758 (GRCm39) C94G probably damaging Het
Met A T 6: 17,549,085 (GRCm39) D979V probably damaging Het
Midn A G 10: 79,986,144 (GRCm39) D78G probably benign Het
Myh1 A T 11: 67,102,052 (GRCm39) M811L probably benign Het
Myh7 T C 14: 55,210,838 (GRCm39) E1693G probably damaging Het
Myo15b A G 11: 115,755,565 (GRCm39) T979A probably benign Het
Myo18b A T 5: 113,006,274 (GRCm39) C879S probably damaging Het
Myom1 A G 17: 71,384,807 (GRCm39) T733A probably damaging Het
Ndufa9 A T 6: 126,821,362 (GRCm39) M76K possibly damaging Het
Nectin3 A G 16: 46,215,542 (GRCm39) C74R possibly damaging Het
Obscn A G 11: 58,970,972 (GRCm39) F2514L probably damaging Het
Or4a69 G A 2: 89,313,471 (GRCm39) Q3* probably null Het
Or52d3 T C 7: 104,229,149 (GRCm39) S99P probably damaging Het
Or5p81 CAAATA CA 7: 108,266,869 (GRCm39) probably null Het
P2ry2 A T 7: 100,647,706 (GRCm39) S200T probably benign Het
Pcdha5 G T 18: 37,094,542 (GRCm39) M350I probably benign Het
Pcdha5 G A 18: 37,094,834 (GRCm39) V448M probably damaging Het
Pex12 C T 11: 83,188,455 (GRCm39) R180H possibly damaging Het
Pip4p1 C G 14: 51,167,749 (GRCm39) V59L probably damaging Het
Pkd1l1 A T 11: 8,912,701 (GRCm39) V168E probably damaging Het
Prokr2 T A 2: 132,223,095 (GRCm39) D149V probably damaging Het
Rnf123 A G 9: 107,940,720 (GRCm39) V707A probably benign Het
Ryr2 T C 13: 11,774,589 (GRCm39) E1189G probably damaging Het
Scarf1 T C 11: 75,406,117 (GRCm39) F134L probably damaging Het
Sfxn5 A G 6: 85,309,260 (GRCm39) probably null Het
Shfl A T 9: 20,784,473 (GRCm39) I186F possibly damaging Het
Skic3 A G 13: 76,330,986 (GRCm39) E1472G probably damaging Het
Slc17a5 A T 9: 78,445,556 (GRCm39) V433D probably damaging Het
Snapc1 A G 12: 74,011,417 (GRCm39) T28A probably benign Het
Soat1 T C 1: 156,258,669 (GRCm39) Y528C probably damaging Het
Spem1 G A 11: 69,712,344 (GRCm39) R107C possibly damaging Het
Srcap T C 7: 127,141,319 (GRCm39) S1639P probably damaging Het
Sycp2 A T 2: 178,016,388 (GRCm39) N691K probably damaging Het
Syne2 A T 12: 76,142,311 (GRCm39) I6183F probably damaging Het
Tas2r110 A T 6: 132,845,433 (GRCm39) M155L probably benign Het
Tenm3 G A 8: 48,693,305 (GRCm39) T1859I probably damaging Het
Thsd7b T A 1: 130,030,809 (GRCm39) V1048D probably damaging Het
Vav3 T C 3: 109,248,482 (GRCm39) L43P probably damaging Het
Vmn1r30 A T 6: 58,412,437 (GRCm39) F132I probably benign Het
Vmn2r24 A G 6: 123,792,997 (GRCm39) R775G probably damaging Het
Vps13c T A 9: 67,883,189 (GRCm39) probably null Het
Vps37c T A 19: 10,683,569 (GRCm39) probably null Het
Wwp2 A G 8: 108,275,167 (GRCm39) D388G probably damaging Het
Xirp2 A T 2: 67,355,336 (GRCm39) T3366S probably benign Het
Zbtb49 A C 5: 38,360,701 (GRCm39) probably benign Het
Other mutations in Cdh26
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00846:Cdh26 APN 2 178,123,417 (GRCm39) missense possibly damaging 0.86
IGL01341:Cdh26 APN 2 178,099,240 (GRCm39) missense probably damaging 0.99
IGL02636:Cdh26 APN 2 178,091,755 (GRCm39) missense probably damaging 1.00
IGL03144:Cdh26 APN 2 178,109,967 (GRCm39) missense probably damaging 0.99
R0244:Cdh26 UTSW 2 178,123,425 (GRCm39) missense possibly damaging 0.88
R0245:Cdh26 UTSW 2 178,123,425 (GRCm39) missense possibly damaging 0.88
R0466:Cdh26 UTSW 2 178,123,425 (GRCm39) missense possibly damaging 0.88
R0467:Cdh26 UTSW 2 178,123,425 (GRCm39) missense possibly damaging 0.88
R0514:Cdh26 UTSW 2 178,108,621 (GRCm39) critical splice donor site probably null
R0610:Cdh26 UTSW 2 178,091,691 (GRCm39) missense probably damaging 1.00
R0733:Cdh26 UTSW 2 178,128,724 (GRCm39) missense probably damaging 1.00
R1592:Cdh26 UTSW 2 178,091,684 (GRCm39) missense probably damaging 1.00
R3756:Cdh26 UTSW 2 178,111,794 (GRCm39) splice site probably benign
R4617:Cdh26 UTSW 2 178,102,435 (GRCm39) intron probably benign
R4914:Cdh26 UTSW 2 178,091,614 (GRCm39) missense probably benign 0.02
R4915:Cdh26 UTSW 2 178,091,614 (GRCm39) missense probably benign 0.02
R4917:Cdh26 UTSW 2 178,091,614 (GRCm39) missense probably benign 0.02
R4918:Cdh26 UTSW 2 178,091,614 (GRCm39) missense probably benign 0.02
R5086:Cdh26 UTSW 2 178,083,210 (GRCm39) nonsense probably null
R5573:Cdh26 UTSW 2 178,108,482 (GRCm39) missense probably damaging 0.96
R5809:Cdh26 UTSW 2 178,101,919 (GRCm39) nonsense probably null
R5941:Cdh26 UTSW 2 178,123,443 (GRCm39) nonsense probably null
R6284:Cdh26 UTSW 2 178,091,677 (GRCm39) missense probably damaging 1.00
R6341:Cdh26 UTSW 2 178,113,366 (GRCm39) splice site probably null
R6496:Cdh26 UTSW 2 178,091,654 (GRCm39) missense probably damaging 1.00
R7132:Cdh26 UTSW 2 178,128,555 (GRCm39) missense possibly damaging 0.56
R7664:Cdh26 UTSW 2 178,111,835 (GRCm39) missense probably benign 0.02
R7694:Cdh26 UTSW 2 178,101,896 (GRCm39) missense probably damaging 0.96
R7814:Cdh26 UTSW 2 178,111,828 (GRCm39) missense probably damaging 0.98
R8089:Cdh26 UTSW 2 178,099,370 (GRCm39) critical splice donor site probably null
R8103:Cdh26 UTSW 2 178,110,006 (GRCm39) missense probably damaging 1.00
R8412:Cdh26 UTSW 2 178,104,517 (GRCm39) missense probably damaging 0.98
R8413:Cdh26 UTSW 2 178,110,022 (GRCm39) missense probably damaging 0.99
R9025:Cdh26 UTSW 2 178,104,409 (GRCm39) missense probably benign 0.01
R9621:Cdh26 UTSW 2 178,111,983 (GRCm39) missense probably damaging 1.00
R9628:Cdh26 UTSW 2 178,083,213 (GRCm39) missense
RF002:Cdh26 UTSW 2 178,108,424 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AGCCCCATAAGTGATTTGAAAGG -3'
(R):5'- CACCTTATCTGGCTGTCAGC -3'

Sequencing Primer
(F):5'- CCCATAAGTGATTTGAAAGGGATCTG -3'
(R):5'- GTCTGTAGCATTGAAGTATCCCAGC -3'
Posted On 2014-12-04