Mutagenetix > Incidental Mutation

Incidental Mutation 'R0309:Pard3'

25076

Institutional Source

Beutler Lab

Gene Symbol

Pard3

Ensembl Gene

ENSMUSG00000025812

Gene Name

par-3 family cell polarity regulator

Synonyms

Par3, Pard3a, ASIP, D8Ertd580e, PAR-3

MMRRC Submission

038519-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R0309 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

127790643-128338767 bp(+) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

A to T at 128103378 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000124319 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000026921] [ENSMUST00000079777] [ENSMUST00000108752] [ENSMUST00000159537] [ENSMUST00000160272] [ENSMUST00000160581] [ENSMUST00000160717] [ENSMUST00000160766] [ENSMUST00000162602] [ENSMUST00000162309] [ENSMUST00000162531] [ENSMUST00000161355] [ENSMUST00000162176] [ENSMUST00000162456] [ENSMUST00000162536] [ENSMUST00000162907]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000026921

SMART Domains

Protein: ENSMUSP00000026921
Gene: ENSMUSG00000025812

Domain	Start	End	E-Value	Type
Pfam:DUF3534	1	146	1.1e-72	PFAM
low complexity region	234	246	N/A	INTRINSIC
PDZ	282	361	2.34e-6	SMART
low complexity region	431	440	N/A	INTRINSIC
PDZ	469	548	4.1e-20	SMART
PDZ	599	684	9.87e-14	SMART
low complexity region	771	781	N/A	INTRINSIC
PDB:4DC2\|Z	810	837	3e-10	PDB
low complexity region	863	875	N/A	INTRINSIC
low complexity region	892	902	N/A	INTRINSIC
low complexity region	921	950	N/A	INTRINSIC
low complexity region	965	1005	N/A	INTRINSIC
low complexity region	1162	1200	N/A	INTRINSIC
low complexity region	1264	1281	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000079777

SMART Domains

Protein: ENSMUSP00000078710
Gene: ENSMUSG00000025812

Domain	Start	End	E-Value	Type
low complexity region	99	111	N/A	INTRINSIC
PDZ	147	226	2.34e-6	SMART
low complexity region	296	305	N/A	INTRINSIC
PDZ	334	413	4.1e-20	SMART
PDZ	464	549	9.87e-14	SMART
low complexity region	636	646	N/A	INTRINSIC
PDB:4DC2\|Z	675	702	2e-10	PDB
low complexity region	743	755	N/A	INTRINSIC
low complexity region	772	782	N/A	INTRINSIC
low complexity region	801	830	N/A	INTRINSIC
low complexity region	845	885	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000108752

SMART Domains

Protein: ENSMUSP00000104383
Gene: ENSMUSG00000025812

Domain	Start	End	E-Value	Type
low complexity region	99	111	N/A	INTRINSIC
PDZ	147	226	2.34e-6	SMART
low complexity region	296	305	N/A	INTRINSIC
PDZ	334	413	4.1e-20	SMART
PDZ	464	549	9.87e-14	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000159537

SMART Domains

Protein: ENSMUSP00000124934
Gene: ENSMUSG00000025812

Domain	Start	End	E-Value	Type
Pfam:DUF3534	1	146	6.7e-73	PFAM
PDZ	238	317	2.34e-6	SMART
low complexity region	387	396	N/A	INTRINSIC
PDZ	425	504	4.1e-20	SMART
PDZ	542	627	9.87e-14	SMART
low complexity region	717	727	N/A	INTRINSIC
PDB:4DC2\|Z	756	783	2e-10	PDB
low complexity region	823	835	N/A	INTRINSIC
low complexity region	852	862	N/A	INTRINSIC
low complexity region	881	910	N/A	INTRINSIC
low complexity region	925	943	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000160272

SMART Domains

Protein: ENSMUSP00000125453
Gene: ENSMUSG00000025812

Domain	Start	End	E-Value	Type
Pfam:DUF3534	1	146	1.7e-60	PFAM
low complexity region	234	246	N/A	INTRINSIC
PDZ	282	361	2.34e-6	SMART
low complexity region	431	440	N/A	INTRINSIC
PDZ	469	548	4.1e-20	SMART
PDZ	599	684	9.87e-14	SMART
low complexity region	771	781	N/A	INTRINSIC
PDB:4DC2\|Z	810	837	4e-10	PDB
low complexity region	878	890	N/A	INTRINSIC
low complexity region	907	917	N/A	INTRINSIC
low complexity region	936	965	N/A	INTRINSIC
low complexity region	980	1020	N/A	INTRINSIC
low complexity region	1177	1215	N/A	INTRINSIC
low complexity region	1279	1296	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000160581

SMART Domains

Protein: ENSMUSP00000124141
Gene: ENSMUSG00000025812

Domain	Start	End	E-Value	Type
Pfam:DUF3534	4	149	7.1e-73	PFAM
low complexity region	237	249	N/A	INTRINSIC
PDZ	285	364	2.34e-6	SMART
low complexity region	434	443	N/A	INTRINSIC
PDZ	472	551	4.1e-20	SMART
PDZ	589	674	9.87e-14	SMART
low complexity region	764	774	N/A	INTRINSIC
low complexity region	841	853	N/A	INTRINSIC
low complexity region	870	880	N/A	INTRINSIC
low complexity region	899	928	N/A	INTRINSIC
low complexity region	943	983	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000160593

Predicted Effect

probably benign
Transcript: ENSMUST00000160717

SMART Domains

Protein: ENSMUSP00000125612
Gene: ENSMUSG00000025812

Domain	Start	End	E-Value	Type
low complexity region	99	111	N/A	INTRINSIC
PDZ	147	226	2.34e-6	SMART
low complexity region	296	305	N/A	INTRINSIC
PDZ	334	413	4.1e-20	SMART
PDZ	464	549	9.87e-14	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000160766

SMART Domains

Protein: ENSMUSP00000124533
Gene: ENSMUSG00000025812

Domain	Start	End	E-Value	Type
Pfam:DUF3534	1	146	1e-72	PFAM
PDZ	238	317	2.34e-6	SMART
low complexity region	387	396	N/A	INTRINSIC
PDZ	425	504	4.1e-20	SMART
PDZ	542	627	9.87e-14	SMART
low complexity region	714	724	N/A	INTRINSIC
low complexity region	791	803	N/A	INTRINSIC
low complexity region	820	830	N/A	INTRINSIC
low complexity region	849	878	N/A	INTRINSIC
low complexity region	893	933	N/A	INTRINSIC
low complexity region	1090	1128	N/A	INTRINSIC
low complexity region	1192	1209	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000162602

SMART Domains

Protein: ENSMUSP00000125450
Gene: ENSMUSG00000025812

Domain	Start	End	E-Value	Type
Pfam:DUF3534	1	146	7.6e-73	PFAM
low complexity region	234	246	N/A	INTRINSIC
PDZ	282	361	2.34e-6	SMART
low complexity region	431	440	N/A	INTRINSIC
PDZ	469	548	4.1e-20	SMART
PDZ	599	684	9.87e-14	SMART
low complexity region	774	784	N/A	INTRINSIC
PDB:4DC2\|Z	813	840	2e-10	PDB
low complexity region	881	893	N/A	INTRINSIC
low complexity region	910	920	N/A	INTRINSIC
low complexity region	939	968	N/A	INTRINSIC
low complexity region	983	1023	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000161277

SMART Domains

Protein: ENSMUSP00000124789
Gene: ENSMUSG00000025812

Domain	Start	End	E-Value	Type
Pfam:DUF3534	3	122	9.6e-37	PFAM
PDZ	214	293	2.34e-6	SMART
low complexity region	363	372	N/A	INTRINSIC
PDZ	401	480	4.1e-20	SMART
PDZ	518	603	9.87e-14	SMART
low complexity region	693	703	N/A	INTRINSIC
PDB:4DC2\|Z	732	759	2e-10	PDB
low complexity region	799	811	N/A	INTRINSIC
low complexity region	828	838	N/A	INTRINSIC
low complexity region	857	886	N/A	INTRINSIC
low complexity region	901	919	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000162309

SMART Domains

Protein: ENSMUSP00000124282
Gene: ENSMUSG00000025812

Domain	Start	End	E-Value	Type
Pfam:DUF3534	1	146	6.2e-73	PFAM
low complexity region	234	246	N/A	INTRINSIC
PDZ	282	361	2.34e-6	SMART
low complexity region	431	440	N/A	INTRINSIC
PDZ	469	548	4.1e-20	SMART
PDZ	599	684	9.87e-14	SMART
low complexity region	771	781	N/A	INTRINSIC
PDB:4DC2\|Z	810	837	4e-10	PDB
low complexity region	877	889	N/A	INTRINSIC
low complexity region	906	916	N/A	INTRINSIC
low complexity region	935	964	N/A	INTRINSIC
low complexity region	979	1019	N/A	INTRINSIC
low complexity region	1176	1214	N/A	INTRINSIC
low complexity region	1278	1295	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000162531

SMART Domains

Protein: ENSMUSP00000125610
Gene: ENSMUSG00000025812

Domain	Start	End	E-Value	Type
Pfam:DUF3534	1	146	8.4e-73	PFAM
low complexity region	234	246	N/A	INTRINSIC
PDZ	282	361	2.34e-6	SMART
low complexity region	431	440	N/A	INTRINSIC
PDZ	469	548	4.1e-20	SMART
PDZ	586	671	9.87e-14	SMART
low complexity region	761	771	N/A	INTRINSIC
low complexity region	838	850	N/A	INTRINSIC
low complexity region	867	877	N/A	INTRINSIC
low complexity region	896	925	N/A	INTRINSIC
low complexity region	940	980	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000162665

SMART Domains

Protein: ENSMUSP00000124718
Gene: ENSMUSG00000025812

Domain	Start	End	E-Value	Type
Pfam:DUF3534	21	166	1.4e-60	PFAM
low complexity region	254	266	N/A	INTRINSIC
PDZ	302	381	2.34e-6	SMART
low complexity region	451	460	N/A	INTRINSIC
PDZ	489	568	4.1e-20	SMART
PDZ	619	704	9.87e-14	SMART
low complexity region	791	801	N/A	INTRINSIC
low complexity region	868	880	N/A	INTRINSIC
low complexity region	897	907	N/A	INTRINSIC
low complexity region	926	955	N/A	INTRINSIC
low complexity region	970	1010	N/A	INTRINSIC
low complexity region	1167	1205	N/A	INTRINSIC
low complexity region	1269	1286	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000161355

SMART Domains

Protein: ENSMUSP00000125064
Gene: ENSMUSG00000025812

Domain	Start	End	E-Value	Type
Pfam:DUF3534	1	146	7.2e-73	PFAM
low complexity region	234	246	N/A	INTRINSIC
PDZ	282	361	2.34e-6	SMART
low complexity region	431	440	N/A	INTRINSIC
PDZ	469	548	4.1e-20	SMART
PDZ	599	684	9.87e-14	SMART
low complexity region	771	781	N/A	INTRINSIC
low complexity region	847	859	N/A	INTRINSIC
low complexity region	876	886	N/A	INTRINSIC
low complexity region	905	934	N/A	INTRINSIC
low complexity region	949	989	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000162176

SMART Domains

Protein: ENSMUSP00000123944
Gene: ENSMUSG00000025812

Domain	Start	End	E-Value	Type
PDZ	1	83	4.11e-2	SMART
low complexity region	153	162	N/A	INTRINSIC
PDZ	191	270	4.1e-20	SMART
PDZ	321	406	9.87e-14	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000162456

SMART Domains

Protein: ENSMUSP00000124162
Gene: ENSMUSG00000025812

Domain	Start	End	E-Value	Type
low complexity region	99	111	N/A	INTRINSIC
PDZ	147	226	2.34e-6	SMART
low complexity region	296	305	N/A	INTRINSIC
PDZ	334	413	4.1e-20	SMART
PDZ	464	549	9.87e-14	SMART
low complexity region	636	646	N/A	INTRINSIC
PDB:4DC2\|Z	675	702	2e-10	PDB
low complexity region	743	755	N/A	INTRINSIC
low complexity region	772	782	N/A	INTRINSIC
low complexity region	801	830	N/A	INTRINSIC
low complexity region	845	885	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000162536

SMART Domains

Protein: ENSMUSP00000125212
Gene: ENSMUSG00000025812

Domain	Start	End	E-Value	Type
Pfam:DUF3534	1	146	1e-72	PFAM
PDZ	238	317	2.34e-6	SMART
low complexity region	387	396	N/A	INTRINSIC
PDZ	425	504	4.1e-20	SMART
PDZ	555	640	9.87e-14	SMART
low complexity region	727	737	N/A	INTRINSIC
PDB:4DC2\|Z	766	793	3e-10	PDB
low complexity region	833	845	N/A	INTRINSIC
low complexity region	862	872	N/A	INTRINSIC
low complexity region	891	920	N/A	INTRINSIC
low complexity region	935	975	N/A	INTRINSIC
low complexity region	1132	1170	N/A	INTRINSIC
low complexity region	1234	1251	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000162907

SMART Domains

Protein: ENSMUSP00000124319
Gene: ENSMUSG00000025812

Domain	Start	End	E-Value	Type
Pfam:DUF3534	1	146	4.6e-73	PFAM
low complexity region	234	246	N/A	INTRINSIC
PDZ	282	361	2.34e-6	SMART
low complexity region	431	440	N/A	INTRINSIC
PDZ	469	548	4.1e-20	SMART
PDZ	599	684	9.87e-14	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000163021

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 98.7%
3x: 97.6%
10x: 94.3%
20x: 86.4%

Validation Efficiency

98% (125/127)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the PARD protein family. PARD family members interact with other PARD family members and other proteins; they affect asymmetrical cell division and direct polarized cell growth. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011]
PHENOTYPE: Mice homozygous for a null allele exhibit embryonic lethality at E12.5 associated with growth retardation, abnormal heart development, and abnormal epicardial cell development. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 126 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930402F06Rik	T	C	2: 35,266,271 (GRCm39)	D133G	possibly damaging	Het
Abcb4	A	C	5: 8,989,835 (GRCm39)	D796A	probably damaging	Het
Actg2	A	T	6: 83,496,896 (GRCm39)	V147E	probably damaging	Het
Adamts13	A	C	2: 26,877,001 (GRCm39)	T534P	probably damaging	Het
Ago1	T	C	4: 126,336,959 (GRCm39)	T249A	probably benign	Het
Ahnak	T	A	19: 8,979,859 (GRCm39)	I381N	probably damaging	Het
Akap9	A	G	5: 4,119,038 (GRCm39)	D3515G	probably benign	Het
Angptl3	T	C	4: 98,922,706 (GRCm39)	V249A	probably benign	Het
Ank	A	G	15: 27,567,658 (GRCm39)	T294A	possibly damaging	Het
Ank1	A	T	8: 23,594,825 (GRCm39)	H204L	probably damaging	Het
Apbb2	A	G	5: 66,468,331 (GRCm39)		probably benign	Het
Arhgap28	A	T	17: 68,208,424 (GRCm39)	S15T	probably benign	Het
Aspm	T	C	1: 139,410,249 (GRCm39)		probably benign	Het
Atp1a4	T	C	1: 172,062,554 (GRCm39)	E651G	probably damaging	Het
B3gnt2	A	T	11: 22,786,860 (GRCm39)	F109L	probably damaging	Het
Bpifb4	T	C	2: 153,801,603 (GRCm39)	F575L	probably damaging	Het
Calhm4	A	G	10: 33,920,043 (GRCm39)	W75R	probably damaging	Het
Calr	C	A	8: 85,569,660 (GRCm39)	K322N	probably benign	Het
Ccdc188	T	C	16: 18,037,169 (GRCm39)	S247P	possibly damaging	Het
Cdr1	T	A	X: 60,228,908 (GRCm39)	D86V	unknown	Het
Cep97	C	T	16: 55,745,421 (GRCm39)	V48I	probably damaging	Het
Chaf1b	T	A	16: 93,681,399 (GRCm39)	C6S	probably damaging	Het
Chd3	C	T	11: 69,247,844 (GRCm39)	D920N	probably damaging	Het
Clk1	T	C	1: 58,452,192 (GRCm39)		probably benign	Het
Cntnap3	T	A	13: 64,905,250 (GRCm39)		probably benign	Het
Col12a1	T	A	9: 79,507,293 (GRCm39)		probably null	Het
Col17a1	G	T	19: 47,659,801 (GRCm39)		probably benign	Het
Coq7	T	A	7: 118,128,940 (GRCm39)	I32F	possibly damaging	Het
Cox6a2	A	T	7: 127,805,107 (GRCm39)	F59I	probably damaging	Het
Cpq	A	G	15: 33,594,297 (GRCm39)	D436G	probably damaging	Het
Ctso	G	A	3: 81,852,168 (GRCm39)		probably null	Het
Cxadr	A	T	16: 78,131,836 (GRCm39)	H274L	probably benign	Het
Cyp2c40	A	T	19: 39,766,495 (GRCm39)	C367S	possibly damaging	Het
Cyp2c70	T	G	19: 40,149,115 (GRCm39)	M344L	possibly damaging	Het
Defa35	G	A	8: 21,555,871 (GRCm39)	V77I	probably benign	Het
Dhx57	A	G	17: 80,582,310 (GRCm39)	Y432H	probably damaging	Het
Dhx9	A	T	1: 153,341,441 (GRCm39)	D601E	probably benign	Het
Dnah7a	C	G	1: 53,444,849 (GRCm39)	D3952H	probably damaging	Het
Dnah9	C	A	11: 65,917,798 (GRCm39)		probably benign	Het
Dstyk	C	A	1: 132,384,602 (GRCm39)		probably benign	Het
Efcab2	T	A	1: 178,303,469 (GRCm39)		probably benign	Het
Ehbp1l1	T	C	19: 5,770,598 (GRCm39)	E287G	possibly damaging	Het
Epgn	A	G	5: 91,180,073 (GRCm39)	T87A	probably benign	Het
Erc2	A	C	14: 27,863,182 (GRCm39)	E803A	probably damaging	Het
Fer	A	G	17: 64,446,011 (GRCm39)	*454W	probably null	Het
Glyr1	T	C	16: 4,849,836 (GRCm39)	D179G	probably damaging	Het
Gm12830	T	A	4: 114,702,173 (GRCm39)		probably benign	Het
Gm9922	C	A	14: 101,967,129 (GRCm39)		probably benign	Het
Gsta3	C	T	1: 21,335,118 (GRCm39)	P200S	possibly damaging	Het
Hmgxb3	G	A	18: 61,288,200 (GRCm39)		probably benign	Het
Hsh2d	G	A	8: 72,954,304 (GRCm39)	D229N	probably benign	Het
Il16	T	C	7: 83,371,762 (GRCm39)	K15E	probably damaging	Het
Kcnip2	T	A	19: 45,782,514 (GRCm39)		probably benign	Het
Kdm4c	T	C	4: 74,263,804 (GRCm39)	V696A	probably benign	Het
Kdr	A	G	5: 76,107,587 (GRCm39)		probably benign	Het
Klhl33	T	G	14: 51,128,868 (GRCm39)	H787P	probably damaging	Het
Klk14	A	T	7: 43,343,769 (GRCm39)	T159S	probably benign	Het
Lancl2	A	G	6: 57,680,117 (GRCm39)	N16D	probably damaging	Het
Lemd3	T	C	10: 120,773,015 (GRCm39)	N583S	possibly damaging	Het
Map3k4	TGCTGGCTTCAGGGCCACAGTCCGCTG	TGCTG	17: 12,489,902 (GRCm39)		probably null	Het
Mpl	T	G	4: 118,303,235 (GRCm39)		probably benign	Het
Myh7b	T	C	2: 155,472,592 (GRCm39)		probably benign	Het
Mylk	A	C	16: 34,732,667 (GRCm39)		probably benign	Het
Myof	A	T	19: 37,969,714 (GRCm39)	M316K	probably benign	Het
Nfib	T	A	4: 82,214,974 (GRCm39)	N543I	probably damaging	Het
Nfix	A	G	8: 85,448,403 (GRCm39)	S375P	probably damaging	Het
Nkrf	T	C	X: 36,153,769 (GRCm39)	Q171R	probably damaging	Het
Nmnat2	T	A	1: 152,952,747 (GRCm39)		probably benign	Het
Npffr2	G	A	5: 89,731,206 (GRCm39)	E379K	probably benign	Het
Npr2	T	C	4: 43,640,904 (GRCm39)		probably benign	Het
Nup98	A	C	7: 101,801,635 (GRCm39)	D212E	probably null	Het
Nwd2	T	C	5: 63,964,561 (GRCm39)	Y1382H	probably damaging	Het
Ocstamp	T	C	2: 165,237,912 (GRCm39)	R451G	possibly damaging	Het
Or52s1	T	A	7: 102,861,928 (GRCm39)	I287K	probably damaging	Het
Or6c6c	A	G	10: 129,541,008 (GRCm39)	D87G	probably benign	Het
Pabpc1	C	T	15: 36,597,737 (GRCm39)	A551T	possibly damaging	Het
Pcdhb12	G	T	18: 37,569,174 (GRCm39)	V107L	probably benign	Het
Pik3cd	A	T	4: 149,747,677 (GRCm39)	V22D	probably damaging	Het
Pkd1l2	A	G	8: 117,724,315 (GRCm39)	V2396A	probably damaging	Het
Pnpla7	T	C	2: 24,877,207 (GRCm39)	I167T	probably damaging	Het
Pphln1	A	T	15: 93,339,588 (GRCm39)	H114L	possibly damaging	Het
Ppm1h	A	G	10: 122,756,687 (GRCm39)	N444S	probably damaging	Het
Prdm9	G	A	17: 15,777,646 (GRCm39)	T146I	probably damaging	Het
Prrc2a	A	G	17: 35,369,891 (GRCm39)		probably benign	Het
Prrx1	T	C	1: 163,140,128 (GRCm39)	D26G	possibly damaging	Het
Ptpn5	T	C	7: 46,729,042 (GRCm39)	E495G	probably damaging	Het
Rab23	A	C	1: 33,773,942 (GRCm39)		probably null	Het
Ralgps1	C	T	2: 33,047,935 (GRCm39)	M348I	probably benign	Het
Ranbp2	A	G	10: 58,315,690 (GRCm39)	T2137A	probably benign	Het
Rapgef4	G	T	2: 72,056,374 (GRCm39)	G654V	probably benign	Het
Rc3h2	A	T	2: 37,269,020 (GRCm39)		probably benign	Het
Reg2	G	A	6: 78,383,169 (GRCm39)	A39T	possibly damaging	Het
Sema4d	C	A	13: 51,879,347 (GRCm39)	V7F	probably benign	Het
Sgip1	T	C	4: 102,772,354 (GRCm39)		probably benign	Het
Sgpl1	C	T	10: 60,949,216 (GRCm39)		probably null	Het
Shisa9	G	A	16: 11,814,987 (GRCm39)	V212M	probably damaging	Het
Shq1	G	A	6: 100,550,588 (GRCm39)	P450L	probably benign	Het
Sin3a	A	G	9: 57,018,196 (GRCm39)	T872A	probably benign	Het
Sipa1l3	C	T	7: 29,047,775 (GRCm39)	R1371Q	probably benign	Het
Skint8	T	C	4: 111,796,064 (GRCm39)	V246A	probably benign	Het
Slc22a20	A	T	19: 6,022,985 (GRCm39)	V386D	probably damaging	Het
Slc28a2b	A	T	2: 122,348,034 (GRCm39)	T253S	probably benign	Het
Slc2a7	G	A	4: 150,242,528 (GRCm39)		probably benign	Het
Slc35a2	T	A	X: 7,755,901 (GRCm39)	Y48N	probably damaging	Het
Slc4a2	G	T	5: 24,639,344 (GRCm39)	S413I	probably damaging	Het
Sntg2	T	C	12: 30,276,772 (GRCm39)	T427A	probably benign	Het
Soat1	T	C	1: 156,270,023 (GRCm39)	Y132C	probably damaging	Het
Stn1	G	T	19: 47,490,112 (GRCm39)	H342N	probably benign	Het
Tarbp1	T	A	8: 127,165,667 (GRCm39)		probably benign	Het
Tas2r113	A	C	6: 132,870,341 (GRCm39)	K123T	probably damaging	Het
Tbck	C	T	3: 132,440,168 (GRCm39)	Q504*	probably null	Het
Tenm3	C	T	8: 48,794,069 (GRCm39)	C380Y	probably damaging	Het
Tent4a	A	T	13: 69,648,051 (GRCm39)	V781E	possibly damaging	Het
Triobp	A	G	15: 78,860,740 (GRCm39)	D1389G	probably damaging	Het
Trpm4	A	T	7: 44,958,130 (GRCm39)	F780I	probably damaging	Het
Tubb4a	G	T	17: 57,388,182 (GRCm39)	Y281*	probably null	Het
Txndc15	T	C	13: 55,872,395 (GRCm39)	F261S	probably damaging	Het
Ube3b	T	C	5: 114,557,530 (GRCm39)		probably benign	Het
Unc5c	G	C	3: 141,439,694 (GRCm39)	V196L	probably benign	Het
Upf3a	G	A	8: 13,845,500 (GRCm39)		probably null	Het
Vmn2r20	T	C	6: 123,363,063 (GRCm39)	K574E	probably benign	Het
Vps50	A	G	6: 3,536,853 (GRCm39)	M275V	possibly damaging	Het
Xrcc5	A	G	1: 72,346,735 (GRCm39)		probably benign	Het
Zbtb18	T	C	1: 177,276,182 (GRCm39)	L505S	probably damaging	Het
Zbtb41	T	C	1: 139,366,722 (GRCm39)	I567T	probably damaging	Het
Zfp598	T	C	17: 24,897,558 (GRCm39)		probably benign	Het

Other mutations in Pard3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00161:Pard3	APN	8	128,086,299 (GRCm39)	splice site	probably benign
IGL00484:Pard3	APN	8	128,098,327 (GRCm39)	missense	probably benign	0.05
IGL00674:Pard3	APN	8	128,115,159 (GRCm39)	missense	probably damaging	1.00
IGL01471:Pard3	APN	8	128,104,727 (GRCm39)	missense	probably benign	0.01
IGL01505:Pard3	APN	8	128,050,544 (GRCm39)	missense	probably damaging	1.00
IGL02252:Pard3	APN	8	128,125,237 (GRCm39)	missense	probably benign	0.09
IGL02511:Pard3	APN	8	127,888,070 (GRCm39)	splice site	probably benign
IGL02838:Pard3	APN	8	128,153,128 (GRCm39)	missense	probably damaging	0.99
IGL02948:Pard3	APN	8	128,032,975 (GRCm39)	missense	probably benign	0.00
IGL02987:Pard3	APN	8	128,115,972 (GRCm39)	missense	probably damaging	0.98
IGL03037:Pard3	APN	8	128,032,975 (GRCm39)	missense	probably benign	0.00
IGL03084:Pard3	APN	8	128,319,573 (GRCm39)	missense	probably damaging	0.96
BB001:Pard3	UTSW	8	128,137,231 (GRCm39)	missense	probably benign
BB011:Pard3	UTSW	8	128,137,231 (GRCm39)	missense	probably benign
R0025:Pard3	UTSW	8	127,888,058 (GRCm39)	missense	probably damaging	1.00
R0025:Pard3	UTSW	8	127,888,058 (GRCm39)	missense	probably damaging	1.00
R0029:Pard3	UTSW	8	128,153,239 (GRCm39)	splice site	probably benign
R0109:Pard3	UTSW	8	128,125,147 (GRCm39)	missense	probably damaging	1.00
R0415:Pard3	UTSW	8	128,337,047 (GRCm39)	missense	probably damaging	1.00
R0507:Pard3	UTSW	8	128,097,967 (GRCm39)	splice site	probably benign
R1055:Pard3	UTSW	8	128,104,761 (GRCm39)	missense	probably benign	0.34
R1305:Pard3	UTSW	8	128,032,891 (GRCm39)	missense	possibly damaging	0.62
R1619:Pard3	UTSW	8	128,106,983 (GRCm39)	missense	probably benign	0.02
R1855:Pard3	UTSW	8	128,174,293 (GRCm39)	splice site	probably null
R2001:Pard3	UTSW	8	127,791,097 (GRCm39)	splice site	probably null
R2060:Pard3	UTSW	8	128,125,085 (GRCm39)	missense	probably benign	0.05
R2064:Pard3	UTSW	8	128,337,092 (GRCm39)	missense	probably damaging	1.00
R2113:Pard3	UTSW	8	128,115,018 (GRCm39)	missense	probably damaging	1.00
R2136:Pard3	UTSW	8	128,103,366 (GRCm39)	critical splice donor site	probably null
R2224:Pard3	UTSW	8	128,086,257 (GRCm39)	missense	probably damaging	1.00
R2252:Pard3	UTSW	8	128,337,080 (GRCm39)	missense	probably damaging	1.00
R3870:Pard3	UTSW	8	128,136,167 (GRCm39)	missense	probably damaging	1.00
R4154:Pard3	UTSW	8	128,200,877 (GRCm39)	missense	probably damaging	1.00
R4212:Pard3	UTSW	8	128,336,939 (GRCm39)	missense	probably benign	0.43
R4243:Pard3	UTSW	8	128,098,128 (GRCm39)	missense	probably benign	0.09
R4523:Pard3	UTSW	8	128,125,108 (GRCm39)	missense	probably benign	0.08
R4857:Pard3	UTSW	8	128,050,535 (GRCm39)	missense	probably damaging	0.98
R4876:Pard3	UTSW	8	128,287,950 (GRCm39)	intron	probably benign
R4877:Pard3	UTSW	8	128,115,018 (GRCm39)	missense	probably damaging	1.00
R5197:Pard3	UTSW	8	127,800,040 (GRCm39)	splice site	probably null
R5215:Pard3	UTSW	8	128,104,745 (GRCm39)	missense	probably damaging	1.00
R5279:Pard3	UTSW	8	128,186,867 (GRCm39)	critical splice donor site	probably null
R5349:Pard3	UTSW	8	128,142,224 (GRCm39)	missense	probably damaging	1.00
R5479:Pard3	UTSW	8	128,096,836 (GRCm39)	missense	probably damaging	1.00
R5514:Pard3	UTSW	8	128,153,086 (GRCm39)	missense	probably damaging	1.00
R5681:Pard3	UTSW	8	128,115,914 (GRCm39)	missense	possibly damaging	0.81
R5934:Pard3	UTSW	8	128,115,819 (GRCm39)	missense	probably damaging	1.00
R6034:Pard3	UTSW	8	127,791,077 (GRCm39)	utr 5 prime	probably benign
R6034:Pard3	UTSW	8	127,791,077 (GRCm39)	utr 5 prime	probably benign
R6187:Pard3	UTSW	8	127,800,023 (GRCm39)	missense	probably benign	0.00
R6382:Pard3	UTSW	8	128,103,264 (GRCm39)	missense	probably damaging	1.00
R6774:Pard3	UTSW	8	128,137,228 (GRCm39)	missense	probably damaging	0.98
R7130:Pard3	UTSW	8	128,142,164 (GRCm39)	missense	probably damaging	1.00
R7267:Pard3	UTSW	8	128,098,056 (GRCm39)	missense	probably damaging	0.97
R7358:Pard3	UTSW	8	128,319,573 (GRCm39)	missense	probably damaging	0.98
R7528:Pard3	UTSW	8	128,329,646 (GRCm39)	missense	probably damaging	1.00
R7537:Pard3	UTSW	8	128,337,063 (GRCm39)	missense	probably damaging	1.00
R7679:Pard3	UTSW	8	128,098,327 (GRCm39)	missense	probably benign	0.05
R7924:Pard3	UTSW	8	128,137,231 (GRCm39)	missense	probably benign
R8076:Pard3	UTSW	8	128,142,077 (GRCm39)	missense	probably damaging	1.00
R8258:Pard3	UTSW	8	128,098,021 (GRCm39)	nonsense	probably null
R8259:Pard3	UTSW	8	128,098,021 (GRCm39)	nonsense	probably null
R8345:Pard3	UTSW	8	128,050,549 (GRCm39)	missense	probably damaging	1.00
R8421:Pard3	UTSW	8	127,867,158 (GRCm39)	intron	probably benign
R8500:Pard3	UTSW	8	128,186,784 (GRCm39)	missense	probably damaging	1.00
R8742:Pard3	UTSW	8	128,050,592 (GRCm39)	missense	possibly damaging	0.85
R8918:Pard3	UTSW	8	128,098,011 (GRCm39)	missense	probably benign	0.29
R9005:Pard3	UTSW	8	128,003,647 (GRCm39)	missense	probably damaging	1.00
R9629:Pard3	UTSW	8	128,136,153 (GRCm39)	missense	possibly damaging	0.94
R9643:Pard3	UTSW	8	128,115,900 (GRCm39)	missense	possibly damaging	0.87

Predicted Primers

PCR Primer
(F):5'- AGGACTGGGATTCAGCATCACCTC -3'
(R):5'- ACCTTTTGGCCTTCTGTGCAAGAC -3'

Sequencing Primer
(F):5'- GGCTCAGCTCCCATTTATGT -3'
(R):5'- CTGTGCAAGACCATGTTCAC -3'

Posted On

2013-04-16