Incidental Mutation 'R0309:Ranbp2'
| ID |
25081 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Ranbp2
|
| Ensembl Gene |
ENSMUSG00000003226 |
| Gene Name |
RAN binding protein 2 |
| Synonyms |
A430087B05Rik |
| MMRRC Submission |
038519-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R0309 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
10 |
| Chromosomal Location |
58282674-58329977 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 58315690 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Alanine
at position 2137
(T2137A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000003310
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000003310]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000003310
AA Change: T2137A
PolyPhen 2
Score 0.044 (Sensitivity: 0.94; Specificity: 0.83)
|
| SMART Domains |
Protein: ENSMUSP00000003310
Gene: ENSMUSG00000003226
AA Change: T2137A
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TPR_1
|
60 |
93 |
1.8e-7 |
PFAM |
|
Pfam:TPR_8
|
60 |
93 |
8.9e-6 |
PFAM |
|
low complexity region
|
235 |
247 |
N/A |
INTRINSIC |
|
low complexity region
|
778 |
801 |
N/A |
INTRINSIC |
|
coiled coil region
|
808 |
832 |
N/A |
INTRINSIC |
|
RanBD
|
1166 |
1295 |
6.47e-64 |
SMART |
|
ZnF_RBZ
|
1348 |
1372 |
5.49e-2 |
SMART |
|
ZnF_RBZ
|
1412 |
1436 |
3.06e-6 |
SMART |
|
ZnF_RBZ
|
1471 |
1495 |
4.16e-8 |
SMART |
|
ZnF_RBZ
|
1500 |
1524 |
4.57e-5 |
SMART |
|
ZnF_RBZ
|
1560 |
1584 |
3.52e-6 |
SMART |
|
ZnF_RBZ
|
1619 |
1643 |
1.35e-7 |
SMART |
|
RanBD
|
1850 |
1979 |
2.84e-60 |
SMART |
|
low complexity region
|
2034 |
2048 |
N/A |
INTRINSIC |
|
low complexity region
|
2069 |
2090 |
N/A |
INTRINSIC |
|
low complexity region
|
2106 |
2121 |
N/A |
INTRINSIC |
|
RanBD
|
2147 |
2276 |
4.96e-83 |
SMART |
|
low complexity region
|
2310 |
2317 |
N/A |
INTRINSIC |
|
low complexity region
|
2328 |
2342 |
N/A |
INTRINSIC |
|
Pfam:IR1-M
|
2468 |
2530 |
2.5e-27 |
PFAM |
|
Pfam:IR1-M
|
2544 |
2604 |
7e-30 |
PFAM |
|
low complexity region
|
2673 |
2684 |
N/A |
INTRINSIC |
|
low complexity region
|
2722 |
2732 |
N/A |
INTRINSIC |
|
RanBD
|
2741 |
2869 |
5e-79 |
SMART |
|
Pfam:Pro_isomerase
|
2896 |
3052 |
4.5e-45 |
PFAM |
|
| Meta Mutation Damage Score |
0.0595 |
| Coding Region Coverage |
- 1x: 98.7%
- 3x: 97.6%
- 10x: 94.3%
- 20x: 86.4%
|
| Validation Efficiency |
98% (125/127) |
| MGI Phenotype |
PHENOTYPE: Mice homozygous for a gene trap allele display embryonic lethality. Heterozygous mice on some backgrounds display reduced ATP levels in the CNS, decreased glucose clearance, decreased weight gain on a high fat diet, and reduced scotopic responses. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 126 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930402F06Rik |
T |
C |
2: 35,266,271 (GRCm39) |
D133G |
possibly damaging |
Het |
| Abcb4 |
A |
C |
5: 8,989,835 (GRCm39) |
D796A |
probably damaging |
Het |
| Actg2 |
A |
T |
6: 83,496,896 (GRCm39) |
V147E |
probably damaging |
Het |
| Adamts13 |
A |
C |
2: 26,877,001 (GRCm39) |
T534P |
probably damaging |
Het |
| Ago1 |
T |
C |
4: 126,336,959 (GRCm39) |
T249A |
probably benign |
Het |
| Ahnak |
T |
A |
19: 8,979,859 (GRCm39) |
I381N |
probably damaging |
Het |
| Akap9 |
A |
G |
5: 4,119,038 (GRCm39) |
D3515G |
probably benign |
Het |
| Angptl3 |
T |
C |
4: 98,922,706 (GRCm39) |
V249A |
probably benign |
Het |
| Ank |
A |
G |
15: 27,567,658 (GRCm39) |
T294A |
possibly damaging |
Het |
| Ank1 |
A |
T |
8: 23,594,825 (GRCm39) |
H204L |
probably damaging |
Het |
| Apbb2 |
A |
G |
5: 66,468,331 (GRCm39) |
|
probably benign |
Het |
| Arhgap28 |
A |
T |
17: 68,208,424 (GRCm39) |
S15T |
probably benign |
Het |
| Aspm |
T |
C |
1: 139,410,249 (GRCm39) |
|
probably benign |
Het |
| Atp1a4 |
T |
C |
1: 172,062,554 (GRCm39) |
E651G |
probably damaging |
Het |
| B3gnt2 |
A |
T |
11: 22,786,860 (GRCm39) |
F109L |
probably damaging |
Het |
| Bpifb4 |
T |
C |
2: 153,801,603 (GRCm39) |
F575L |
probably damaging |
Het |
| Calhm4 |
A |
G |
10: 33,920,043 (GRCm39) |
W75R |
probably damaging |
Het |
| Calr |
C |
A |
8: 85,569,660 (GRCm39) |
K322N |
probably benign |
Het |
| Ccdc188 |
T |
C |
16: 18,037,169 (GRCm39) |
S247P |
possibly damaging |
Het |
| Cdr1 |
T |
A |
X: 60,228,908 (GRCm39) |
D86V |
unknown |
Het |
| Cep97 |
C |
T |
16: 55,745,421 (GRCm39) |
V48I |
probably damaging |
Het |
| Chaf1b |
T |
A |
16: 93,681,399 (GRCm39) |
C6S |
probably damaging |
Het |
| Chd3 |
C |
T |
11: 69,247,844 (GRCm39) |
D920N |
probably damaging |
Het |
| Clk1 |
T |
C |
1: 58,452,192 (GRCm39) |
|
probably benign |
Het |
| Cntnap3 |
T |
A |
13: 64,905,250 (GRCm39) |
|
probably benign |
Het |
| Col12a1 |
T |
A |
9: 79,507,293 (GRCm39) |
|
probably null |
Het |
| Col17a1 |
G |
T |
19: 47,659,801 (GRCm39) |
|
probably benign |
Het |
| Coq7 |
T |
A |
7: 118,128,940 (GRCm39) |
I32F |
possibly damaging |
Het |
| Cox6a2 |
A |
T |
7: 127,805,107 (GRCm39) |
F59I |
probably damaging |
Het |
| Cpq |
A |
G |
15: 33,594,297 (GRCm39) |
D436G |
probably damaging |
Het |
| Ctso |
G |
A |
3: 81,852,168 (GRCm39) |
|
probably null |
Het |
| Cxadr |
A |
T |
16: 78,131,836 (GRCm39) |
H274L |
probably benign |
Het |
| Cyp2c40 |
A |
T |
19: 39,766,495 (GRCm39) |
C367S |
possibly damaging |
Het |
| Cyp2c70 |
T |
G |
19: 40,149,115 (GRCm39) |
M344L |
possibly damaging |
Het |
| Defa35 |
G |
A |
8: 21,555,871 (GRCm39) |
V77I |
probably benign |
Het |
| Dhx57 |
A |
G |
17: 80,582,310 (GRCm39) |
Y432H |
probably damaging |
Het |
| Dhx9 |
A |
T |
1: 153,341,441 (GRCm39) |
D601E |
probably benign |
Het |
| Dnah7a |
C |
G |
1: 53,444,849 (GRCm39) |
D3952H |
probably damaging |
Het |
| Dnah9 |
C |
A |
11: 65,917,798 (GRCm39) |
|
probably benign |
Het |
| Dstyk |
C |
A |
1: 132,384,602 (GRCm39) |
|
probably benign |
Het |
| Efcab2 |
T |
A |
1: 178,303,469 (GRCm39) |
|
probably benign |
Het |
| Ehbp1l1 |
T |
C |
19: 5,770,598 (GRCm39) |
E287G |
possibly damaging |
Het |
| Epgn |
A |
G |
5: 91,180,073 (GRCm39) |
T87A |
probably benign |
Het |
| Erc2 |
A |
C |
14: 27,863,182 (GRCm39) |
E803A |
probably damaging |
Het |
| Fer |
A |
G |
17: 64,446,011 (GRCm39) |
*454W |
probably null |
Het |
| Glyr1 |
T |
C |
16: 4,849,836 (GRCm39) |
D179G |
probably damaging |
Het |
| Gm12830 |
T |
A |
4: 114,702,173 (GRCm39) |
|
probably benign |
Het |
| Gm9922 |
C |
A |
14: 101,967,129 (GRCm39) |
|
probably benign |
Het |
| Gsta3 |
C |
T |
1: 21,335,118 (GRCm39) |
P200S |
possibly damaging |
Het |
| Hmgxb3 |
G |
A |
18: 61,288,200 (GRCm39) |
|
probably benign |
Het |
| Hsh2d |
G |
A |
8: 72,954,304 (GRCm39) |
D229N |
probably benign |
Het |
| Il16 |
T |
C |
7: 83,371,762 (GRCm39) |
K15E |
probably damaging |
Het |
| Kcnip2 |
T |
A |
19: 45,782,514 (GRCm39) |
|
probably benign |
Het |
| Kdm4c |
T |
C |
4: 74,263,804 (GRCm39) |
V696A |
probably benign |
Het |
| Kdr |
A |
G |
5: 76,107,587 (GRCm39) |
|
probably benign |
Het |
| Klhl33 |
T |
G |
14: 51,128,868 (GRCm39) |
H787P |
probably damaging |
Het |
| Klk14 |
A |
T |
7: 43,343,769 (GRCm39) |
T159S |
probably benign |
Het |
| Lancl2 |
A |
G |
6: 57,680,117 (GRCm39) |
N16D |
probably damaging |
Het |
| Lemd3 |
T |
C |
10: 120,773,015 (GRCm39) |
N583S |
possibly damaging |
Het |
| Map3k4 |
TGCTGGCTTCAGGGCCACAGTCCGCTG |
TGCTG |
17: 12,489,902 (GRCm39) |
|
probably null |
Het |
| Mpl |
T |
G |
4: 118,303,235 (GRCm39) |
|
probably benign |
Het |
| Myh7b |
T |
C |
2: 155,472,592 (GRCm39) |
|
probably benign |
Het |
| Mylk |
A |
C |
16: 34,732,667 (GRCm39) |
|
probably benign |
Het |
| Myof |
A |
T |
19: 37,969,714 (GRCm39) |
M316K |
probably benign |
Het |
| Nfib |
T |
A |
4: 82,214,974 (GRCm39) |
N543I |
probably damaging |
Het |
| Nfix |
A |
G |
8: 85,448,403 (GRCm39) |
S375P |
probably damaging |
Het |
| Nkrf |
T |
C |
X: 36,153,769 (GRCm39) |
Q171R |
probably damaging |
Het |
| Nmnat2 |
T |
A |
1: 152,952,747 (GRCm39) |
|
probably benign |
Het |
| Npffr2 |
G |
A |
5: 89,731,206 (GRCm39) |
E379K |
probably benign |
Het |
| Npr2 |
T |
C |
4: 43,640,904 (GRCm39) |
|
probably benign |
Het |
| Nup98 |
A |
C |
7: 101,801,635 (GRCm39) |
D212E |
probably null |
Het |
| Nwd2 |
T |
C |
5: 63,964,561 (GRCm39) |
Y1382H |
probably damaging |
Het |
| Ocstamp |
T |
C |
2: 165,237,912 (GRCm39) |
R451G |
possibly damaging |
Het |
| Or52s1 |
T |
A |
7: 102,861,928 (GRCm39) |
I287K |
probably damaging |
Het |
| Or6c6c |
A |
G |
10: 129,541,008 (GRCm39) |
D87G |
probably benign |
Het |
| Pabpc1 |
C |
T |
15: 36,597,737 (GRCm39) |
A551T |
possibly damaging |
Het |
| Pard3 |
A |
T |
8: 128,103,378 (GRCm39) |
|
probably benign |
Het |
| Pcdhb12 |
G |
T |
18: 37,569,174 (GRCm39) |
V107L |
probably benign |
Het |
| Pik3cd |
A |
T |
4: 149,747,677 (GRCm39) |
V22D |
probably damaging |
Het |
| Pkd1l2 |
A |
G |
8: 117,724,315 (GRCm39) |
V2396A |
probably damaging |
Het |
| Pnpla7 |
T |
C |
2: 24,877,207 (GRCm39) |
I167T |
probably damaging |
Het |
| Pphln1 |
A |
T |
15: 93,339,588 (GRCm39) |
H114L |
possibly damaging |
Het |
| Ppm1h |
A |
G |
10: 122,756,687 (GRCm39) |
N444S |
probably damaging |
Het |
| Prdm9 |
G |
A |
17: 15,777,646 (GRCm39) |
T146I |
probably damaging |
Het |
| Prrc2a |
A |
G |
17: 35,369,891 (GRCm39) |
|
probably benign |
Het |
| Prrx1 |
T |
C |
1: 163,140,128 (GRCm39) |
D26G |
possibly damaging |
Het |
| Ptpn5 |
T |
C |
7: 46,729,042 (GRCm39) |
E495G |
probably damaging |
Het |
| Rab23 |
A |
C |
1: 33,773,942 (GRCm39) |
|
probably null |
Het |
| Ralgps1 |
C |
T |
2: 33,047,935 (GRCm39) |
M348I |
probably benign |
Het |
| Rapgef4 |
G |
T |
2: 72,056,374 (GRCm39) |
G654V |
probably benign |
Het |
| Rc3h2 |
A |
T |
2: 37,269,020 (GRCm39) |
|
probably benign |
Het |
| Reg2 |
G |
A |
6: 78,383,169 (GRCm39) |
A39T |
possibly damaging |
Het |
| Sema4d |
C |
A |
13: 51,879,347 (GRCm39) |
V7F |
probably benign |
Het |
| Sgip1 |
T |
C |
4: 102,772,354 (GRCm39) |
|
probably benign |
Het |
| Sgpl1 |
C |
T |
10: 60,949,216 (GRCm39) |
|
probably null |
Het |
| Shisa9 |
G |
A |
16: 11,814,987 (GRCm39) |
V212M |
probably damaging |
Het |
| Shq1 |
G |
A |
6: 100,550,588 (GRCm39) |
P450L |
probably benign |
Het |
| Sin3a |
A |
G |
9: 57,018,196 (GRCm39) |
T872A |
probably benign |
Het |
| Sipa1l3 |
C |
T |
7: 29,047,775 (GRCm39) |
R1371Q |
probably benign |
Het |
| Skint8 |
T |
C |
4: 111,796,064 (GRCm39) |
V246A |
probably benign |
Het |
| Slc22a20 |
A |
T |
19: 6,022,985 (GRCm39) |
V386D |
probably damaging |
Het |
| Slc28a2b |
A |
T |
2: 122,348,034 (GRCm39) |
T253S |
probably benign |
Het |
| Slc2a7 |
G |
A |
4: 150,242,528 (GRCm39) |
|
probably benign |
Het |
| Slc35a2 |
T |
A |
X: 7,755,901 (GRCm39) |
Y48N |
probably damaging |
Het |
| Slc4a2 |
G |
T |
5: 24,639,344 (GRCm39) |
S413I |
probably damaging |
Het |
| Sntg2 |
T |
C |
12: 30,276,772 (GRCm39) |
T427A |
probably benign |
Het |
| Soat1 |
T |
C |
1: 156,270,023 (GRCm39) |
Y132C |
probably damaging |
Het |
| Stn1 |
G |
T |
19: 47,490,112 (GRCm39) |
H342N |
probably benign |
Het |
| Tarbp1 |
T |
A |
8: 127,165,667 (GRCm39) |
|
probably benign |
Het |
| Tas2r113 |
A |
C |
6: 132,870,341 (GRCm39) |
K123T |
probably damaging |
Het |
| Tbck |
C |
T |
3: 132,440,168 (GRCm39) |
Q504* |
probably null |
Het |
| Tenm3 |
C |
T |
8: 48,794,069 (GRCm39) |
C380Y |
probably damaging |
Het |
| Tent4a |
A |
T |
13: 69,648,051 (GRCm39) |
V781E |
possibly damaging |
Het |
| Triobp |
A |
G |
15: 78,860,740 (GRCm39) |
D1389G |
probably damaging |
Het |
| Trpm4 |
A |
T |
7: 44,958,130 (GRCm39) |
F780I |
probably damaging |
Het |
| Tubb4a |
G |
T |
17: 57,388,182 (GRCm39) |
Y281* |
probably null |
Het |
| Txndc15 |
T |
C |
13: 55,872,395 (GRCm39) |
F261S |
probably damaging |
Het |
| Ube3b |
T |
C |
5: 114,557,530 (GRCm39) |
|
probably benign |
Het |
| Unc5c |
G |
C |
3: 141,439,694 (GRCm39) |
V196L |
probably benign |
Het |
| Upf3a |
G |
A |
8: 13,845,500 (GRCm39) |
|
probably null |
Het |
| Vmn2r20 |
T |
C |
6: 123,363,063 (GRCm39) |
K574E |
probably benign |
Het |
| Vps50 |
A |
G |
6: 3,536,853 (GRCm39) |
M275V |
possibly damaging |
Het |
| Xrcc5 |
A |
G |
1: 72,346,735 (GRCm39) |
|
probably benign |
Het |
| Zbtb18 |
T |
C |
1: 177,276,182 (GRCm39) |
L505S |
probably damaging |
Het |
| Zbtb41 |
T |
C |
1: 139,366,722 (GRCm39) |
I567T |
probably damaging |
Het |
| Zfp598 |
T |
C |
17: 24,897,558 (GRCm39) |
|
probably benign |
Het |
|
| Other mutations in Ranbp2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00229:Ranbp2
|
APN |
10 |
58,313,078 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00336:Ranbp2
|
APN |
10 |
58,287,806 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00486:Ranbp2
|
APN |
10 |
58,313,434 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL00800:Ranbp2
|
APN |
10 |
58,326,526 (GRCm39) |
missense |
probably benign |
|
|
IGL00834:Ranbp2
|
APN |
10 |
58,289,145 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL00852:Ranbp2
|
APN |
10 |
58,313,723 (GRCm39) |
missense |
probably benign |
|
|
IGL00984:Ranbp2
|
APN |
10 |
58,297,786 (GRCm39) |
nonsense |
probably null |
|
|
IGL01299:Ranbp2
|
APN |
10 |
58,328,639 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01325:Ranbp2
|
APN |
10 |
58,312,120 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01444:Ranbp2
|
APN |
10 |
58,311,122 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
IGL01545:Ranbp2
|
APN |
10 |
58,314,703 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
IGL01619:Ranbp2
|
APN |
10 |
58,299,900 (GRCm39) |
splice site |
probably null |
|
|
IGL01782:Ranbp2
|
APN |
10 |
58,314,131 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02020:Ranbp2
|
APN |
10 |
58,315,769 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02096:Ranbp2
|
APN |
10 |
58,297,789 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02182:Ranbp2
|
APN |
10 |
58,321,582 (GRCm39) |
nonsense |
probably null |
|
|
IGL02211:Ranbp2
|
APN |
10 |
58,314,064 (GRCm39) |
missense |
probably benign |
|
|
IGL02249:Ranbp2
|
APN |
10 |
58,315,900 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
IGL02268:Ranbp2
|
APN |
10 |
58,329,475 (GRCm39) |
unclassified |
probably benign |
|
|
IGL02421:Ranbp2
|
APN |
10 |
58,316,376 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03080:Ranbp2
|
APN |
10 |
58,312,613 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03119:Ranbp2
|
APN |
10 |
58,287,825 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03206:Ranbp2
|
APN |
10 |
58,301,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03237:Ranbp2
|
APN |
10 |
58,328,783 (GRCm39) |
missense |
probably damaging |
0.98 |
|
En_passant
|
UTSW |
10 |
58,287,839 (GRCm39) |
missense |
probably damaging |
1.00 |
|
red_river
|
UTSW |
10 |
58,301,489 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02799:Ranbp2
|
UTSW |
10 |
58,316,086 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0058:Ranbp2
|
UTSW |
10 |
58,316,353 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0058:Ranbp2
|
UTSW |
10 |
58,316,353 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0145:Ranbp2
|
UTSW |
10 |
58,315,868 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0375:Ranbp2
|
UTSW |
10 |
58,313,105 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0441:Ranbp2
|
UTSW |
10 |
58,321,590 (GRCm39) |
missense |
probably benign |
0.40 |
|
R0494:Ranbp2
|
UTSW |
10 |
58,303,254 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R0542:Ranbp2
|
UTSW |
10 |
58,314,236 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0565:Ranbp2
|
UTSW |
10 |
58,312,158 (GRCm39) |
missense |
probably benign |
0.41 |
|
R0608:Ranbp2
|
UTSW |
10 |
58,329,720 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0661:Ranbp2
|
UTSW |
10 |
58,314,555 (GRCm39) |
missense |
probably benign |
|
|
R0670:Ranbp2
|
UTSW |
10 |
58,316,520 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0760:Ranbp2
|
UTSW |
10 |
58,312,613 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R0811:Ranbp2
|
UTSW |
10 |
58,301,351 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0812:Ranbp2
|
UTSW |
10 |
58,301,351 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1180:Ranbp2
|
UTSW |
10 |
58,301,285 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1196:Ranbp2
|
UTSW |
10 |
58,312,875 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1216:Ranbp2
|
UTSW |
10 |
58,319,034 (GRCm39) |
splice site |
probably benign |
|
|
R1374:Ranbp2
|
UTSW |
10 |
58,321,715 (GRCm39) |
splice site |
probably benign |
|
|
R1541:Ranbp2
|
UTSW |
10 |
58,318,916 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R1589:Ranbp2
|
UTSW |
10 |
58,299,808 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1711:Ranbp2
|
UTSW |
10 |
58,296,341 (GRCm39) |
missense |
probably benign |
0.11 |
|
R1761:Ranbp2
|
UTSW |
10 |
58,321,563 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1831:Ranbp2
|
UTSW |
10 |
58,315,044 (GRCm39) |
nonsense |
probably null |
|
|
R1840:Ranbp2
|
UTSW |
10 |
58,314,588 (GRCm39) |
missense |
probably benign |
0.41 |
|
R1869:Ranbp2
|
UTSW |
10 |
58,328,383 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1871:Ranbp2
|
UTSW |
10 |
58,328,383 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1892:Ranbp2
|
UTSW |
10 |
58,299,921 (GRCm39) |
missense |
probably benign |
0.36 |
|
R2270:Ranbp2
|
UTSW |
10 |
58,291,749 (GRCm39) |
missense |
probably benign |
0.06 |
|
R2363:Ranbp2
|
UTSW |
10 |
58,314,758 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R3844:Ranbp2
|
UTSW |
10 |
58,313,717 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R3937:Ranbp2
|
UTSW |
10 |
58,312,294 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3938:Ranbp2
|
UTSW |
10 |
58,312,294 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4025:Ranbp2
|
UTSW |
10 |
58,316,378 (GRCm39) |
missense |
probably benign |
0.23 |
|
R4183:Ranbp2
|
UTSW |
10 |
58,301,488 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R4247:Ranbp2
|
UTSW |
10 |
58,314,686 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R4334:Ranbp2
|
UTSW |
10 |
58,299,816 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4656:Ranbp2
|
UTSW |
10 |
58,289,244 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R4746:Ranbp2
|
UTSW |
10 |
58,328,492 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4852:Ranbp2
|
UTSW |
10 |
58,312,878 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R4863:Ranbp2
|
UTSW |
10 |
58,328,243 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5011:Ranbp2
|
UTSW |
10 |
58,297,717 (GRCm39) |
missense |
probably benign |
0.36 |
|
R5014:Ranbp2
|
UTSW |
10 |
58,299,942 (GRCm39) |
missense |
probably benign |
0.40 |
|
R5145:Ranbp2
|
UTSW |
10 |
58,315,860 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5178:Ranbp2
|
UTSW |
10 |
58,312,607 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5199:Ranbp2
|
UTSW |
10 |
58,300,265 (GRCm39) |
missense |
probably benign |
|
|
R5294:Ranbp2
|
UTSW |
10 |
58,314,490 (GRCm39) |
missense |
probably benign |
0.23 |
|
R5508:Ranbp2
|
UTSW |
10 |
58,315,827 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5511:Ranbp2
|
UTSW |
10 |
58,329,561 (GRCm39) |
missense |
probably benign |
0.29 |
|
R5575:Ranbp2
|
UTSW |
10 |
58,328,405 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5617:Ranbp2
|
UTSW |
10 |
58,301,489 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5630:Ranbp2
|
UTSW |
10 |
58,314,898 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5733:Ranbp2
|
UTSW |
10 |
58,321,658 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5751:Ranbp2
|
UTSW |
10 |
58,300,086 (GRCm39) |
splice site |
probably null |
|
|
R5767:Ranbp2
|
UTSW |
10 |
58,312,647 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6122:Ranbp2
|
UTSW |
10 |
58,301,351 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6147:Ranbp2
|
UTSW |
10 |
58,315,250 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6286:Ranbp2
|
UTSW |
10 |
58,315,394 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6344:Ranbp2
|
UTSW |
10 |
58,319,708 (GRCm39) |
splice site |
probably null |
|
|
R6452:Ranbp2
|
UTSW |
10 |
58,313,979 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6487:Ranbp2
|
UTSW |
10 |
58,321,563 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6620:Ranbp2
|
UTSW |
10 |
58,291,629 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R6759:Ranbp2
|
UTSW |
10 |
58,293,559 (GRCm39) |
nonsense |
probably null |
|
|
R7010:Ranbp2
|
UTSW |
10 |
58,290,393 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R7071:Ranbp2
|
UTSW |
10 |
58,328,659 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7083:Ranbp2
|
UTSW |
10 |
58,315,052 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7088:Ranbp2
|
UTSW |
10 |
58,299,728 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7102:Ranbp2
|
UTSW |
10 |
58,299,772 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7194:Ranbp2
|
UTSW |
10 |
58,312,591 (GRCm39) |
missense |
probably benign |
0.05 |
|
R7217:Ranbp2
|
UTSW |
10 |
58,287,839 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7318:Ranbp2
|
UTSW |
10 |
58,318,909 (GRCm39) |
nonsense |
probably null |
|
|
R7341:Ranbp2
|
UTSW |
10 |
58,321,619 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R7398:Ranbp2
|
UTSW |
10 |
58,303,099 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7424:Ranbp2
|
UTSW |
10 |
58,315,016 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7727:Ranbp2
|
UTSW |
10 |
58,291,260 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7795:Ranbp2
|
UTSW |
10 |
58,319,729 (GRCm39) |
nonsense |
probably null |
|
|
R7812:Ranbp2
|
UTSW |
10 |
58,303,224 (GRCm39) |
missense |
probably benign |
|
|
R7845:Ranbp2
|
UTSW |
10 |
58,282,844 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7875:Ranbp2
|
UTSW |
10 |
58,314,277 (GRCm39) |
nonsense |
probably null |
|
|
R7934:Ranbp2
|
UTSW |
10 |
58,312,297 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8022:Ranbp2
|
UTSW |
10 |
58,321,683 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R8050:Ranbp2
|
UTSW |
10 |
58,315,441 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8100:Ranbp2
|
UTSW |
10 |
58,326,470 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R8194:Ranbp2
|
UTSW |
10 |
58,291,747 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R8258:Ranbp2
|
UTSW |
10 |
58,291,755 (GRCm39) |
missense |
probably benign |
0.04 |
|
R8259:Ranbp2
|
UTSW |
10 |
58,291,755 (GRCm39) |
missense |
probably benign |
0.04 |
|
R8461:Ranbp2
|
UTSW |
10 |
58,312,216 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8722:Ranbp2
|
UTSW |
10 |
58,312,049 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8755:Ranbp2
|
UTSW |
10 |
58,300,969 (GRCm39) |
nonsense |
probably null |
|
|
R8794:Ranbp2
|
UTSW |
10 |
58,328,414 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8879:Ranbp2
|
UTSW |
10 |
58,313,711 (GRCm39) |
missense |
probably benign |
0.10 |
|
R8994:Ranbp2
|
UTSW |
10 |
58,315,891 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R9023:Ranbp2
|
UTSW |
10 |
58,315,343 (GRCm39) |
nonsense |
probably null |
|
|
R9124:Ranbp2
|
UTSW |
10 |
58,328,719 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9133:Ranbp2
|
UTSW |
10 |
58,313,050 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9145:Ranbp2
|
UTSW |
10 |
58,291,736 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9190:Ranbp2
|
UTSW |
10 |
58,313,117 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9369:Ranbp2
|
UTSW |
10 |
58,316,486 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9394:Ranbp2
|
UTSW |
10 |
58,291,698 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9642:Ranbp2
|
UTSW |
10 |
58,318,907 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9673:Ranbp2
|
UTSW |
10 |
58,300,963 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0018:Ranbp2
|
UTSW |
10 |
58,314,406 (GRCm39) |
missense |
probably benign |
0.13 |
|
X0022:Ranbp2
|
UTSW |
10 |
58,300,977 (GRCm39) |
missense |
probably benign |
0.33 |
|
Z1088:Ranbp2
|
UTSW |
10 |
58,328,715 (GRCm39) |
missense |
probably benign |
0.35 |
|
Z1088:Ranbp2
|
UTSW |
10 |
58,313,805 (GRCm39) |
frame shift |
probably null |
|
|
Z1088:Ranbp2
|
UTSW |
10 |
58,313,794 (GRCm39) |
frame shift |
probably null |
|
|
Z1176:Ranbp2
|
UTSW |
10 |
58,297,708 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Ranbp2
|
UTSW |
10 |
58,329,713 (GRCm39) |
nonsense |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- GCAGCAGCTCAGTTCATGCTTCTC -3'
(R):5'- CCCTTCTCATCACGATGCGAACTTG -3'
Sequencing Primer
(F):5'- GCTTCTCCATTGGCAAGCAG -3'
(R):5'- CACGATGCGAACTTGTTTATTATC -3'
|
| Posted On |
2013-04-16 |
Incidental Mutation