Incidental Mutation 'R2696:Slc2a5'
ID 251026
Institutional Source Beutler Lab
Gene Symbol Slc2a5
Ensembl Gene ENSMUSG00000028976
Gene Name solute carrier family 2 (facilitated glucose transporter), member 5
Synonyms GLUT5
MMRRC Submission 040434-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.080) question?
Stock # R2696 (G1)
Quality Score 83
Status Not validated
Chromosome 4
Chromosomal Location 150203801-150228625 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 150205203 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Threonine at position 4 (K4T)
Ref Sequence ENSEMBL: ENSMUSP00000030826 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000030826]
AlphaFold Q9WV38
Predicted Effect probably benign
Transcript: ENSMUST00000030826
AA Change: K4T

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000030826
Gene: ENSMUSG00000028976
AA Change: K4T

DomainStartEndE-ValueType
Pfam:MFS_1 16 397 1e-19 PFAM
Pfam:Sugar_tr 19 474 2.1e-138 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000126212
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.0%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a fructose transporter responsible for fructose uptake by the small intestine. The encoded protein also is necessary for the increase in blood pressure due to high dietary fructose consumption. [provided by RefSeq, Jun 2016]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit normal cochlear morphology and physiology with no detectable alterations in outer hair cell morphology, electromotility or nonlinear capacitance. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930562C15Rik A T 16: 4,668,228 (GRCm39) T540S probably benign Het
Acp7 G T 7: 28,314,001 (GRCm39) H369Q probably benign Het
Adgrg3 A G 8: 95,747,702 (GRCm39) N65S probably benign Het
Anln A G 9: 22,272,259 (GRCm39) V620A probably benign Het
Atp10a T A 7: 58,463,366 (GRCm39) S966R probably benign Het
Atp8b3 T A 10: 80,370,017 (GRCm39) Q132L possibly damaging Het
Col4a1 T A 8: 11,285,092 (GRCm39) probably null Het
Ddx21 T C 10: 62,429,871 (GRCm39) H291R possibly damaging Het
Dlgap3 A G 4: 127,088,416 (GRCm39) Y4C probably damaging Het
Dnah5 A G 15: 28,278,722 (GRCm39) N1106D probably benign Het
Esyt1 T C 10: 128,352,914 (GRCm39) D662G probably damaging Het
F830016B08Rik T A 18: 60,433,808 (GRCm39) V297E possibly damaging Het
Faf1 T A 4: 109,698,525 (GRCm39) N328K possibly damaging Het
Gdf3 A C 6: 122,583,859 (GRCm39) F169L probably benign Het
Ifi213 G A 1: 173,417,590 (GRCm39) T274I probably benign Het
Igf2r T C 17: 12,914,231 (GRCm39) D1746G possibly damaging Het
Ighv1-75 T C 12: 115,797,826 (GRCm39) K32R probably benign Het
Ipo8 T A 6: 148,698,239 (GRCm39) Q594L probably benign Het
Krt87 A T 15: 101,384,890 (GRCm39) I402N probably benign Het
Med18 G A 4: 132,187,281 (GRCm39) R118W probably damaging Het
Mmrn2 A G 14: 34,120,372 (GRCm39) E414G probably damaging Het
Myo6 A G 9: 80,168,176 (GRCm39) T447A probably benign Het
Ncoa6 T C 2: 155,279,935 (GRCm39) E27G probably benign Het
Ngly1 T C 14: 16,283,439 (GRCm38) L406S possibly damaging Het
Or14j1 T C 17: 38,145,998 (GRCm39) I36T probably benign Het
Or51l4 A G 7: 103,404,735 (GRCm39) I19T probably damaging Het
Phldb1 T C 9: 44,629,585 (GRCm39) Y156C probably damaging Het
Pkd2l1 T A 19: 44,145,708 (GRCm39) T172S probably benign Het
Pknox2 G A 9: 36,820,987 (GRCm39) R292* probably null Het
Plod3 G C 5: 137,017,000 (GRCm39) A50P probably benign Het
Polr3e T C 7: 120,532,600 (GRCm39) L212P probably damaging Het
Ppp4r4 A G 12: 103,547,653 (GRCm39) I215M possibly damaging Het
Psmg2 T C 18: 67,781,288 (GRCm39) Y127H possibly damaging Het
Ptch1 T G 13: 63,672,773 (GRCm39) E944A probably benign Het
Ptp4a1 A T 1: 30,985,213 (GRCm39) M4K probably benign Het
R3hcc1l A T 19: 42,552,427 (GRCm39) I475L possibly damaging Het
Rbp3 C T 14: 33,677,975 (GRCm39) T641M probably damaging Het
Rsf1 GGC GGCGGCGGCGGC 7: 97,229,140 (GRCm39) probably benign Het
Sec63 T A 10: 42,659,522 (GRCm39) I70N probably benign Het
Slc4a3 A G 1: 75,532,119 (GRCm39) Y939C possibly damaging Het
Slc7a15 T C 12: 8,579,345 (GRCm39) *229W probably null Het
Slco1a6 C A 6: 142,058,662 (GRCm39) G206C probably damaging Het
Spata9 A G 13: 76,125,895 (GRCm39) Q126R probably benign Het
Speg A T 1: 75,383,570 (GRCm39) D1186V probably benign Het
Spink5 T G 18: 44,115,359 (GRCm39) M197R probably damaging Het
Stab2 T C 10: 86,697,363 (GRCm39) D1975G probably benign Het
Syngap1 T A 17: 27,176,385 (GRCm39) C224* probably null Het
Ttn T C 2: 76,698,807 (GRCm39) probably benign Het
Txnrd1 G A 10: 82,721,116 (GRCm39) E397K probably benign Het
Ugt2b36 A T 5: 87,237,344 (GRCm39) M313K probably damaging Het
Ulk3 A G 9: 57,497,724 (GRCm39) I74V possibly damaging Het
Zcchc4 T C 5: 52,953,573 (GRCm39) V194A probably damaging Het
Zfp27 C T 7: 29,595,792 (GRCm39) A58T possibly damaging Het
Zfp398 T G 6: 47,843,879 (GRCm39) *512E probably null Het
Other mutations in Slc2a5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00819:Slc2a5 APN 4 150,210,113 (GRCm39) missense probably damaging 1.00
IGL01071:Slc2a5 APN 4 150,205,190 (GRCm39) utr 5 prime probably benign
IGL01977:Slc2a5 APN 4 150,226,675 (GRCm39) missense probably damaging 0.97
IGL03271:Slc2a5 APN 4 150,220,040 (GRCm39) missense probably damaging 1.00
BB006:Slc2a5 UTSW 4 150,223,942 (GRCm39) missense probably benign 0.39
BB016:Slc2a5 UTSW 4 150,223,942 (GRCm39) missense probably benign 0.39
R0760:Slc2a5 UTSW 4 150,224,124 (GRCm39) missense probably benign
R0906:Slc2a5 UTSW 4 150,227,287 (GRCm39) missense probably benign 0.21
R1099:Slc2a5 UTSW 4 150,226,636 (GRCm39) missense probably benign 0.01
R1809:Slc2a5 UTSW 4 150,227,514 (GRCm39) missense probably damaging 1.00
R2099:Slc2a5 UTSW 4 150,227,634 (GRCm39) nonsense probably null
R2152:Slc2a5 UTSW 4 150,210,095 (GRCm39) missense probably damaging 1.00
R2253:Slc2a5 UTSW 4 150,224,447 (GRCm39) missense possibly damaging 0.78
R4835:Slc2a5 UTSW 4 150,224,462 (GRCm39) missense probably benign 0.06
R4926:Slc2a5 UTSW 4 150,205,199 (GRCm39) nonsense probably null
R5123:Slc2a5 UTSW 4 150,224,262 (GRCm39) nonsense probably null
R5397:Slc2a5 UTSW 4 150,224,280 (GRCm39) splice site probably null
R6209:Slc2a5 UTSW 4 150,227,557 (GRCm39) missense probably benign 0.00
R6342:Slc2a5 UTSW 4 150,223,983 (GRCm39) missense possibly damaging 0.93
R6547:Slc2a5 UTSW 4 150,220,076 (GRCm39) missense possibly damaging 0.94
R7340:Slc2a5 UTSW 4 150,224,439 (GRCm39) missense probably benign 0.44
R7507:Slc2a5 UTSW 4 150,210,107 (GRCm39) missense probably damaging 1.00
R7537:Slc2a5 UTSW 4 150,213,526 (GRCm39) missense possibly damaging 0.89
R7572:Slc2a5 UTSW 4 150,226,642 (GRCm39) missense probably benign 0.33
R7751:Slc2a5 UTSW 4 150,227,591 (GRCm39) missense probably damaging 1.00
R7929:Slc2a5 UTSW 4 150,223,942 (GRCm39) missense probably benign 0.39
R8058:Slc2a5 UTSW 4 150,227,590 (GRCm39) missense probably damaging 1.00
R8318:Slc2a5 UTSW 4 150,224,115 (GRCm39) missense possibly damaging 0.90
R8477:Slc2a5 UTSW 4 150,210,119 (GRCm39) missense probably benign 0.09
R8498:Slc2a5 UTSW 4 150,210,590 (GRCm39) missense probably benign 0.01
R8975:Slc2a5 UTSW 4 150,224,270 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CTGAGTCCACAGTTTCAGGG -3'
(R):5'- CTTCTGAGCAAACTGCCCTC -3'

Sequencing Primer
(F):5'- GCTTAGCCAAACTCTACATGTTTAAC -3'
(R):5'- TGAGCAAACTGCCCTCTTCCAG -3'
Posted On 2014-12-04