Incidental Mutation 'R2698:Vmn2r66'
ID 251325
Institutional Source Beutler Lab
Gene Symbol Vmn2r66
Ensembl Gene ENSMUSG00000094950
Gene Name vomeronasal 2, receptor 66
Synonyms F830104D24Rik
MMRRC Submission 040436-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.079) question?
Stock # R2698 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 84643853-84661228 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 84644607 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Aspartic acid at position 601 (V601D)
Ref Sequence ENSEMBL: ENSMUSP00000122645 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000124773]
AlphaFold A0A3B2W842
Predicted Effect probably damaging
Transcript: ENSMUST00000124773
AA Change: V601D

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000122645
Gene: ENSMUSG00000094950
AA Change: V601D

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:ANF_receptor 77 463 5e-31 PFAM
Pfam:NCD3G 507 559 6e-21 PFAM
Pfam:7tm_3 589 827 3.8e-52 PFAM
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.6%
Validation Efficiency 100% (63/63)
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc9 T C 6: 142,578,862 (GRCm39) R901G possibly damaging Het
Abhd18 T A 3: 40,885,401 (GRCm39) M262K probably benign Het
Ano2 C A 6: 125,689,309 (GRCm39) L145I probably benign Het
Ckap5 T C 2: 91,408,426 (GRCm39) W874R probably damaging Het
Cox4i1 G T 8: 121,396,102 (GRCm39) probably benign Het
Cwc27 A T 13: 104,943,259 (GRCm39) N94K probably damaging Het
Dcaf11 T C 14: 55,804,342 (GRCm39) S372P probably damaging Het
Dpysl4 A G 7: 138,676,681 (GRCm39) N356S probably damaging Het
Dusp8 A G 7: 141,635,701 (GRCm39) probably benign Het
Erc2 G A 14: 27,993,662 (GRCm39) V894M probably benign Het
Fbxo28 T A 1: 182,144,719 (GRCm39) I282F probably benign Het
Fsd2 T C 7: 81,195,608 (GRCm39) T434A probably damaging Het
Gabra4 T C 5: 71,729,421 (GRCm39) H453R probably benign Het
Glrx T A 13: 75,988,065 (GRCm39) probably null Het
Gm11541 A T 11: 94,586,441 (GRCm39) L102* probably null Het
Gm5113 T A 7: 29,878,150 (GRCm39) Y79* probably null Het
Gpr87 T A 3: 59,086,587 (GRCm39) N306I probably damaging Het
Hydin T A 8: 111,336,561 (GRCm39) Y5113N possibly damaging Het
Iqsec3 C T 6: 121,390,430 (GRCm39) probably benign Het
Kbtbd8 C A 6: 95,103,570 (GRCm39) Y406* probably null Het
Lamb1 G T 12: 31,348,882 (GRCm39) R590L probably benign Het
Lin54 A T 5: 100,628,109 (GRCm39) N31K probably damaging Het
Lnpk T C 2: 74,367,845 (GRCm39) E165G probably damaging Het
Lrp4 C T 2: 91,305,557 (GRCm39) R276C probably damaging Het
Lrrc7 T A 3: 157,841,028 (GRCm39) T1384S probably benign Het
Mia2 T C 12: 59,217,780 (GRCm39) probably null Het
Morc2a T C 11: 3,635,400 (GRCm39) V797A probably damaging Het
Mrps23 T C 11: 88,096,193 (GRCm39) probably benign Het
Muc17 A T 5: 137,175,484 (GRCm39) I62K probably damaging Het
Nlrp4g T A 9: 124,349,630 (GRCm38) noncoding transcript Het
Nptx1 A T 11: 119,435,669 (GRCm39) probably benign Het
Or1j20 T A 2: 36,760,208 (GRCm39) I210K possibly damaging Het
Pabpc1l T G 2: 163,886,302 (GRCm39) probably null Het
Pdcd6ip A T 9: 113,503,575 (GRCm39) probably null Het
Plcg1 A G 2: 160,603,383 (GRCm39) T1185A possibly damaging Het
Plcxd1 A G 5: 110,250,349 (GRCm39) Q230R probably benign Het
Psme4 T A 11: 30,824,282 (GRCm39) probably null Het
Ptch1 T G 13: 63,672,773 (GRCm39) E944A probably benign Het
Ptch1 T A 13: 63,690,038 (GRCm39) N320Y probably damaging Het
Qars1 G A 9: 108,385,642 (GRCm39) V60I possibly damaging Het
Rbp3 C T 14: 33,677,975 (GRCm39) T641M probably damaging Het
Rhag T C 17: 41,147,367 (GRCm39) S410P probably damaging Het
Rnf213 A G 11: 119,300,970 (GRCm39) K297E probably benign Het
Rps6ka4 T C 19: 6,814,720 (GRCm39) E294G probably benign Het
Scaf4 T A 16: 90,041,244 (GRCm39) I695F unknown Het
Scrn2 T C 11: 96,923,122 (GRCm39) probably benign Het
Scx T A 15: 76,342,363 (GRCm39) C188S probably damaging Het
Sdk1 G T 5: 142,197,805 (GRCm39) V1893L possibly damaging Het
Sema5a C A 15: 32,673,546 (GRCm39) Q795K probably damaging Het
Slc24a3 A G 2: 145,455,487 (GRCm39) S459G probably benign Het
Smurf1 A G 5: 144,820,372 (GRCm39) probably benign Het
Taar4 T C 10: 23,837,328 (GRCm39) Y313H probably damaging Het
Tmprss11c A G 5: 86,419,322 (GRCm39) F79S probably damaging Het
Tnfaip8l2 T A 3: 95,047,672 (GRCm39) I64F possibly damaging Het
Trbv13-1 A G 6: 41,093,372 (GRCm39) T102A probably damaging Het
Trpa1 A T 1: 14,976,222 (GRCm39) N160K probably damaging Het
Ttc22 A G 4: 106,496,435 (GRCm39) Y495C probably benign Het
Usp50 A G 2: 126,619,949 (GRCm39) I121T probably damaging Het
Vmn2r117 A G 17: 23,678,885 (GRCm39) S780P probably damaging Het
Wapl G A 14: 34,413,734 (GRCm39) A199T probably benign Het
Zfp658 A G 7: 43,222,969 (GRCm39) T415A possibly damaging Het
Zfp760 C T 17: 21,939,935 (GRCm39) T9I probably damaging Het
Zfp998 A G 13: 66,581,495 (GRCm39) S59P probably damaging Het
Other mutations in Vmn2r66
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00321:Vmn2r66 APN 7 84,656,299 (GRCm39) missense probably benign
IGL01562:Vmn2r66 APN 7 84,656,495 (GRCm39) missense probably benign 0.03
IGL01689:Vmn2r66 APN 7 84,657,033 (GRCm39) missense probably damaging 1.00
IGL02237:Vmn2r66 APN 7 84,643,908 (GRCm39) missense probably benign
IGL02415:Vmn2r66 APN 7 84,656,020 (GRCm39) missense probably damaging 0.97
IGL02439:Vmn2r66 APN 7 84,654,455 (GRCm39) splice site probably benign
IGL02545:Vmn2r66 APN 7 84,655,798 (GRCm39) missense possibly damaging 0.50
IGL02708:Vmn2r66 APN 7 84,655,796 (GRCm39) missense probably benign 0.00
IGL02794:Vmn2r66 APN 7 84,644,623 (GRCm39) missense probably benign 0.00
IGL02885:Vmn2r66 APN 7 84,644,723 (GRCm39) missense probably benign 0.00
IGL02975:Vmn2r66 APN 7 84,656,182 (GRCm39) missense probably damaging 0.98
IGL03027:Vmn2r66 APN 7 84,644,777 (GRCm39) splice site probably benign
IGL03081:Vmn2r66 APN 7 84,657,138 (GRCm39) missense probably benign
PIT4131001:Vmn2r66 UTSW 7 84,644,301 (GRCm39) missense probably damaging 1.00
R0098:Vmn2r66 UTSW 7 84,654,965 (GRCm39) missense probably damaging 1.00
R0504:Vmn2r66 UTSW 7 84,656,023 (GRCm39) missense probably damaging 0.99
R0557:Vmn2r66 UTSW 7 84,643,972 (GRCm39) missense probably damaging 1.00
R0617:Vmn2r66 UTSW 7 84,644,484 (GRCm39) missense probably benign 0.02
R0883:Vmn2r66 UTSW 7 84,657,070 (GRCm39) missense probably benign
R1159:Vmn2r66 UTSW 7 84,644,613 (GRCm39) missense probably benign 0.44
R1168:Vmn2r66 UTSW 7 84,656,062 (GRCm39) missense possibly damaging 0.46
R1172:Vmn2r66 UTSW 7 84,654,799 (GRCm39) missense probably benign 0.04
R1175:Vmn2r66 UTSW 7 84,654,799 (GRCm39) missense probably benign 0.04
R1538:Vmn2r66 UTSW 7 84,644,166 (GRCm39) missense possibly damaging 0.84
R1658:Vmn2r66 UTSW 7 84,656,955 (GRCm39) missense probably benign 0.07
R1937:Vmn2r66 UTSW 7 84,644,344 (GRCm39) missense probably damaging 0.99
R1989:Vmn2r66 UTSW 7 84,661,201 (GRCm39) missense probably benign 0.01
R2890:Vmn2r66 UTSW 7 84,661,027 (GRCm39) splice site probably null
R3686:Vmn2r66 UTSW 7 84,644,397 (GRCm39) missense probably damaging 0.96
R4152:Vmn2r66 UTSW 7 84,654,800 (GRCm39) missense probably benign 0.08
R4500:Vmn2r66 UTSW 7 84,657,162 (GRCm39) missense probably damaging 1.00
R4618:Vmn2r66 UTSW 7 84,644,296 (GRCm39) missense possibly damaging 0.62
R4656:Vmn2r66 UTSW 7 84,661,204 (GRCm39) missense possibly damaging 0.87
R4668:Vmn2r66 UTSW 7 84,643,905 (GRCm39) missense probably damaging 1.00
R4942:Vmn2r66 UTSW 7 84,656,980 (GRCm39) missense probably damaging 1.00
R5163:Vmn2r66 UTSW 7 84,656,017 (GRCm39) missense probably benign 0.01
R5223:Vmn2r66 UTSW 7 84,657,093 (GRCm39) missense probably benign
R5377:Vmn2r66 UTSW 7 84,656,026 (GRCm39) missense probably damaging 0.99
R5512:Vmn2r66 UTSW 7 84,657,149 (GRCm39) missense probably damaging 1.00
R5611:Vmn2r66 UTSW 7 84,654,951 (GRCm39) nonsense probably null
R5749:Vmn2r66 UTSW 7 84,655,979 (GRCm39) nonsense probably null
R6131:Vmn2r66 UTSW 7 84,644,224 (GRCm39) missense probably damaging 1.00
R6183:Vmn2r66 UTSW 7 84,644,766 (GRCm39) missense possibly damaging 0.81
R6509:Vmn2r66 UTSW 7 84,656,054 (GRCm39) missense probably benign 0.12
R6930:Vmn2r66 UTSW 7 84,661,216 (GRCm39) missense possibly damaging 0.80
R6992:Vmn2r66 UTSW 7 84,654,436 (GRCm39) missense possibly damaging 0.90
R7015:Vmn2r66 UTSW 7 84,644,766 (GRCm39) missense possibly damaging 0.81
R7302:Vmn2r66 UTSW 7 84,654,423 (GRCm39) missense probably benign 0.00
R7516:Vmn2r66 UTSW 7 84,661,176 (GRCm39) missense possibly damaging 0.51
R7763:Vmn2r66 UTSW 7 84,654,909 (GRCm39) missense probably benign 0.01
R7814:Vmn2r66 UTSW 7 84,656,472 (GRCm39) missense probably benign 0.02
R8077:Vmn2r66 UTSW 7 84,656,093 (GRCm39) missense probably benign
R8307:Vmn2r66 UTSW 7 84,656,270 (GRCm39) missense probably benign
R8315:Vmn2r66 UTSW 7 84,643,932 (GRCm39) missense possibly damaging 0.90
R8490:Vmn2r66 UTSW 7 84,654,794 (GRCm39) critical splice donor site probably null
R8511:Vmn2r66 UTSW 7 84,656,026 (GRCm39) missense probably damaging 0.99
R8781:Vmn2r66 UTSW 7 84,644,355 (GRCm39) nonsense probably null
R8812:Vmn2r66 UTSW 7 84,654,893 (GRCm39) missense probably damaging 0.99
R9203:Vmn2r66 UTSW 7 84,654,950 (GRCm39) missense probably benign 0.01
R9277:Vmn2r66 UTSW 7 84,661,164 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- GCCTTGAATGCCAATACTACAG -3'
(R):5'- TCTGTACTAGACATGGATCAGTGTG -3'

Sequencing Primer
(F):5'- TTGTCTTAGCCAAGATAGTAGAGGC -3'
(R):5'- ACATGGATCAGTGTGTGAAGTGTCC -3'
Posted On 2014-12-04