Incidental Mutation 'R2844:Zfp84'
ID |
251426 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Zfp84
|
Ensembl Gene |
ENSMUSG00000046185 |
Gene Name |
zinc finger protein 84 |
Synonyms |
KRAB18, C86188, Zfp69, 2210410P13Rik, 4633401C23Rik |
MMRRC Submission |
040437-MU
|
Accession Numbers |
|
Essential gene? |
Non essential
(E-score: 0.000)
|
Stock # |
R2844 (G1)
|
Quality Score |
225 |
Status
|
Validated
|
Chromosome |
7 |
Chromosomal Location |
29467977-29479246 bp(+) (GRCm39) |
Type of Mutation |
splice site |
DNA Base Change (assembly) |
T to G
at 29474758 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
|
Ref Sequence |
ENSEMBL: ENSMUSP00000032802
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000032802]
|
AlphaFold |
Q9D654 |
Predicted Effect |
probably null
Transcript: ENSMUST00000032802
|
SMART Domains |
Protein: ENSMUSP00000032802 Gene: ENSMUSG00000046185
Domain | Start | End | E-Value | Type |
KRAB
|
14 |
74 |
9.09e-36 |
SMART |
ZnF_C2H2
|
249 |
271 |
1.67e-2 |
SMART |
ZnF_C2H2
|
277 |
299 |
1.43e-1 |
SMART |
ZnF_C2H2
|
305 |
327 |
5.81e-2 |
SMART |
ZnF_C2H2
|
333 |
355 |
1.95e-3 |
SMART |
ZnF_C2H2
|
361 |
383 |
8.6e-5 |
SMART |
ZnF_C2H2
|
389 |
411 |
2.32e-1 |
SMART |
ZnF_C2H2
|
417 |
439 |
3.89e-3 |
SMART |
ZnF_C2H2
|
445 |
467 |
1.69e-3 |
SMART |
ZnF_C2H2
|
473 |
495 |
9.58e-3 |
SMART |
ZnF_C2H2
|
501 |
523 |
1.38e-3 |
SMART |
ZnF_C2H2
|
529 |
551 |
1.58e-3 |
SMART |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000158514
|
Meta Mutation Damage Score |
0.9755 |
Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.2%
- 20x: 94.8%
|
Validation Efficiency |
98% (42/43) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 40 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Aadacl2fm1 |
G |
A |
3: 59,843,830 (GRCm39) |
V175I |
probably benign |
Het |
Abcb1a |
A |
T |
5: 8,736,164 (GRCm39) |
I186F |
probably benign |
Het |
Afg3l1 |
T |
C |
8: 124,221,678 (GRCm39) |
|
probably benign |
Het |
Atg4a |
G |
A |
X: 139,893,589 (GRCm39) |
E106K |
probably benign |
Het |
Ccdc50 |
A |
G |
16: 27,225,479 (GRCm39) |
E64G |
probably damaging |
Het |
Celsr3 |
G |
T |
9: 108,706,507 (GRCm39) |
G997W |
probably damaging |
Het |
Chd8 |
C |
T |
14: 52,441,952 (GRCm39) |
E2138K |
possibly damaging |
Het |
Col19a1 |
C |
T |
1: 24,598,762 (GRCm39) |
G77E |
unknown |
Het |
Dnaaf11 |
A |
G |
15: 66,319,525 (GRCm39) |
|
probably benign |
Het |
Fhad1 |
G |
T |
4: 141,632,279 (GRCm39) |
Q1287K |
probably benign |
Het |
Fzr1 |
G |
T |
10: 81,205,252 (GRCm39) |
T159K |
probably damaging |
Het |
Gm10608 |
CAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGA |
CAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGA |
9: 118,989,784 (GRCm39) |
|
probably null |
Het |
Gna13 |
T |
C |
11: 109,253,951 (GRCm39) |
I51T |
probably damaging |
Het |
Gorab |
A |
G |
1: 163,224,375 (GRCm39) |
|
probably null |
Het |
Hydin |
T |
C |
8: 111,245,746 (GRCm39) |
V2153A |
probably benign |
Het |
Ints6 |
A |
G |
14: 62,942,275 (GRCm39) |
V486A |
probably damaging |
Het |
Irx2 |
A |
G |
13: 72,779,709 (GRCm39) |
K331R |
probably damaging |
Het |
Mark2 |
T |
C |
19: 7,264,227 (GRCm39) |
E116G |
probably damaging |
Het |
Med14 |
A |
T |
X: 12,550,235 (GRCm39) |
H684Q |
probably benign |
Het |
Or1e25 |
A |
T |
11: 73,494,209 (GRCm39) |
T268S |
probably benign |
Het |
Pde5a |
T |
C |
3: 122,645,357 (GRCm39) |
L755P |
probably damaging |
Het |
Pex14 |
A |
T |
4: 149,047,968 (GRCm39) |
I203N |
probably benign |
Het |
Pi4ka |
T |
C |
16: 17,168,657 (GRCm39) |
E691G |
probably damaging |
Het |
Plekha1 |
G |
T |
7: 130,510,095 (GRCm39) |
W280C |
probably damaging |
Het |
Pnoc |
A |
T |
14: 65,642,284 (GRCm39) |
F160I |
probably damaging |
Het |
Ppfia3 |
C |
A |
7: 45,005,852 (GRCm39) |
R348L |
probably damaging |
Het |
Ppil6 |
A |
T |
10: 41,377,689 (GRCm39) |
|
probably benign |
Het |
Psmd13 |
C |
A |
7: 140,477,653 (GRCm39) |
|
probably benign |
Het |
Psme4 |
T |
C |
11: 30,795,173 (GRCm39) |
|
probably benign |
Het |
Rfx3 |
T |
C |
19: 27,784,186 (GRCm39) |
|
probably benign |
Het |
Rnase11 |
A |
G |
14: 51,287,227 (GRCm39) |
L109S |
probably damaging |
Het |
Rngtt |
A |
G |
4: 33,368,678 (GRCm39) |
T404A |
probably benign |
Het |
Sbf1 |
A |
G |
15: 89,187,421 (GRCm39) |
|
probably null |
Het |
Sema5b |
A |
G |
16: 35,480,301 (GRCm39) |
N656S |
probably damaging |
Het |
Ssh3 |
T |
C |
19: 4,315,324 (GRCm39) |
Y338C |
probably damaging |
Het |
Tgfbr3l |
A |
G |
8: 4,299,280 (GRCm39) |
D49G |
probably damaging |
Het |
Thbs1 |
C |
T |
2: 117,948,109 (GRCm39) |
T423I |
probably benign |
Het |
Ttc17 |
A |
T |
2: 94,206,419 (GRCm39) |
Y243* |
probably null |
Het |
Zbtb8os |
A |
T |
4: 129,235,309 (GRCm39) |
E54D |
probably damaging |
Het |
Zfp648 |
A |
T |
1: 154,080,881 (GRCm39) |
K347* |
probably null |
Het |
|
Other mutations in Zfp84 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01768:Zfp84
|
APN |
7 |
29,476,091 (GRCm39) |
missense |
probably benign |
0.16 |
IGL03022:Zfp84
|
APN |
7 |
29,474,759 (GRCm39) |
splice site |
probably benign |
|
R0666:Zfp84
|
UTSW |
7 |
29,476,276 (GRCm39) |
missense |
probably damaging |
1.00 |
R0781:Zfp84
|
UTSW |
7 |
29,470,797 (GRCm39) |
start codon destroyed |
probably null |
0.02 |
R1110:Zfp84
|
UTSW |
7 |
29,470,797 (GRCm39) |
start codon destroyed |
probably null |
0.02 |
R1353:Zfp84
|
UTSW |
7 |
29,475,600 (GRCm39) |
missense |
probably benign |
0.02 |
R1495:Zfp84
|
UTSW |
7 |
29,476,728 (GRCm39) |
nonsense |
probably null |
|
R1496:Zfp84
|
UTSW |
7 |
29,476,039 (GRCm39) |
missense |
possibly damaging |
0.53 |
R1681:Zfp84
|
UTSW |
7 |
29,476,825 (GRCm39) |
missense |
probably damaging |
1.00 |
R1827:Zfp84
|
UTSW |
7 |
29,476,768 (GRCm39) |
missense |
possibly damaging |
0.91 |
R1854:Zfp84
|
UTSW |
7 |
29,474,796 (GRCm39) |
missense |
possibly damaging |
0.84 |
R2209:Zfp84
|
UTSW |
7 |
29,476,607 (GRCm39) |
missense |
probably damaging |
0.99 |
R2843:Zfp84
|
UTSW |
7 |
29,474,758 (GRCm39) |
splice site |
probably null |
|
R4691:Zfp84
|
UTSW |
7 |
29,476,505 (GRCm39) |
missense |
probably damaging |
1.00 |
R5453:Zfp84
|
UTSW |
7 |
29,475,722 (GRCm39) |
missense |
possibly damaging |
0.82 |
R5474:Zfp84
|
UTSW |
7 |
29,476,514 (GRCm39) |
missense |
probably damaging |
1.00 |
R5578:Zfp84
|
UTSW |
7 |
29,474,856 (GRCm39) |
missense |
possibly damaging |
0.93 |
R5646:Zfp84
|
UTSW |
7 |
29,475,818 (GRCm39) |
missense |
probably benign |
0.05 |
R5963:Zfp84
|
UTSW |
7 |
29,476,378 (GRCm39) |
missense |
probably damaging |
1.00 |
R6830:Zfp84
|
UTSW |
7 |
29,475,911 (GRCm39) |
missense |
probably benign |
0.00 |
R8129:Zfp84
|
UTSW |
7 |
29,475,862 (GRCm39) |
missense |
probably benign |
0.00 |
R8138:Zfp84
|
UTSW |
7 |
29,474,797 (GRCm39) |
missense |
probably damaging |
0.99 |
R9180:Zfp84
|
UTSW |
7 |
29,474,873 (GRCm39) |
missense |
probably damaging |
0.97 |
R9401:Zfp84
|
UTSW |
7 |
29,476,297 (GRCm39) |
missense |
probably damaging |
1.00 |
R9489:Zfp84
|
UTSW |
7 |
29,476,264 (GRCm39) |
missense |
possibly damaging |
0.89 |
R9555:Zfp84
|
UTSW |
7 |
29,476,102 (GRCm39) |
missense |
probably damaging |
0.99 |
R9605:Zfp84
|
UTSW |
7 |
29,476,264 (GRCm39) |
missense |
possibly damaging |
0.89 |
V3553:Zfp84
|
UTSW |
7 |
29,476,672 (GRCm39) |
missense |
probably benign |
0.36 |
Z1186:Zfp84
|
UTSW |
7 |
29,470,805 (GRCm39) |
missense |
probably damaging |
0.98 |
|
Predicted Primers |
PCR Primer
(F):5'- AGGTCAAGGTCTCAGGCATAC -3'
(R):5'- CATCCCTAGCCCTTACAGAGAG -3'
Sequencing Primer
(F):5'- CCTCATCAGGCTGGAAATCAAGG -3'
(R):5'- CTAGCCCTTACAGAGAGGTACAG -3'
|
Posted On |
2014-12-04 |