Incidental Mutation 'R2508:Mgam'
| ID |
251495 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Mgam
|
| Ensembl Gene |
ENSMUSG00000068587 |
| Gene Name |
maltase-glucoamylase |
| Synonyms |
6030407P20Rik |
| MMRRC Submission |
040414-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.231)
|
| Stock # |
R2508 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
6 |
| Chromosomal Location |
40605765-40746057 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 40736717 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Valine
at position 872
(D872V)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000144680
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000071535]
[ENSMUST00000201148]
[ENSMUST00000202779]
[ENSMUST00000202966]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000071535
AA Change: D1618V
PolyPhen 2
Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000071466
Gene: ENSMUSG00000068587
AA Change: D1618V
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
12 |
34 |
N/A |
INTRINSIC |
|
low complexity region
|
47 |
59 |
N/A |
INTRINSIC |
|
PD
|
63 |
111 |
1.81e-8 |
SMART |
|
Pfam:NtCtMGAM_N
|
124 |
233 |
6.2e-36 |
PFAM |
|
Pfam:Glyco_hydro_31
|
323 |
795 |
3.4e-145 |
PFAM |
|
PD
|
924 |
977 |
4.52e-9 |
SMART |
|
Pfam:NtCtMGAM_N
|
988 |
1101 |
1.5e-30 |
PFAM |
|
Blast:ANK
|
1141 |
1171 |
1e-7 |
BLAST |
|
Pfam:Glyco_hydro_31
|
1189 |
1691 |
2e-139 |
PFAM |
|
low complexity region
|
1776 |
1791 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000201148
AA Change: D1618V
PolyPhen 2
Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000143946
Gene: ENSMUSG00000068587
AA Change: D1618V
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
12 |
34 |
N/A |
INTRINSIC |
|
low complexity region
|
47 |
59 |
N/A |
INTRINSIC |
|
PD
|
63 |
111 |
1.81e-8 |
SMART |
|
Pfam:NtCtMGAM_N
|
124 |
233 |
6.2e-36 |
PFAM |
|
Pfam:Glyco_hydro_31
|
323 |
795 |
3.4e-145 |
PFAM |
|
PD
|
924 |
977 |
4.52e-9 |
SMART |
|
Pfam:NtCtMGAM_N
|
988 |
1101 |
1.5e-30 |
PFAM |
|
Blast:ANK
|
1141 |
1171 |
1e-7 |
BLAST |
|
Pfam:Glyco_hydro_31
|
1189 |
1691 |
2e-139 |
PFAM |
|
low complexity region
|
1776 |
1791 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000202775
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000202779
AA Change: D991V
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000144627
Gene: ENSMUSG00000068587
AA Change: D991V
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Glyco_hydro_31
|
2 |
170 |
1.4e-53 |
PFAM |
|
PD
|
297 |
350 |
1.4e-14 |
SMART |
|
Pfam:NtCtMGAM_N
|
361 |
474 |
1.5e-26 |
PFAM |
|
Blast:ANK
|
514 |
544 |
7e-8 |
BLAST |
|
Pfam:Glyco_hydro_31
|
562 |
1064 |
2.2e-137 |
PFAM |
|
low complexity region
|
1149 |
1164 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000202966
AA Change: D872V
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000144680
Gene: ENSMUSG00000068587
AA Change: D872V
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
2 |
88 |
2.6e-19 |
PROSPERO |
|
PD
|
178 |
231 |
1.4e-14 |
SMART |
|
Pfam:NtCtMGAM_N
|
242 |
355 |
1.1e-26 |
PFAM |
|
Blast:ANK
|
395 |
425 |
6e-8 |
BLAST |
|
Pfam:Glyco_hydro_31
|
443 |
945 |
1.3e-137 |
PFAM |
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.3%
- 20x: 95.1%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes maltase-glucoamylase, which is a brush border membrane enzyme that plays a role in the final steps of digestion of starch. The protein has two catalytic sites identical to those of sucrase-isomaltase, but the proteins are only 59% homologous. Both are members of glycosyl hydrolase family 31, which has a variety of substrate specificities. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a null allele display abnormalities in starch digestion and prandial glucose homeostasis. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 110 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 6430548M08Rik |
C |
T |
8: 120,872,132 (GRCm39) |
T20I |
probably benign |
Het |
| Adamts2 |
C |
T |
11: 50,679,516 (GRCm39) |
T832I |
possibly damaging |
Het |
| Agbl1 |
G |
A |
7: 76,239,298 (GRCm39) |
|
probably null |
Het |
| Ankrd61 |
T |
C |
5: 143,833,894 (GRCm39) |
|
probably benign |
Het |
| Anpep |
T |
G |
7: 79,488,039 (GRCm39) |
Y506S |
possibly damaging |
Het |
| Aox1 |
T |
A |
1: 58,382,832 (GRCm39) |
H1037Q |
probably benign |
Het |
| Auh |
G |
A |
13: 53,052,755 (GRCm39) |
R47* |
probably null |
Het |
| B4galt5 |
T |
A |
2: 167,148,558 (GRCm39) |
M187L |
probably benign |
Het |
| Bub1 |
A |
T |
2: 127,643,343 (GRCm39) |
D1000E |
probably benign |
Het |
| Cacna1f |
T |
G |
X: 7,492,687 (GRCm39) |
|
probably null |
Het |
| Cdh3 |
T |
C |
8: 107,279,039 (GRCm39) |
L667P |
probably damaging |
Het |
| Cenpe |
A |
T |
3: 134,946,834 (GRCm39) |
R1116S |
possibly damaging |
Het |
| Ces1b |
T |
A |
8: 93,799,969 (GRCm39) |
M136L |
possibly damaging |
Het |
| Cfap54 |
T |
C |
10: 92,833,236 (GRCm39) |
E1130G |
possibly damaging |
Het |
| Chd9 |
C |
T |
8: 91,760,615 (GRCm39) |
P2120L |
probably benign |
Het |
| Clu |
T |
C |
14: 66,212,452 (GRCm39) |
V135A |
probably damaging |
Het |
| Cmip |
T |
A |
8: 118,163,432 (GRCm39) |
S388T |
probably benign |
Het |
| Cnga1 |
C |
T |
5: 72,776,404 (GRCm39) |
V20I |
possibly damaging |
Het |
| Cox4i1 |
T |
A |
8: 121,400,029 (GRCm39) |
V51E |
possibly damaging |
Het |
| Crym |
T |
C |
7: 119,801,050 (GRCm39) |
N33S |
probably benign |
Het |
| Ctcf |
T |
A |
8: 106,398,016 (GRCm39) |
V434E |
probably damaging |
Het |
| Daam1 |
G |
A |
12: 72,021,997 (GRCm39) |
D732N |
probably damaging |
Het |
| Dcaf13 |
A |
G |
15: 39,008,547 (GRCm39) |
Y383C |
probably benign |
Het |
| Dock2 |
T |
C |
11: 34,262,485 (GRCm39) |
T957A |
probably benign |
Het |
| Duox1 |
A |
G |
2: 122,163,619 (GRCm39) |
D817G |
probably benign |
Het |
| Eif1ad16 |
T |
C |
12: 87,985,258 (GRCm39) |
Y95C |
probably damaging |
Het |
| Fads3 |
A |
G |
19: 10,033,818 (GRCm39) |
Y401C |
probably damaging |
Het |
| Fam72a |
T |
C |
1: 131,456,592 (GRCm39) |
|
probably null |
Het |
| Fbxw21 |
C |
A |
9: 108,974,553 (GRCm39) |
K322N |
probably benign |
Het |
| Fdxr |
G |
A |
11: 115,162,806 (GRCm39) |
T100I |
probably damaging |
Het |
| Galnt11 |
C |
G |
5: 25,452,610 (GRCm39) |
P41A |
probably damaging |
Het |
| Glb1l |
T |
C |
1: 75,178,473 (GRCm39) |
T322A |
probably damaging |
Het |
| Gm6871 |
T |
A |
7: 41,197,414 (GRCm39) |
T149S |
probably benign |
Het |
| Gpr26 |
C |
T |
7: 131,568,823 (GRCm39) |
T56I |
probably damaging |
Het |
| Grik4 |
C |
A |
9: 42,533,438 (GRCm39) |
G361C |
probably damaging |
Het |
| Gsr |
T |
G |
8: 34,170,316 (GRCm39) |
D200E |
probably benign |
Het |
| Igsf5 |
T |
A |
16: 96,165,247 (GRCm39) |
D7E |
probably benign |
Het |
| Inpp5e |
T |
A |
2: 26,289,355 (GRCm39) |
I522F |
probably damaging |
Het |
| Insm2 |
C |
A |
12: 55,647,096 (GRCm39) |
T280K |
probably benign |
Het |
| Itih4 |
T |
C |
14: 30,617,435 (GRCm39) |
V585A |
probably damaging |
Het |
| Katnip |
T |
A |
7: 125,394,515 (GRCm39) |
V197D |
probably benign |
Het |
| Knl1 |
A |
T |
2: 118,888,849 (GRCm39) |
R17* |
probably null |
Het |
| Lag3 |
G |
T |
6: 124,888,272 (GRCm39) |
L15I |
possibly damaging |
Het |
| Lepr |
T |
A |
4: 101,648,093 (GRCm39) |
S861T |
probably damaging |
Het |
| Mcur1 |
A |
T |
13: 43,697,941 (GRCm39) |
Y320N |
probably damaging |
Het |
| Mlycd |
T |
C |
8: 120,134,446 (GRCm39) |
|
probably null |
Het |
| Mpl |
C |
A |
4: 118,312,954 (GRCm39) |
C193F |
probably damaging |
Het |
| Mycbp2 |
C |
A |
14: 103,368,681 (GRCm39) |
A4142S |
probably damaging |
Het |
| Myh1 |
T |
A |
11: 67,104,424 (GRCm39) |
D993E |
possibly damaging |
Het |
| N4bp2 |
T |
A |
5: 65,947,404 (GRCm39) |
D11E |
probably benign |
Het |
| Neb |
T |
C |
2: 52,085,533 (GRCm39) |
I1521V |
probably benign |
Het |
| Notch1 |
A |
G |
2: 26,355,485 (GRCm39) |
V1744A |
possibly damaging |
Het |
| Numa1 |
T |
C |
7: 101,644,731 (GRCm39) |
S236P |
possibly damaging |
Het |
| Or4p20 |
T |
C |
2: 88,253,800 (GRCm39) |
T190A |
possibly damaging |
Het |
| Or6c66 |
T |
A |
10: 129,461,784 (GRCm39) |
I49L |
probably benign |
Het |
| Or8k23 |
A |
G |
2: 86,186,708 (GRCm39) |
L6P |
possibly damaging |
Het |
| Otogl |
A |
G |
10: 107,710,361 (GRCm39) |
L576P |
probably damaging |
Het |
| P2ry1 |
C |
T |
3: 60,910,900 (GRCm39) |
T13M |
probably damaging |
Het |
| Pak6 |
A |
T |
2: 118,525,050 (GRCm39) |
R559* |
probably null |
Het |
| Parvb |
A |
T |
15: 84,182,171 (GRCm39) |
M234L |
probably benign |
Het |
| Pcdha11 |
T |
C |
18: 37,145,907 (GRCm39) |
V666A |
possibly damaging |
Het |
| Pde3b |
T |
A |
7: 114,126,092 (GRCm39) |
Y775* |
probably null |
Het |
| Pgam5 |
A |
G |
5: 110,413,869 (GRCm39) |
L98P |
probably damaging |
Het |
| Phip |
T |
C |
9: 82,797,392 (GRCm39) |
H537R |
possibly damaging |
Het |
| Pkib |
T |
G |
10: 57,604,205 (GRCm39) |
D4E |
probably damaging |
Het |
| Plcb1 |
A |
T |
2: 135,102,428 (GRCm39) |
I202F |
probably benign |
Het |
| Pold3 |
A |
G |
7: 99,770,590 (GRCm39) |
V14A |
probably damaging |
Het |
| Prdm1 |
T |
A |
10: 44,322,803 (GRCm39) |
T249S |
probably benign |
Het |
| Prpf39 |
T |
A |
12: 65,104,589 (GRCm39) |
F551L |
probably benign |
Het |
| Prune2 |
A |
G |
19: 17,099,986 (GRCm39) |
E1830G |
probably benign |
Het |
| Ralgapa1 |
G |
A |
12: 55,764,986 (GRCm39) |
P889S |
probably damaging |
Het |
| Rassf2 |
A |
T |
2: 131,840,163 (GRCm39) |
|
probably null |
Het |
| Rnf185 |
A |
G |
11: 3,368,067 (GRCm39) |
Y204H |
probably benign |
Het |
| Rpap1 |
A |
G |
2: 119,610,535 (GRCm39) |
|
probably null |
Het |
| Rufy3 |
T |
C |
5: 88,797,757 (GRCm39) |
S645P |
probably damaging |
Het |
| Scn11a |
T |
A |
9: 119,594,595 (GRCm39) |
Y1266F |
probably damaging |
Het |
| Senp7 |
T |
A |
16: 55,971,725 (GRCm39) |
H287Q |
probably benign |
Het |
| Sgsm3 |
T |
C |
15: 80,888,073 (GRCm39) |
|
probably null |
Het |
| Slc25a11 |
A |
T |
11: 70,536,658 (GRCm39) |
V104E |
possibly damaging |
Het |
| Slc25a13 |
G |
A |
6: 6,117,190 (GRCm39) |
T175I |
probably benign |
Het |
| Slc26a3 |
T |
A |
12: 31,520,902 (GRCm39) |
F702Y |
probably damaging |
Het |
| Smco2 |
T |
A |
6: 146,761,465 (GRCm39) |
L184H |
probably damaging |
Het |
| Ssc4d |
A |
T |
5: 135,994,461 (GRCm39) |
C90S |
probably damaging |
Het |
| Sspo |
T |
C |
6: 48,441,298 (GRCm39) |
S1835P |
probably damaging |
Het |
| Stk35 |
A |
G |
2: 129,643,435 (GRCm39) |
T140A |
probably damaging |
Het |
| Syngr1 |
C |
T |
15: 79,995,941 (GRCm39) |
T160M |
probably damaging |
Het |
| Tent2 |
A |
G |
13: 93,320,726 (GRCm39) |
L109S |
probably damaging |
Het |
| Tgfb1i1 |
A |
G |
7: 127,848,085 (GRCm39) |
|
probably null |
Het |
| Thoc1 |
T |
A |
18: 9,977,947 (GRCm39) |
V296E |
probably damaging |
Het |
| Timp2 |
C |
T |
11: 118,201,412 (GRCm39) |
C75Y |
probably damaging |
Het |
| Tlr1 |
T |
C |
5: 65,082,639 (GRCm39) |
Y646C |
probably damaging |
Het |
| Tprn |
G |
A |
2: 25,158,940 (GRCm39) |
E655K |
possibly damaging |
Het |
| Trbv14 |
A |
C |
6: 41,112,424 (GRCm39) |
I74L |
probably benign |
Het |
| Trbv5 |
T |
A |
6: 41,039,555 (GRCm39) |
Y53* |
probably null |
Het |
| Trpm5 |
T |
C |
7: 142,642,656 (GRCm39) |
Q97R |
possibly damaging |
Het |
| Tut1 |
A |
G |
19: 8,932,931 (GRCm39) |
D88G |
probably damaging |
Het |
| Ucp2 |
A |
T |
7: 100,147,620 (GRCm39) |
I200F |
probably benign |
Het |
| Unc45a |
G |
A |
7: 79,988,623 (GRCm39) |
S131L |
probably benign |
Het |
| Uty |
A |
T |
Y: 1,158,182 (GRCm39) |
H573Q |
probably damaging |
Het |
| Vmn1r17 |
T |
A |
6: 57,337,855 (GRCm39) |
Y121F |
possibly damaging |
Het |
| Vmn1r53 |
T |
C |
6: 90,200,554 (GRCm39) |
I257V |
probably benign |
Het |
| Vmn2r90 |
C |
T |
17: 17,954,229 (GRCm39) |
L798F |
probably damaging |
Het |
| Vmn2r94 |
A |
T |
17: 18,477,736 (GRCm39) |
M225K |
probably benign |
Het |
| Wdr24 |
A |
T |
17: 26,043,273 (GRCm39) |
I32F |
possibly damaging |
Het |
| Zc3h11a |
T |
A |
1: 133,552,521 (GRCm39) |
T529S |
probably benign |
Het |
| Zc3h4 |
A |
G |
7: 16,168,264 (GRCm39) |
H791R |
unknown |
Het |
| Zfp24 |
A |
G |
18: 24,150,927 (GRCm39) |
L73P |
probably damaging |
Het |
| Zfp616 |
T |
C |
11: 73,974,121 (GRCm39) |
I130T |
probably benign |
Het |
| Zim1 |
ACAGCAG |
ACAGCAGCAG |
7: 6,680,429 (GRCm39) |
|
probably benign |
Het |
| Zim1 |
CAG |
CAGAAG |
7: 6,680,430 (GRCm39) |
|
probably benign |
Het |
|
| Other mutations in Mgam |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01024:Mgam
|
APN |
6 |
40,619,944 (GRCm39) |
missense |
probably benign |
|
|
IGL01065:Mgam
|
APN |
6 |
40,639,644 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01402:Mgam
|
APN |
6 |
40,621,879 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01404:Mgam
|
APN |
6 |
40,621,879 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01413:Mgam
|
APN |
6 |
40,638,211 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01546:Mgam
|
APN |
6 |
40,631,627 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01596:Mgam
|
APN |
6 |
40,635,204 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02133:Mgam
|
APN |
6 |
40,620,010 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02734:Mgam
|
APN |
6 |
40,639,628 (GRCm39) |
missense |
probably damaging |
1.00 |
|
BB002:Mgam
|
UTSW |
6 |
40,735,985 (GRCm39) |
missense |
probably damaging |
0.99 |
|
BB012:Mgam
|
UTSW |
6 |
40,735,985 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0012:Mgam
|
UTSW |
6 |
40,742,190 (GRCm39) |
splice site |
probably null |
|
|
R0116:Mgam
|
UTSW |
6 |
40,635,921 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0310:Mgam
|
UTSW |
6 |
40,737,969 (GRCm39) |
splice site |
probably benign |
|
|
R0452:Mgam
|
UTSW |
6 |
40,736,024 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0497:Mgam
|
UTSW |
6 |
40,641,826 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0699:Mgam
|
UTSW |
6 |
40,619,953 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R0738:Mgam
|
UTSW |
6 |
40,731,869 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1033:Mgam
|
UTSW |
6 |
40,657,558 (GRCm39) |
missense |
probably benign |
0.07 |
|
R1403:Mgam
|
UTSW |
6 |
40,643,815 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R1403:Mgam
|
UTSW |
6 |
40,643,815 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R1430:Mgam
|
UTSW |
6 |
40,733,305 (GRCm39) |
missense |
probably benign |
0.08 |
|
R1432:Mgam
|
UTSW |
6 |
40,733,301 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1443:Mgam
|
UTSW |
6 |
40,736,714 (GRCm39) |
nonsense |
probably null |
|
|
R1470:Mgam
|
UTSW |
6 |
40,736,062 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1470:Mgam
|
UTSW |
6 |
40,736,062 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1519:Mgam
|
UTSW |
6 |
40,638,617 (GRCm39) |
missense |
probably benign |
0.45 |
|
R1654:Mgam
|
UTSW |
6 |
40,734,421 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1667:Mgam
|
UTSW |
6 |
40,653,978 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R1730:Mgam
|
UTSW |
6 |
40,641,794 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R1781:Mgam
|
UTSW |
6 |
40,646,797 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1783:Mgam
|
UTSW |
6 |
40,641,794 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R1829:Mgam
|
UTSW |
6 |
40,643,826 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1833:Mgam
|
UTSW |
6 |
40,631,652 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1872:Mgam
|
UTSW |
6 |
40,638,234 (GRCm39) |
nonsense |
probably null |
|
|
R1912:Mgam
|
UTSW |
6 |
40,741,119 (GRCm39) |
nonsense |
probably null |
|
|
R1977:Mgam
|
UTSW |
6 |
40,641,814 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2048:Mgam
|
UTSW |
6 |
40,633,363 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R2086:Mgam
|
UTSW |
6 |
40,737,962 (GRCm39) |
splice site |
probably null |
|
|
R2138:Mgam
|
UTSW |
6 |
40,733,384 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2224:Mgam
|
UTSW |
6 |
40,741,208 (GRCm39) |
splice site |
probably null |
|
|
R2408:Mgam
|
UTSW |
6 |
40,663,456 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2842:Mgam
|
UTSW |
6 |
40,638,279 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2847:Mgam
|
UTSW |
6 |
40,629,649 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R2848:Mgam
|
UTSW |
6 |
40,629,649 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R2965:Mgam
|
UTSW |
6 |
40,745,154 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R2966:Mgam
|
UTSW |
6 |
40,745,154 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R3035:Mgam
|
UTSW |
6 |
40,640,464 (GRCm39) |
missense |
probably benign |
|
|
R3895:Mgam
|
UTSW |
6 |
40,736,054 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4027:Mgam
|
UTSW |
6 |
40,731,836 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4030:Mgam
|
UTSW |
6 |
40,731,836 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4302:Mgam
|
UTSW |
6 |
40,740,019 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4707:Mgam
|
UTSW |
6 |
40,691,566 (GRCm39) |
splice site |
probably null |
|
|
R4826:Mgam
|
UTSW |
6 |
40,657,582 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R4898:Mgam
|
UTSW |
6 |
40,619,988 (GRCm39) |
missense |
probably benign |
|
|
R5438:Mgam
|
UTSW |
6 |
40,661,455 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5492:Mgam
|
UTSW |
6 |
40,733,297 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5770:Mgam
|
UTSW |
6 |
40,646,738 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5839:Mgam
|
UTSW |
6 |
40,716,998 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R5845:Mgam
|
UTSW |
6 |
40,652,257 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R5847:Mgam
|
UTSW |
6 |
40,660,989 (GRCm39) |
missense |
probably benign |
0.42 |
|
R5891:Mgam
|
UTSW |
6 |
40,721,282 (GRCm39) |
missense |
probably benign |
|
|
R6158:Mgam
|
UTSW |
6 |
40,734,648 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6193:Mgam
|
UTSW |
6 |
40,724,854 (GRCm39) |
nonsense |
probably null |
|
|
R6423:Mgam
|
UTSW |
6 |
40,653,979 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R6706:Mgam
|
UTSW |
6 |
40,721,720 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6813:Mgam
|
UTSW |
6 |
40,727,099 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6863:Mgam
|
UTSW |
6 |
40,705,943 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6906:Mgam
|
UTSW |
6 |
40,724,853 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7091:Mgam
|
UTSW |
6 |
40,745,210 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R7099:Mgam
|
UTSW |
6 |
40,638,650 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7282:Mgam
|
UTSW |
6 |
40,740,045 (GRCm39) |
missense |
probably benign |
|
|
R7282:Mgam
|
UTSW |
6 |
40,633,446 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R7354:Mgam
|
UTSW |
6 |
40,721,732 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7374:Mgam
|
UTSW |
6 |
40,734,373 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R7399:Mgam
|
UTSW |
6 |
40,643,788 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7406:Mgam
|
UTSW |
6 |
40,640,459 (GRCm39) |
missense |
probably benign |
0.13 |
|
R7446:Mgam
|
UTSW |
6 |
40,723,266 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7466:Mgam
|
UTSW |
6 |
40,721,723 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7525:Mgam
|
UTSW |
6 |
40,742,954 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7530:Mgam
|
UTSW |
6 |
40,686,152 (GRCm39) |
splice site |
probably null |
|
|
R7570:Mgam
|
UTSW |
6 |
40,723,367 (GRCm39) |
missense |
probably benign |
0.16 |
|
R7669:Mgam
|
UTSW |
6 |
40,635,944 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7679:Mgam
|
UTSW |
6 |
40,619,980 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7746:Mgam
|
UTSW |
6 |
40,645,127 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7859:Mgam
|
UTSW |
6 |
40,717,113 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R7925:Mgam
|
UTSW |
6 |
40,735,985 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8206:Mgam
|
UTSW |
6 |
40,657,169 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8244:Mgam
|
UTSW |
6 |
40,727,520 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8309:Mgam
|
UTSW |
6 |
40,722,111 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R8472:Mgam
|
UTSW |
6 |
40,671,460 (GRCm39) |
splice site |
probably null |
|
|
R8758:Mgam
|
UTSW |
6 |
40,705,977 (GRCm39) |
missense |
probably benign |
0.41 |
|
R8777:Mgam
|
UTSW |
6 |
40,632,185 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8777-TAIL:Mgam
|
UTSW |
6 |
40,632,185 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8783:Mgam
|
UTSW |
6 |
40,633,423 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8939:Mgam
|
UTSW |
6 |
40,740,137 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8968:Mgam
|
UTSW |
6 |
40,734,745 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R8987:Mgam
|
UTSW |
6 |
40,706,570 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9055:Mgam
|
UTSW |
6 |
40,691,663 (GRCm39) |
intron |
probably benign |
|
|
R9171:Mgam
|
UTSW |
6 |
40,745,146 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R9252:Mgam
|
UTSW |
6 |
40,706,577 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9258:Mgam
|
UTSW |
6 |
40,657,121 (GRCm39) |
missense |
probably benign |
|
|
R9262:Mgam
|
UTSW |
6 |
40,723,422 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9287:Mgam
|
UTSW |
6 |
40,705,905 (GRCm39) |
intron |
probably benign |
|
|
R9521:Mgam
|
UTSW |
6 |
40,722,118 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9589:Mgam
|
UTSW |
6 |
40,727,519 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9658:Mgam
|
UTSW |
6 |
40,721,311 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R9784:Mgam
|
UTSW |
6 |
40,736,024 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF011:Mgam
|
UTSW |
6 |
40,734,370 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF020:Mgam
|
UTSW |
6 |
40,662,243 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF023:Mgam
|
UTSW |
6 |
40,657,642 (GRCm39) |
missense |
probably benign |
|
|
X0021:Mgam
|
UTSW |
6 |
40,635,981 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1088:Mgam
|
UTSW |
6 |
40,619,994 (GRCm39) |
missense |
probably benign |
0.01 |
|
Z1176:Mgam
|
UTSW |
6 |
40,706,000 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Mgam
|
UTSW |
6 |
40,654,578 (GRCm39) |
critical splice donor site |
probably null |
|
|
Z1177:Mgam
|
UTSW |
6 |
40,717,005 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGGCCAAATTCCTTCTGTGG -3'
(R):5'- ACTTCACCTCAATTGCCAGTAGG -3'
Sequencing Primer
(F):5'- CCAAATTCCTTCTGTGGTTTGAG -3'
(R):5'- TCTGTACTCAGCCTGACA -3'
|
| Posted On |
2014-12-04 |
Incidental Mutation