Incidental Mutation 'R2508:Crym'
ID 251531
Institutional Source Beutler Lab
Gene Symbol Crym
Ensembl Gene ENSMUSG00000030905
Gene Name crystallin, mu
Synonyms
MMRRC Submission 040414-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R2508 (G1)
Quality Score 193
Status Not validated
Chromosome 7
Chromosomal Location 119785603-119801212 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 119801050 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Serine at position 33 (N33S)
Ref Sequence ENSEMBL: ENSMUSP00000033198 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000033198] [ENSMUST00000084640]
AlphaFold O54983
PDB Structure Crystal structure of the apo form of mouse Mu-crystallin. [X-RAY DIFFRACTION]
Crystal structure of the NADPH form of mouse Mu-crystallin. [X-RAY DIFFRACTION]
Cristal structure of the NADPH-T3 form of mouse Mu-crystallin. [X-RAY DIFFRACTION]
Predicted Effect probably benign
Transcript: ENSMUST00000033198
AA Change: N33S

PolyPhen 2 Score 0.078 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000033198
Gene: ENSMUSG00000030905
AA Change: N33S

DomainStartEndE-ValueType
Pfam:OCD_Mu_crystall 3 313 7.1e-113 PFAM
Pfam:Shikimate_DH 124 227 7.1e-11 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000084640
SMART Domains Protein: ENSMUSP00000081690
Gene: ENSMUSG00000062017

DomainStartEndE-ValueType
Pfam:ABC2_membrane_3 24 463 5.7e-23 PFAM
AAA 548 729 1.59e-10 SMART
Pfam:ABC2_membrane_3 902 1296 1.2e-36 PFAM
AAA 1384 1568 1.33e-3 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000130646
Predicted Effect noncoding transcript
Transcript: ENSMUST00000134067
Predicted Effect noncoding transcript
Transcript: ENSMUST00000134268
Predicted Effect noncoding transcript
Transcript: ENSMUST00000143257
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.1%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Crystallins are separated into two classes: taxon-specific and ubiquitous. The former class is also called phylogenetically-restricted crystallins. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. This gene encodes a taxon-specific crystallin protein that binds NADPH and has sequence similarity to bacterial ornithine cyclodeaminases. The encoded protein does not perform a structural role in lens tissue, and instead it binds thyroid hormone for possible regulatory or developmental roles. Mutations in this gene have been associated with autosomal dominant non-syndromic deafness. [provided by RefSeq, Sep 2014]
PHENOTYPE: At the euthyroid state, homozygotes display a normal growth curve, heart rate and hearing ability but have significantly reduced serum concentrations of triiodothyronine (T3) and thyroxine (T4). [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 110 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
6430548M08Rik C T 8: 120,872,132 (GRCm39) T20I probably benign Het
Adamts2 C T 11: 50,679,516 (GRCm39) T832I possibly damaging Het
Agbl1 G A 7: 76,239,298 (GRCm39) probably null Het
Ankrd61 T C 5: 143,833,894 (GRCm39) probably benign Het
Anpep T G 7: 79,488,039 (GRCm39) Y506S possibly damaging Het
Aox1 T A 1: 58,382,832 (GRCm39) H1037Q probably benign Het
Auh G A 13: 53,052,755 (GRCm39) R47* probably null Het
B4galt5 T A 2: 167,148,558 (GRCm39) M187L probably benign Het
Bub1 A T 2: 127,643,343 (GRCm39) D1000E probably benign Het
Cacna1f T G X: 7,492,687 (GRCm39) probably null Het
Cdh3 T C 8: 107,279,039 (GRCm39) L667P probably damaging Het
Cenpe A T 3: 134,946,834 (GRCm39) R1116S possibly damaging Het
Ces1b T A 8: 93,799,969 (GRCm39) M136L possibly damaging Het
Cfap54 T C 10: 92,833,236 (GRCm39) E1130G possibly damaging Het
Chd9 C T 8: 91,760,615 (GRCm39) P2120L probably benign Het
Clu T C 14: 66,212,452 (GRCm39) V135A probably damaging Het
Cmip T A 8: 118,163,432 (GRCm39) S388T probably benign Het
Cnga1 C T 5: 72,776,404 (GRCm39) V20I possibly damaging Het
Cox4i1 T A 8: 121,400,029 (GRCm39) V51E possibly damaging Het
Ctcf T A 8: 106,398,016 (GRCm39) V434E probably damaging Het
Daam1 G A 12: 72,021,997 (GRCm39) D732N probably damaging Het
Dcaf13 A G 15: 39,008,547 (GRCm39) Y383C probably benign Het
Dock2 T C 11: 34,262,485 (GRCm39) T957A probably benign Het
Duox1 A G 2: 122,163,619 (GRCm39) D817G probably benign Het
Eif1ad16 T C 12: 87,985,258 (GRCm39) Y95C probably damaging Het
Fads3 A G 19: 10,033,818 (GRCm39) Y401C probably damaging Het
Fam72a T C 1: 131,456,592 (GRCm39) probably null Het
Fbxw21 C A 9: 108,974,553 (GRCm39) K322N probably benign Het
Fdxr G A 11: 115,162,806 (GRCm39) T100I probably damaging Het
Galnt11 C G 5: 25,452,610 (GRCm39) P41A probably damaging Het
Glb1l T C 1: 75,178,473 (GRCm39) T322A probably damaging Het
Gm6871 T A 7: 41,197,414 (GRCm39) T149S probably benign Het
Gpr26 C T 7: 131,568,823 (GRCm39) T56I probably damaging Het
Grik4 C A 9: 42,533,438 (GRCm39) G361C probably damaging Het
Gsr T G 8: 34,170,316 (GRCm39) D200E probably benign Het
Igsf5 T A 16: 96,165,247 (GRCm39) D7E probably benign Het
Inpp5e T A 2: 26,289,355 (GRCm39) I522F probably damaging Het
Insm2 C A 12: 55,647,096 (GRCm39) T280K probably benign Het
Itih4 T C 14: 30,617,435 (GRCm39) V585A probably damaging Het
Katnip T A 7: 125,394,515 (GRCm39) V197D probably benign Het
Knl1 A T 2: 118,888,849 (GRCm39) R17* probably null Het
Lag3 G T 6: 124,888,272 (GRCm39) L15I possibly damaging Het
Lepr T A 4: 101,648,093 (GRCm39) S861T probably damaging Het
Mcur1 A T 13: 43,697,941 (GRCm39) Y320N probably damaging Het
Mgam A T 6: 40,736,717 (GRCm39) D872V probably damaging Het
Mlycd T C 8: 120,134,446 (GRCm39) probably null Het
Mpl C A 4: 118,312,954 (GRCm39) C193F probably damaging Het
Mycbp2 C A 14: 103,368,681 (GRCm39) A4142S probably damaging Het
Myh1 T A 11: 67,104,424 (GRCm39) D993E possibly damaging Het
N4bp2 T A 5: 65,947,404 (GRCm39) D11E probably benign Het
Neb T C 2: 52,085,533 (GRCm39) I1521V probably benign Het
Notch1 A G 2: 26,355,485 (GRCm39) V1744A possibly damaging Het
Numa1 T C 7: 101,644,731 (GRCm39) S236P possibly damaging Het
Or4p20 T C 2: 88,253,800 (GRCm39) T190A possibly damaging Het
Or6c66 T A 10: 129,461,784 (GRCm39) I49L probably benign Het
Or8k23 A G 2: 86,186,708 (GRCm39) L6P possibly damaging Het
Otogl A G 10: 107,710,361 (GRCm39) L576P probably damaging Het
P2ry1 C T 3: 60,910,900 (GRCm39) T13M probably damaging Het
Pak6 A T 2: 118,525,050 (GRCm39) R559* probably null Het
Parvb A T 15: 84,182,171 (GRCm39) M234L probably benign Het
Pcdha11 T C 18: 37,145,907 (GRCm39) V666A possibly damaging Het
Pde3b T A 7: 114,126,092 (GRCm39) Y775* probably null Het
Pgam5 A G 5: 110,413,869 (GRCm39) L98P probably damaging Het
Phip T C 9: 82,797,392 (GRCm39) H537R possibly damaging Het
Pkib T G 10: 57,604,205 (GRCm39) D4E probably damaging Het
Plcb1 A T 2: 135,102,428 (GRCm39) I202F probably benign Het
Pold3 A G 7: 99,770,590 (GRCm39) V14A probably damaging Het
Prdm1 T A 10: 44,322,803 (GRCm39) T249S probably benign Het
Prpf39 T A 12: 65,104,589 (GRCm39) F551L probably benign Het
Prune2 A G 19: 17,099,986 (GRCm39) E1830G probably benign Het
Ralgapa1 G A 12: 55,764,986 (GRCm39) P889S probably damaging Het
Rassf2 A T 2: 131,840,163 (GRCm39) probably null Het
Rnf185 A G 11: 3,368,067 (GRCm39) Y204H probably benign Het
Rpap1 A G 2: 119,610,535 (GRCm39) probably null Het
Rufy3 T C 5: 88,797,757 (GRCm39) S645P probably damaging Het
Scn11a T A 9: 119,594,595 (GRCm39) Y1266F probably damaging Het
Senp7 T A 16: 55,971,725 (GRCm39) H287Q probably benign Het
Sgsm3 T C 15: 80,888,073 (GRCm39) probably null Het
Slc25a11 A T 11: 70,536,658 (GRCm39) V104E possibly damaging Het
Slc25a13 G A 6: 6,117,190 (GRCm39) T175I probably benign Het
Slc26a3 T A 12: 31,520,902 (GRCm39) F702Y probably damaging Het
Smco2 T A 6: 146,761,465 (GRCm39) L184H probably damaging Het
Ssc4d A T 5: 135,994,461 (GRCm39) C90S probably damaging Het
Sspo T C 6: 48,441,298 (GRCm39) S1835P probably damaging Het
Stk35 A G 2: 129,643,435 (GRCm39) T140A probably damaging Het
Syngr1 C T 15: 79,995,941 (GRCm39) T160M probably damaging Het
Tent2 A G 13: 93,320,726 (GRCm39) L109S probably damaging Het
Tgfb1i1 A G 7: 127,848,085 (GRCm39) probably null Het
Thoc1 T A 18: 9,977,947 (GRCm39) V296E probably damaging Het
Timp2 C T 11: 118,201,412 (GRCm39) C75Y probably damaging Het
Tlr1 T C 5: 65,082,639 (GRCm39) Y646C probably damaging Het
Tprn G A 2: 25,158,940 (GRCm39) E655K possibly damaging Het
Trbv14 A C 6: 41,112,424 (GRCm39) I74L probably benign Het
Trbv5 T A 6: 41,039,555 (GRCm39) Y53* probably null Het
Trpm5 T C 7: 142,642,656 (GRCm39) Q97R possibly damaging Het
Tut1 A G 19: 8,932,931 (GRCm39) D88G probably damaging Het
Ucp2 A T 7: 100,147,620 (GRCm39) I200F probably benign Het
Unc45a G A 7: 79,988,623 (GRCm39) S131L probably benign Het
Uty A T Y: 1,158,182 (GRCm39) H573Q probably damaging Het
Vmn1r17 T A 6: 57,337,855 (GRCm39) Y121F possibly damaging Het
Vmn1r53 T C 6: 90,200,554 (GRCm39) I257V probably benign Het
Vmn2r90 C T 17: 17,954,229 (GRCm39) L798F probably damaging Het
Vmn2r94 A T 17: 18,477,736 (GRCm39) M225K probably benign Het
Wdr24 A T 17: 26,043,273 (GRCm39) I32F possibly damaging Het
Zc3h11a T A 1: 133,552,521 (GRCm39) T529S probably benign Het
Zc3h4 A G 7: 16,168,264 (GRCm39) H791R unknown Het
Zfp24 A G 18: 24,150,927 (GRCm39) L73P probably damaging Het
Zfp616 T C 11: 73,974,121 (GRCm39) I130T probably benign Het
Zim1 ACAGCAG ACAGCAGCAG 7: 6,680,429 (GRCm39) probably benign Het
Zim1 CAG CAGAAG 7: 6,680,430 (GRCm39) probably benign Het
Other mutations in Crym
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01562:Crym APN 7 119,794,622 (GRCm39) missense probably damaging 0.98
IGL03355:Crym APN 7 119,798,536 (GRCm39) splice site probably null
R0393:Crym UTSW 7 119,788,972 (GRCm39) missense probably benign 0.00
R1538:Crym UTSW 7 119,796,938 (GRCm39) missense probably benign 0.05
R3836:Crym UTSW 7 119,800,439 (GRCm39) missense probably benign 0.03
R4328:Crym UTSW 7 119,794,562 (GRCm39) missense probably damaging 1.00
R4723:Crym UTSW 7 119,800,298 (GRCm39) critical splice donor site probably null
R5046:Crym UTSW 7 119,794,667 (GRCm39) missense possibly damaging 0.71
R5122:Crym UTSW 7 119,794,718 (GRCm39) missense probably benign 0.00
R5266:Crym UTSW 7 119,798,517 (GRCm39) missense probably benign 0.00
R5427:Crym UTSW 7 119,798,445 (GRCm39) unclassified probably benign
R5567:Crym UTSW 7 119,801,116 (GRCm39) missense probably benign 0.00
R5570:Crym UTSW 7 119,801,116 (GRCm39) missense probably benign 0.00
R5704:Crym UTSW 7 119,801,163 (GRCm39) splice site probably null
R6835:Crym UTSW 7 119,785,868 (GRCm39) missense probably benign
R7274:Crym UTSW 7 119,789,742 (GRCm39) missense probably benign 0.03
R7536:Crym UTSW 7 119,800,331 (GRCm39) missense probably damaging 1.00
R8062:Crym UTSW 7 119,800,391 (GRCm39) missense probably damaging 1.00
R8281:Crym UTSW 7 119,801,250 (GRCm39) unclassified probably benign
R8940:Crym UTSW 7 119,794,703 (GRCm39) missense probably benign 0.16
R9015:Crym UTSW 7 119,801,090 (GRCm39) missense probably benign
R9324:Crym UTSW 7 119,789,005 (GRCm39) missense probably damaging 0.99
R9740:Crym UTSW 7 119,794,661 (GRCm39) missense probably benign 0.17
Predicted Primers PCR Primer
(F):5'- CGCTTTCTTGGTAGAAGCCC -3'
(R):5'- AGTCCGCTCATTTAGGGCTC -3'

Sequencing Primer
(F):5'- GTTAGTGCCCCTTAAGTAGCAGC -3'
(R):5'- ATTTAGGGCTCAGCTCCTGGAAC -3'
Posted On 2014-12-04