Incidental Mutation 'R2846:Vmn1r212'
ID251611
Institutional Source Beutler Lab
Gene Symbol Vmn1r212
Ensembl Gene ENSMUSG00000071490
Gene Namevomeronasal 1 receptor 212
SynonymsV1rh18
MMRRC Submission 040439-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.079) question?
Stock #R2846 (G1)
Quality Score225
Status Not validated
Chromosome13
Chromosomal Location22883042-22884205 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 22884092 bp
ZygosityHeterozygous
Amino Acid Change Serine to Proline at position 24 (S24P)
Ref Sequence ENSEMBL: ENSMUSP00000093655 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000095960]
Predicted Effect probably damaging
Transcript: ENSMUST00000095960
AA Change: S24P

PolyPhen 2 Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000093655
Gene: ENSMUSG00000071490
AA Change: S24P

DomainStartEndE-ValueType
Pfam:TAS2R 2 292 1.2e-7 PFAM
Pfam:V1R 34 297 5.4e-36 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000158990
Predicted Effect noncoding transcript
Transcript: ENSMUST00000226672
Predicted Effect noncoding transcript
Transcript: ENSMUST00000226881
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.4%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Atg4a G A X: 140,992,840 E106K probably benign Het
Bahd1 G A 2: 118,922,523 R757H probably damaging Het
Cdnf T A 2: 3,513,128 M1K probably null Het
Ddx4 T A 13: 112,604,612 K496M probably damaging Het
Dlg1 T C 16: 31,863,197 S779P probably damaging Het
Dtna T A 18: 23,651,503 probably null Het
Fhad1 G T 4: 141,904,968 Q1287K probably benign Het
Gal3st2c A T 1: 93,996,400 Q8L possibly damaging Het
Hsd3b1 T C 3: 98,852,778 E299G probably damaging Het
Hydin T C 8: 110,519,114 V2153A probably benign Het
Irs4 C A X: 141,724,340 G287W probably damaging Het
Kif21a T C 15: 90,934,464 I1570V probably benign Het
Kremen1 GG GGGCG 11: 5,201,793 probably benign Het
Mark2 T C 19: 7,286,862 E116G probably damaging Het
Mfsd13a C T 19: 46,371,992 R328C probably damaging Het
Mindy4 T C 6: 55,278,100 V521A probably damaging Het
Olfr119 T C 17: 37,700,823 I51T probably damaging Het
Olfr384 A T 11: 73,603,383 T268S probably benign Het
Pdgfrb C T 18: 61,064,016 P175S probably benign Het
Pign C A 1: 105,657,796 L9F possibly damaging Het
Plekha1 G T 7: 130,908,365 W280C probably damaging Het
Ppfia3 C A 7: 45,356,428 R348L probably damaging Het
Prr12 G C 7: 45,046,012 S1343R unknown Het
Psmd13 C A 7: 140,897,740 probably benign Het
Qpct A G 17: 79,070,742 T114A probably damaging Het
Sec24d A G 3: 123,350,746 D624G probably damaging Het
Shank2 A G 7: 144,070,055 Y259C probably damaging Het
Slc15a4 A G 5: 127,604,536 probably null Het
Smarcb1 C A 10: 75,897,541 R332L probably damaging Het
Ssh3 T C 19: 4,265,296 Y338C probably damaging Het
St18 T A 1: 6,845,587 C819S probably damaging Het
Tas2r124 A G 6: 132,755,267 N180D possibly damaging Het
Tgfbr3l A G 8: 4,249,280 D49G probably damaging Het
Tmem204 G A 17: 25,080,333 H71Y probably benign Het
Vmn2r6 A G 3: 64,556,790 S208P possibly damaging Het
Zbtb8os A T 4: 129,341,516 E54D probably damaging Het
Zmiz1 A G 14: 25,645,675 S259G probably benign Het
Other mutations in Vmn1r212
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01131:Vmn1r212 APN 13 22883159 missense unknown
IGL01678:Vmn1r212 APN 13 22883911 missense probably damaging 1.00
R0798:Vmn1r212 UTSW 13 22883698 missense probably damaging 1.00
R1237:Vmn1r212 UTSW 13 22883468 nonsense probably null
R1331:Vmn1r212 UTSW 13 22883392 missense probably benign 0.33
R2064:Vmn1r212 UTSW 13 22884115 missense probably benign 0.28
R2356:Vmn1r212 UTSW 13 22883950 nonsense probably null
R3896:Vmn1r212 UTSW 13 22883897 missense probably benign 0.00
R3937:Vmn1r212 UTSW 13 22883188 missense unknown
R4722:Vmn1r212 UTSW 13 22883908 missense probably damaging 1.00
R5233:Vmn1r212 UTSW 13 22883134 missense unknown
R6043:Vmn1r212 UTSW 13 22884088 missense probably damaging 0.98
R7199:Vmn1r212 UTSW 13 22883561 missense probably benign 0.12
R7413:Vmn1r212 UTSW 13 22883548 missense probably damaging 1.00
R7840:Vmn1r212 UTSW 13 22883153 missense unknown
R8054:Vmn1r212 UTSW 13 22883765 missense probably benign 0.25
R8844:Vmn1r212 UTSW 13 22883356 missense probably benign 0.00
R8929:Vmn1r212 UTSW 13 22883324 missense not run
Z1088:Vmn1r212 UTSW 13 22883762 missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AACAATGGTCTTACAGCCTATGTC -3'
(R):5'- TACCACTGCCTCTCGAACAG -3'

Sequencing Primer
(F):5'- GGTCTTACAGCCTATGTCATCTAGG -3'
(R):5'- CAGATGTGCTGTCCAGATCG -3'
Posted On2014-12-04