Incidental Mutation 'R2509:Greb1'
| ID |
251823 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Greb1
|
| Ensembl Gene |
ENSMUSG00000036523 |
| Gene Name |
gene regulated by estrogen in breast cancer protein |
| Synonyms |
5730583K22Rik |
| MMRRC Submission |
040415-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R2509 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
12 |
| Chromosomal Location |
16720616-16850887 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 16774923 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Alanine
at position 158
(V158A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000125339
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000048064]
[ENSMUST00000159120]
[ENSMUST00000162112]
|
| AlphaFold |
Q3UHK3 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000048064
AA Change: V158A
PolyPhen 2
Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000044454
Gene: ENSMUSG00000036523
AA Change: V158A
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:GREB1
|
1 |
1954 |
N/A |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000159120
AA Change: V158A
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000125339
Gene: ENSMUSG00000036523
AA Change: V158A
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
52 |
71 |
N/A |
INTRINSIC |
|
low complexity region
|
292 |
303 |
N/A |
INTRINSIC |
|
low complexity region
|
437 |
453 |
N/A |
INTRINSIC |
|
low complexity region
|
480 |
503 |
N/A |
INTRINSIC |
|
low complexity region
|
631 |
643 |
N/A |
INTRINSIC |
|
low complexity region
|
1100 |
1118 |
N/A |
INTRINSIC |
|
low complexity region
|
1196 |
1207 |
N/A |
INTRINSIC |
|
low complexity region
|
1251 |
1265 |
N/A |
INTRINSIC |
|
low complexity region
|
1596 |
1607 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000159573
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000161036
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000162112
AA Change: V158A
PolyPhen 2
Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000124348
Gene: ENSMUSG00000036523
AA Change: V158A
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
52 |
71 |
N/A |
INTRINSIC |
|
low complexity region
|
292 |
303 |
N/A |
INTRINSIC |
|
low complexity region
|
437 |
453 |
N/A |
INTRINSIC |
|
low complexity region
|
480 |
503 |
N/A |
INTRINSIC |
|
low complexity region
|
631 |
643 |
N/A |
INTRINSIC |
|
low complexity region
|
1128 |
1146 |
N/A |
INTRINSIC |
|
low complexity region
|
1224 |
1235 |
N/A |
INTRINSIC |
|
low complexity region
|
1279 |
1293 |
N/A |
INTRINSIC |
|
low complexity region
|
1624 |
1635 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.1138 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.4%
- 20x: 95.4%
|
| Validation Efficiency |
96% (105/109) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is an estrogen-responsive gene that is an early response gene in the estrogen receptor-regulated pathway. It is thought to play an important role in hormone-responsive tissues and cancer. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 108 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700006A11Rik |
T |
C |
3: 124,200,102 (GRCm39) |
I497V |
probably benign |
Het |
| 4930571K23Rik |
C |
A |
7: 124,968,311 (GRCm39) |
|
noncoding transcript |
Het |
| Abca17 |
G |
T |
17: 24,508,587 (GRCm39) |
|
probably benign |
Het |
| Ablim1 |
C |
T |
19: 57,140,791 (GRCm39) |
R196Q |
probably damaging |
Het |
| Acot11 |
T |
C |
4: 106,612,516 (GRCm39) |
I379V |
possibly damaging |
Het |
| Acot4 |
G |
A |
12: 84,088,647 (GRCm39) |
G165D |
probably damaging |
Het |
| Agrn |
A |
T |
4: 156,250,881 (GRCm39) |
|
probably null |
Het |
| Ahctf1 |
T |
C |
1: 179,598,258 (GRCm39) |
S945G |
possibly damaging |
Het |
| Akr1c13 |
C |
T |
13: 4,248,583 (GRCm39) |
R263C |
probably damaging |
Het |
| Arfgap1 |
T |
A |
2: 180,615,846 (GRCm39) |
|
probably benign |
Het |
| Arhgef3 |
A |
G |
14: 27,101,633 (GRCm39) |
K103R |
probably damaging |
Het |
| Cabp1 |
A |
T |
5: 115,310,843 (GRCm39) |
N211K |
probably damaging |
Het |
| Cacna1c |
T |
A |
6: 118,711,943 (GRCm39) |
D261V |
probably damaging |
Het |
| Car11 |
G |
A |
7: 45,350,783 (GRCm39) |
G93E |
probably damaging |
Het |
| Card10 |
A |
G |
15: 78,664,473 (GRCm39) |
I821T |
probably benign |
Het |
| Cast |
T |
C |
13: 74,885,735 (GRCm39) |
I277V |
probably benign |
Het |
| Cenpj |
T |
C |
14: 56,769,694 (GRCm39) |
K1165R |
probably null |
Het |
| Cenpk |
A |
G |
13: 104,370,675 (GRCm39) |
|
probably null |
Het |
| Cfap251 |
A |
G |
5: 123,394,169 (GRCm39) |
K353E |
probably benign |
Het |
| Cmya5 |
T |
C |
13: 93,230,066 (GRCm39) |
Q1674R |
probably benign |
Het |
| Cnnm1 |
T |
A |
19: 43,430,325 (GRCm39) |
V481D |
probably damaging |
Het |
| Cracdl |
T |
C |
1: 37,664,381 (GRCm39) |
M506V |
probably benign |
Het |
| Csmd3 |
CCTTTGCGCTT |
CCTT |
15: 47,604,632 (GRCm39) |
|
probably null |
Het |
| Cyp2c50 |
G |
A |
19: 40,079,013 (GRCm39) |
V119I |
probably benign |
Het |
| Dnah7b |
A |
G |
1: 46,234,447 (GRCm39) |
T1460A |
probably damaging |
Het |
| Dnah8 |
G |
A |
17: 30,994,019 (GRCm39) |
D3379N |
probably benign |
Het |
| Dnajc4 |
C |
T |
19: 6,968,111 (GRCm39) |
R55H |
probably damaging |
Het |
| Ebf4 |
C |
T |
2: 130,148,482 (GRCm39) |
R98* |
probably null |
Het |
| Epha4 |
G |
A |
1: 77,488,339 (GRCm39) |
A47V |
possibly damaging |
Het |
| Ercc8 |
T |
C |
13: 108,320,251 (GRCm39) |
|
probably benign |
Het |
| Exo1 |
T |
C |
1: 175,733,399 (GRCm39) |
F75S |
probably damaging |
Het |
| Fam168a |
G |
T |
7: 100,483,391 (GRCm39) |
|
probably null |
Het |
| Fat3 |
G |
A |
9: 15,836,310 (GRCm39) |
R4065W |
possibly damaging |
Het |
| Gm5431 |
T |
A |
11: 48,779,536 (GRCm39) |
N740I |
probably benign |
Het |
| Gm5900 |
T |
A |
7: 104,599,571 (GRCm39) |
|
noncoding transcript |
Het |
| Gpi1 |
A |
G |
7: 33,905,348 (GRCm39) |
S359P |
probably damaging |
Het |
| Gpr156 |
A |
G |
16: 37,768,149 (GRCm39) |
R22G |
probably benign |
Het |
| Grin2c |
T |
A |
11: 115,141,894 (GRCm39) |
K842* |
probably null |
Het |
| Gsta5 |
T |
A |
9: 78,202,089 (GRCm39) |
M1K |
probably null |
Het |
| Hnf4a |
T |
A |
2: 163,408,161 (GRCm39) |
L329Q |
probably damaging |
Het |
| Hsp90ab1 |
A |
G |
17: 45,880,267 (GRCm39) |
L92P |
probably damaging |
Het |
| Ido1 |
T |
A |
8: 25,074,501 (GRCm39) |
R290* |
probably null |
Het |
| Ifnlr1 |
G |
T |
4: 135,432,559 (GRCm39) |
D332Y |
probably damaging |
Het |
| Ift172 |
T |
C |
5: 31,420,312 (GRCm39) |
N1108S |
probably benign |
Het |
| Igkv3-9 |
T |
A |
6: 70,565,728 (GRCm39) |
M109K |
probably benign |
Het |
| Igsf10 |
T |
C |
3: 59,239,287 (GRCm39) |
D298G |
probably damaging |
Het |
| Iqck |
T |
G |
7: 118,475,505 (GRCm39) |
M98R |
probably benign |
Het |
| Klk1b1 |
T |
C |
7: 43,618,803 (GRCm39) |
V60A |
probably damaging |
Het |
| Krtap1-3 |
C |
T |
11: 99,481,653 (GRCm39) |
E165K |
unknown |
Het |
| Lair1 |
A |
G |
7: 4,013,782 (GRCm39) |
L155P |
probably damaging |
Het |
| Maco1 |
A |
G |
4: 134,531,699 (GRCm39) |
S657P |
probably damaging |
Het |
| Mast4 |
G |
T |
13: 102,990,350 (GRCm39) |
S57Y |
probably damaging |
Het |
| Mical3 |
T |
C |
6: 121,011,118 (GRCm39) |
H360R |
probably damaging |
Het |
| Muc5b |
A |
T |
7: 141,412,798 (GRCm39) |
N1915Y |
unknown |
Het |
| Myh1 |
A |
G |
11: 67,096,423 (GRCm39) |
I301V |
probably benign |
Het |
| Nck2 |
T |
A |
1: 43,593,393 (GRCm39) |
V200E |
probably damaging |
Het |
| Odad4 |
T |
G |
11: 100,444,361 (GRCm39) |
L222R |
probably damaging |
Het |
| Or2y1b |
T |
G |
11: 49,209,048 (GRCm39) |
L225R |
probably damaging |
Het |
| Or4b12 |
T |
C |
2: 90,096,030 (GRCm39) |
Y248C |
possibly damaging |
Het |
| Or4c109 |
T |
G |
2: 88,817,775 (GRCm39) |
Y257S |
probably damaging |
Het |
| Or4f60 |
T |
A |
2: 111,902,837 (GRCm39) |
L30F |
probably benign |
Het |
| Or4k38 |
C |
T |
2: 111,166,076 (GRCm39) |
V116I |
probably damaging |
Het |
| Or52n2c |
G |
A |
7: 104,574,894 (GRCm39) |
H26Y |
probably benign |
Het |
| Or5b101 |
T |
A |
19: 13,005,058 (GRCm39) |
I212F |
probably damaging |
Het |
| Or8b12i |
A |
G |
9: 20,082,525 (GRCm39) |
L114P |
probably damaging |
Het |
| Otoa |
C |
T |
7: 120,759,695 (GRCm39) |
T1099I |
probably benign |
Het |
| Pask |
T |
A |
1: 93,258,485 (GRCm39) |
I288F |
possibly damaging |
Het |
| Pcnx4 |
T |
C |
12: 72,613,746 (GRCm39) |
W564R |
probably damaging |
Het |
| Pip4p1 |
A |
T |
14: 51,167,115 (GRCm39) |
Y129* |
probably null |
Het |
| Pitpnm2 |
T |
C |
5: 124,274,389 (GRCm39) |
E240G |
probably damaging |
Het |
| Ppp1r16b |
A |
G |
2: 158,603,383 (GRCm39) |
Y436C |
possibly damaging |
Het |
| Pramel27 |
G |
A |
4: 143,578,561 (GRCm39) |
V274I |
probably benign |
Het |
| Prkca |
T |
C |
11: 107,870,032 (GRCm39) |
Y37C |
probably damaging |
Het |
| Rad18 |
T |
G |
6: 112,652,883 (GRCm39) |
H238P |
possibly damaging |
Het |
| Rap1b |
T |
A |
10: 117,654,444 (GRCm39) |
Q1L |
probably damaging |
Het |
| Rgs9 |
T |
C |
11: 109,159,798 (GRCm39) |
Y178C |
probably benign |
Het |
| Rpl3l |
A |
T |
17: 24,951,360 (GRCm39) |
D87V |
possibly damaging |
Het |
| Scrn2 |
T |
C |
11: 96,923,992 (GRCm39) |
V292A |
possibly damaging |
Het |
| Sdad1 |
A |
G |
5: 92,453,684 (GRCm39) |
Y35H |
probably benign |
Het |
| Sez6l2 |
T |
C |
7: 126,552,944 (GRCm39) |
S177P |
probably benign |
Het |
| Sh3bp1 |
C |
T |
15: 78,795,706 (GRCm39) |
P612S |
probably damaging |
Het |
| Shank1 |
T |
C |
7: 44,001,148 (GRCm39) |
S956P |
unknown |
Het |
| Shank1 |
G |
A |
7: 44,001,547 (GRCm39) |
A1089T |
unknown |
Het |
| Shprh |
G |
A |
10: 11,042,468 (GRCm39) |
C817Y |
probably damaging |
Het |
| Spata22 |
C |
T |
11: 73,236,593 (GRCm39) |
P300S |
probably damaging |
Het |
| Sstr2 |
A |
T |
11: 113,515,749 (GRCm39) |
I223F |
probably damaging |
Het |
| Stom |
C |
T |
2: 35,210,354 (GRCm39) |
A217T |
probably damaging |
Het |
| Stpg1 |
T |
C |
4: 135,263,960 (GRCm39) |
V341A |
probably benign |
Het |
| Tagap |
A |
G |
17: 8,147,586 (GRCm39) |
T99A |
probably benign |
Het |
| Tas1r2 |
A |
G |
4: 139,387,162 (GRCm39) |
N207S |
probably damaging |
Het |
| Thbs2 |
A |
G |
17: 14,906,105 (GRCm39) |
V265A |
probably benign |
Het |
| Thyn1 |
A |
G |
9: 26,911,316 (GRCm39) |
R3G |
possibly damaging |
Het |
| Tia1 |
T |
A |
6: 86,401,312 (GRCm39) |
|
probably null |
Het |
| Tktl2 |
A |
G |
8: 66,965,504 (GRCm39) |
E354G |
probably benign |
Het |
| Tmc8 |
A |
G |
11: 117,683,511 (GRCm39) |
T689A |
possibly damaging |
Het |
| Tmem11 |
A |
T |
11: 60,755,807 (GRCm39) |
|
probably null |
Het |
| Tnik |
T |
C |
3: 28,722,064 (GRCm39) |
V1310A |
probably damaging |
Het |
| Trappc10 |
A |
G |
10: 78,047,357 (GRCm39) |
S380P |
possibly damaging |
Het |
| Trim8 |
C |
T |
19: 46,503,734 (GRCm39) |
P429S |
probably benign |
Het |
| Ttn |
C |
A |
2: 76,687,756 (GRCm39) |
|
probably benign |
Het |
| Ulk2 |
T |
C |
11: 61,678,340 (GRCm39) |
Y793C |
probably benign |
Het |
| Vill |
G |
A |
9: 118,899,370 (GRCm39) |
V337M |
possibly damaging |
Het |
| Vps53 |
C |
A |
11: 75,957,661 (GRCm39) |
V364F |
possibly damaging |
Het |
| Zan |
A |
T |
5: 137,454,848 (GRCm39) |
I1396N |
unknown |
Het |
| Zfa-ps |
A |
C |
10: 52,420,339 (GRCm39) |
|
noncoding transcript |
Het |
| Zfp426 |
T |
C |
9: 20,381,977 (GRCm39) |
T337A |
possibly damaging |
Het |
| Zfp536 |
T |
C |
7: 37,267,403 (GRCm39) |
E671G |
possibly damaging |
Het |
| Zfp985 |
A |
G |
4: 147,667,443 (GRCm39) |
T104A |
possibly damaging |
Het |
|
| Other mutations in Greb1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00155:Greb1
|
APN |
12 |
16,761,962 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01316:Greb1
|
APN |
12 |
16,748,587 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL01464:Greb1
|
APN |
12 |
16,764,827 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01474:Greb1
|
APN |
12 |
16,734,502 (GRCm39) |
missense |
probably benign |
|
|
IGL01522:Greb1
|
APN |
12 |
16,751,202 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01824:Greb1
|
APN |
12 |
16,761,717 (GRCm39) |
nonsense |
probably null |
|
|
IGL01837:Greb1
|
APN |
12 |
16,734,452 (GRCm39) |
missense |
probably benign |
0.19 |
|
IGL01991:Greb1
|
APN |
12 |
16,749,682 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01996:Greb1
|
APN |
12 |
16,740,846 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
IGL02213:Greb1
|
APN |
12 |
16,756,233 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02267:Greb1
|
APN |
12 |
16,767,209 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02512:Greb1
|
APN |
12 |
16,742,713 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
IGL02583:Greb1
|
APN |
12 |
16,756,296 (GRCm39) |
splice site |
probably benign |
|
|
IGL02613:Greb1
|
APN |
12 |
16,789,889 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02648:Greb1
|
APN |
12 |
16,758,683 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02679:Greb1
|
APN |
12 |
16,758,724 (GRCm39) |
missense |
probably damaging |
1.00 |
|
begraben
|
UTSW |
12 |
16,734,374 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
Eared
|
UTSW |
12 |
16,723,864 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Humpback
|
UTSW |
12 |
16,751,172 (GRCm39) |
missense |
probably damaging |
1.00 |
|
pied_billed
|
UTSW |
12 |
16,774,858 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
rednecked
|
UTSW |
12 |
16,732,153 (GRCm39) |
missense |
probably damaging |
0.99 |
|
G1patch:Greb1
|
UTSW |
12 |
16,738,568 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03048:Greb1
|
UTSW |
12 |
16,783,332 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0083:Greb1
|
UTSW |
12 |
16,746,452 (GRCm39) |
missense |
probably benign |
|
|
R0100:Greb1
|
UTSW |
12 |
16,730,225 (GRCm39) |
missense |
probably benign |
0.41 |
|
R0100:Greb1
|
UTSW |
12 |
16,730,225 (GRCm39) |
missense |
probably benign |
0.41 |
|
R0220:Greb1
|
UTSW |
12 |
16,732,287 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0245:Greb1
|
UTSW |
12 |
16,746,457 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0540:Greb1
|
UTSW |
12 |
16,732,194 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0547:Greb1
|
UTSW |
12 |
16,773,412 (GRCm39) |
missense |
probably benign |
|
|
R0563:Greb1
|
UTSW |
12 |
16,730,268 (GRCm39) |
missense |
probably benign |
0.23 |
|
R0607:Greb1
|
UTSW |
12 |
16,732,194 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0610:Greb1
|
UTSW |
12 |
16,746,443 (GRCm39) |
missense |
probably benign |
|
|
R0652:Greb1
|
UTSW |
12 |
16,746,457 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0659:Greb1
|
UTSW |
12 |
16,730,213 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0945:Greb1
|
UTSW |
12 |
16,723,803 (GRCm39) |
missense |
probably benign |
0.31 |
|
R1055:Greb1
|
UTSW |
12 |
16,732,252 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1445:Greb1
|
UTSW |
12 |
16,757,852 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1471:Greb1
|
UTSW |
12 |
16,761,775 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1503:Greb1
|
UTSW |
12 |
16,774,820 (GRCm39) |
nonsense |
probably null |
|
|
R1566:Greb1
|
UTSW |
12 |
16,761,829 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1614:Greb1
|
UTSW |
12 |
16,751,172 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1623:Greb1
|
UTSW |
12 |
16,724,771 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1751:Greb1
|
UTSW |
12 |
16,773,439 (GRCm39) |
splice site |
probably benign |
|
|
R1778:Greb1
|
UTSW |
12 |
16,740,895 (GRCm39) |
missense |
probably benign |
|
|
R1842:Greb1
|
UTSW |
12 |
16,746,244 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2040:Greb1
|
UTSW |
12 |
16,752,651 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2153:Greb1
|
UTSW |
12 |
16,749,533 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2178:Greb1
|
UTSW |
12 |
16,746,388 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2194:Greb1
|
UTSW |
12 |
16,740,909 (GRCm39) |
missense |
probably benign |
0.08 |
|
R2248:Greb1
|
UTSW |
12 |
16,730,379 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R2474:Greb1
|
UTSW |
12 |
16,764,954 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R2860:Greb1
|
UTSW |
12 |
16,761,746 (GRCm39) |
missense |
probably benign |
0.28 |
|
R2861:Greb1
|
UTSW |
12 |
16,761,746 (GRCm39) |
missense |
probably benign |
0.28 |
|
R2862:Greb1
|
UTSW |
12 |
16,761,746 (GRCm39) |
missense |
probably benign |
0.28 |
|
R2866:Greb1
|
UTSW |
12 |
16,749,551 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2890:Greb1
|
UTSW |
12 |
16,754,479 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3056:Greb1
|
UTSW |
12 |
16,738,592 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R3863:Greb1
|
UTSW |
12 |
16,752,421 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3864:Greb1
|
UTSW |
12 |
16,752,421 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3956:Greb1
|
UTSW |
12 |
16,732,300 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4493:Greb1
|
UTSW |
12 |
16,748,611 (GRCm39) |
missense |
probably benign |
0.14 |
|
R4548:Greb1
|
UTSW |
12 |
16,749,676 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4683:Greb1
|
UTSW |
12 |
16,761,774 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R4739:Greb1
|
UTSW |
12 |
16,746,329 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4770:Greb1
|
UTSW |
12 |
16,731,357 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4838:Greb1
|
UTSW |
12 |
16,734,361 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4925:Greb1
|
UTSW |
12 |
16,731,472 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4982:Greb1
|
UTSW |
12 |
16,774,762 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5009:Greb1
|
UTSW |
12 |
16,774,858 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R5086:Greb1
|
UTSW |
12 |
16,758,023 (GRCm39) |
intron |
probably benign |
|
|
R5213:Greb1
|
UTSW |
12 |
16,764,791 (GRCm39) |
nonsense |
probably null |
|
|
R5310:Greb1
|
UTSW |
12 |
16,766,760 (GRCm39) |
missense |
probably benign |
0.09 |
|
R5353:Greb1
|
UTSW |
12 |
16,738,567 (GRCm39) |
nonsense |
probably null |
|
|
R5544:Greb1
|
UTSW |
12 |
16,723,797 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5605:Greb1
|
UTSW |
12 |
16,758,727 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5708:Greb1
|
UTSW |
12 |
16,723,843 (GRCm39) |
missense |
probably benign |
0.11 |
|
R5837:Greb1
|
UTSW |
12 |
16,738,586 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5890:Greb1
|
UTSW |
12 |
16,783,422 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R5938:Greb1
|
UTSW |
12 |
16,767,259 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6049:Greb1
|
UTSW |
12 |
16,731,395 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6093:Greb1
|
UTSW |
12 |
16,734,487 (GRCm39) |
missense |
probably benign |
|
|
R6120:Greb1
|
UTSW |
12 |
16,758,622 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6175:Greb1
|
UTSW |
12 |
16,724,771 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6247:Greb1
|
UTSW |
12 |
16,766,676 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6274:Greb1
|
UTSW |
12 |
16,785,152 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6376:Greb1
|
UTSW |
12 |
16,749,580 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6523:Greb1
|
UTSW |
12 |
16,734,374 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R6557:Greb1
|
UTSW |
12 |
16,760,384 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6602:Greb1
|
UTSW |
12 |
16,759,441 (GRCm39) |
missense |
probably benign |
0.44 |
|
R6621:Greb1
|
UTSW |
12 |
16,742,718 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6645:Greb1
|
UTSW |
12 |
16,748,580 (GRCm39) |
missense |
probably benign |
0.07 |
|
R6725:Greb1
|
UTSW |
12 |
16,738,568 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6750:Greb1
|
UTSW |
12 |
16,738,584 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6863:Greb1
|
UTSW |
12 |
16,734,421 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6914:Greb1
|
UTSW |
12 |
16,757,903 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6996:Greb1
|
UTSW |
12 |
16,773,355 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7083:Greb1
|
UTSW |
12 |
16,773,315 (GRCm39) |
missense |
probably benign |
|
|
R7147:Greb1
|
UTSW |
12 |
16,783,428 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7238:Greb1
|
UTSW |
12 |
16,724,673 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7290:Greb1
|
UTSW |
12 |
16,761,739 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7358:Greb1
|
UTSW |
12 |
16,774,882 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7395:Greb1
|
UTSW |
12 |
16,759,431 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7526:Greb1
|
UTSW |
12 |
16,766,766 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7530:Greb1
|
UTSW |
12 |
16,767,207 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7536:Greb1
|
UTSW |
12 |
16,732,186 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7643:Greb1
|
UTSW |
12 |
16,761,997 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7732:Greb1
|
UTSW |
12 |
16,723,864 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7740:Greb1
|
UTSW |
12 |
16,790,122 (GRCm39) |
start gained |
probably benign |
|
|
R7747:Greb1
|
UTSW |
12 |
16,724,796 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7760:Greb1
|
UTSW |
12 |
16,773,417 (GRCm39) |
missense |
probably benign |
|
|
R7937:Greb1
|
UTSW |
12 |
16,766,670 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8043:Greb1
|
UTSW |
12 |
16,761,790 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8259:Greb1
|
UTSW |
12 |
16,774,925 (GRCm39) |
nonsense |
probably null |
|
|
R8553:Greb1
|
UTSW |
12 |
16,773,328 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8559:Greb1
|
UTSW |
12 |
16,746,436 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8690:Greb1
|
UTSW |
12 |
16,746,548 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8830:Greb1
|
UTSW |
12 |
16,738,520 (GRCm39) |
missense |
probably benign |
0.35 |
|
R8911:Greb1
|
UTSW |
12 |
16,740,903 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R8963:Greb1
|
UTSW |
12 |
16,774,885 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8986:Greb1
|
UTSW |
12 |
16,734,457 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9013:Greb1
|
UTSW |
12 |
16,789,970 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9279:Greb1
|
UTSW |
12 |
16,732,153 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9360:Greb1
|
UTSW |
12 |
16,790,037 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9563:Greb1
|
UTSW |
12 |
16,774,824 (GRCm39) |
missense |
probably benign |
0.06 |
|
R9616:Greb1
|
UTSW |
12 |
16,790,038 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9627:Greb1
|
UTSW |
12 |
16,756,167 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9731:Greb1
|
UTSW |
12 |
16,738,598 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9761:Greb1
|
UTSW |
12 |
16,751,275 (GRCm39) |
missense |
probably benign |
0.05 |
|
Z1176:Greb1
|
UTSW |
12 |
16,746,757 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1177:Greb1
|
UTSW |
12 |
16,752,492 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GAATGCATACCCAGCTCCCTTC -3'
(R):5'- TCAAGCTTGCCCAGACTCTC -3'
Sequencing Primer
(F):5'- GCAGATTGCAGCCCCTC -3'
(R):5'- GGGTCCAGTCTCTTCGGTC -3'
|
| Posted On |
2014-12-04 |
Incidental Mutation