Mutagenetix > Incidental Mutation

Incidental Mutation 'R2509:Dnah8'

251865

Institutional Source

Beutler Lab

Gene Symbol

Dnah8

Ensembl Gene

ENSMUSG00000033826

Gene Name

dynein, axonemal, heavy chain 8

Synonyms

Dnahc8, P1-Loop, Hst6.7b

MMRRC Submission

040415-MU

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.423) question?

Stock #

R2509 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

30624354-30875264 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 30775045 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Asparagine at position 3379 (D3379N)

Ref Sequence

ENSEMBL: ENSMUSP00000127878 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000170651]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000170651
AA Change: D3379N

PolyPhen 2 Score 0.017 (Sensitivity: 0.95; Specificity: 0.80)

SMART Domains

Protein: ENSMUSP00000127878
Gene: ENSMUSG00000033826
AA Change: D3379N

Domain	Start	End	E-Value	Type
low complexity region	2	54	N/A	INTRINSIC
Pfam:DHC_N1	379	936	8.4e-159	PFAM
low complexity region	1069	1080	N/A	INTRINSIC
low complexity region	1224	1237	N/A	INTRINSIC
Pfam:DHC_N2	1509	1917	1.6e-134	PFAM
AAA	2082	2226	1.38e-1	SMART
AAA	2363	2516	2.04e-1	SMART
AAA	2689	2837	8.15e-2	SMART
Pfam:AAA_8	3022	3294	4e-72	PFAM
Pfam:MT	3306	3656	3.6e-48	PFAM
Pfam:AAA_9	3676	3901	6.7e-85	PFAM
Pfam:Dynein_heavy	4039	4728	8.4e-250	PFAM

Meta Mutation Damage Score

0.1080

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.4%
20x: 95.4%

Validation Efficiency

96% (105/109)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a heavy chain of an axonemal dynein involved in sperm and respiratory cilia motility. Axonemal dyneins generate force through hydrolysis of ATP and binding to microtubules. [provided by RefSeq, Jan 2012]

Allele List at MGI

Other mutations in this stock

Total: 108 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700006A11Rik	T	C	3: 124,406,453 (GRCm38)	I497V	probably benign	Het
2010300C02Rik	T	C	1: 37,625,300 (GRCm38)	M506V	probably benign	Het
4930571K23Rik	C	A	7: 125,369,139 (GRCm38)		noncoding transcript	Het
Abca17	G	T	17: 24,289,613 (GRCm38)		probably benign	Het
Ablim1	C	T	19: 57,152,359 (GRCm38)	R196Q	probably damaging	Het
Acot11	T	C	4: 106,755,319 (GRCm38)	I379V	possibly damaging	Het
Acot4	G	A	12: 84,041,873 (GRCm38)	G165D	probably damaging	Het
Agrn	A	T	4: 156,166,424 (GRCm38)		probably null	Het
Ahctf1	T	C	1: 179,770,693 (GRCm38)	S945G	possibly damaging	Het
Akr1c13	C	T	13: 4,198,584 (GRCm38)	R263C	probably damaging	Het
Arfgap1	T	A	2: 180,974,053 (GRCm38)		probably benign	Het
Arhgef3	A	G	14: 27,379,676 (GRCm38)	K103R	probably damaging	Het
Cabp1	A	T	5: 115,172,784 (GRCm38)	N211K	probably damaging	Het
Cacna1c	T	A	6: 118,734,982 (GRCm38)	D261V	probably damaging	Het
Car11	G	A	7: 45,701,359 (GRCm38)	G93E	probably damaging	Het
Card10	A	G	15: 78,780,273 (GRCm38)	I821T	probably benign	Het
Cast	T	C	13: 74,737,616 (GRCm38)	I277V	probably benign	Het
Cenpj	T	C	14: 56,532,237 (GRCm38)	K1165R	probably null	Het
Cenpk	A	G	13: 104,234,167 (GRCm38)		probably null	Het
Cmya5	T	C	13: 93,093,558 (GRCm38)	Q1674R	probably benign	Het
Cnnm1	T	A	19: 43,441,886 (GRCm38)	V481D	probably damaging	Het
Csmd3	CCTTTGCGCTT	CCTT	15: 47,741,236 (GRCm38)		probably null	Het
Cyp2c50	G	A	19: 40,090,569 (GRCm38)	V119I	probably benign	Het
Dnah7b	A	G	1: 46,195,287 (GRCm38)	T1460A	probably damaging	Het
Dnajc4	C	T	19: 6,990,743 (GRCm38)	R55H	probably damaging	Het
Ebf4	C	T	2: 130,306,562 (GRCm38)	R98*	probably null	Het
Epha4	G	A	1: 77,511,702 (GRCm38)	A47V	possibly damaging	Het
Ercc8	T	C	13: 108,183,717 (GRCm38)		probably benign	Het
Exo1	T	C	1: 175,905,833 (GRCm38)	F75S	probably damaging	Het
Fam168a	G	T	7: 100,834,184 (GRCm38)		probably null	Het
Fat3	G	A	9: 15,925,014 (GRCm38)	R4065W	possibly damaging	Het
Gm10639	T	A	9: 78,294,807 (GRCm38)	M1K	probably null	Het
Gm13103	G	A	4: 143,851,991 (GRCm38)	V274I	probably benign	Het
Gm5431	T	A	11: 48,888,709 (GRCm38)	N740I	probably benign	Het
Gm5900	T	A	7: 104,950,364 (GRCm38)		noncoding transcript	Het
Gpi1	A	G	7: 34,205,923 (GRCm38)	S359P	probably damaging	Het
Gpr156	A	G	16: 37,947,787 (GRCm38)	R22G	probably benign	Het
Greb1	A	G	12: 16,724,922 (GRCm38)	V158A	probably damaging	Het
Grin2c	T	A	11: 115,251,068 (GRCm38)	K842*	probably null	Het
Hnf4a	T	A	2: 163,566,241 (GRCm38)	L329Q	probably damaging	Het
Hsp90ab1	A	G	17: 45,569,341 (GRCm38)	L92P	probably damaging	Het
Ido1	T	A	8: 24,584,485 (GRCm38)	R290*	probably null	Het
Ifnlr1	G	T	4: 135,705,248 (GRCm38)	D332Y	probably damaging	Het
Ift172	T	C	5: 31,262,968 (GRCm38)	N1108S	probably benign	Het
Igkv3-9	T	A	6: 70,588,744 (GRCm38)	M109K	probably benign	Het
Igsf10	T	C	3: 59,331,866 (GRCm38)	D298G	probably damaging	Het
Iqck	T	G	7: 118,876,282 (GRCm38)	M98R	probably benign	Het
Klk1b1	T	C	7: 43,969,379 (GRCm38)	V60A	probably damaging	Het
Krtap1-3	C	T	11: 99,590,827 (GRCm38)	E165K	unknown	Het
Lair1	A	G	7: 4,010,783 (GRCm38)	L155P	probably damaging	Het
Mast4	G	T	13: 102,853,842 (GRCm38)	S57Y	probably damaging	Het
Mical3	T	C	6: 121,034,157 (GRCm38)	H360R	probably damaging	Het
Muc5b	A	T	7: 141,859,061 (GRCm38)	N1915Y	unknown	Het
Myh1	A	G	11: 67,205,597 (GRCm38)	I301V	probably benign	Het
Nck2	T	A	1: 43,554,233 (GRCm38)	V200E	probably damaging	Het
Olfr10	T	G	11: 49,318,221 (GRCm38)	L225R	probably damaging	Het
Olfr1214	T	G	2: 88,987,431 (GRCm38)	Y257S	probably damaging	Het
Olfr1271	T	C	2: 90,265,686 (GRCm38)	Y248C	possibly damaging	Het
Olfr1282	C	T	2: 111,335,731 (GRCm38)	V116I	probably damaging	Het
Olfr1313	T	A	2: 112,072,492 (GRCm38)	L30F	probably benign	Het
Olfr1453	T	A	19: 13,027,694 (GRCm38)	I212F	probably damaging	Het
Olfr668	G	A	7: 104,925,687 (GRCm38)	H26Y	probably benign	Het
Olfr870	A	G	9: 20,171,229 (GRCm38)	L114P	probably damaging	Het
Otoa	C	T	7: 121,160,472 (GRCm38)	T1099I	probably benign	Het
Pask	T	A	1: 93,330,763 (GRCm38)	I288F	possibly damaging	Het
Pcnx4	T	C	12: 72,566,972 (GRCm38)	W564R	probably damaging	Het
Pitpnm2	T	C	5: 124,136,326 (GRCm38)	E240G	probably damaging	Het
Ppp1r16b	A	G	2: 158,761,463 (GRCm38)	Y436C	possibly damaging	Het
Prkca	T	C	11: 107,979,206 (GRCm38)	Y37C	probably damaging	Het
Rad18	T	G	6: 112,675,922 (GRCm38)	H238P	possibly damaging	Het
Rap1b	T	A	10: 117,818,539 (GRCm38)	Q1L	probably damaging	Het
Rgs9	T	C	11: 109,268,972 (GRCm38)	Y178C	probably benign	Het
Rpl3l	A	T	17: 24,732,386 (GRCm38)	D87V	possibly damaging	Het
Scrn2	T	C	11: 97,033,166 (GRCm38)	V292A	possibly damaging	Het
Sdad1	A	G	5: 92,305,825 (GRCm38)	Y35H	probably benign	Het
Sez6l2	T	C	7: 126,953,772 (GRCm38)	S177P	probably benign	Het
Sh3bp1	C	T	15: 78,911,506 (GRCm38)	P612S	probably damaging	Het
Shank1	G	A	7: 44,352,123 (GRCm38)	A1089T	unknown	Het
Shank1	T	C	7: 44,351,724 (GRCm38)	S956P	unknown	Het
Shprh	G	A	10: 11,166,724 (GRCm38)	C817Y	probably damaging	Het
Spata22	C	T	11: 73,345,767 (GRCm38)	P300S	probably damaging	Het
Sstr2	A	T	11: 113,624,923 (GRCm38)	I223F	probably damaging	Het
Stom	C	T	2: 35,320,342 (GRCm38)	A217T	probably damaging	Het
Stpg1	T	C	4: 135,536,649 (GRCm38)	V341A	probably benign	Het
Tagap	A	G	17: 7,928,754 (GRCm38)	T99A	probably benign	Het
Tas1r2	A	G	4: 139,659,851 (GRCm38)	N207S	probably damaging	Het
Thbs2	A	G	17: 14,685,843 (GRCm38)	V265A	probably benign	Het
Thyn1	A	G	9: 27,000,020 (GRCm38)	R3G	possibly damaging	Het
Tia1	T	A	6: 86,424,330 (GRCm38)		probably null	Het
Tktl2	A	G	8: 66,512,852 (GRCm38)	E354G	probably benign	Het
Tmc8	A	G	11: 117,792,685 (GRCm38)	T689A	possibly damaging	Het
Tmem11	A	T	11: 60,864,981 (GRCm38)		probably null	Het
Tmem55b	A	T	14: 50,929,658 (GRCm38)	Y129*	probably null	Het
Tmem57	A	G	4: 134,804,388 (GRCm38)	S657P	probably damaging	Het
Tnik	T	C	3: 28,667,915 (GRCm38)	V1310A	probably damaging	Het
Trappc10	A	G	10: 78,211,523 (GRCm38)	S380P	possibly damaging	Het
Trim8	C	T	19: 46,515,295 (GRCm38)	P429S	probably benign	Het
Ttc25	T	G	11: 100,553,535 (GRCm38)	L222R	probably damaging	Het
Ttn	C	A	2: 76,857,412 (GRCm38)		probably benign	Het
Ulk2	T	C	11: 61,787,514 (GRCm38)	Y793C	probably benign	Het
Vill	G	A	9: 119,070,302 (GRCm38)	V337M	possibly damaging	Het
Vps53	C	A	11: 76,066,835 (GRCm38)	V364F	possibly damaging	Het
Wdr66	A	G	5: 123,256,106 (GRCm38)	K353E	probably benign	Het
Zan	A	T	5: 137,456,586 (GRCm38)	I1396N	unknown	Het
Zfa-ps	A	C	10: 52,544,243 (GRCm38)		noncoding transcript	Het
Zfp426	T	C	9: 20,470,681 (GRCm38)	T337A	possibly damaging	Het
Zfp536	T	C	7: 37,567,978 (GRCm38)	E671G	possibly damaging	Het
Zfp985	A	G	4: 147,582,986 (GRCm38)	T104A	possibly damaging	Het

Other mutations in Dnah8

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00498:Dnah8	APN	17	30,677,176 (GRCm38)	missense	probably benign	0.06
IGL00508:Dnah8	APN	17	30,855,930 (GRCm38)	missense	probably damaging	1.00
IGL00547:Dnah8	APN	17	30,815,703 (GRCm38)	nonsense	probably null
IGL00551:Dnah8	APN	17	30,663,478 (GRCm38)	nonsense	probably null
IGL00732:Dnah8	APN	17	30,656,641 (GRCm38)	missense	probably damaging	1.00
IGL00775:Dnah8	APN	17	30,767,906 (GRCm38)	nonsense	probably null
IGL00840:Dnah8	APN	17	30,790,941 (GRCm38)	missense	probably damaging	1.00
IGL00845:Dnah8	APN	17	30,819,276 (GRCm38)	critical splice donor site	probably null
IGL00953:Dnah8	APN	17	30,706,457 (GRCm38)	nonsense	probably null
IGL00976:Dnah8	APN	17	30,851,710 (GRCm38)	missense	probably damaging	0.98
IGL01395:Dnah8	APN	17	30,636,005 (GRCm38)	missense	probably benign	0.06
IGL01467:Dnah8	APN	17	30,779,916 (GRCm38)	missense	probably damaging	1.00
IGL01469:Dnah8	APN	17	30,683,714 (GRCm38)	splice site	probably benign
IGL01515:Dnah8	APN	17	30,648,485 (GRCm38)	missense	probably benign
IGL01723:Dnah8	APN	17	30,708,471 (GRCm38)	missense	probably damaging	1.00
IGL01837:Dnah8	APN	17	30,751,591 (GRCm38)	critical splice donor site	probably null
IGL01921:Dnah8	APN	17	30,736,141 (GRCm38)	missense	probably benign
IGL01958:Dnah8	APN	17	30,855,895 (GRCm38)	splice site	probably benign
IGL01968:Dnah8	APN	17	30,656,598 (GRCm38)	nonsense	probably null
IGL02093:Dnah8	APN	17	30,717,880 (GRCm38)	missense	probably damaging	0.99
IGL02151:Dnah8	APN	17	30,648,417 (GRCm38)	missense	possibly damaging	0.50
IGL02182:Dnah8	APN	17	30,794,763 (GRCm38)	missense	possibly damaging	0.45
IGL02233:Dnah8	APN	17	30,706,513 (GRCm38)	critical splice donor site	probably null
IGL02236:Dnah8	APN	17	30,649,773 (GRCm38)	nonsense	probably null
IGL02259:Dnah8	APN	17	30,759,614 (GRCm38)	missense	probably benign
IGL02263:Dnah8	APN	17	30,729,165 (GRCm38)	missense	probably benign	0.00
IGL02303:Dnah8	APN	17	30,713,047 (GRCm38)	missense	probably benign	0.03
IGL02341:Dnah8	APN	17	30,747,257 (GRCm38)	missense	probably damaging	1.00
IGL02351:Dnah8	APN	17	30,767,811 (GRCm38)	missense	probably damaging	1.00
IGL02358:Dnah8	APN	17	30,767,811 (GRCm38)	missense	probably damaging	1.00
IGL02377:Dnah8	APN	17	30,794,796 (GRCm38)	missense	probably damaging	0.98
IGL02390:Dnah8	APN	17	30,830,845 (GRCm38)	missense	probably benign	0.01
IGL02392:Dnah8	APN	17	30,818,051 (GRCm38)	splice site	probably benign
IGL02414:Dnah8	APN	17	30,700,413 (GRCm38)	missense	probably benign
IGL02455:Dnah8	APN	17	30,672,334 (GRCm38)	missense	probably damaging	0.99
IGL02817:Dnah8	APN	17	30,668,295 (GRCm38)	missense	probably benign
IGL02831:Dnah8	APN	17	30,712,276 (GRCm38)	missense	probably benign	0.23
IGL02863:Dnah8	APN	17	30,769,697 (GRCm38)	missense	probably damaging	1.00
IGL02894:Dnah8	APN	17	30,721,110 (GRCm38)	nonsense	probably null
IGL02954:Dnah8	APN	17	30,704,835 (GRCm38)	missense	probably benign	0.30
IGL02964:Dnah8	APN	17	30,746,761 (GRCm38)	missense	probably damaging	1.00
IGL03080:Dnah8	APN	17	30,719,006 (GRCm38)	missense	probably benign	0.01
IGL03081:Dnah8	APN	17	30,686,373 (GRCm38)	splice site	probably benign
IGL03086:Dnah8	APN	17	30,742,780 (GRCm38)	missense	probably damaging	1.00
IGL03087:Dnah8	APN	17	30,784,144 (GRCm38)	missense	probably benign
IGL03176:Dnah8	APN	17	30,694,037 (GRCm38)	missense	probably benign
IGL03191:Dnah8	APN	17	30,726,830 (GRCm38)	missense	probably damaging	0.99
IGL03210:Dnah8	APN	17	30,815,665 (GRCm38)	missense	probably damaging	0.96
IGL03252:Dnah8	APN	17	30,673,920 (GRCm38)	splice site	probably null
IGL03255:Dnah8	APN	17	30,741,381 (GRCm38)	missense	probably damaging	1.00
IGL03288:Dnah8	APN	17	30,672,349 (GRCm38)	missense	probably benign
IGL03348:Dnah8	APN	17	30,746,986 (GRCm38)	missense	probably damaging	0.99
Alternator	UTSW	17	30,765,635 (GRCm38)	missense	probably benign
armature	UTSW	17	30,708,390 (GRCm38)	missense	probably benign	0.02
Brush	UTSW	17	30,746,990 (GRCm38)	missense	probably damaging	1.00
Dynos	UTSW	17	30,715,509 (GRCm38)	missense	possibly damaging	0.84
joule	UTSW	17	30,713,098 (GRCm38)	critical splice donor site	probably null
solenoid	UTSW	17	30,741,178 (GRCm38)	missense	probably damaging	1.00
FR4340:Dnah8	UTSW	17	30,635,463 (GRCm38)	small deletion	probably benign
FR4737:Dnah8	UTSW	17	30,635,477 (GRCm38)	small deletion	probably benign
FR4737:Dnah8	UTSW	17	30,635,465 (GRCm38)	small deletion	probably benign
I2288:Dnah8	UTSW	17	30,663,454 (GRCm38)	missense	probably benign
P0029:Dnah8	UTSW	17	30,765,720 (GRCm38)	missense	probably damaging	1.00
PIT4812001:Dnah8	UTSW	17	30,708,445 (GRCm38)	missense	probably benign	0.04
R0016:Dnah8	UTSW	17	30,663,316 (GRCm38)	missense	probably benign
R0035:Dnah8	UTSW	17	30,683,621 (GRCm38)	splice site	probably benign
R0035:Dnah8	UTSW	17	30,683,621 (GRCm38)	splice site	probably benign
R0062:Dnah8	UTSW	17	30,765,711 (GRCm38)	missense	probably damaging	1.00
R0062:Dnah8	UTSW	17	30,765,711 (GRCm38)	missense	probably damaging	1.00
R0087:Dnah8	UTSW	17	30,755,119 (GRCm38)	missense	probably damaging	1.00
R0090:Dnah8	UTSW	17	30,784,090 (GRCm38)	missense	probably benign	0.20
R0119:Dnah8	UTSW	17	30,715,509 (GRCm38)	missense	possibly damaging	0.84
R0164:Dnah8	UTSW	17	30,748,665 (GRCm38)	missense	probably benign
R0164:Dnah8	UTSW	17	30,748,665 (GRCm38)	missense	probably benign
R0184:Dnah8	UTSW	17	30,683,683 (GRCm38)	missense	probably benign	0.04
R0240:Dnah8	UTSW	17	30,765,679 (GRCm38)	missense	probably damaging	0.98
R0240:Dnah8	UTSW	17	30,765,679 (GRCm38)	missense	probably damaging	0.98
R0241:Dnah8	UTSW	17	30,765,679 (GRCm38)	missense	probably damaging	0.98
R0241:Dnah8	UTSW	17	30,765,679 (GRCm38)	missense	probably damaging	0.98
R0265:Dnah8	UTSW	17	30,690,271 (GRCm38)	missense	probably benign
R0268:Dnah8	UTSW	17	30,769,707 (GRCm38)	missense	probably damaging	1.00
R0282:Dnah8	UTSW	17	30,736,156 (GRCm38)	missense	probably damaging	1.00
R0299:Dnah8	UTSW	17	30,715,509 (GRCm38)	missense	possibly damaging	0.84
R0334:Dnah8	UTSW	17	30,871,351 (GRCm38)	missense	probably damaging	0.99
R0393:Dnah8	UTSW	17	30,708,390 (GRCm38)	missense	probably benign	0.02
R0423:Dnah8	UTSW	17	30,701,981 (GRCm38)	missense	probably benign
R0470:Dnah8	UTSW	17	30,708,540 (GRCm38)	splice site	probably benign
R0477:Dnah8	UTSW	17	30,755,080 (GRCm38)	missense	probably damaging	1.00
R0490:Dnah8	UTSW	17	30,700,419 (GRCm38)	missense	probably benign
R0499:Dnah8	UTSW	17	30,715,509 (GRCm38)	missense	possibly damaging	0.84
R0582:Dnah8	UTSW	17	30,718,961 (GRCm38)	missense	probably benign	0.01
R0601:Dnah8	UTSW	17	30,708,358 (GRCm38)	missense	probably benign	0.06
R0646:Dnah8	UTSW	17	30,684,173 (GRCm38)	missense	probably damaging	0.97
R0665:Dnah8	UTSW	17	30,736,155 (GRCm38)	missense	probably damaging	0.99
R0800:Dnah8	UTSW	17	30,704,662 (GRCm38)	missense	probably benign
R0843:Dnah8	UTSW	17	30,813,095 (GRCm38)	missense	probably damaging	1.00
R0940:Dnah8	UTSW	17	30,803,243 (GRCm38)	missense	probably damaging	1.00
R0964:Dnah8	UTSW	17	30,673,920 (GRCm38)	splice site	probably null
R1102:Dnah8	UTSW	17	30,854,764 (GRCm38)	splice site	probably null
R1137:Dnah8	UTSW	17	30,855,936 (GRCm38)	missense	probably damaging	1.00
R1342:Dnah8	UTSW	17	30,721,000 (GRCm38)	missense	probably damaging	0.99
R1375:Dnah8	UTSW	17	30,737,295 (GRCm38)	missense	probably damaging	1.00
R1377:Dnah8	UTSW	17	30,840,622 (GRCm38)	nonsense	probably null
R1464:Dnah8	UTSW	17	30,695,173 (GRCm38)	missense	possibly damaging	0.81
R1464:Dnah8	UTSW	17	30,695,173 (GRCm38)	missense	possibly damaging	0.81
R1470:Dnah8	UTSW	17	30,747,277 (GRCm38)	nonsense	probably null
R1470:Dnah8	UTSW	17	30,747,277 (GRCm38)	nonsense	probably null
R1497:Dnah8	UTSW	17	30,752,075 (GRCm38)	missense	probably damaging	1.00
R1513:Dnah8	UTSW	17	30,673,888 (GRCm38)	missense	probably benign
R1541:Dnah8	UTSW	17	30,747,247 (GRCm38)	missense	probably damaging	1.00
R1563:Dnah8	UTSW	17	30,635,664 (GRCm38)	missense	probably benign	0.07
R1634:Dnah8	UTSW	17	30,713,098 (GRCm38)	critical splice donor site	probably null
R1670:Dnah8	UTSW	17	30,725,124 (GRCm38)	missense	probably damaging	1.00
R1710:Dnah8	UTSW	17	30,854,940 (GRCm38)	missense	probably damaging	1.00
R1743:Dnah8	UTSW	17	30,769,651 (GRCm38)	missense	probably benign	0.28
R1761:Dnah8	UTSW	17	30,779,916 (GRCm38)	missense	probably damaging	1.00
R1785:Dnah8	UTSW	17	30,722,937 (GRCm38)	missense	probably damaging	0.98
R1804:Dnah8	UTSW	17	30,708,407 (GRCm38)	missense	probably benign	0.00
R1808:Dnah8	UTSW	17	30,684,186 (GRCm38)	missense	probably damaging	1.00
R1824:Dnah8	UTSW	17	30,731,180 (GRCm38)	missense	possibly damaging	0.67
R1836:Dnah8	UTSW	17	30,874,927 (GRCm38)	missense	possibly damaging	0.94
R1935:Dnah8	UTSW	17	30,635,505 (GRCm38)	missense	unknown
R1935:Dnah8	UTSW	17	30,726,896 (GRCm38)	splice site	probably benign
R1940:Dnah8	UTSW	17	30,731,207 (GRCm38)	missense	probably damaging	1.00
R1946:Dnah8	UTSW	17	30,712,385 (GRCm38)	missense	probably benign	0.00
R2025:Dnah8	UTSW	17	30,731,159 (GRCm38)	missense	probably damaging	0.99
R2038:Dnah8	UTSW	17	30,758,281 (GRCm38)	missense	probably damaging	1.00
R2042:Dnah8	UTSW	17	30,635,658 (GRCm38)	missense	probably benign	0.01
R2148:Dnah8	UTSW	17	30,737,258 (GRCm38)	missense	probably damaging	1.00
R2177:Dnah8	UTSW	17	30,653,393 (GRCm38)	missense	probably benign
R2180:Dnah8	UTSW	17	30,840,647 (GRCm38)	missense	probably benign	0.00
R2262:Dnah8	UTSW	17	30,673,835 (GRCm38)	missense	probably damaging	1.00
R2263:Dnah8	UTSW	17	30,673,835 (GRCm38)	missense	probably damaging	1.00
R2328:Dnah8	UTSW	17	30,794,744 (GRCm38)	missense	probably damaging	1.00
R2357:Dnah8	UTSW	17	30,771,872 (GRCm38)	missense	probably benign
R2357:Dnah8	UTSW	17	30,874,935 (GRCm38)	missense	probably benign	0.00
R2360:Dnah8	UTSW	17	30,677,204 (GRCm38)	missense	probably benign	0.22
R2496:Dnah8	UTSW	17	30,851,731 (GRCm38)	missense	probably damaging	1.00
R2497:Dnah8	UTSW	17	30,741,365 (GRCm38)	nonsense	probably null
R3114:Dnah8	UTSW	17	30,833,568 (GRCm38)	missense	probably benign	0.04
R3708:Dnah8	UTSW	17	30,739,657 (GRCm38)	missense	probably damaging	0.98
R3720:Dnah8	UTSW	17	30,854,898 (GRCm38)	missense	probably damaging	1.00
R3722:Dnah8	UTSW	17	30,854,898 (GRCm38)	missense	probably damaging	1.00
R3727:Dnah8	UTSW	17	30,739,648 (GRCm38)	nonsense	probably null
R3747:Dnah8	UTSW	17	30,784,174 (GRCm38)	nonsense	probably null
R3748:Dnah8	UTSW	17	30,784,174 (GRCm38)	nonsense	probably null
R3749:Dnah8	UTSW	17	30,784,174 (GRCm38)	nonsense	probably null
R3787:Dnah8	UTSW	17	30,755,041 (GRCm38)	missense	probably damaging	1.00
R3790:Dnah8	UTSW	17	30,854,898 (GRCm38)	missense	probably damaging	1.00
R3804:Dnah8	UTSW	17	30,670,647 (GRCm38)	missense	probably benign	0.00
R3857:Dnah8	UTSW	17	30,663,422 (GRCm38)	missense	probably damaging	0.96
R3898:Dnah8	UTSW	17	30,854,898 (GRCm38)	missense	probably damaging	1.00
R3899:Dnah8	UTSW	17	30,854,898 (GRCm38)	missense	probably damaging	1.00
R3938:Dnah8	UTSW	17	30,854,937 (GRCm38)	missense	probably damaging	1.00
R3943:Dnah8	UTSW	17	30,694,065 (GRCm38)	splice site	probably benign
R4091:Dnah8	UTSW	17	30,769,839 (GRCm38)	missense	probably damaging	1.00
R4291:Dnah8	UTSW	17	30,748,559 (GRCm38)	missense	probably benign
R4326:Dnah8	UTSW	17	30,752,092 (GRCm38)	missense	probably benign	0.04
R4346:Dnah8	UTSW	17	30,725,098 (GRCm38)	missense	possibly damaging	0.92
R4429:Dnah8	UTSW	17	30,752,146 (GRCm38)	missense	probably damaging	1.00
R4457:Dnah8	UTSW	17	30,813,151 (GRCm38)	missense	probably benign
R4475:Dnah8	UTSW	17	30,656,985 (GRCm38)	missense	probably benign	0.12
R4565:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R4566:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R4568:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R4573:Dnah8	UTSW	17	30,700,406 (GRCm38)	missense	probably benign	0.00
R4580:Dnah8	UTSW	17	30,662,052 (GRCm38)	missense	probably benign	0.00
R4585:Dnah8	UTSW	17	30,751,567 (GRCm38)	missense	probably benign	0.01
R4611:Dnah8	UTSW	17	30,684,237 (GRCm38)	missense	probably damaging	1.00
R4720:Dnah8	UTSW	17	30,683,634 (GRCm38)	missense	probably benign	0.08
R4721:Dnah8	UTSW	17	30,725,166 (GRCm38)	missense	probably damaging	1.00
R4727:Dnah8	UTSW	17	30,851,747 (GRCm38)	missense	probably damaging	1.00
R4731:Dnah8	UTSW	17	30,775,061 (GRCm38)	missense	probably null	0.02
R4732:Dnah8	UTSW	17	30,775,061 (GRCm38)	missense	probably null	0.02
R4733:Dnah8	UTSW	17	30,775,061 (GRCm38)	missense	probably null	0.02
R4798:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R4814:Dnah8	UTSW	17	30,767,924 (GRCm38)	missense	probably damaging	1.00
R4892:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R4894:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R4900:Dnah8	UTSW	17	30,746,975 (GRCm38)	missense	probably damaging	1.00
R4901:Dnah8	UTSW	17	30,840,714 (GRCm38)	critical splice donor site	probably null
R4913:Dnah8	UTSW	17	30,819,139 (GRCm38)	missense	probably damaging	0.99
R4931:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R4932:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R4933:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R4942:Dnah8	UTSW	17	30,729,142 (GRCm38)	missense	probably benign
R4969:Dnah8	UTSW	17	30,723,014 (GRCm38)	missense	probably damaging	1.00
R4975:Dnah8	UTSW	17	30,656,985 (GRCm38)	missense	probably benign	0.12
R4977:Dnah8	UTSW	17	30,663,301 (GRCm38)	missense	probably benign	0.00
R5001:Dnah8	UTSW	17	30,787,185 (GRCm38)	missense	probably damaging	1.00
R5011:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R5013:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R5014:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R5024:Dnah8	UTSW	17	30,736,096 (GRCm38)	missense	probably damaging	1.00
R5075:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R5075:Dnah8	UTSW	17	30,800,531 (GRCm38)	missense	probably damaging	1.00
R5075:Dnah8	UTSW	17	30,739,757 (GRCm38)	critical splice donor site	probably null
R5112:Dnah8	UTSW	17	30,731,038 (GRCm38)	missense	probably benign	0.02
R5121:Dnah8	UTSW	17	30,810,353 (GRCm38)	missense	probably benign	0.14
R5138:Dnah8	UTSW	17	30,765,597 (GRCm38)	missense	probably damaging	0.99
R5151:Dnah8	UTSW	17	30,712,295 (GRCm38)	missense	probably benign	0.06
R5191:Dnah8	UTSW	17	30,746,765 (GRCm38)	missense	probably damaging	1.00
R5238:Dnah8	UTSW	17	30,790,917 (GRCm38)	missense	probably damaging	1.00
R5260:Dnah8	UTSW	17	30,700,419 (GRCm38)	missense	probably benign
R5358:Dnah8	UTSW	17	30,746,954 (GRCm38)	missense	probably damaging	1.00
R5403:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R5404:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R5482:Dnah8	UTSW	17	30,800,547 (GRCm38)	missense	probably damaging	0.96
R5489:Dnah8	UTSW	17	30,790,956 (GRCm38)	missense	probably damaging	1.00
R5513:Dnah8	UTSW	17	30,752,916 (GRCm38)	missense	probably damaging	0.99
R5635:Dnah8	UTSW	17	30,706,386 (GRCm38)	missense	probably benign	0.00
R5640:Dnah8	UTSW	17	30,803,108 (GRCm38)	missense	probably damaging	1.00
R5649:Dnah8	UTSW	17	30,800,587 (GRCm38)	missense	probably benign	0.13
R5662:Dnah8	UTSW	17	30,737,333 (GRCm38)	missense	probably damaging	1.00
R5673:Dnah8	UTSW	17	30,803,261 (GRCm38)	missense	probably damaging	1.00
R5677:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R5699:Dnah8	UTSW	17	30,810,324 (GRCm38)	missense	probably benign	0.22
R5737:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R5738:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R5739:Dnah8	UTSW	17	30,719,007 (GRCm38)	missense	probably benign	0.00
R5766:Dnah8	UTSW	17	30,690,261 (GRCm38)	missense	probably benign	0.01
R5790:Dnah8	UTSW	17	30,875,004 (GRCm38)	missense	probably damaging	0.98
R5848:Dnah8	UTSW	17	30,728,191 (GRCm38)	missense	possibly damaging	0.69
R5854:Dnah8	UTSW	17	30,794,763 (GRCm38)	missense	possibly damaging	0.45
R5885:Dnah8	UTSW	17	30,794,717 (GRCm38)	missense	probably damaging	1.00
R5886:Dnah8	UTSW	17	30,794,717 (GRCm38)	missense	probably damaging	1.00
R5887:Dnah8	UTSW	17	30,794,717 (GRCm38)	missense	probably damaging	1.00
R5899:Dnah8	UTSW	17	30,656,685 (GRCm38)	missense	probably benign	0.32
R5979:Dnah8	UTSW	17	30,815,664 (GRCm38)	nonsense	probably null
R5986:Dnah8	UTSW	17	30,851,630 (GRCm38)	missense	possibly damaging	0.83
R5999:Dnah8	UTSW	17	30,663,305 (GRCm38)	missense	probably benign	0.32
R6042:Dnah8	UTSW	17	30,747,265 (GRCm38)	missense	probably damaging	1.00
R6175:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R6181:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R6237:Dnah8	UTSW	17	30,747,854 (GRCm38)	nonsense	probably null
R6239:Dnah8	UTSW	17	30,810,359 (GRCm38)	missense	probably damaging	0.99
R6337:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R6365:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R6416:Dnah8	UTSW	17	30,765,635 (GRCm38)	missense	probably benign
R6443:Dnah8	UTSW	17	30,771,885 (GRCm38)	missense	probably benign	0.10
R6478:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R6479:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R6480:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R6481:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R6533:Dnah8	UTSW	17	30,746,990 (GRCm38)	missense	probably damaging	1.00
R6606:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R6608:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R6610:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R6675:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R6723:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R6724:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R6754:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R6755:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R6759:Dnah8	UTSW	17	30,663,292 (GRCm38)	splice site	probably null
R6765:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R6766:Dnah8	UTSW	17	30,748,568 (GRCm38)	missense	probably benign	0.00
R6778:Dnah8	UTSW	17	30,635,666 (GRCm38)	missense	probably benign	0.00
R6781:Dnah8	UTSW	17	30,765,724 (GRCm38)	frame shift	probably null
R6788:Dnah8	UTSW	17	30,648,465 (GRCm38)	missense	probably benign	0.14
R6814:Dnah8	UTSW	17	30,762,679 (GRCm38)	missense	probably damaging	1.00
R6825:Dnah8	UTSW	17	30,741,173 (GRCm38)	missense	probably damaging	1.00
R6838:Dnah8	UTSW	17	30,710,551 (GRCm38)	missense	probably damaging	1.00
R6872:Dnah8	UTSW	17	30,762,679 (GRCm38)	missense	probably damaging	1.00
R6877:Dnah8	UTSW	17	30,746,959 (GRCm38)	missense	probably damaging	1.00
R6944:Dnah8	UTSW	17	30,794,659 (GRCm38)	missense	probably benign	0.09
R6982:Dnah8	UTSW	17	30,767,925 (GRCm38)	missense	probably benign	0.03
R6984:Dnah8	UTSW	17	30,739,738 (GRCm38)	missense	probably damaging	1.00
R6987:Dnah8	UTSW	17	30,662,091 (GRCm38)	missense	possibly damaging	0.95
R6988:Dnah8	UTSW	17	30,643,275 (GRCm38)	missense	probably damaging	1.00
R7099:Dnah8	UTSW	17	30,704,724 (GRCm38)	missense	possibly damaging	0.93
R7106:Dnah8	UTSW	17	30,741,178 (GRCm38)	missense	probably damaging	1.00
R7112:Dnah8	UTSW	17	30,871,392 (GRCm38)	missense	possibly damaging	0.79
R7146:Dnah8	UTSW	17	30,769,644 (GRCm38)	missense	possibly damaging	0.90
R7146:Dnah8	UTSW	17	30,644,617 (GRCm38)	missense	probably benign	0.01
R7309:Dnah8	UTSW	17	30,875,014 (GRCm38)	missense	probably damaging	1.00
R7324:Dnah8	UTSW	17	30,784,125 (GRCm38)	missense	probably benign	0.01
R7373:Dnah8	UTSW	17	30,767,965 (GRCm38)	critical splice donor site	probably null
R7423:Dnah8	UTSW	17	30,704,769 (GRCm38)	missense	possibly damaging	0.86
R7430:Dnah8	UTSW	17	30,706,389 (GRCm38)	missense	probably damaging	0.98
R7450:Dnah8	UTSW	17	30,787,191 (GRCm38)	missense	probably damaging	0.99
R7580:Dnah8	UTSW	17	30,775,103 (GRCm38)	missense	probably damaging	0.98
R7604:Dnah8	UTSW	17	30,813,095 (GRCm38)	missense	probably damaging	1.00
R7635:Dnah8	UTSW	17	30,785,107 (GRCm38)	missense	probably damaging	1.00
R7646:Dnah8	UTSW	17	30,649,677 (GRCm38)	missense	probably benign	0.00
R7685:Dnah8	UTSW	17	30,657,973 (GRCm38)	missense	probably damaging	1.00
R7793:Dnah8	UTSW	17	30,855,944 (GRCm38)	missense	probably benign	0.20
R7827:Dnah8	UTSW	17	30,760,867 (GRCm38)	frame shift	probably null
R7866:Dnah8	UTSW	17	30,874,927 (GRCm38)	missense	possibly damaging	0.94
R7877:Dnah8	UTSW	17	30,663,374 (GRCm38)	missense	probably benign
R7891:Dnah8	UTSW	17	30,712,289 (GRCm38)	missense	probably benign	0.09
R7977:Dnah8	UTSW	17	30,744,524 (GRCm38)	missense	probably damaging	1.00
R7987:Dnah8	UTSW	17	30,744,524 (GRCm38)	missense	probably damaging	1.00
R8025:Dnah8	UTSW	17	30,741,337 (GRCm38)	nonsense	probably null
R8076:Dnah8	UTSW	17	30,784,153 (GRCm38)	missense	possibly damaging	0.94
R8170:Dnah8	UTSW	17	30,673,823 (GRCm38)	missense	probably damaging	1.00
R8199:Dnah8	UTSW	17	30,871,419 (GRCm38)	missense	probably benign	0.06
R8253:Dnah8	UTSW	17	30,760,867 (GRCm38)	frame shift	probably null
R8270:Dnah8	UTSW	17	30,840,713 (GRCm38)	missense	probably damaging	1.00
R8291:Dnah8	UTSW	17	30,765,727 (GRCm38)	missense	probably damaging	1.00
R8334:Dnah8	UTSW	17	30,769,831 (GRCm38)	missense	probably benign	0.12
R8348:Dnah8	UTSW	17	30,673,840 (GRCm38)	missense	probably benign
R8348:Dnah8	UTSW	17	30,736,147 (GRCm38)	missense	probably damaging	0.96
R8354:Dnah8	UTSW	17	30,643,260 (GRCm38)	missense	probably benign	0.17
R8355:Dnah8	UTSW	17	30,695,178 (GRCm38)	missense	possibly damaging	0.89
R8439:Dnah8	UTSW	17	30,760,867 (GRCm38)	frame shift	probably null
R8448:Dnah8	UTSW	17	30,673,840 (GRCm38)	missense	probably benign
R8459:Dnah8	UTSW	17	30,725,247 (GRCm38)	critical splice donor site	probably null
R8462:Dnah8	UTSW	17	30,656,629 (GRCm38)	missense	probably damaging	1.00
R8506:Dnah8	UTSW	17	30,721,134 (GRCm38)	missense	probably benign
R8524:Dnah8	UTSW	17	30,715,498 (GRCm38)	missense	possibly damaging	0.95
R8555:Dnah8	UTSW	17	30,721,110 (GRCm38)	nonsense	probably null
R8698:Dnah8	UTSW	17	30,875,035 (GRCm38)	missense	probably damaging	1.00
R8719:Dnah8	UTSW	17	30,741,315 (GRCm38)	missense	probably damaging	0.97
R8778:Dnah8	UTSW	17	30,760,867 (GRCm38)	frame shift	probably null
R8781:Dnah8	UTSW	17	30,725,104 (GRCm38)	missense	probably damaging	1.00
R8821:Dnah8	UTSW	17	30,794,738 (GRCm38)	missense	probably damaging	1.00
R8864:Dnah8	UTSW	17	30,762,642 (GRCm38)	missense	possibly damaging	0.95
R8885:Dnah8	UTSW	17	30,708,312 (GRCm38)	missense	possibly damaging	0.83
R8983:Dnah8	UTSW	17	30,851,654 (GRCm38)	missense	probably damaging	0.98
R8994:Dnah8	UTSW	17	30,790,833 (GRCm38)	missense	probably benign	0.05
R9031:Dnah8	UTSW	17	30,737,427 (GRCm38)	missense	probably damaging	1.00
R9068:Dnah8	UTSW	17	30,756,755 (GRCm38)	missense	possibly damaging	0.63
R9225:Dnah8	UTSW	17	30,635,673 (GRCm38)	missense	probably benign	0.01
R9280:Dnah8	UTSW	17	30,785,097 (GRCm38)	missense	possibly damaging	0.52
R9291:Dnah8	UTSW	17	30,725,125 (GRCm38)	missense	probably damaging	1.00
R9314:Dnah8	UTSW	17	30,771,883 (GRCm38)	missense	probably benign
R9347:Dnah8	UTSW	17	30,708,359 (GRCm38)	missense	probably benign	0.00
R9393:Dnah8	UTSW	17	30,653,387 (GRCm38)	missense	possibly damaging	0.53
R9415:Dnah8	UTSW	17	30,810,323 (GRCm38)	missense	probably benign	0.02
R9458:Dnah8	UTSW	17	30,830,803 (GRCm38)	missense	probably damaging	1.00
R9465:Dnah8	UTSW	17	30,760,867 (GRCm38)	frame shift	probably null
R9518:Dnah8	UTSW	17	30,760,867 (GRCm38)	frame shift	probably null
R9524:Dnah8	UTSW	17	30,760,867 (GRCm38)	frame shift	probably null
R9564:Dnah8	UTSW	17	30,713,047 (GRCm38)	missense	probably benign	0.07
R9587:Dnah8	UTSW	17	30,760,867 (GRCm38)	frame shift	probably null
R9599:Dnah8	UTSW	17	30,760,867 (GRCm38)	frame shift	probably null
R9641:Dnah8	UTSW	17	30,713,055 (GRCm38)	missense	probably benign	0.13
R9674:Dnah8	UTSW	17	30,779,138 (GRCm38)	missense	possibly damaging	0.84
R9679:Dnah8	UTSW	17	30,818,141 (GRCm38)	missense	probably benign
R9789:Dnah8	UTSW	17	30,761,130 (GRCm38)	critical splice donor site	probably null
RF027:Dnah8	UTSW	17	30,635,476 (GRCm38)	frame shift	probably null
X0001:Dnah8	UTSW	17	30,748,680 (GRCm38)	missense	probably damaging	1.00
X0013:Dnah8	UTSW	17	30,819,186 (GRCm38)	missense	possibly damaging	0.71
Z1176:Dnah8	UTSW	17	30,648,540 (GRCm38)	missense	probably benign
Z1177:Dnah8	UTSW	17	30,713,095 (GRCm38)	missense	probably null	1.00
Z1177:Dnah8	UTSW	17	30,694,033 (GRCm38)	missense	probably benign

Predicted Primers

PCR Primer
(F):5'- TGACTTAGATGGGAATCTTTGCTC -3'
(R):5'- CAGAGGTGATTTGTGCAGCG -3'

Sequencing Primer
(F):5'- ATGGGAATCTTTGCTCTTAGTTTCTC -3'
(R):5'- ATTTGTGCAGCGAGAGTGG -3'

Posted On

2014-12-04