Incidental Mutation 'R2504:Celsr2'
| ID |
252095 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Celsr2
|
| Ensembl Gene |
ENSMUSG00000068740 |
| Gene Name |
cadherin, EGF LAG seven-pass G-type receptor 2 |
| Synonyms |
EGFL2, Adgrc2, flamingo, mfmi1 |
| MMRRC Submission |
040412-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R2504 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
3 |
| Chromosomal Location |
108298167-108323383 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 108320907 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Glutamic Acid
at position 635
(V635E)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000088046
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000090558]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000090558
AA Change: V635E
PolyPhen 2
Score 0.113 (Sensitivity: 0.93; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000088046
Gene: ENSMUSG00000068740
AA Change: V635E
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
31 |
N/A |
INTRINSIC |
|
low complexity region
|
35 |
53 |
N/A |
INTRINSIC |
|
CA
|
203 |
287 |
1.36e-26 |
SMART |
|
CA
|
311 |
397 |
1.33e-29 |
SMART |
|
CA
|
421 |
503 |
2.59e-27 |
SMART |
|
CA
|
527 |
608 |
3.33e-30 |
SMART |
|
CA
|
632 |
710 |
5.18e-18 |
SMART |
|
CA
|
734 |
813 |
1.08e-29 |
SMART |
|
CA
|
837 |
919 |
8.08e-29 |
SMART |
|
low complexity region
|
920 |
932 |
N/A |
INTRINSIC |
|
CA
|
943 |
1021 |
4.3e-24 |
SMART |
|
CA
|
1049 |
1125 |
1.87e-1 |
SMART |
|
low complexity region
|
1188 |
1198 |
N/A |
INTRINSIC |
|
EGF
|
1231 |
1286 |
1.81e-3 |
SMART |
|
EGF_CA
|
1288 |
1324 |
2.24e-8 |
SMART |
|
EGF
|
1331 |
1366 |
6.65e-2 |
SMART |
|
LamG
|
1387 |
1554 |
8.4e-30 |
SMART |
|
EGF
|
1577 |
1610 |
8e-5 |
SMART |
|
LamG
|
1636 |
1770 |
1.56e-24 |
SMART |
|
EGF
|
1796 |
1829 |
2.35e-2 |
SMART |
|
EGF
|
1831 |
1867 |
3.88e-3 |
SMART |
|
TNFR
|
1908 |
1943 |
1.35e-1 |
SMART |
|
EGF_Lam
|
1924 |
1969 |
9.54e-12 |
SMART |
|
HormR
|
1972 |
2034 |
1.57e-20 |
SMART |
|
Pfam:GAIN
|
2046 |
2289 |
3e-62 |
PFAM |
|
GPS
|
2315 |
2368 |
1.86e-25 |
SMART |
|
Pfam:7tm_2
|
2373 |
2605 |
1.1e-48 |
PFAM |
|
low complexity region
|
2715 |
2733 |
N/A |
INTRINSIC |
|
low complexity region
|
2857 |
2873 |
N/A |
INTRINSIC |
|
low complexity region
|
2874 |
2881 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.7%
- 10x: 97.4%
- 20x: 95.4%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for disruptions in this allele have mild to moderately dilated lateral ventricles in the brain but are otherwise normal. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(4) : Targeted, knock-out(1) Targeted, other(3)
|
| Other mutations in this stock |
Total: 113 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aatk |
T |
C |
11: 119,909,681 (GRCm39) |
D28G |
probably benign |
Het |
| Abcg1 |
T |
A |
17: 31,311,369 (GRCm39) |
S125T |
probably damaging |
Het |
| Actbl2 |
T |
C |
13: 111,392,717 (GRCm39) |
S351P |
possibly damaging |
Het |
| Ankrd34b |
A |
G |
13: 92,575,569 (GRCm39) |
|
probably null |
Het |
| BC051665 |
C |
T |
13: 60,930,468 (GRCm39) |
V295I |
probably benign |
Het |
| C1qtnf2 |
A |
G |
11: 43,381,983 (GRCm39) |
N265S |
probably damaging |
Het |
| Ccdc14 |
C |
T |
16: 34,542,220 (GRCm39) |
R573* |
probably null |
Het |
| Cd55b |
A |
T |
1: 130,337,612 (GRCm39) |
Y247N |
probably damaging |
Het |
| Clec16a |
T |
C |
16: 10,377,551 (GRCm39) |
|
probably benign |
Het |
| Clec4b1 |
A |
G |
6: 123,042,904 (GRCm39) |
Y41C |
probably damaging |
Het |
| Cntn5 |
A |
T |
9: 10,172,126 (GRCm39) |
D19E |
probably benign |
Het |
| Cop1 |
A |
G |
1: 159,060,375 (GRCm39) |
N53S |
probably damaging |
Het |
| Cplane1 |
G |
A |
15: 8,248,700 (GRCm39) |
E1750K |
probably damaging |
Het |
| Csad |
A |
T |
15: 102,097,102 (GRCm39) |
M1K |
probably null |
Het |
| Cyb5rl |
A |
G |
4: 106,938,142 (GRCm39) |
I200V |
probably benign |
Het |
| Cyp26a1 |
A |
G |
19: 37,686,790 (GRCm39) |
T81A |
probably damaging |
Het |
| Cyp2d12 |
A |
T |
15: 82,443,237 (GRCm39) |
H433L |
probably benign |
Het |
| D7Ertd443e |
T |
A |
7: 133,951,208 (GRCm39) |
|
probably null |
Het |
| Dennd1b |
A |
G |
1: 139,097,908 (GRCm39) |
|
probably benign |
Het |
| Dmap1 |
G |
T |
4: 117,532,495 (GRCm39) |
T357K |
probably damaging |
Het |
| Dzip1 |
G |
T |
14: 119,118,456 (GRCm39) |
T759K |
probably benign |
Het |
| Elmo2 |
A |
G |
2: 165,140,607 (GRCm39) |
V300A |
probably damaging |
Het |
| Eml5 |
T |
C |
12: 98,810,364 (GRCm39) |
D864G |
possibly damaging |
Het |
| Ep400 |
A |
G |
5: 110,816,511 (GRCm39) |
V2670A |
probably damaging |
Het |
| Epha3 |
T |
A |
16: 63,423,988 (GRCm39) |
I534F |
probably damaging |
Het |
| Epha4 |
A |
C |
1: 77,359,628 (GRCm39) |
Y742D |
probably damaging |
Het |
| Ergic2 |
A |
G |
6: 148,106,272 (GRCm39) |
|
probably null |
Het |
| Ero1a |
A |
T |
14: 45,536,545 (GRCm39) |
|
probably null |
Het |
| Fam229a |
A |
G |
4: 129,385,279 (GRCm39) |
D70G |
probably damaging |
Het |
| Fbn2 |
C |
T |
18: 58,226,431 (GRCm39) |
R781Q |
probably damaging |
Het |
| Fbxo16 |
A |
T |
14: 65,508,163 (GRCm39) |
|
probably benign |
Het |
| Fbxo39 |
T |
A |
11: 72,208,111 (GRCm39) |
S154R |
probably benign |
Het |
| Fer |
T |
A |
17: 64,298,575 (GRCm39) |
|
probably null |
Het |
| Filip1l |
A |
T |
16: 57,391,410 (GRCm39) |
D428V |
probably damaging |
Het |
| Filip1l |
A |
G |
16: 57,391,025 (GRCm39) |
I538V |
possibly damaging |
Het |
| Fsip2 |
T |
C |
2: 82,809,954 (GRCm39) |
I2091T |
possibly damaging |
Het |
| Glyat |
A |
C |
19: 12,628,762 (GRCm39) |
T186P |
possibly damaging |
Het |
| Gm10604 |
A |
G |
4: 11,980,083 (GRCm39) |
S74P |
unknown |
Het |
| Gm4787 |
T |
G |
12: 81,425,911 (GRCm39) |
K82N |
possibly damaging |
Het |
| Hectd4 |
T |
C |
5: 121,358,683 (GRCm39) |
I50T |
unknown |
Het |
| Hectd4 |
T |
C |
5: 121,402,030 (GRCm39) |
S373P |
possibly damaging |
Het |
| Hmcn1 |
A |
T |
1: 150,562,618 (GRCm39) |
C2313* |
probably null |
Het |
| Hrob |
T |
C |
11: 102,146,122 (GRCm39) |
Y133H |
possibly damaging |
Het |
| Igfn1 |
A |
T |
1: 135,897,054 (GRCm39) |
S1171T |
probably benign |
Het |
| Ints8 |
T |
C |
4: 11,241,642 (GRCm39) |
D267G |
probably benign |
Het |
| Itln1 |
A |
G |
1: 171,356,727 (GRCm39) |
C251R |
probably damaging |
Het |
| Jcad |
C |
T |
18: 4,674,026 (GRCm39) |
T596M |
probably damaging |
Het |
| Kcnj16 |
C |
T |
11: 110,916,409 (GRCm39) |
T357M |
probably benign |
Het |
| Kif13a |
G |
A |
13: 46,967,676 (GRCm39) |
T346M |
probably damaging |
Het |
| Klhl24 |
G |
A |
16: 19,938,917 (GRCm39) |
A491T |
probably benign |
Het |
| Kntc1 |
C |
T |
5: 123,916,410 (GRCm39) |
Q748* |
probably null |
Het |
| Krt25 |
T |
A |
11: 99,208,122 (GRCm39) |
K369* |
probably null |
Het |
| Krt75 |
C |
T |
15: 101,476,466 (GRCm39) |
R433Q |
probably benign |
Het |
| Krt76 |
A |
G |
15: 101,793,293 (GRCm39) |
F582L |
unknown |
Het |
| Lysmd1 |
G |
A |
3: 95,045,708 (GRCm39) |
V182I |
probably benign |
Het |
| Mab21l2 |
T |
A |
3: 86,454,862 (GRCm39) |
E46V |
probably damaging |
Het |
| Magi2 |
A |
T |
5: 20,563,934 (GRCm39) |
K355N |
probably damaging |
Het |
| Marchf10 |
T |
C |
11: 105,276,398 (GRCm39) |
D630G |
probably damaging |
Het |
| Mast4 |
A |
T |
13: 102,875,147 (GRCm39) |
I1215N |
probably damaging |
Het |
| Nckap1 |
G |
A |
2: 80,360,562 (GRCm39) |
T523I |
probably benign |
Het |
| Nexmif |
T |
A |
X: 103,127,999 (GRCm39) |
D1306V |
probably damaging |
Het |
| Nfkb1 |
A |
C |
3: 135,295,090 (GRCm39) |
I918R |
possibly damaging |
Het |
| Nt5el |
A |
G |
13: 105,246,250 (GRCm39) |
I270M |
probably benign |
Het |
| Nup50 |
A |
T |
15: 84,817,859 (GRCm39) |
T93S |
probably benign |
Het |
| Nwd2 |
T |
C |
5: 63,961,717 (GRCm39) |
Y434H |
probably benign |
Het |
| Or13a28 |
T |
C |
7: 140,218,397 (GRCm39) |
V261A |
probably benign |
Het |
| Osbpl1a |
C |
A |
18: 13,038,088 (GRCm39) |
V288L |
probably benign |
Het |
| Pan3 |
A |
G |
5: 147,463,846 (GRCm39) |
E562G |
possibly damaging |
Het |
| Pappa |
T |
A |
4: 65,099,126 (GRCm39) |
Y548* |
probably null |
Het |
| Phf3 |
A |
T |
1: 30,849,870 (GRCm39) |
L1181Q |
probably damaging |
Het |
| Phip |
T |
C |
9: 82,797,392 (GRCm39) |
H537R |
possibly damaging |
Het |
| Pkhd1l1 |
T |
C |
15: 44,348,824 (GRCm39) |
I240T |
probably damaging |
Het |
| Pole |
G |
A |
5: 110,438,368 (GRCm39) |
|
probably null |
Het |
| Polq |
T |
A |
16: 36,832,304 (GRCm39) |
S15T |
unknown |
Het |
| Prrt2 |
T |
C |
7: 126,619,396 (GRCm39) |
E23G |
possibly damaging |
Het |
| Prss37 |
A |
T |
6: 40,494,760 (GRCm39) |
|
probably null |
Het |
| Prune2 |
T |
C |
19: 16,977,400 (GRCm39) |
L45P |
probably damaging |
Het |
| Psd |
A |
T |
19: 46,313,352 (GRCm39) |
M6K |
possibly damaging |
Het |
| Psmd1 |
A |
G |
1: 86,017,719 (GRCm39) |
E510G |
possibly damaging |
Het |
| Ptch1 |
T |
G |
13: 63,672,773 (GRCm39) |
E944A |
probably benign |
Het |
| Pxdn |
T |
A |
12: 30,053,405 (GRCm39) |
I1194N |
probably damaging |
Het |
| Rbp3 |
C |
T |
14: 33,677,975 (GRCm39) |
T641M |
probably damaging |
Het |
| Rgmb |
C |
A |
17: 16,027,909 (GRCm39) |
R270L |
probably benign |
Het |
| Rpgrip1l |
A |
G |
8: 92,007,344 (GRCm39) |
|
probably null |
Het |
| Rps2 |
G |
A |
17: 24,939,353 (GRCm39) |
|
probably benign |
Het |
| Rsbn1l |
G |
T |
5: 21,107,364 (GRCm39) |
A550E |
probably damaging |
Het |
| S1pr4 |
C |
T |
10: 81,335,138 (GRCm39) |
R112H |
probably benign |
Het |
| Scfd2 |
T |
C |
5: 74,691,838 (GRCm39) |
N148S |
probably damaging |
Het |
| Scin |
C |
T |
12: 40,131,705 (GRCm39) |
M276I |
probably benign |
Het |
| Sec24d |
T |
C |
3: 123,147,255 (GRCm39) |
I708T |
possibly damaging |
Het |
| Skint11 |
T |
A |
4: 114,086,009 (GRCm39) |
F41I |
possibly damaging |
Het |
| Slc15a4 |
A |
T |
5: 127,694,303 (GRCm39) |
F44Y |
possibly damaging |
Het |
| Slc6a18 |
A |
G |
13: 73,823,925 (GRCm39) |
Y72H |
probably benign |
Het |
| Slc7a11 |
A |
T |
3: 50,332,195 (GRCm39) |
|
probably null |
Het |
| Slc7a14 |
G |
T |
3: 31,291,650 (GRCm39) |
N209K |
possibly damaging |
Het |
| Sstr2 |
T |
C |
11: 113,515,257 (GRCm39) |
C59R |
probably damaging |
Het |
| Stab1 |
A |
G |
14: 30,884,997 (GRCm39) |
|
probably null |
Het |
| Stag1 |
G |
T |
9: 100,748,263 (GRCm39) |
S475I |
probably damaging |
Het |
| Stxbp5l |
A |
G |
16: 36,936,029 (GRCm39) |
Y1183H |
probably damaging |
Het |
| Svep1 |
A |
T |
4: 58,135,628 (GRCm39) |
|
probably null |
Het |
| Tm9sf2 |
A |
G |
14: 122,396,096 (GRCm39) |
T653A |
probably benign |
Het |
| Tmeff1 |
T |
C |
4: 48,662,059 (GRCm39) |
S366P |
possibly damaging |
Het |
| Tnnt2 |
G |
T |
1: 135,779,803 (GRCm39) |
W300L |
probably damaging |
Het |
| Traj32 |
A |
G |
14: 54,423,560 (GRCm39) |
|
probably benign |
Het |
| Trp53bp2 |
A |
T |
1: 182,269,204 (GRCm39) |
M223L |
probably benign |
Het |
| Tsga10 |
G |
A |
1: 37,854,758 (GRCm39) |
T246M |
probably damaging |
Het |
| Txn2 |
A |
T |
15: 77,810,870 (GRCm39) |
|
probably benign |
Het |
| Ubr3 |
T |
A |
2: 69,768,542 (GRCm39) |
F450I |
probably damaging |
Het |
| Usp47 |
T |
C |
7: 111,703,677 (GRCm39) |
|
probably null |
Het |
| Vars2 |
C |
T |
17: 35,975,685 (GRCm39) |
R244Q |
probably damaging |
Het |
| Xrra1 |
T |
A |
7: 99,546,803 (GRCm39) |
F251L |
probably damaging |
Het |
| Zfp804a |
G |
A |
2: 82,087,863 (GRCm39) |
R564Q |
probably benign |
Het |
| Zfp983 |
T |
C |
17: 21,877,883 (GRCm39) |
C29R |
probably damaging |
Het |
|
| Other mutations in Celsr2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00898:Celsr2
|
APN |
3 |
108,321,195 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
IGL01020:Celsr2
|
APN |
3 |
108,310,586 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01420:Celsr2
|
APN |
3 |
108,301,079 (GRCm39) |
missense |
probably benign |
0.13 |
|
IGL01448:Celsr2
|
APN |
3 |
108,300,555 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01559:Celsr2
|
APN |
3 |
108,314,183 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
IGL01674:Celsr2
|
APN |
3 |
108,322,159 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01863:Celsr2
|
APN |
3 |
108,301,338 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02309:Celsr2
|
APN |
3 |
108,303,327 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02325:Celsr2
|
APN |
3 |
108,320,187 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02409:Celsr2
|
APN |
3 |
108,321,271 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02514:Celsr2
|
APN |
3 |
108,304,826 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02812:Celsr2
|
APN |
3 |
108,321,429 (GRCm39) |
missense |
probably benign |
0.25 |
|
IGL02894:Celsr2
|
APN |
3 |
108,302,526 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03281:Celsr2
|
APN |
3 |
108,320,256 (GRCm39) |
missense |
probably damaging |
1.00 |
|
barrow
|
UTSW |
3 |
108,302,281 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
goldeneye
|
UTSW |
3 |
108,302,235 (GRCm39) |
missense |
probably damaging |
1.00 |
|
1mM(1):Celsr2
|
UTSW |
3 |
108,308,154 (GRCm39) |
missense |
probably benign |
0.01 |
|
ANU74:Celsr2
|
UTSW |
3 |
108,319,815 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02799:Celsr2
|
UTSW |
3 |
108,321,378 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0011:Celsr2
|
UTSW |
3 |
108,320,718 (GRCm39) |
missense |
probably benign |
0.19 |
|
R0031:Celsr2
|
UTSW |
3 |
108,320,379 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0049:Celsr2
|
UTSW |
3 |
108,304,570 (GRCm39) |
missense |
probably benign |
0.12 |
|
R0049:Celsr2
|
UTSW |
3 |
108,304,570 (GRCm39) |
missense |
probably benign |
0.12 |
|
R0090:Celsr2
|
UTSW |
3 |
108,300,643 (GRCm39) |
splice site |
probably benign |
|
|
R0140:Celsr2
|
UTSW |
3 |
108,305,249 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0524:Celsr2
|
UTSW |
3 |
108,308,903 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0607:Celsr2
|
UTSW |
3 |
108,311,211 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0662:Celsr2
|
UTSW |
3 |
108,305,836 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0690:Celsr2
|
UTSW |
3 |
108,322,293 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0691:Celsr2
|
UTSW |
3 |
108,319,939 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0710:Celsr2
|
UTSW |
3 |
108,320,028 (GRCm39) |
missense |
probably benign |
0.42 |
|
R0730:Celsr2
|
UTSW |
3 |
108,305,922 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0815:Celsr2
|
UTSW |
3 |
108,308,617 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R0848:Celsr2
|
UTSW |
3 |
108,321,654 (GRCm39) |
missense |
probably benign |
|
|
R0989:Celsr2
|
UTSW |
3 |
108,310,588 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1185:Celsr2
|
UTSW |
3 |
108,307,025 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1185:Celsr2
|
UTSW |
3 |
108,307,025 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1185:Celsr2
|
UTSW |
3 |
108,307,025 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1469:Celsr2
|
UTSW |
3 |
108,321,424 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1469:Celsr2
|
UTSW |
3 |
108,321,424 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1474:Celsr2
|
UTSW |
3 |
108,301,055 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R1608:Celsr2
|
UTSW |
3 |
108,309,799 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1653:Celsr2
|
UTSW |
3 |
108,320,836 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R1659:Celsr2
|
UTSW |
3 |
108,321,411 (GRCm39) |
missense |
probably benign |
|
|
R1689:Celsr2
|
UTSW |
3 |
108,314,620 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R1848:Celsr2
|
UTSW |
3 |
108,308,626 (GRCm39) |
missense |
probably benign |
0.35 |
|
R1859:Celsr2
|
UTSW |
3 |
108,303,946 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1918:Celsr2
|
UTSW |
3 |
108,305,966 (GRCm39) |
missense |
probably benign |
0.05 |
|
R1974:Celsr2
|
UTSW |
3 |
108,321,530 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2042:Celsr2
|
UTSW |
3 |
108,309,811 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2167:Celsr2
|
UTSW |
3 |
108,320,509 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R2333:Celsr2
|
UTSW |
3 |
108,305,921 (GRCm39) |
missense |
probably benign |
0.16 |
|
R2434:Celsr2
|
UTSW |
3 |
108,311,795 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3420:Celsr2
|
UTSW |
3 |
108,321,732 (GRCm39) |
missense |
probably benign |
0.03 |
|
R3712:Celsr2
|
UTSW |
3 |
108,308,155 (GRCm39) |
missense |
probably benign |
|
|
R3723:Celsr2
|
UTSW |
3 |
108,304,731 (GRCm39) |
splice site |
probably benign |
|
|
R3809:Celsr2
|
UTSW |
3 |
108,310,555 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R4018:Celsr2
|
UTSW |
3 |
108,302,281 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R4126:Celsr2
|
UTSW |
3 |
108,309,413 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R4177:Celsr2
|
UTSW |
3 |
108,321,294 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4232:Celsr2
|
UTSW |
3 |
108,321,088 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4293:Celsr2
|
UTSW |
3 |
108,300,993 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4458:Celsr2
|
UTSW |
3 |
108,302,313 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4621:Celsr2
|
UTSW |
3 |
108,302,532 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R4645:Celsr2
|
UTSW |
3 |
108,303,285 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4700:Celsr2
|
UTSW |
3 |
108,304,547 (GRCm39) |
missense |
probably benign |
0.24 |
|
R4732:Celsr2
|
UTSW |
3 |
108,306,268 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4733:Celsr2
|
UTSW |
3 |
108,306,268 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4901:Celsr2
|
UTSW |
3 |
108,314,303 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R4932:Celsr2
|
UTSW |
3 |
108,310,074 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4989:Celsr2
|
UTSW |
3 |
108,319,945 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R5052:Celsr2
|
UTSW |
3 |
108,319,674 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5093:Celsr2
|
UTSW |
3 |
108,320,689 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R5114:Celsr2
|
UTSW |
3 |
108,301,312 (GRCm39) |
missense |
probably benign |
0.05 |
|
R5120:Celsr2
|
UTSW |
3 |
108,300,436 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5135:Celsr2
|
UTSW |
3 |
108,305,975 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5247:Celsr2
|
UTSW |
3 |
108,304,946 (GRCm39) |
missense |
probably benign |
0.34 |
|
R5381:Celsr2
|
UTSW |
3 |
108,310,073 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5412:Celsr2
|
UTSW |
3 |
108,307,311 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5445:Celsr2
|
UTSW |
3 |
108,299,974 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5528:Celsr2
|
UTSW |
3 |
108,320,610 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5598:Celsr2
|
UTSW |
3 |
108,310,119 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R5652:Celsr2
|
UTSW |
3 |
108,304,051 (GRCm39) |
missense |
probably null |
0.49 |
|
R5697:Celsr2
|
UTSW |
3 |
108,311,237 (GRCm39) |
nonsense |
probably null |
|
|
R5718:Celsr2
|
UTSW |
3 |
108,300,674 (GRCm39) |
missense |
probably benign |
|
|
R5869:Celsr2
|
UTSW |
3 |
108,321,225 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5876:Celsr2
|
UTSW |
3 |
108,321,259 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6021:Celsr2
|
UTSW |
3 |
108,308,561 (GRCm39) |
missense |
probably benign |
|
|
R6054:Celsr2
|
UTSW |
3 |
108,314,279 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R6244:Celsr2
|
UTSW |
3 |
108,300,444 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6313:Celsr2
|
UTSW |
3 |
108,308,530 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6322:Celsr2
|
UTSW |
3 |
108,319,890 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6555:Celsr2
|
UTSW |
3 |
108,302,235 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6682:Celsr2
|
UTSW |
3 |
108,307,817 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7062:Celsr2
|
UTSW |
3 |
108,309,826 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R7110:Celsr2
|
UTSW |
3 |
108,305,181 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7139:Celsr2
|
UTSW |
3 |
108,322,675 (GRCm39) |
missense |
unknown |
|
|
R7326:Celsr2
|
UTSW |
3 |
108,302,311 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R7425:Celsr2
|
UTSW |
3 |
108,309,773 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7452:Celsr2
|
UTSW |
3 |
108,320,406 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R7461:Celsr2
|
UTSW |
3 |
108,302,956 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7502:Celsr2
|
UTSW |
3 |
108,306,218 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7613:Celsr2
|
UTSW |
3 |
108,302,956 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7644:Celsr2
|
UTSW |
3 |
108,320,806 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7666:Celsr2
|
UTSW |
3 |
108,305,904 (GRCm39) |
missense |
probably benign |
|
|
R7687:Celsr2
|
UTSW |
3 |
108,305,085 (GRCm39) |
missense |
probably benign |
0.27 |
|
R7695:Celsr2
|
UTSW |
3 |
108,310,069 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8002:Celsr2
|
UTSW |
3 |
108,311,285 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8052:Celsr2
|
UTSW |
3 |
108,319,971 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8283:Celsr2
|
UTSW |
3 |
108,303,771 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8356:Celsr2
|
UTSW |
3 |
108,320,847 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R8381:Celsr2
|
UTSW |
3 |
108,302,952 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8427:Celsr2
|
UTSW |
3 |
108,299,949 (GRCm39) |
makesense |
probably null |
|
|
R8435:Celsr2
|
UTSW |
3 |
108,321,715 (GRCm39) |
missense |
probably benign |
|
|
R8438:Celsr2
|
UTSW |
3 |
108,301,139 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8458:Celsr2
|
UTSW |
3 |
108,306,218 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8460:Celsr2
|
UTSW |
3 |
108,304,093 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R8462:Celsr2
|
UTSW |
3 |
108,320,167 (GRCm39) |
nonsense |
probably null |
|
|
R8479:Celsr2
|
UTSW |
3 |
108,306,218 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8480:Celsr2
|
UTSW |
3 |
108,306,218 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8512:Celsr2
|
UTSW |
3 |
108,321,154 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8694:Celsr2
|
UTSW |
3 |
108,314,176 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8772:Celsr2
|
UTSW |
3 |
108,304,389 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R8843:Celsr2
|
UTSW |
3 |
108,303,443 (GRCm39) |
splice site |
probably benign |
|
|
R8888:Celsr2
|
UTSW |
3 |
108,320,880 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8895:Celsr2
|
UTSW |
3 |
108,320,880 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8917:Celsr2
|
UTSW |
3 |
108,303,882 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9119:Celsr2
|
UTSW |
3 |
108,309,288 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R9169:Celsr2
|
UTSW |
3 |
108,309,862 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9209:Celsr2
|
UTSW |
3 |
108,321,349 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9342:Celsr2
|
UTSW |
3 |
108,320,442 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9416:Celsr2
|
UTSW |
3 |
108,322,084 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9493:Celsr2
|
UTSW |
3 |
108,301,074 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9564:Celsr2
|
UTSW |
3 |
108,321,834 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9598:Celsr2
|
UTSW |
3 |
108,322,578 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R9629:Celsr2
|
UTSW |
3 |
108,308,915 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9691:Celsr2
|
UTSW |
3 |
108,301,551 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0020:Celsr2
|
UTSW |
3 |
108,303,426 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0050:Celsr2
|
UTSW |
3 |
108,308,588 (GRCm39) |
missense |
probably benign |
0.09 |
|
Z1088:Celsr2
|
UTSW |
3 |
108,321,433 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Celsr2
|
UTSW |
3 |
108,319,657 (GRCm39) |
missense |
probably benign |
0.07 |
|
Z1176:Celsr2
|
UTSW |
3 |
108,300,447 (GRCm39) |
missense |
probably benign |
0.10 |
|
Z1177:Celsr2
|
UTSW |
3 |
108,320,887 (GRCm39) |
missense |
probably benign |
0.32 |
|
Z1177:Celsr2
|
UTSW |
3 |
108,319,536 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1191:Celsr2
|
UTSW |
3 |
108,321,865 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGTTGGCATCGGTGACATTC -3'
(R):5'- GAAGAGGTTGATTTCTACAGCTTTG -3'
Sequencing Primer
(F):5'- GTTGGCATCGGTGACATTCACTAC -3'
(R):5'- ACAGCTTTGGTGTAGAGGCCC -3'
|
| Posted On |
2014-12-04 |
Incidental Mutation