Incidental Mutation 'IGL00225:Ivns1abp'
ID2523
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ivns1abp
Ensembl Gene ENSMUSG00000023150
Gene Nameinfluenza virus NS1A binding protein
SynonymsNS-1, Nd1-L, Nd1-S, 1700126I16Rik, 1190004M08Rik, ND1, HSPC068, NS1-BP
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.437) question?
Stock #IGL00225
Quality Score
Status
Chromosome1
Chromosomal Location151344477-151364422 bp(+) (GRCm38)
Type of Mutationsplice site (3 bp from exon)
DNA Base Change (assembly) A to G at 151351112 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000107518 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023918] [ENSMUST00000097543] [ENSMUST00000111887] [ENSMUST00000186745]
Predicted Effect probably null
Transcript: ENSMUST00000023918
SMART Domains Protein: ENSMUSP00000023918
Gene: ENSMUSG00000023150

DomainStartEndE-ValueType
BTB 32 129 1.89e-25 SMART
BACK 134 233 3.39e-8 SMART
low complexity region 325 338 N/A INTRINSIC
Kelch 369 415 4.78e-15 SMART
Kelch 416 463 2.16e-13 SMART
Kelch 464 512 2.15e-8 SMART
Kelch 513 559 1.58e-15 SMART
Kelch 560 606 1.61e-12 SMART
Kelch 607 641 1.85e-1 SMART
Predicted Effect probably null
Transcript: ENSMUST00000097543
SMART Domains Protein: ENSMUSP00000095150
Gene: ENSMUSG00000023150

DomainStartEndE-ValueType
BTB 32 129 1.89e-25 SMART
Pfam:BACK 134 189 3.3e-8 PFAM
low complexity region 283 296 N/A INTRINSIC
Kelch 327 373 4.78e-15 SMART
Kelch 374 421 2.16e-13 SMART
Kelch 422 470 2.15e-8 SMART
Kelch 471 517 1.58e-15 SMART
Kelch 518 564 1.61e-12 SMART
Kelch 565 599 1.85e-1 SMART
Predicted Effect probably null
Transcript: ENSMUST00000111887
SMART Domains Protein: ENSMUSP00000107518
Gene: ENSMUSG00000023150

DomainStartEndE-ValueType
BTB 32 129 1.89e-25 SMART
BACK 134 219 7.04e-6 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000186745
SMART Domains Protein: ENSMUSP00000140708
Gene: ENSMUSG00000023150

DomainStartEndE-ValueType
BTB 32 129 1.89e-25 SMART
BACK 134 219 7.04e-6 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit some early lethality, increased cellular sensitivity to cytochalasin and doxorubicin, and doxorubicin-induced cardiotoxicity. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 20 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Flii T C 11: 60,723,415 N93D probably benign Het
Gm8356 T C 14: 6,537,141 K24E probably damaging Het
Hars G A 18: 36,768,172 T409M probably damaging Het
Kcnq4 G A 4: 120,698,016 Q657* probably null Het
Kdm4c T G 4: 74,345,567 V696G probably benign Het
Klrb1f T A 6: 129,053,175 probably benign Het
Lrp4 G A 2: 91,495,026 V1399I probably benign Het
Mki67 A G 7: 135,690,120 V3168A probably benign Het
Nf1 T A 11: 79,395,905 I177K probably damaging Het
Nnt A T 13: 119,369,997 N371K probably damaging Het
Olfr472 C T 7: 107,903,104 P129L probably damaging Het
Olfr60 A G 7: 140,345,210 Y260H probably damaging Het
Oraov1 G A 7: 144,917,668 G86D possibly damaging Het
Prkdc G T 16: 15,809,644 V3389L possibly damaging Het
Prr16 T A 18: 51,303,120 Y224N possibly damaging Het
Ptgs1 G A 2: 36,237,219 C39Y probably damaging Het
Sla T C 15: 66,782,630 D269G possibly damaging Het
Stk38l T A 6: 146,758,473 M1K probably null Het
Trim24 T A 6: 37,903,648 N160K possibly damaging Het
Zfp451 A G 1: 33,786,540 probably benign Het
Other mutations in Ivns1abp
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01616:Ivns1abp APN 1 151361543 missense possibly damaging 0.69
IGL02061:Ivns1abp APN 1 151351573 missense probably damaging 0.97
IGL02630:Ivns1abp APN 1 151359635 missense probably damaging 1.00
H8562:Ivns1abp UTSW 1 151354695 missense probably damaging 0.98
PIT1430001:Ivns1abp UTSW 1 151361605 missense probably damaging 1.00
R0107:Ivns1abp UTSW 1 151361570 missense probably damaging 0.99
R0609:Ivns1abp UTSW 1 151360145 missense probably benign 0.02
R1104:Ivns1abp UTSW 1 151360109 missense probably benign 0.42
R1463:Ivns1abp UTSW 1 151361540 missense probably benign 0.05
R1512:Ivns1abp UTSW 1 151360936 missense possibly damaging 0.87
R1512:Ivns1abp UTSW 1 151360937 missense probably benign 0.02
R1521:Ivns1abp UTSW 1 151351558 missense probably damaging 1.00
R1550:Ivns1abp UTSW 1 151361491 missense probably damaging 1.00
R2047:Ivns1abp UTSW 1 151351631 missense possibly damaging 0.83
R2435:Ivns1abp UTSW 1 151363310 missense probably benign 0.04
R4471:Ivns1abp UTSW 1 151361239 missense probably benign 0.29
R5011:Ivns1abp UTSW 1 151363202 missense possibly damaging 0.76
R5667:Ivns1abp UTSW 1 151354009 missense probably benign 0.01
R5671:Ivns1abp UTSW 1 151354009 missense probably benign 0.01
R6505:Ivns1abp UTSW 1 151360993 missense probably benign 0.00
Z1176:Ivns1abp UTSW 1 151351033 missense probably damaging 0.99
Posted On2011-12-09